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Erschienen in: Surgical Endoscopy 9/2017

11.01.2017

Endotherapy in case of relapse of neoplastic Barrett’s esophagus after successful initial endoscopic resection

verfasst von: Sébastien Godat, Fabrice Caillol, Aurélie Autret, Erwan Bories, Christian Pesenti, Jean Philippe Ratone, Chiara De Cassan, Flora Poizat, Marc Giovannini

Erschienen in: Surgical Endoscopy | Ausgabe 9/2017

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Abstract

Background

Endotherapy in cases of neoplastic Barrett esophagus (BE) relapse after successful initial endoscopic management is commonly accepted, but few studies analyze this topic and also take into account the metachronous lesions.

Aims

To evaluate the efficiency of endotherapy in the case of neoplastic BE relapse after successful complete endoscopic eradication of neoplastic BE and metaplastic BE.

Methods

Retrospective review of medical records was collected in a computerized and prospective manner between 2000 and 2015, in a single tertiary care center. Recurrence was defined by histological presence of high-grade dysplasia or superficial adenocarcinoma at least 6 months after the end of successful initial endotherapy.

Results

Eighteen patients were assessed (1F/17 M). Delay between initial treatment and relapse was 16.6 months (range 6–33). Endotherapy for relapse obtained a sustained and complete remission for 8/18 (44%) patients, with an average endoscopic follow-up of 28 months. The complication rate of endotherapy was 6%. Surgical management was required in 33% (2 pT2N0M0, 2 pTisN0M0, 1 pTm2N0M0 and 1 pTm3N0M0) and salvage radiochemotherapy in 17% (3/18). One patient treated by 6 sessions of ER was considered as a failure given the multiple sessions of endotherapy. Multivariate analysis showed that length of BE (>5 cm), late stenosis adverse events and the quality of vertical margin during initial ER are predictive factors for disease-free survival (p value < 0.01, Hazard Ratio up to 0.076).

Conclusion

Endotherapy could be a treatment for management of neoplastic BE relapse, but should be carefully used, with strict follow-up.
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Metadaten
Titel
Endotherapy in case of relapse of neoplastic Barrett’s esophagus after successful initial endoscopic resection
verfasst von
Sébastien Godat
Fabrice Caillol
Aurélie Autret
Erwan Bories
Christian Pesenti
Jean Philippe Ratone
Chiara De Cassan
Flora Poizat
Marc Giovannini
Publikationsdatum
11.01.2017
Verlag
Springer US
Erschienen in
Surgical Endoscopy / Ausgabe 9/2017
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-016-5409-5

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