Skip to main content
Erschienen in: Journal of Gastrointestinal Surgery 3/2017

18.01.2017 | Original Article

Enhanced Recovery after Surgery Programs for Liver Resection: a Meta-analysis

verfasst von: Cheng Wang, Guoqun Zheng, Wenlong Zhang, Fabiao Zhang, Shangdong Lv, Aidong Wang, Zheping Fang

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Background and Aims

Due to the limited number of high-quality randomized controlled trials on enhanced recovery after surgery for hepatectomy, previous reviews have not been sufficiently comprehensive. Our objectives were to evaluate and compare the safety and efficacy of enhanced recovery after surgery programs and traditional care in patients undergoing open or laparoscopic surgery and to assess the optimized items for hepatectomy.

Methods

We searched the PubMed, Embase, and the Cochrane Library databases for all the relevant studies regardless of study design. We assessed the methodological quality of the included studies and excluded studies of poor quality. We performed a meta-analysis using RevMan 5.3 software.

Results

In total, 19 original studies with 2575 patients, including four randomized controlled trials and 15 non-randomized controlled trials, were analyzed. The meta-analysis demonstrated that enhanced recovery after surgery programs could reduce morbidity, hospital stays and cost, blood loss, and time to bowel function recovery for both open and laparoscopic surgery without increasing mortality, readmission rate, or transfusion rate. Twelve items were essential for liver surgery.

