Background
Methods
Results
Characteristics of the study population
Characteristics | All (N = 125) | NEM (N = 70) | EM (N = 55) | p value |
---|---|---|---|---|
Age (years) | 51.6 ± 7.8 | 52.9 ± 8.5 | 49.9 ± 6.4 | 0.030 |
Parity | 0.9 ± 0.5 | 1.0 ± 0.5 | 0.8 ± 0.5 | 0.040 |
Nulliparous (%) | 20 (16.1%) (n = 124) | 8 (11.6%) (n = 69) | 12 (21.8%) (n = 55) | 0.145 |
Tumor size (cm) | 11.3 ± 4.6 (n = 118) | 12.3 ± 5.0 (n = 66) | 9.9 ± 3.7 (n = 52) | 0.005 |
Serum CA 125 (U/mL) | 295.0 ± 934.7 | 433.5 ± 1188.2 | 94.7 ± 198.4 | 0.005 |
Normal (%) | 40 (34.8%) | 20 (29.4%) | 20 (42.6%) | 0.167 |
Elevated (%) | 75 (65.2%) (n = 115) | 48 (70.6%) (n = 68) | 27 (57.4%) (n = 47) | |
Laterality (%) | 0.045 | |||
Left | 61 (48.8%) | 32 (45.7%) | 29 (52.7%) | |
Right | 52 (41.6%) | 28 (40.0%) | 24 (43.6%) | |
Both | 12 (9.6%) | 10 (14.3%) | 2 (3.6%) | |
FIGO stage (%) | 0.000 | |||
I | 82 (65.6%) | 36 (51.4%) | 46 (83.6%) | |
II | 12(9.6%) | 7 (10.0%) | 5 (9.1%) | |
III | 28 (22.4%) | 24 (34.3%) | 4 (7.3%) | |
IV | 3 (2.4%) | 3 (4.3%) | 0 (0%) | |
Surgical method (%) | 0.070 | |||
Laparoscopy | 21 (16.8%) | 8 (11.4%) | 13 (23.6%) | |
Laparotomy | 104 (83.2%) | 62 (88.6%) | 42 (76.4%) | |
Comprehensive staging (%) | 0.829 | |||
Yes | 114 (91.2%) | 63 (90.0%) | 51 (92.7%) | |
No | 11 (8.8%) | 7 (10.0%) | 4 (7.3%) | |
Ascites (%) | 48 (38.4%) | 37 (52.9%) | 11 (20%) | 0.000 |
Ascites positivity (%) | 20 (41.7%) | 18 (48.6%) | 2 (18.2%) | 0.147 |
Lymph nodes status (%) | 0.031 | |||
Positive | 12 (10.6%) | 10 (16.9%) | 2 (1.8%) | |
Negative | 101 (89.4%) (n = 113) | 49 (83.1%) (n = 59) | 52 (96.3%) (n = 54) | |
Residual lesion (%) | 120 (96.0%) | 66 (94.3%) | 54 (98.2%) | 0.520 |
0 | 113 (90.4%) | 60 (85.7%) | 53 (96.4%) | |
≤1 cm | 7 (5.6%) | 6 (8.6%) | 1 (1.8%) | |
> 1 cm | 5 (4.0%) | 4 (5.7%) | 1 (1.8%) | |
Cycles of chemotherapy | 6.3 ± 1.8 | 6.4 ± 1.9 | 6.1 ± 1.6 | 0.382 |
Chemosensitivity (%) | 0.003 | |||
Sensitive | 85 (76.6%) | 42 (66.7%) | 43 (89.6%) | |
Resistant | 26 (23.4%) (n = 111) | 21 (33.3%) (n = 63) | 5 (10.4%) (n = 48) |
Comparison of clinical and pathological features between the two groups
Index | NEM | EM | p valuea |
---|---|---|---|
ER | 0.50 ± 1.00 | 0.56 ± 0.91 | 0.478 |
PR | 0.21 ± 0.51 | 0.12 ± 0.44 | 0.207 |
p53 | 0.93 ± 0.97 | 0.77 ± 0.61 | 0.769 |
Ki-67 | 32.54 ± 24.15 | 32.35 ± 19.30 | 0.662 |
