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Erschienen in: Endocrine 2/2022

27.04.2022 | Review

Endocrine disruptor chemicals, adipokines and reproductive functions

verfasst von: Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Natalia Respekta, Karolina Pich, Loïse Serra, Joëlle Dupont, Agnieszka Rak

Erschienen in: Endocrine | Ausgabe 2/2022

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Abstract

The prevalence of adult obesity has risen markedly in recent decades. The endocrine system precisely regulates energy balance, fat abundance and fat deposition. Interestingly, white adipose tissue is an endocrine gland producing adipokines, which regulate whole-body physiology, including energy balance and reproduction. Endocrine disruptor chemicals (EDCs) include natural substances or chemicals that affect the endocrine system by multiple mechanisms and increase the risk of adverse health outcomes. Numerous studies have associated exposure to EDCs with obesity, classifying them as obesogens by their ability to activate different mechanisms, including the differentiation of adipocytes, increasing the storage of triglycerides, or elevating the number of adipocytes. Moreover, in recent years, not only industrial deception and obesity have intensified but also the problem of human infertility. Reproductive functions depend on hormone interactions, the balance of which may be disrupted by various EDCs or obesity. This review gives a brief summary of common EDCs linked with obesity, the mechanisms of their action, and the effect on adipokine levels, reproduction and connected disorders, such as polycystic ovarian syndrome, decrease in sperm motility, preeclampsia, intrauterine growth restriction in females and decrease of sperm motility in males.
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Metadaten
Titel
Endocrine disruptor chemicals, adipokines and reproductive functions
verfasst von
Patrycja Kurowska
Ewa Mlyczyńska
Monika Dawid
Natalia Respekta
Karolina Pich
Loïse Serra
Joëlle Dupont
Agnieszka Rak
Publikationsdatum
27.04.2022
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-022-03061-4

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