Conclusions

Enhanced recovery after surgery programs for hepatectomy are feasible and efficient. Further studies should optimize perioperative outcomes for liver surgery.
Literatur
1.
Zurück zum Zitat Basse L, Hjort Jakobsen D, Billesbolle P, Werner M, Kehlet H. A clinical pathway to accelerate recovery after colonic resection. Ann Surg 2000;232:51–57.CrossRefPubMedPubMedCentral Basse L, Hjort Jakobsen D, Billesbolle P, Werner M, Kehlet H. A clinical pathway to accelerate recovery after colonic resection. Ann Surg 2000;232:51–57.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth 1997;78:606–617.CrossRefPubMed Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth 1997;78:606–617.CrossRefPubMed
3.
Zurück zum Zitat Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg 2002;183:630–641.CrossRefPubMed Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg 2002;183:630–641.CrossRefPubMed
4.
Zurück zum Zitat Lassen K, Soop M, Nygren J, Cox PB, Hendry PO, Spies C, von Meyenfeldt MF, Fearon KC, Revhaug A, Norderval S, Ljungqvist O, Lobo DN, Dejong CH, Enhanced Recovery After Surgery Group. Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery Group (ERAS) recommendations. Arch Surg 2009;144:961–969. doi:10.1001/archsurg.2009.170.CrossRefPubMed Lassen K, Soop M, Nygren J, Cox PB, Hendry PO, Spies C, von Meyenfeldt MF, Fearon KC, Revhaug A, Norderval S, Ljungqvist O, Lobo DN, Dejong CH, Enhanced Recovery After Surgery Group. Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery Group (ERAS) recommendations. Arch Surg 2009;144:961–969. doi:10.​1001/​archsurg.​2009.​170.CrossRefPubMed
6.
Zurück zum Zitat Kim JW, Kim WS, Cheong JH, Hyung WJ, Choi SH, Noh SH. Safety and efficacy of fast-track surgery in laparoscopic distal gastrectomy for gastric cancer: a randomized clinical trial. World J Surg 2012;36:2879–2887. doi:10.1007/s00268-012-1741-7.CrossRefPubMed Kim JW, Kim WS, Cheong JH, Hyung WJ, Choi SH, Noh SH. Safety and efficacy of fast-track surgery in laparoscopic distal gastrectomy for gastric cancer: a randomized clinical trial. World J Surg 2012;36:2879–2887. doi:10.​1007/​s00268-012-1741-7.CrossRefPubMed
7.
Zurück zum Zitat Muehling B, Schelzig H, Steffen P, Meierhenrich R, Sunder-Plassmann L, Orend KH. A prospective randomized trial comparing traditional and fast-track patient care in elective open infrarenal aneurysm repair. World J Surg 2009;33:577–585. doi:10.1007/s00268-008-9892-2.CrossRefPubMed Muehling B, Schelzig H, Steffen P, Meierhenrich R, Sunder-Plassmann L, Orend KH. A prospective randomized trial comparing traditional and fast-track patient care in elective open infrarenal aneurysm repair. World J Surg 2009;33:577–585. doi:10.​1007/​s00268-008-9892-2.CrossRefPubMed
10.
Zurück zum Zitat Kirsh EJ, Worwag EM, Sinner M, Chodak GW. Using outcome data and patient satisfaction surveys to develop policies regarding minimum length of hospitalization after radical prostatectomy. Urology 2000;56:106–107.CrossRef Kirsh EJ, Worwag EM, Sinner M, Chodak GW. Using outcome data and patient satisfaction surveys to develop policies regarding minimum length of hospitalization after radical prostatectomy. Urology 2000;56:106–107.CrossRef
12.
Zurück zum Zitat van den Broek MA, van Dam RM, van Breukelen GJ, Bemelmans MH, Oussoultzoglou E, Pessaux P, Dejong CH, Freemantle N, Olde Damink SW. Development of a composite endpoint for randomized controlled trials in liver surgery. Br J Surg 2011;98:1138–1145. doi:10.1002/bjs.7503.CrossRefPubMed van den Broek MA, van Dam RM, van Breukelen GJ, Bemelmans MH, Oussoultzoglou E, Pessaux P, Dejong CH, Freemantle N, Olde Damink SW. Development of a composite endpoint for randomized controlled trials in liver surgery. Br J Surg 2011;98:1138–1145. doi:10.​1002/​bjs.​7503.CrossRefPubMed
13.
Zurück zum Zitat Wainess RM, Cowan JA. National trends in the use and outcomes of hepatic resection. J Am Coll Surg 2004;199:31–38.PubMed Wainess RM, Cowan JA. National trends in the use and outcomes of hepatic resection. J Am Coll Surg 2004;199:31–38.PubMed
15.
