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Inflammation Research
Erschienen in: Inflammation Research 9/2018

14.07.2018 | Review

Emerging role of lncRNAs in the normal and diseased intestinal barrier

verfasst von: Jie Chen, Jianhua Wan, Jianfang Ye, Liang Xia, Nonghua Lu

Erschienen in: Inflammation Research | Ausgabe 9/2018

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Abstract

Objective

A significant effort has been made to understand the intestinal barrier, but the effective means to prevent, reduce, and restore intestinal mucosal damage remains unclear. Recently, a few of studies have explained the mechanism of the intestinal barrier in long noncoding RNAs (lncRNAs). This review aims to summarize recent views on the function of lncRNAs in the intestinal barrier and discuss the emerging role of lncRNAs in intestinal barrier diseases caused by inflammatory diseases.

Methods

Observations led us to believe that lncRNAs participate in inflammatory responses, cell proliferation, and control microbial susceptibility. In view of these, lncRNAs have been proved to involve in the intestinal barrier.

Results

lncRNAs directly or indirectly affect TJ mRNA translation and intestinal epithelial cells (IECs) paracellular permeability, as well as IECs proliferation and susceptibility to apoptosis, to modulate the function of the intestinal barrier. miRNAs play a pivotal role in this process.

Conclusions

lncRNAs have been shown to be fundamentally involved in intestinal mucosal regeneration, protection, and epithelial barrier function. It may emerge as new and potential factors to be evaluated in the intestinal barrier diseases caused by acute pancreatitis, inflammatory bowel diseases, and imbalance of intestinal flora.
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Metadaten
Titel
Emerging role of lncRNAs in the normal and diseased intestinal barrier
verfasst von
Jie Chen
Jianhua Wan
Jianfang Ye
Liang Xia
Nonghua Lu
Publikationsdatum
14.07.2018
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 9/2018
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-018-1170-7

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