Skip to main content
Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 4/2016

01.04.2016 | Chronische myeloische Leukämie | Leitthema

Entstehung, Entwicklung und Erfolge des Kompetenznetzes Akute und Chronische Leukämien (KNL)

verfasst von: Ute Kossak-Roth, Susanne Saußele, Carlo Aul, Thomas Büchner, Hartmut Döhner, Martin Dugas, Gerhard Ehninger, Arnold Ganser, Aristoteles Giagounidis, Nicola Gökbuget, Martin Griesshammer, Jörg Hasford, Michael Heuser, Wolfgang Hiddemann, Andreas Hochhaus, Dieter Hoelzer, Dietger Niederwieser, Andreas Reiter, Christoph Röllig, Prof. Dr. Rüdiger Hehlmann

Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Zusammenfassung

Im Jahr 1997 wurde durch den Zusammenschluss der führenden Leukämie-Studiengruppen in Deutschland das Kompetenznetz Akute und Chronische Leukämien (KNL) gegründet. Wichtige Resultate sind neue Kooperationsstudien und Forschungsprojekte, die Fortführung und Erweiterung bestehender und die Gründung neuer nationaler Studiengruppen, die Verbesserung der Studieninfrastruktur sowie die Einrichtung von Patientenregistern und Biomaterialbanken. 2003 führte das Konzept des KNL zur Gründung des European LeukemiaNet (ELN). In der Folge wurden in internationaler Kooperation zahlreiche europäische Managementleitlinien erarbeitet und mehrere länderübergreifende Projekte und Studien durchgeführt. Ziel des Netzes ist die Heilung der Leukämien durch kooperative Forschung.
Literatur
1.
Zurück zum Zitat Hehlmann R, Berger U, Aul C et al (2004) Das Kompetenznetzwerk akute und chronische Leukämien. Dtsch Med Wochenschr 129:2660–2665PubMedCrossRef Hehlmann R, Berger U, Aul C et al (2004) Das Kompetenznetzwerk akute und chronische Leukämien. Dtsch Med Wochenschr 129:2660–2665PubMedCrossRef
2.
Zurück zum Zitat Hehlmann R, Berger U, Aul C et al (2004) The German competence network ’Acute and chronic leukemias‘. Leukemia 18:665–669PubMedCrossRef Hehlmann R, Berger U, Aul C et al (2004) The German competence network ’Acute and chronic leukemias‘. Leukemia 18:665–669PubMedCrossRef
3.
Zurück zum Zitat Büchner T, Schlenk RF, Schaich M et al (2012) Acute Myeloid Leukemia (AML): different treatment strategies versus a common standard arm-combined prospective analysis by the German AML Intergroup. J Clin Oncol 30:3604–3610PubMedCrossRef Büchner T, Schlenk RF, Schaich M et al (2012) Acute Myeloid Leukemia (AML): different treatment strategies versus a common standard arm-combined prospective analysis by the German AML Intergroup. J Clin Oncol 30:3604–3610PubMedCrossRef
4.
Zurück zum Zitat Hoelzer D, Bassan R, Dombret H et al (in press) Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology Hoelzer D, Bassan R, Dombret H et al (in press) Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology
6.
Zurück zum Zitat Döhner H, Weisdorf DJ, Bloomfield CD (2015) Acute Myeloid leukemia. N Engl J Med 373:1136–1152PubMedCrossRef Döhner H, Weisdorf DJ, Bloomfield CD (2015) Acute Myeloid leukemia. N Engl J Med 373:1136–1152PubMedCrossRef
7.
Zurück zum Zitat Döhner H, Estey EH, Amadori S et al (2010) Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115:453–474PubMedCrossRef Döhner H, Estey EH, Amadori S et al (2010) Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115:453–474PubMedCrossRef
8.
Zurück zum Zitat Sanz MA, Grimwade D, Tallman MS et al (2009) Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 113:1875–1891PubMedCrossRef Sanz MA, Grimwade D, Tallman MS et al (2009) Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 113:1875–1891PubMedCrossRef
9.
Zurück zum Zitat Cornelissen JJ, Gratwohl A, Schlenk RF et al (2012) The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol 9:579–590PubMedCrossRef Cornelissen JJ, Gratwohl A, Schlenk RF et al (2012) The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol 9:579–590PubMedCrossRef
10.
Zurück zum Zitat Hallek M, Cheson BD, Catovsky D et al (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111:5446–5456PubMedPubMedCentralCrossRef Hallek M, Cheson BD, Catovsky D et al (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111:5446–5456PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Pospisilova S, Gonzalez D, Malcikova J et al (2012) ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26:1458–1461PubMedCrossRef Pospisilova S, Gonzalez D, Malcikova J et al (2012) ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26:1458–1461PubMedCrossRef
12.
Zurück zum Zitat Rawstron AC, Böttcher S, Letestu R et al (2013) Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL. Leukemia 27:142–149PubMedCrossRef Rawstron AC, Böttcher S, Letestu R et al (2013) Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL. Leukemia 27:142–149PubMedCrossRef
13.