Zurück zum Zitat Melloul E, Hübner M, Scott M, Snowden C, Prentis J, Dejong CHC, Garden OJ, Farges O, Kokudo N, Vauthey JN. Guidelines for perioperative care for liver surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations. World J Surg 2016;40:2425–2440. Melloul E, Hübner M, Scott M, Snowden C, Prentis J, Dejong CHC, Garden OJ, Farges O, Kokudo N, Vauthey JN. Guidelines for perioperative care for liver surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations. World J Surg 2016;40:2425–2440.
16.
17.
Zurück zum Zitat Coolsen MM, Wong-Lun-Hing EM, van Dam RM, van der Wilt AA, Slim K, Lassen K, Dejong CH. A systematic review of outcomes in patients undergoing liver surgery in an enhanced recovery after surgery pathways. HPB (Oxford) 2013;15:245–251. doi:10.1111/j.1477-2574.2012.00572.x.CrossRef Coolsen MM, Wong-Lun-Hing EM, van Dam RM, van der Wilt AA, Slim K, Lassen K, Dejong CH. A systematic review of outcomes in patients undergoing liver surgery in an enhanced recovery after surgery pathways. HPB (Oxford) 2013;15:245–251. doi:10.​1111/​j.​1477-2574.​2012.​00572.​x.CrossRef
19.
Zurück zum Zitat Ni TG, Yang HT, Zhang H, Meng HP, Li B. Enhanced recovery after surgery programs in patients undergoing hepatectomy: a meta-analysis. World J Gastroenterol 2015;21:9209–9216.CrossRefPubMedPubMedCentral Ni TG, Yang HT, Zhang H, Meng HP, Li B. Enhanced recovery after surgery programs in patients undergoing hepatectomy: a meta-analysis. World J Gastroenterol 2015;21:9209–9216.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Lei Q, Wang X, Tan S, Xia X, Zheng H, Wu C. Fast-track programs versus traditional care in hepatectomy: a meta-analysis of randomized controlled trials. Dig Surg 2014;31:392–399. doi:10.1159/000369219.CrossRefPubMed Lei Q, Wang X, Tan S, Xia X, Zheng H, Wu C. Fast-track programs versus traditional care in hepatectomy: a meta-analysis of randomized controlled trials. Dig Surg 2014;31:392–399. doi:10.​1159/​000369219.CrossRefPubMed
23.
Zurück zum Zitat Higgins JPT, Altman DG, Sterne JAC. Assessing risk of bias in included studies. In Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. Higgins JPT, Altman DG, Sterne JAC. Assessing risk of bias in included studies. In Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011.
26.
27.
Zurück zum Zitat Deeks JJ, Higgins JPT, Altman DG. Analyzing data and undertaking meta-analyses. In Higgins JPT, Green S, Altman DG, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. Deeks JJ, Higgins JPT, Altman DG. Analyzing data and undertaking meta-analyses. In Higgins JPT, Green S, Altman DG, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011.
28.
Zurück zum Zitat Sterne JAC, Egger M, Moher D. Addressing reporting biases. In Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. Sterne JAC, Egger M, Moher D. Addressing reporting biases. In Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011.
30.
31.
Zurück zum Zitat Lu H, Fan Y, Zhang F, Li G, Zhang C, Lu L. Fast-track surgery improves postoperative outcomes after hepatectomy. Hepatogastroenterology 2014;61:168–172. Lu H and Fan Y shared co-first authorship.PubMed Lu H, Fan Y, Zhang F, Li G, Zhang C, Lu L. Fast-track surgery improves postoperative outcomes after hepatectomy. Hepatogastroenterology 2014;61:168–172. Lu H and Fan Y shared co-first authorship.PubMed
32.
Zurück zum Zitat Ni CY, Yang Y, Chang YQ, Cai H, Xu B, Yang F, Lau WY, Wang ZH, Zhou WP. Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: a prospective randomized controlled trial. Eur J Surg Oncol 2013;39:542–547. doi:10.1016/j.ejso.2013.03.013. Ni CY and Yang Y shared co-first authorship.CrossRefPubMed Ni CY, Yang Y, Chang YQ, Cai H, Xu B, Yang F, Lau WY, Wang ZH, Zhou WP. Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: a prospective randomized controlled trial. Eur J Surg Oncol 2013;39:542–547. doi:10.​1016/​j.​ejso.​2013.​03.​013. Ni CY and Yang Y shared co-first authorship.CrossRefPubMed
33.