Comparison of survival outcomes between the two groups
Predictors of survival in univariate and multivariate survival analysis
Variables | 5 year-PFS % | p valuea | p valueb | HR (95%CI) | 5 year-OS % | p valuea | p valueb | HR (95%CI) |
---|---|---|---|---|---|---|---|---|
Endometriosis | 0.001 | 0.295 | 0.013 | 0.677 | ||||
With | 87.9 | 89.4 | ||||||
Without | 53.3 | 67.7 | ||||||
Age (years) | 0.628 | 0.550 | ||||||
< 60 | 72.0 | 79.6 | ||||||
≥60 | 47.8 | 69.6 | ||||||
CA-125 (U/mL) | 0.001 | 0.620 | 0.142 | |||||
< 200 | 76.6 | 80.0 | ||||||
≥200 | 38.4 | 64.4 | ||||||
Parity | 0.342 | 0.382 | ||||||
0 | 70.8 | 89.5 | ||||||
≥1 | 53.6 | 75.9 | ||||||
Laterality | 0.034 | 0.093 | 0.028 | 0.360 | ||||
Unilateral | 70.1 | 79.3 | ||||||
Bilateral | 46.7 | 56.2 | ||||||
Tumor diameter | 0.084 | 0.662 | 0.236 | |||||
< 10 | 77.7 | 83.4 | ||||||
≥10 | 59.8 | 70.0 | ||||||
Comprehensive staging | 0.348 | 0.070 | 0.441 | |||||
Yes | 68.6 | 79.0 | ||||||
No | 58.9 | 56.2 | ||||||
Residual lesion | 0.000 | 0.126 | 0.001 | 0.731 | ||||
Yes | 72.8 | 82.6 | ||||||
No | 25.0 | 33.3 | ||||||
Ascites | 0.000 | 0.016 | 0.001 | 0.052 | ||||
Yes | 45.9 | 2.78 (1.21–6.47) | 60.8 | |||||
No | 82.0 | 87.6 | ||||||
Lymph nodes status | 0.000 | 0.324 | 0.012 | 0.395 | ||||
Positive | 33.3 | 58.3 | ||||||
Negative | 76.0 | 85.6 | ||||||
FIGO stage | 0.000 | 0.033 | 1.61 (1.04–2.49) | 0.000 | 0.874 | |||
I | 88.8 | 89.9 | ||||||
II | 55.6 | 80.2 | ||||||
III | 22.4 | 45.5 | ||||||
IV | 33.3 | 33.3 | ||||||
Chemotherapy cycles | 0.050 | 0.290 | 0.421 | |||||
≥6 | 72.5 | 78.4 | ||||||
> 6 | 49.9 | 69.5 | ||||||
Chemosensitivity | 0.000 | 0.000 | 101.60 (29.45–350.49) | 0.000 | 0.000 | 109.55 | ||
Sensitive | 87.3 | 96.5 | (23.46–511.51) | |||||
Resistant | 0 | 9.2 |
Factors related to chemosensitivity in the logistic regression model
Variables | p valuea | Correlation Coefficent | p valueb | Exp (B) (95% CI) |
---|---|---|---|---|
Age | 0.995 | |||
Tumor diameter | 0.396 | |||
CA125 value | 0.028 | −0.216 | 0.887 | |
Number of live birth | 0.448 | |||
Ascites | 0.004 | −0.267 | 0.673 | |
Residual lesion | 0.000 | −0.348 | 0.467 | |
Lymph nodes positivity | 0.002 | −0.306 | 0.858 | |
FIGO stage | 0.000 | −0.546 | 0.005 | 0.292 (0.123–0.693) |
Bilaterality | 0.060 | |||
Endometriosis | 0.003 | 0.279 | 0.671 | |
ER | 0.579 | |||
PR | 0.191 | |||
p53 | 0.990 | |||
Ki67 | 0.681 |