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Journal of Medical Ultrasonics

Erschienen in:

11.10.2019 | Special Feature: Review Article

Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms

verfasst von: Eizaburo Ohno, Yoshiki Hirooka, Hiroki Kawashima, Takuya Ishikawa, Mitsuhiro Fujishiro

Erschienen in: Journal of Medical Ultrasonics | Ausgabe 3/2020

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Abstract

Endoscopic ultrasonography (EUS) is a modality with high spatial resolution that enables comprehensive observation of the entire pancreas and plays an important role in the diagnosis of pancreatic lesions. Recent advances in diagnostic imaging methods such as ultrasound, computed tomography, and magnetic resonance imaging have increased the incidental detection of pancreatic cystic lesions (PCLs). EUS has been recognized as an essential diagnostic method for the detection and evaluation of PCLs. EUS has two important roles: as a detailed (high-resolution) imaging diagnostic method and as an approach for collecting cyst fluid content by EUS-guided fine needle aspiration for pathological diagnosis or biomarker evaluation. Furthermore, in recent years, the usefulness of contrast-enhanced EUS for the differential diagnosis of PCLs or evaluation of grade of malignancy, and a novel imaging technique called needle-based confocal laser endomicroscopy to observe intraductal structures through a needle, has been reported. An understanding of the morphological characteristics of PCLs depicted by ultrasound imaging and of the benefits and limitations of EUS diagnosis in daily practice is needed.

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Binmoeller KF, Soehendra N. Endoscopic ultrasonography in the diagnosis and treatment of pancreatic pseudocysts. Gastrointest Endosc Clin N Am. 1995;5:805–16.PubMed

Pausawasdi N, Ratanachu-Ek T. Endoscopic ultrasonography evaluation for pancreatic cysts: necessity or overkill? Dig Endosc. 2017;29:444–54.PubMed

Kamata K, Kitano M. Endoscopic diagnosis of cystic lesions of the pancreas. Dig Endosc. 2019;31:5–15.PubMed

Hijioka S, Hara K, Yamao K, et al. Morphological differentiation and follow-up of pancreatic cystic neoplasms using endoscopic ultrasound. Endosc Ultrasound. 2015;4:312–8. https://doi.org/10.4103/2303-9027.170423.CrossRefPubMedPubMedCentral

Hruban R, Pitman M, Klimstra D. AFIP atlas of tumor pathology, Series 4 fascicle 6: Tumors of the Pancreas. Washington DC: American Registry of Pathology, Armed Forces Institute of Pathology; 2007. p. 6.

Kubo H, Nakamura K, Itaba S, et al. Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy. 2009;41:684–9.PubMed

Ohno E, Hirooka Y, Goto H, NSPINAL study group, et al. Natural history of pancreatic cystic lesions: a multicenter prospective observational study for evaluating the risk of pancreatic cancer. J Gastroenterol Hepatol. 2018;33:320–8.PubMed

Yamao K, Yanagisawa A, Takahashi K, et al. Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: a multi-institutional study of the Japan Pancreas Society. Pancreas. 2011;40:67–71.PubMed

Nilsson LN, Keane MG, Laukkarinen J, et al. Nature and management of pancreatic mucinous cystic neoplasm (MCN): a systematic review of the literature. Pancreatology. 2016;16:1028–36.PubMed

10.

Acar M, Tatli S. Cystic tumors of the pancreas: a radiological perspective. Diagn Interv Radiol. 2011;17:143–9.PubMed

11.

Sano M, Driscoll DR, De Jesus-Monge WE, et al. Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms. Gastroenterology. 2014;146:257–67.PubMed

12.

Ishikawa T, Haruta J, Yamaguchi T, et al. A case of mucinous cystic neoplasm of the pancreas misdiagnosed as a pancreatic pseudocyst at the initial exam and resected after a 2-year follow-up. J Med Ultrason. 2015;42:257–65. https://doi.org/10.1007/s10396-014-0581-5.CrossRef

13.

Tseng JF, Warshaw AL, Sahani DV, et al. Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. Ann Surg. 2005;242:413–21.PubMedPubMedCentral

14.

Jais B, Rebours V, Levy P, et al. Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut. 2016;65:305–12.PubMed

15.

Kimura W, Moriya T, Hirai I, et al. Multicenter study of serous cystic neoplasm of the Japan Pancreas Society. Pancreas. 2012;41:380–7.PubMed

16.

Tanaka M, Fernández-del Castillo C, Adsay V, International Association of Pancreatology, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183–97.PubMed

17.

Tanaka M, Fernandez-del Castillo C, Kamisawa T, et al. Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology. 2017;17:738–53.PubMed

18.

