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Archives of Gynecology and Obstetrics
Erschienen in:

06.04.2019 | Gynecologic Endocrinology and Reproductive Medicine

Endometrial human chorionic gonadotropin (hCG) expression is a marker for adequate secretory transformation of the endometrium

verfasst von: Sindy Schug, Anja Baunacke, Maren Goeckenjan, Lars-Christian Horn, Gabriele Pretzsch, Gerolf Zimmermann, Henry Alexander

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2019

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Abstract

Purpose

Successful embryo implantation into the endometrium depends on embryonic characteristics and proper endometrial development. Reproductive medicine often focuses on embryo quality, whereas reliable diagnostic tests for endometrial receptivity are still needed. We previously found that human chorionic gonadotropin (hCG), one of the earliest proteins secreted by the embryo, was also expressed by the luteal phase endometrium around the implantation window. Here, we tested our hypothesis of endometrial hCG as an implantation marker.

Methods

Endometrial biopsies and serum samples were taken from patients undergoing routine infertility diagnostics. Correlations of immunohistochemically detected endometrial hCG expression with adequate endometrial secretory transformation, the infiltration of CD45-positive leukocytes, clinical diagnostic parameters, and endometrial thickness were analyzed.

Results

A highly significant correlation between the endometrial score, as a measurement for regular secretory transformation, and the intensity of hCG staining was found. The invasion of CD45-positive leukocytes increased with progressing endometrial secretory transformation and rising endometrial hCG expression. In addition, serum progesterone concentrations correlated with hCG expression by the endometrial glands.

Conclusions

Our results suggest endometrial hCG as a possible diagnostic parameter characterizing the endometrial secretory transformation and, thus, possibly also its implantation capability.
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Metadaten
Titel
Endometrial human chorionic gonadotropin (hCG) expression is a marker for adequate secretory transformation of the endometrium
verfasst von
Sindy Schug
Anja Baunacke
Maren Goeckenjan
Lars-Christian Horn
Gabriele Pretzsch
Gerolf Zimmermann
Henry Alexander
Publikationsdatum
06.04.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 6/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-019-05130-y

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