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Erschienen in: Archives of Dermatological Research 2/2012

01.03.2012 | Original Paper

Endothelial and axon reflex vasodilatation to acetylcholine in rosacea-affected skin

verfasst von: Peter D. Drummond, Daphne Su

Erschienen in: Archives of Dermatological Research | Ausgabe 2/2012

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Abstract

Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in 29 controls of similar age and sex distribution. During the iontophoresis, current strengths doubled in eight steps from 2.5 to 320 μA. For each step, skin blood flow was monitored during 60 s of iontophoresis and for 2 min afterwards with laser Doppler flow probes at the site of iontophoresis and 5–8 mm away in the region of axon reflex vasodilatation. Vascular responses to acetylcholine were similar in patients and controls, but stinging sensations were greater in patients than in controls at the most intense current strength. In addition, axon reflex vasodilatation was greater in patients with severe than mild rosacea. These findings suggest that activation of nociceptive nerve fibres contributes to skin sensitivity in patients with rosacea, and that axon reflexes augment flushing in patients with the most severe symptoms.
Literatur
1.
Zurück zum Zitat Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R (2002) Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol 92:780–788PubMed Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R (2002) Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol 92:780–788PubMed
2.
Zurück zum Zitat Borrie P (1955) The state of the blood vessels of the face in rosacea. I. Br J Dermatol 67:5–8PubMedCrossRef Borrie P (1955) The state of the blood vessels of the face in rosacea. I. Br J Dermatol 67:5–8PubMedCrossRef
3.
Zurück zum Zitat Borrie P (1955) The state of the blood vessels of the face in rosacea. II. Br J Dermatol 67:73–75PubMedCrossRef Borrie P (1955) The state of the blood vessels of the face in rosacea. II. Br J Dermatol 67:73–75PubMedCrossRef
4.
Zurück zum Zitat Braverman IM, Keh A, Goldminz D (1990) Correlation of laser Doppler wave patterns with underlying microvascular anatomy. J Invest Dermatol 95:283–286PubMedCrossRef Braverman IM, Keh A, Goldminz D (1990) Correlation of laser Doppler wave patterns with underlying microvascular anatomy. J Invest Dermatol 95:283–286PubMedCrossRef
5.
Zurück zum Zitat Culp B, Scheinfeld N (2009) Rosacea: a review. P & T 34:38–45 Culp B, Scheinfeld N (2009) Rosacea: a review. P & T 34:38–45
6.
Zurück zum Zitat Curry FR, Adamson RH (2010) Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovasc Res 87:218–229PubMedCrossRef Curry FR, Adamson RH (2010) Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovasc Res 87:218–229PubMedCrossRef
7.
Zurück zum Zitat Drummond PD (2002) Prior iontophoresis of saline enhances vasoconstriction to phenylephrine and clonidine in the skin of the human forearm. Br J Clin Pharmacol 54:45–50PubMedCrossRef Drummond PD (2002) Prior iontophoresis of saline enhances vasoconstriction to phenylephrine and clonidine in the skin of the human forearm. Br J Clin Pharmacol 54:45–50PubMedCrossRef
8.
Zurück zum Zitat Elewski BE, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M (2011) Rosacea—global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol 25:188–200PubMedCrossRef Elewski BE, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M (2011) Rosacea—global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol 25:188–200PubMedCrossRef
9.
Zurück zum Zitat Grossmann M, Jamieson MJ, Kellogg DL Jr, Kosiba WA, Pergola PE, Crandall CG, Shepherd AM (1995) The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res 50:444–452PubMedCrossRef Grossmann M, Jamieson MJ, Kellogg DL Jr, Kosiba WA, Pergola PE, Crandall CG, Shepherd AM (1995) The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res 50:444–452PubMedCrossRef
10.
Zurück zum Zitat Guarrera M, Parodi A, Cipriani C, Divano C, Rebora A (1982) Flushing in rosacea: a possible mechanism. Arch Dermatol Res 272:311–316PubMedCrossRef Guarrera M, Parodi A, Cipriani C, Divano C, Rebora A (1982) Flushing in rosacea: a possible mechanism. Arch Dermatol Res 272:311–316PubMedCrossRef
11.
Zurück zum Zitat Hodges GJ, Johnson JM (2009) Adrenergic control of the human cutaneous circulation. Appl Physiol Nutr Metab 34:829–839PubMedCrossRef Hodges GJ, Johnson JM (2009) Adrenergic control of the human cutaneous circulation. Appl Physiol Nutr Metab 34:829–839PubMedCrossRef
12.