Adsay V, Mino-Kenudson M, Furukawa T, Members of the Verona Consensus Meeting, 2013, et al. Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: Recommendations of Verona Consensus Meeting. Ann Surg. 2016;263:162–77.PubMed

19.

Fukushima N, Mukai K, Kanai Y, et al. Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 cases. Hum Pathol. 1997;28:1010–7.PubMed

20.

Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an ‘intestinal’ pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28:839–48.PubMed

21.

Maguchi H, Tanno S, Mizuno N, et al. Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: a multicenter study in Japan. Pancreas. 2011;40:364–70.PubMed

22.

Kobayashi G, Fujita N, Takasawa O, et al. Ultrasonographic findings and natural history of intraductal papillary-mucinous neoplasms of the pancreas. J Med Ultrason. 2008;35:85–96. https://doi.org/10.1007/s10396-008-0188-9(Review).CrossRef

23.

Shimizu Y, Kanemitsu Y, Yamao K, et al. A nomogram for predicting the probability of carcinoma in patients with intraductal papillary-mucinous neoplasm. World J Surg. 2010;34:2932–8.PubMed

24.

Shimizu Y, Yamaue H, Maguchi H, et al. Validation of a nomogram for predicting the probability of carcinoma in patients with intraductal papillary mucinous neoplasm in 180 pancreatic resection patients at 3 high-volume centers. Pancreas. 2015;44:459–64.PubMed

25.

Kobayashi N, Sugimori K, Nakajima A, et al. Endoscopic ultrasonography findings predict the risk of carcinoma in branch duct intraductal papillary mucinous neoplasms of the pancreas. Pancreatology. 2012;12:141–5.PubMed

26.

Ohno E, Hirooka Y, Itoh A, et al. Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules. Ann Surg. 2009;249:628–34.PubMed

27.

Du C, Chai NL, Yang J, et al. Incidents and adverse events of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cystic lesions. World J Gastroenterol. 2017;23:5610–8.PubMedPubMedCentral

28.

Zhong N, Zhang L, Topazian M, et al. Histologic and imaging features of mural nodules in mucinous pancreatic cysts. Clin Gastroenterol Hepatol. 2012;10:192–8.PubMed

29.

Khashab MA, Kim K, Canto MI, et al. Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas. 2013;42:717–21.PubMed

30.

Kamata K, Kitano M, Kudo M, et al. Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms. Endoscopy. 2014;46:22–9.PubMed

31.

Takenaka M, Masuda A, Azuma T, et al. Chronic pancreatitis finding by endoscopic ultrasonography in the pancreatic parenchyma of intraductal papillary mucinous neoplasms is associated with invasive intraductal papillary mucinous carcinoma. Oncology. 2017;93:61–8. https://doi.org/10.1159/000481232Epub 2017 Dec 20.CrossRefPubMed

32.

Mandai K, Uno K, Yasuda K, et al. Association between hyperechogenic pancreas and pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasms. J Med Ultrason. 2019. https://doi.org/10.1007/s10396-019-00949-z.CrossRef

33.

Koito K, Namieno T, Morita K, et al. Solitary cystic tumor of the pancreas: EUS-pathologic correlation. Gastrointest Endosc. 1997;45:268–76.PubMed

34.

Kubo H, Nakamura K, Itaba S, et al. Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy. 2009;41:684–9.PubMed

35.

Zhang W, Linghu E, Li H, et al. New criteria to differentiate between mucinous cystic neoplasm and serous cystic neoplasm in pancreas by endoscopic ultrasound: a preliminarily confirmed outcome of 41 patients. Endosc Ultrasound. 2017;6:116–22.PubMedPubMedCentral

36.

Aithal GP, Chen RYM, Cunningham JT, et al. Accuracy of EUS for detection of intraductal papillary mucinous tumor of the pancreas. Gastrointest Endosc. 2002;56:701–7.PubMed

37.

Baba T, Yamagichi T, Ishihara T, et al. Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques. Pancreas. 2004;29:212–27.PubMed

38.

Gress F, Gottieb K, Lehman G, et al. Endoscopic ultrasound characteristics of mucinous cystic neoplasms of the pancreas. Am J Gastroenterol. 2000;95:961–5.PubMed

39.

Sedlack R, Affi A, Clain JE, Wiersema MJ, et al. Utility of EUS in the evaluation of cystic pancreatic lesions. Gastrointest Endosc. 2002;56:53–7.

40.

Ahmad NA, Kochman ML, Brensinger C, et al. Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc. 2003;58:59–64.PubMed

41.

Brugge WR, Lewandrowski K, Lee-Lewandrowski E, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology. 2004;126:1330–6.PubMed

42.

Gerke H, Jaffe TA, Mitchell RM, et al. Endoscopic ultrasound and computer tomography are inaccurate methods of classifying cystic pancreatic lesions. Dig Liver Dis. 2006;38:39–44.PubMed

43.

