Endothelial dysfunction influences augmented aortic hemodynamic responses to metaboreflex activation in postmenopausal women
- 12.04.2024
- Original Article
Erschienen in:
- Verfasst von
- Mauricio A. Martinez
- Katherine N. Dillon
- Yejin Kang
- Arun Maharaj
- Stephen M. Fischer
- Arturo Figueroa
- Erschienen in
- European Journal of Applied Physiology | Ausgabe 9/2024
Abstract
Purpose
Postmenopausal women experience augmented aortic hemodynamic responses to isometric handgrip (IHG) exercise and metaboreflex activation post-exercise muscle ischemia (PEMI). Relationships between endothelial function brachial artery flow-mediated dilation (FMD) and aortic stiffness carotid-femoral pulse wave velocity (cfPWV) with aortic pulsatile hemodynamics during IHG and PEMI have not been determined. The relationships between aortic hemodynamic responses to PEMI were evaluated.
Methods
Aortic blood pressure (BP), wave reflection, and pressure of forward (Pf) and backward (Pb) waves were measured using arterial tonometry at rest, IHG at 30% maximal force, and PEMI in 30 (15/group) postmenopausal women with low (≤ 4.5%) and normal (≥ 5.5%) FMD. Hemodynamic responses were analyzed as the change (Δ) from rest to the last minute of IHG and PEMI.
Results
Brachial and aortic systolic BP (SBP) responses to IHG were higher in the low vs normal FMD group (P < 0.05). Aortic SBP (Δ20 ± 8 vs Δ11 ± 7 mmHg), pulse pressure (PP) (Δ12 ± 8 vs Δ6 ± 4 mmHg), augmented pressure (AP) (Δ5 ± 3 vs Δ2 ± 2 mmHg), and Pb (Δ6 ± 4 vs Δ3 ± 2 mmHg) responses to PEMI were greater (P < 0.05) in women with low vs. normal FMD. FMD was negatively correlated with aortic SBP, PP, AP, and Pb (P < 0.05) responses to PEMI. cfPWV was not correlated with responses to PEMI.
Conclusion
Endothelial dysfunction relates to augmented aortic pulsatile load during metaboreflex activation, which may increase cardiovascular risk in postmenopausal women.
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- Titel
- Endothelial dysfunction influences augmented aortic hemodynamic responses to metaboreflex activation in postmenopausal women
- Verfasst von
-
Mauricio A. Martinez
Katherine N. Dillon
Yejin Kang
Arun Maharaj
Stephen M. Fischer
Arturo Figueroa
- Publikationsdatum
- 12.04.2024
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Journal of Applied Physiology / Ausgabe 9/2024
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327 - DOI
- https://doi.org/10.1007/s00421-024-05476-5
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