Zurück zum Zitat Baccarani M, Deininger MW, Rosti G et al (2013) European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 122:872–884PubMedPubMedCentralCrossRef Baccarani M, Deininger MW, Rosti G et al (2013) European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 122:872–884PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Baccarani M, Cortes J, Pane F et al (2009) Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 27:6041–6051PubMedPubMedCentralCrossRef Baccarani M, Cortes J, Pane F et al (2009) Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 27:6041–6051PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Hehlmann R, Hochhaus A, Baccarani M et al (2007) Chronic myeloid leukaemia. Lancet 370:342–350PubMedCrossRef Hehlmann R, Hochhaus A, Baccarani M et al (2007) Chronic myeloid leukaemia. Lancet 370:342–350PubMedCrossRef
17.
Zurück zum Zitat Guilhot J, Baccarani M, Clark RE et al (2012) Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet. Blood 119:5963–5971PubMedCrossRef Guilhot J, Baccarani M, Clark RE et al (2012) Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet. Blood 119:5963–5971PubMedCrossRef
18.
Zurück zum Zitat Pfirrmann M, Hochhaus A, Lauseker M et al (2011) Recommendations to meet statistical challenges arising from endpoints beyond overall survival in clinical trials on chronic myeloid leukemia. Leukemia 25:1433–1438PubMedCrossRef Pfirrmann M, Hochhaus A, Lauseker M et al (2011) Recommendations to meet statistical challenges arising from endpoints beyond overall survival in clinical trials on chronic myeloid leukemia. Leukemia 25:1433–1438PubMedCrossRef
19.
Zurück zum Zitat White HE, Hedges J, Bendit I et al (2013) Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale. Clin Chem 59:938–948PubMedCrossRef White HE, Hedges J, Bendit I et al (2013) Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale. Clin Chem 59:938–948PubMedCrossRef
20.
Zurück zum Zitat Cross NC, White HE, Müller MC et al (2012) Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 26:2172–2175PubMedCrossRef Cross NC, White HE, Müller MC et al (2012) Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 26:2172–2175PubMedCrossRef
21.
Zurück zum Zitat White HE, Matejtschuk P, Rigsby P et al (2010) Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA. Blood 116:111–117CrossRef White HE, Matejtschuk P, Rigsby P et al (2010) Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA. Blood 116:111–117CrossRef
22.
Zurück zum Zitat Müller MC, Cross NC, Erben P et al (2009) Harmonization of molecular monitoring of CML therapy in Europe. Leukemia 23:1957–1963PubMedCrossRef Müller MC, Cross NC, Erben P et al (2009) Harmonization of molecular monitoring of CML therapy in Europe. Leukemia 23:1957–1963PubMedCrossRef
23.
Zurück zum Zitat Branford S, Cross NC, Hochhaus A et al (2006) Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia. Leukemia 20:1925–1930PubMedCrossRef Branford S, Cross NC, Hochhaus A et al (2006) Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia. Leukemia 20:1925–1930PubMedCrossRef
24.
Zurück zum Zitat Hughes T, Deininger M, Hochhaus A et al (2006) Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 108:28–37PubMedPubMedCentralCrossRef Hughes T, Deininger M, Hochhaus A et al (2006) Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 108:28–37PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Cross NC, White HE, Colomer D et al (2015) Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia. Leukemia 29:999–1003PubMedPubMedCentralCrossRef Cross NC, White HE, Colomer D et al (2015) Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia. Leukemia 29:999–1003PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Soverini S, Hochhaus A, Nicolini FE et al (2011) BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 118:1208–1215PubMedCrossRef Soverini S, Hochhaus A, Nicolini FE et al (2011) BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 118:1208–1215PubMedCrossRef
27.
Zurück zum Zitat Malcovati L, Hellström-Lindberg E, Bowen D et al (2013) Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood 122:2943–2964PubMedPubMedCentralCrossRef Malcovati L, Hellström-Lindberg E, Bowen D et al (2013) Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood 122:2943–2964PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Barbui T, Barosi G, Birgegard G et al (2011) Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 29:761–770PubMedPubMedCentralCrossRef Barbui T, Barosi G, Birgegard G et al (2011) Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 29:761–770PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Barosi G, Birgegard G, Finazzi G et al (2009) A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus process. Br J Haematol 148:961–963PubMedCrossRef Barosi G, Birgegard G, Finazzi G et al (2009) A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus process. Br J Haematol 148:961–963PubMedCrossRef
30.
Zurück zum Zitat Barosi G, Birgegard G, Finazzi G et al (2009) Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference. Blood 113:4829–4833PubMedCrossRef Barosi G, Birgegard G, Finazzi G et al (2009) Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference. Blood 113:4829–4833PubMedCrossRef
31.