Pais SA, Attasaranya S, DeWitt J, et al. Role of endoscopic ultrasound in the diagnosis of intraductal papillary mucinous neoplasms: correlation with surgical histopathology. Clin Gastroenterol Hepatol. 2007;5:489–95.PubMed

44.

Kitano M, Sakamoto H, Matsui U, et al. A novel perfusion imaging technique of the pancreas: contrast-enhanced harmonic EUS (with video). Gastrointest Endosc. 2008;67:141–50.PubMed

45.

Hirooka Y, Goto H, Ito A, et al. Contrast-enhanced endoscopic ultrasonography in pancreatic diseases: a preliminary study. Am J Gastroenterol. 1998;93:632–5.PubMed

46.

Hocke M, Cui XW, Domagk D, et al. Pancreatic cystic lesions: the value of contrast-enhanced endoscopic ultrasound to influence the clinical pathway. Endosc Ultrasound. 2014;3:123–30.PubMedPubMedCentral

47.

Fusaroli P, Serrani M, De Giorgio R, et al. Contrast harmonic-endoscopic ultrasound is useful to identify neoplastic features of pancreatic cysts (with videos). Pancreas. 2016;45:265–8.PubMed

48.

Kamata K, Kitano M, Omoto S, et al. Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts. Endoscopy. 2016;48:35–41.PubMed

49.

Yamashita Y, Ueda K, Itonaga M, et al. Usefulness of contrast enhanced endoscopic sonography for discriminating mural nodules from mucous clots in intraductal papillary mucinous neoplasms: a single-center prospective study. J Ultrasound Med. 2013;32:61–8.PubMed

50.

Harima H, Kaino S, Shinoda S, et al. Differential diagnosis of benign and malignant branch duct intraductal papillary mucinous neoplasm using contrast-enhanced endoscopic ultrasonography. World J Gastroenterol. 2015;21:6252–60.PubMedPubMedCentral

51.

Yamamoto N, Kato H, Tomoda T, et al. Contrast-enhanced harmonic endoscopic ultrasonography with time-intensity curve analysis for intraductal papillary. Endoscopy. 2016;48:26–34.PubMed

52.

Marchegiani G, Andrianello S, Salvia R, et al. Systematic review, meta-analysis, and a high-volume center experience supporting the new role of mural nodules proposed by the updated 2017 international guidelines on IPMN of the pancreas. Surgery. 2018;163:1272–9.PubMed

53.

Fujita M, Itoi T, Moriyasu F, et al. Effectiveness of contrast-enhanced endoscopic ultrasound for detecting mural nodules in intraductal papillary mucinous neoplasm of the pancreas and for making therapeutic decisions. Endosc Ultrasound. 2016;5:377–83.PubMedPubMedCentral

54.

Ohno E, Itoh A, Kawashima H, et al. Malignant transformation of branch duct-type intraductal papillary mucinous neoplasms of the pancreas based on contrast-enhanced endoscopic ultrasonography morphological changes: focus on malignant transformation of intraductal papillary mucinous neoplasm itself. Pancreas. 2012;41:855–62.PubMed

55.

Frossard JL, Amouyal P, Amouyal G, et al. Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions. Am J Gastroenterol. 2003;98:1516–24.PubMed

56.

Maire F, Voitot H, Hammel P, et al. Intraductal papillary mucinous neoplasms of the pancreas: performance of pancreatic fluid analysis for positive diagnosis and the prediction of malignancy. Am J Gastroenterol. 2008;103:2871–7.PubMed

57.

Zhu H, Jiang F, Zhu J, Du Y, Jin Z, Li Z. Assessment of morbidity and mortality associated with endoscopic ultrasound-guided fine-needle aspiration for pancreatic cystic lesions: a systematic review and meta-analysis. Dig Endosc. 2017;29:667–75.PubMed

58.

Rodríguez-D’Jesús A, Fernández-Esparrach G, Ginès A, et al. Adverse events of EUS-guided FNA of pancreatic cystic and solid lesions by using the lexicon proposed in an ASGE workshop: a prospective and comparative study. Gastrointest Endosc. 2016;83:780–4.PubMed

59.

Yoon WJ, Daqlilar ES, Brugge WR, et al. Peritoneal seeding in intraductal papillary mucinous neoplasm of the pancreas patients who underwent endoscopic ultrasound-guided fine-needle aspiration: the PIPE Study. Endoscopy. 2014;46:382–7.PubMed

60.

Levy MJ, Gleeson FC, Clayton A, et al. Prospective cytological assessment of gastrointestinal luminal fluid acquired during EUS: a potential source of false-positive FNA and needle tract seeding. Am J Gastroenterol. 2010;105:1311–8.PubMed

61.

