Background
Methods
Patient selection and clinical findings
Endoscopic examination
Histology and immunohistochemistry
Statistical analysis
Results
Patient characteristics and treatments
Clinical subtype | MEITL | ATLL | Other group | Total |
---|---|---|---|---|
No. of cases | 9 (33%) | 11 (41%) | 7 (26%) | 27 |
Median age (range), y | 63 (47–84) | 64 (50–74) | 54 (43–69) | 60 (43–84) |
Male: female | 6:3 | 7:4 | 6:1 | 19:8 |
Past history of UC | 1 (11%) | 0 | 1 (14%) | 2 (7%) |
Chronic diarrhea | 5 (56%) | 4 (36%) | 2 (29%) | 11 (41%) |
Abdominal pain | 4 (44%) | 3 (27%) | 4 (57%) | 11 (41%) |
Weight loss | 4 (44%) | 2 (18%) | 0 | 6 (22%) |
Fever | 0 | 2 (18%) | 2 (29%) | 4 (15%) |
Total protein (g/dl) | 5.7 (4–6.6) | 6.3 (5.4–7.2) | 7.5 (5.9–8.4) | 6.5 (4–8.4) |
Albumin (g/dl) | 3.1 (2.1–3.8) | 3.4 (2.6–4) | 3.9 (2.7–4.4) | 3.5 (2.1–4.4) |
LDH (U/l) | 191 (112–288)* | 785 (262–2192)* | 184 (123–244) | 387 (112–2192) |
sIL-2R (U/ml) | 1815 (587–4410)* | 51,643 (3501–154,246)* | 10,993 (1330–25,818) | 21,484 (587–154,246) |
Leukemic change | 2 (22%)** | 6/8 (75%)** | 1 (14%) | 9/21 (43%) |
Clinical stage I | 2 (22%) | 0 | 2 (29%) | 4 (15%) |
II (II1, II2, IIE) | 3 (33%) | 1 (9%) | 2 (29%) | 6 (22%) |
II1 | 1 (11%) | 0 | 1 (14%) | 2 (7%) |
II2 | 1 (11%) | 0 | 0 | 1 (4%) |
IIE | 1 (11%) | 1 (9%) | 1 (14%) | 3 (11%) |
IV | 4 (44%)** | 10 (91%)** | 3 (42%) | 17 (63%) |
Surgery | 1 (11%) | 0 | 2 (29%) | 3 (11%) |
Surgery and chemotherapy | 3 (33%) | 1 (9%) | 0 | 4 (15%) |
Chemotherapy | 2 (22%)** | 9 (82%)** | 3 (42%) | 14 (52%) |
Chemotherapy and SCT | 2 (22%) | 1 (9%) | 0 | 3 (11%) |
No treatment | 1 (11%) | 0 | 2 (29%) | 3 (11%) |
Involved GI sites and endoscopic findings of colorectal TNKCL
MEITL (n = 9) | ATLL (n = 11) | Other group (n = 7) | Total (n = 27) | |
---|---|---|---|---|
Gastrointestinal sites | ||||
Colon | 3 (33%) | 7 (64%) | 5 (71%) | 15 (56%) |
Colon+other | 6 (67%) | 4 (36%) | 2 (29%) | 12 (44%) |
Colon+small intestine | 2 (22%) | 1 (9%) | 0 | 3 (11%) |
Colon+small intestine+duodenum | 4 (44%) | 0 | 0 | 4 (15%) |
Colon+duodenum+stomach | 0 | 2 (18%) | 1 (14%) | 3 (11%) |
Colon+stomach | 0 | 1 (9%) | 1 (14%) | 2 (7%) |
Endoscopic findings | ||||
Diffuse-infiltrating | 6 (67%) | 5 (46%) | 2 (29%) | 13 (48%) |
Ulcerative | 1 (11%) | 3 (27%) | 4 (57%) | 8 (30%) |
Polypoid | 2 (22%) | 3 (27%) | 1 (14%) | 6 (22%) |
Involved colon sites | ||||
C/A/T/D/S/R | 5/6/5/4/6/6 | 6/7/8/6/6/6 | 1/4/2/1/2/2 | 12/17/15/11/14/14 |
Localized lesion | 2 (22%) | 4 (36%) | 6 (86%) | 12 (44%) |
Multiple lesions | 7 (78%) | 7 (64%) | 1 (14%) | 15 (56%) |
Two lesions | 3 (33%) | 1 (9%) | 0 | 4 (15%) |
Three lesions (T + D + R) | 0 | 1 (9%) | 0 | 1 (4%) |
Six lesions (C + A + T + D + S + R) | 4 (44%) | 5 (46%) | 1 (14%) | 10 (37%) |
Pathological and immunohistological findings of colorectal TNKCL
MEITL (n = 9) | ATLL (n = 11) | Other group (n = 7) | Total (n = 27) | |
---|---|---|---|---|
Histological findings | ||||
Monomorphic medium-sized cell | 9 (100%)* | 1 (9%)* | 0 (0%) | 10 (37%) |
Pleomorphic medium-sized cell | 0 (0%)* | 8 (73%)* | 3 (42%) | 11 (41%) |
Monomorphic large cell | 0 (0%) | 0 (0%) | 4 (57%) | 4 (15%) |
Pleomorphic large cell | 0 (0%) | 2 (18%) | 0 (0%) | 2 (7%) |
Increased atypical IELs in tumors | 7/8 (88%) | 6/10 (60%) | 0/5 (0%) | 13/23 (57%) |
Lymphocytic proctocolitis | 5 (56%)** | 1 (9%)** | 0 (0%) | 6 (22%) |
Tumor cell markers | ||||
CD3 | 9 (100%) | 11 (100%) | 5 (71%) | 25 (93%) |
CD4 | 1 (11%)* | 9 (82%)* | 3 (42%) | 13 (48%) |
CD8 | 9 (100%)* | 2 (18%)* | 2 (29%) | 13 (48%) |
CD25 | 0/8 (0%)* | 11 (100%)* | 2/6 (33%) | 13/25 (52%) |
CD56 | 8 (89%)* | 1 (9%)* | 1 (14%) | 10 (37%) |
CD30 | 0/8 (0%) | 2/9 (22%) | 4 (57%) | 6/24 (25%) |
CD194 (CCR4) | 0/7 (0%)* | 9/9 (100%)* | 0 (0%) | 9/23 (39%) |
CD103 | 6 (67%) | 4 (36%) | 1 (14%) | 11 (41%) |
TIA-1 | 9 (100%)* | 0/8 (0%)* | 6 (86%) | 15/24 (63%) |
EBERs | 0 (0%) | 0 (0%) | 4 (57%) | 4 (15%) |