Zurück zum Zitat Jones C, Kelliher L, Dickinson M, Riga A, Worthington T, Scott MJ, Vandrevala T, Fry CH, Karanjia N, Quiney N. Randomized clinical trial on enhanced recovery versus standard care following open liver resection. Br J Surg 2013;100:1015–1024. doi:10.1002/bjs.9165.CrossRefPubMed Jones C, Kelliher L, Dickinson M, Riga A, Worthington T, Scott MJ, Vandrevala T, Fry CH, Karanjia N, Quiney N. Randomized clinical trial on enhanced recovery versus standard care following open liver resection. Br J Surg 2013;100:1015–1024. doi:10.​1002/​bjs.​9165.CrossRefPubMed
34.
Zurück zum Zitat Blind PJ, Andersson B, Tingstedt B, Bergenfeldt M, Andersson R, Lindell G, Sturesson C. Fast-track program for liver resection—factors prolonging length of stay. Hepatogastroenterology 2014;61:2340–2344.PubMed Blind PJ, Andersson B, Tingstedt B, Bergenfeldt M, Andersson R, Lindell G, Sturesson C. Fast-track program for liver resection—factors prolonging length of stay. Hepatogastroenterology 2014;61:2340–2344.PubMed
36.
Zurück zum Zitat Dasari BV, Rahman R, Khan S, Bennett D, Hodson J, Isaac J, Marudanayagam R, Mirza DF, Muiesan P, Roberts KJ, Sutcliffe RP. Safety and feasibility of an enhanced recovery pathway after a liver resection: prospective cohort study. HPB (Oxford) 2015;17:700–706. doi:10.1111/hpb.12447.CrossRef Dasari BV, Rahman R, Khan S, Bennett D, Hodson J, Isaac J, Marudanayagam R, Mirza DF, Muiesan P, Roberts KJ, Sutcliffe RP. Safety and feasibility of an enhanced recovery pathway after a liver resection: prospective cohort study. HPB (Oxford) 2015;17:700–706. doi:10.​1111/​hpb.​12447.CrossRef
37.
Zurück zum Zitat Day RW, Cleeland CS, Wang XS, Fielder S, Calhoun J, Conrad C, Vauthey JN, Gottumukkala V, Aloia TA. Patient-reported outcomes accurately measure the value of an enhanced recovery program in liver surgery. J Am Coll Surg 2015;221:1023–1030.e1021-1022. doi:10.1016/j.jamcollsurg.2015.09.011. Day RW, Gottumukkala V, and Aloia TA shared co-first authorship. Day RW, Cleeland CS, Wang XS, Fielder S, Calhoun J, Conrad C, Vauthey JN, Gottumukkala V, Aloia TA. Patient-reported outcomes accurately measure the value of an enhanced recovery program in liver surgery. J Am Coll Surg 2015;221:1023–1030.e1021-1022. doi:10.​1016/​j.​jamcollsurg.​2015.​09.​011. Day RW, Gottumukkala V, and Aloia TA shared co-first authorship.
38.
Zurück zum Zitat Joliat GR, Labgaa I, Hubner M, Blanc C, Griesser AC, Schafer M, Demartines N. Cost-benefit analysis of the implementation of an enhanced recovery program in liver surgery. World J Surg 2016;40:2441–2450. doi:10.1007/s00268-016-3582-2.CrossRefPubMed Joliat GR, Labgaa I, Hubner M, Blanc C, Griesser AC, Schafer M, Demartines N. Cost-benefit analysis of the implementation of an enhanced recovery program in liver surgery. World J Surg 2016;40:2441–2450. doi:10.​1007/​s00268-016-3582-2.CrossRefPubMed
39.
Zurück zum Zitat Kaibori M, Matsui K, Ishizaki M, Iida H, Yoshii K, Asano H, Kon M. Effects of implementing an “enhanced recovery after surgery” program on patients undergoing resection of hepatocellular carcinoma. Surg Today 2016;47:42–51. doi:10.1007/s00595-016-1344-2.CrossRefPubMed Kaibori M, Matsui K, Ishizaki M, Iida H, Yoshii K, Asano H, Kon M. Effects of implementing an “enhanced recovery after surgery” program on patients undergoing resection of hepatocellular carcinoma. Surg Today 2016;47:42–51. doi:10.​1007/​s00595-016-1344-2.CrossRefPubMed
40.
Zurück zum Zitat Labgaa I, Jarrar G, Joliat GR, Allemann P, Gander S, Blanc C, Hubner M, Demartines N. Implementation of enhanced recovery (ERAS) in colorectal surgery has a positive impact on non-ERAS liver surgery patients. World J Surg 2016;40:1082–1091. doi:10.1007/s00268-015-3363-3. Labgaa I and Jarrar G shared co-first authorship.CrossRefPubMed Labgaa I, Jarrar G, Joliat GR, Allemann P, Gander S, Blanc C, Hubner M, Demartines N. Implementation of enhanced recovery (ERAS) in colorectal surgery has a positive impact on non-ERAS liver surgery patients. World J Surg 2016;40:1082–1091. doi:10.​1007/​s00268-015-3363-3. Labgaa I and Jarrar G shared co-first authorship.CrossRefPubMed
41.
