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01.03.2023 | Endometriumkarzinom | Leitthema

Molekulare Klassifikation beim Endometriumkarzinom

verfasst von: Dr. Peter Bronsert, Konrad Kurowski, Prof. Dr. Martin Werner, Dr. Clara Unger, Dr. Sylvia Timme

Erschienen in: Die Gynäkologie | Ausgabe 3/2023

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Zusammenfassung

Die von Bokhman et al. propagierte dualistische Subtypisierung stellte über mehrere Jahrzehnte das Fundament zur Prädiktion von Endometriumkarzinomen dar, das jedoch über die Jahre eine gewisse Unschärfe in Bezug auf Graduierung und Gesamtüberleben der Patientinnen aufwies. Molekulare Analysen identifizierten die Subgruppen POLE-ultramutiert, MMRd („mismatch repair deficient“), p53-mutiert und Endometriumkarzinome mit einem unspezifischen molekularen Profil. Die prädiktive Evidenz der molekularen Subgruppen und ihre Überlegenheit gegenüber dem von Bokhman et al. publizierten Modell, konnte durch mehrere Studien bestätigt werden. Im vorliegenden Übersichtsartikel werden anhand von 5 Fallbeispielen aus der Routinediagnostik die Typisierung von endometrioiden Adenokarzinomen und der zugehörige molekularpathologische Hintergrund beschrieben. Weiterhin wird im letzten Fallbeispiel eine sich aktuell noch nicht in der WHO(World Health Organization)-Klassifikation weiblicher Genitaltumoren genannte Subgruppe beschrieben.

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Titel: Molekulare Klassifikation beim Endometriumkarzinom
verfasst von: Dr. Peter Bronsert
Konrad Kurowski
Prof. Dr. Martin Werner
Dr. Clara Unger
Dr. Sylvia Timme
Publikationsdatum: 01.03.2023
Verlag: Springer Medizin
Schlagwörter: Endometriumkarzinom
Pathologie
Endometriumkarzinom
Erschienen in: Die Gynäkologie / Ausgabe 3/2023
Print ISSN: 2731-7102
Elektronische ISSN: 2731-7110
DOI: https://doi.org/10.1007/s00129-023-05056-2

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