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18.02.2019 | Review | Ausgabe 8/2019

Digestive Diseases and Sciences 8/2019

Endocut Versus Conventional Blended Electrosurgical Current for Endoscopic Biliary Sphincterotomy: A Meta-Analysis of Complications

Zeitschrift:
Digestive Diseases and Sciences > Ausgabe 8/2019
Autoren:
De-feng Li, Mei-feng Yang, Xin Chang, Nan-nan Wang, Fang-fang Tan, Hai-na Xie, Xue Fang, Shu-ling Wang, Wei Fan, Jian-yao Wang, Zhi-chao Yu, Cheng Wei, Feng Xiong, Ting-ting Liu, Ming-han Luo, Li-sheng Wang, Zhao-shen Li, Jun Yao, Yu Bai
Wichtige Hinweise
De-feng Li, Mei-feng Yang, Xin Chang, Nan-nan Wang, Fang-fang Tan and Hai-na Xie contributed equally to the manuscript.
Li-sheng Wang, Zhao-shen Li, Jun Yao and Yu Bai share co-corresponding authorship.

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Abstract

Background and Aims

Endoscopic biliary sphincterotomy (EST) is commonly performed during therapeutic endoscopic retrograde cholangiopancreatography (ERCP), but is an independent risk factor for post-ERCP pancreatitis, bleeding and duodenal perforation. These are partly ascribed to the electrosurgical current mode used for EST, and currently the optimal current model for EST remains controversial. In this study, we aimed to compare the rate of complications undergoing EST using the Endocut versus the blended current.

Methods

A systematic search of databases was performed for relevant published and prospective studies including randomized clinical trials (RCTs) to compare Endocut with blended current modes for EST. Data were collected from inception until 1 July 2018, using post-ERCP pancreatitis, bleeding and perforation as primary outcomes.

Results

Three RCTs including a total of 594 patients met the inclusion criteria. Our meta-analysis results showed the rate of post-ERCP pancreatitis, primarily mild to moderate pancreatitis, was no different between Endocut versus blended current modes [risk ratio (RR) 0.61, 95% confidence interval (CI) 0.25–1.52, P = 0.29]. However, the risk of endoscopically bleeding events, primarily mild bleeding, was lower in studies using Endocut versus blended current (RR 0.54, 95% CI 0.31–0.95, P = 0.03). Notably, none of the patients experienced perforation in these three trials.

Conclusions

The rate of post-ERCP pancreatitis was not significantly different when using the Endocut versus blended current during EST. Nevertheless, compared with the blended current, Endocut reduced the incidence of endoscopically evident bleeding; however, the available data were insufficient to assess the perforation risk.

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