Zurück zum Zitat Liang X, Ying H, Wang H, Xu H, Yu H, Cai L, Wang Y, Tong Y, Ji L, Luo R, Cai XJ. Enhanced recovery program versus traditional care in laparoscopic hepatectomy. Medicine (Baltimore) 2016;95:e2835. doi:10.1097/md.0000000000002835. Liang X and Ying H shared co-first authorship.CrossRef Liang X, Ying H, Wang H, Xu H, Yu H, Cai L, Wang Y, Tong Y, Ji L, Luo R, Cai XJ. Enhanced recovery program versus traditional care in laparoscopic hepatectomy. Medicine (Baltimore) 2016;95:e2835. doi:10.​1097/​md.​0000000000002835​. Liang X and Ying H shared co-first authorship.CrossRef
43.
Zurück zum Zitat Page AJ, Gani F, Crowley KT, Lee KH, Grant MC, Zavadsky TL, Hobson D, Wu C, Wick EC, Pawlik TM. Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection. Br J Surg 2016;103:564–571. doi:10.1002/bjs.10087.CrossRefPubMed Page AJ, Gani F, Crowley KT, Lee KH, Grant MC, Zavadsky TL, Hobson D, Wu C, Wick EC, Pawlik TM. Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection. Br J Surg 2016;103:564–571. doi:10.​1002/​bjs.​10087.CrossRefPubMed
44.
46.
Zurück zum Zitat Stoot JH, van Dam RM, Busch OR, van Hillegersberg R, De Boer M, Olde Damink SWM, Bemelmans MH, Dejong CHC. The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study. HPB 2009;11:140–144.CrossRefPubMedPubMedCentral Stoot JH, van Dam RM, Busch OR, van Hillegersberg R, De Boer M, Olde Damink SWM, Bemelmans MH, Dejong CHC. The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study. HPB 2009;11:140–144.CrossRefPubMedPubMedCentral
47.
Zurück zum Zitat Van Dam RM, Hendry PO, Coolsen MME, Bemelmans MHA, Lassen K, Revhaug A, Fearon KCH, Garden OJ, Dejong CHC. Initial experience with a multimodal enhanced recovery programme in patients undergoing liver resection. Br J Surg 2008;95:969–975.CrossRefPubMed Van Dam RM, Hendry PO, Coolsen MME, Bemelmans MHA, Lassen K, Revhaug A, Fearon KCH, Garden OJ, Dejong CHC. Initial experience with a multimodal enhanced recovery programme in patients undergoing liver resection. Br J Surg 2008;95:969–975.CrossRefPubMed
48.
Zurück zum Zitat Zhu L, Li J, Li XK, Feng JQ, Gao JM. Impact of a clinical pathway on hospital costs, length of stay and early outcomes after hepatectomy for hepatocellular carcinoma. Asian Pac J Cancer Prev 2014;15:5389–5393. Zhu L, Li J, Li XK and Feng JQ shared co-first authorship.CrossRefPubMed Zhu L, Li J, Li XK, Feng JQ, Gao JM. Impact of a clinical pathway on hospital costs, length of stay and early outcomes after hepatectomy for hepatocellular carcinoma. Asian Pac J Cancer Prev 2014;15:5389–5393. Zhu L, Li J, Li XK and Feng JQ shared co-first authorship.CrossRefPubMed
49.
Zurück zum Zitat Khuri SF, Henderson WG, DePalma RG, Mosca C, Healey NA, Kumbhani DJ, Participants in the V. A. National Surgical Quality Improvement Program. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg 2005;242:326–341; discussion 341–323.PubMedPubMedCentral Khuri SF, Henderson WG, DePalma RG, Mosca C, Healey NA, Kumbhani DJ, Participants in the V. A. National Surgical Quality Improvement Program. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg 2005;242:326–341; discussion 341–323.PubMedPubMedCentral
50.
Zurück zum Zitat van Dam RM, Wong-Lun-Hing EM, Breukelen GJV, Stoot JH, Vorst JRVD, Bemelmans MH, Damink SWO, Lassen K, Dejong CH. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II – Trial): study protocol for a randomised controlled trial. Trials 2012;13:1–11. doi:10.1186/1745-6215-13-54.CrossRef van Dam RM, Wong-Lun-Hing EM, Breukelen GJV, Stoot JH, Vorst JRVD, Bemelmans MH, Damink SWO, Lassen K, Dejong CH. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II – Trial): study protocol for a randomised controlled trial. Trials 2012;13:1–11. doi:10.​1186/​1745-6215-13-54.CrossRef
Metadaten
Titel
Enhanced Recovery after Surgery Programs for Liver Resection: a Meta-analysis
verfasst von
Cheng Wang
Guoqun Zheng
Wenlong Zhang
Fabiao Zhang
Shangdong Lv
Aidong Wang
Zheping Fang
Publikationsdatum
18.01.2017
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Surgery / Ausgabe 3/2017
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-017-3360-y

Weitere Artikel der Ausgabe 3/2017

Journal of Gastrointestinal Surgery 3/2017 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.