Hirooka Y, Goto H, Itoh A, et al. A case of intraductual papillary mucinous tumor in which endosonography-guided fine-needle aspiration biopsy caused dissemination. J Gastroenterol Hepatol. 2003;18:1323–7.PubMed

62.

Yamabe A, Irisawa A, Hojo H, et al. Rare condition of needle tract seeding after EUS-guided FNA for intraductal papillary mucinous carcinoma. Endosc Int Open. 2016;4:E756–8.PubMedPubMedCentral

63.

Minaga K, Takenaka M, Kudo M, et al. Needle tract seeding: an overlooked rare complication of endoscopic ultrasound-guided fine-needle aspiration. Oncology. 2017;93:107–12.PubMed

64.

van der Waaij LA, van Dulleman HM, Porte RJ. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc. 2005;62:383–9.PubMed

65.

Thosani N, Thosani S, Guha S, et al. Role of EUS-FNA-based cytology in the diagnosis of mucinous pancreatic cystic lesions: a systematic review and meta-analysis. Dig Dis Sci. 2010;55:2756–66.PubMedPubMedCentral

66.

De Jong K, Poley JW, Fockens P, et al. Endoscopic ultrasound-guided fine-needle aspiration of pancreatic cystic lesions provides inadequate material for cytology and laboratory analysis: initial results from a prospective study. Endoscopy. 2011;43:585–90.PubMed

67.

Al-Haddad M, Gill KR, Wallace MB, et al. Safety and efficacy of cytology brushings versus standard fine-needle aspiration in evaluating cystic pancreatic lesions: a controlled study. Endoscopy. 2010;42:127–32.PubMed

68.

Hong SK, Loren DE, Kowalski TE, et al. Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc. 2012;75:775–82.PubMed

69.

Mittal C, Obuch JC, Wagh MS, et al. Technical feasibility, diagnostic yield, and safety of microforceps biopsies during EUS evaluation of pancreatic cystic lesions (with video). Gastrointest Endosc. 2018;87:1263–9.PubMed

70.

Bruno M, Bosco M, Carucci P, et al. Preliminary experience with a new cytology brush in EUS-guided FNA. Gastrointest Endosc. 2009;70:1220–4.PubMed

71.

Khalid A, Zahid M, Finkelstein SD, et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc. 2009;69:1095–102.PubMed

72.

Gillis A, Cipollone I, Conlon K, et al. Does EUS-FNA molecular analysis carry additional value when compared to cytology in the diagnosis of pancreatic cystic neoplasm? A systematic review. HPB (Oxford). 2015;17:377–86.

73.

Kadayifci A, Atar M, Wang JL, et al. Value of adding GNAS testing to pancreatic cyst fluid KRAS and carcinoembryonic antigen analysis for the diagnosis of intraductal papillary mucinous neoplasms. Dig Endosc. 2017;29:111–7.PubMed

74.

Wu J, Matthaei H, Vogelstein B, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011;3:92ra66.PubMedPubMedCentral

75.

Singhi AD, McGrath K, Brand RE, et al. Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia. Gut. 2018;67:2131–41.PubMed

76.

Nakai Y, Iwashita T, Chang KJ, et al. Diagnosis of pancreatic cysts: EUS-guided, through-the needle confocal laser-induced endomicroscopy and cystoscopy trial: DETECT study. Gastrointest Endosc. 2015;81:1204–14.PubMed

77.

Konda VJ, Aslanian HR, Waxman I, et al. First assessment of needle-based confocal laser endomicroscopy during EUS-FNA procedures of the pancreas (with videos). Gastrointest Endosc. 2011;74:1049–60.PubMed

78.

Konda VJ, Meining A, Jamil LH, et al. A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy under endosonographic guidance. Endoscopy. 2013;45:1006–13.PubMed

79.

Krishna SG, Lee JH. Appraisal of needle-based confocal laser endomicroscopy in the diagnosis of pancreatic cyst. World J Gastroenterol. 2016;22:1701–10.PubMedPubMedCentral

80.

Napoleon B, Lemaistre AI, Pujol B, et al. A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy. Endoscopy. 2015;47:26–32.PubMed

Titel: Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms
verfasst von: Eizaburo Ohno
Yoshiki Hirooka
Hiroki Kawashima
Takuya Ishikawa
Mitsuhiro Fujishiro
Publikationsdatum: 11.10.2019
Verlag: Springer Singapore
Erschienen in: Journal of Medical Ultrasonics / Ausgabe 3/2020
Print ISSN: 1346-4523
Elektronische ISSN: 1613-2254
DOI: https://doi.org/10.1007/s10396-019-00980-0

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Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms

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