Zurück zum Zitat Holowatz LA, Thompson-Torgerson C, Kenney WL (2010) Aging and the control of human skin blood flow. Front Biosci 15:718–739PubMedCrossRef Holowatz LA, Thompson-Torgerson C, Kenney WL (2010) Aging and the control of human skin blood flow. Front Biosci 15:718–739PubMedCrossRef
13.
Zurück zum Zitat Kurkcuoglu N, Alaybeyi F (1991) Substance P immunoreactivity in rosacea. J Am Acad Dermatol 25:725–726PubMedCrossRef Kurkcuoglu N, Alaybeyi F (1991) Substance P immunoreactivity in rosacea. J Am Acad Dermatol 25:725–726PubMedCrossRef
14.
Zurück zum Zitat Lindsey KQ, Caughman SW, Olerud JE, Bunnett NW, Armstrong CA, Ansel JC (2000) Neural regulation of endothelial cell-mediated inflammation. J Investig Dermatol Symp Proc 5:74–78PubMedCrossRef Lindsey KQ, Caughman SW, Olerud JE, Bunnett NW, Armstrong CA, Ansel JC (2000) Neural regulation of endothelial cell-mediated inflammation. J Investig Dermatol Symp Proc 5:74–78PubMedCrossRef
15.
Zurück zum Zitat Lonne-Rahm S, Nordlind K, Edstrom DW, Ros AM, Berg M (2004) Laser treatment of rosacea: a pathoetiological study. Arch Dermatol 140:1345–1349PubMedCrossRef Lonne-Rahm S, Nordlind K, Edstrom DW, Ros AM, Berg M (2004) Laser treatment of rosacea: a pathoetiological study. Arch Dermatol 140:1345–1349PubMedCrossRef
16.
17.
Zurück zum Zitat Peters EM, Ericson ME, Hosoi J, Seiffert K, Hordinsky MK, Ansel JC, Paus R, Scholzen TE (2006) Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol 126:1937–1947PubMedCrossRef Peters EM, Ericson ME, Hosoi J, Seiffert K, Hordinsky MK, Ansel JC, Paus R, Scholzen TE (2006) Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol 126:1937–1947PubMedCrossRef
18.
Zurück zum Zitat Powell FC, Corbally N, Powell D (1993) Substance P and rosacea. J Am Acad Dermatol 28:132–133PubMedCrossRef Powell FC, Corbally N, Powell D (1993) Substance P and rosacea. J Am Acad Dermatol 28:132–133PubMedCrossRef
19.
Zurück zum Zitat Schmelz M, Michael K, Weidner C, Schmidt R, Torebjork HE, Handwerker HO (2000) Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 11:645–648PubMedCrossRef Schmelz M, Michael K, Weidner C, Schmidt R, Torebjork HE, Handwerker HO (2000) Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 11:645–648PubMedCrossRef
20.
Zurück zum Zitat Su D, Drummond PD (2011) Blushing propensity and psychological distress in people with rosacea. Clin Psychol Psychother. doi:10.1002/cpp.763 Su D, Drummond PD (2011) Blushing propensity and psychological distress in people with rosacea. Clin Psychol Psychother. doi:10.​1002/​cpp.​763
21.
Zurück zum Zitat van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S (2010) Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediat Inflamm 2010:792393 van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S (2010) Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediat Inflamm 2010:792393
23.
Zurück zum Zitat Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, Schmelz M (2000) Acute effects of substance P and calcitonin gene-related peptide in human skin—a microdialysis study. J Invest Dermatol 115:1015–1020PubMedCrossRef Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, Schmelz M (2000) Acute effects of substance P and calcitonin gene-related peptide in human skin—a microdialysis study. J Invest Dermatol 115:1015–1020PubMedCrossRef
24.
Zurück zum Zitat Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, Powell F (2002) Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 46:584–587PubMedCrossRef Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, Powell F (2002) Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 46:584–587PubMedCrossRef
25.
26.
Zurück zum Zitat Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL (2007) Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975–980PubMedCrossRef Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL (2007) Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975–980PubMedCrossRef
27.
28.
Zurück zum Zitat Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL (2011) TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688–697PubMedCrossRef Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL (2011) TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688–697PubMedCrossRef
Metadaten
Titel
Endothelial and axon reflex vasodilatation to acetylcholine in rosacea-affected skin
verfasst von
Peter D. Drummond
Daphne Su
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Archives of Dermatological Research / Ausgabe 2/2012
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-011-1177-1

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