Zurück zum Zitat Jovanovic JV, Ivey A, Vannucchi AM et al (2013) Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study. Leukemia 27:2032–2039PubMedPubMedCentralCrossRef Jovanovic JV, Ivey A, Vannucchi AM et al (2013) Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study. Leukemia 27:2032–2039PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Østergaard M, Nyvold CG, Jovanovic JV et al (2011) Development of standardized approaches to reporting of minimal residual disease data using a reporting software package designed within the European LeukemiaNet. Leukemia 25:1168–1173PubMedCrossRef Østergaard M, Nyvold CG, Jovanovic JV et al (2011) Development of standardized approaches to reporting of minimal residual disease data using a reporting software package designed within the European LeukemiaNet. Leukemia 25:1168–1173PubMedCrossRef
33.
Zurück zum Zitat Béné MC, Nebe T, Bettelheim P et al (2011) Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10. Leukemia 25:567–574PubMedCrossRef Béné MC, Nebe T, Bettelheim P et al (2011) Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10. Leukemia 25:567–574PubMedCrossRef
34.
Zurück zum Zitat Haferlach T, Kohlmann A, Wieczorek L et al (2010) Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 28:2529–2537PubMedPubMedCentralCrossRef Haferlach T, Kohlmann A, Wieczorek L et al (2010) Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 28:2529–2537PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Mills KI, Kohlmann A, Williams PM et al (2009) Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome. Blood 114:1063–1072PubMedCrossRef Mills KI, Kohlmann A, Williams PM et al (2009) Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome. Blood 114:1063–1072PubMedCrossRef
36.
Zurück zum Zitat Kohlmann A, Bullinger L, Thiede C et al (2010) Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia 24:1216–1220PubMedCrossRef Kohlmann A, Bullinger L, Thiede C et al (2010) Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia 24:1216–1220PubMedCrossRef
37.
Zurück zum Zitat Kohlmann A, Kipps TJ, Rassenti LZ et al (2008) An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in Leukemia study prephase. Br J Haematol 142:802–807PubMedPubMedCentralCrossRef Kohlmann A, Kipps TJ, Rassenti LZ et al (2008) An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in Leukemia study prephase. Br J Haematol 142:802–807PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Staal FJ, Cario G, Cazzaniga G et al (2006) Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks. Leukemia 20:1385–1392PubMedCrossRef Staal FJ, Cario G, Cazzaniga G et al (2006) Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks. Leukemia 20:1385–1392PubMedCrossRef
39.
Zurück zum Zitat Haferlach C, Rieder H, Lillington DM et al (2007) Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes. Genes Chromosomes Cancer 46:494–499PubMedCrossRef Haferlach C, Rieder H, Lillington DM et al (2007) Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes. Genes Chromosomes Cancer 46:494–499PubMedCrossRef
40.
Zurück zum Zitat Cilloni D, Renneville A, Hermitte F et al (2009) Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study. J Clin Oncol 27:5195–5201PubMedCrossRef Cilloni D, Renneville A, Hermitte F et al (2009) Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study. J Clin Oncol 27:5195–5201PubMedCrossRef
42.
Zurück zum Zitat Kröger NM, Deeg JH, Olavarria E et al (2009) Indication and management of allogeneic stem cell transplantation in primary myelofibrosis: a consensus process by an EBMT/ELN international working group. Leukemia 29:2126–2133CrossRef Kröger NM, Deeg JH, Olavarria E et al (2009) Indication and management of allogeneic stem cell transplantation in primary myelofibrosis: a consensus process by an EBMT/ELN international working group. Leukemia 29:2126–2133CrossRef
43.
Zurück zum Zitat Ruutu T, Gratwohl A, de Witte T et al (2014) Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. Bone Marrow Transplant 49:168–173PubMedCrossRef Ruutu T, Gratwohl A, de Witte T et al (2014) Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. Bone Marrow Transplant 49:168–173PubMedCrossRef
44.
Zurück zum Zitat Ruutu T, van Biezen A, Hertenstein B et al (2012) Prophylaxis and treatment of GVHD after allogeneic haematopoietic SCT: a survey of centre strategies by the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 47:1459–1464PubMedCrossRef Ruutu T, van Biezen A, Hertenstein B et al (2012) Prophylaxis and treatment of GVHD after allogeneic haematopoietic SCT: a survey of centre strategies by the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 47:1459–1464PubMedCrossRef
45.
Zurück zum Zitat Ruutu T, Barosi G, Benjamin RJ et al (2007) Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica 92:95–100PubMedCrossRef Ruutu T, Barosi G, Benjamin RJ et al (2007) Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica 92:95–100PubMedCrossRef
46.
Zurück zum Zitat Dreger P, Corradini P, Kimby E et al (2007) Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21:12–17PubMedCrossRef Dreger P, Corradini P, Kimby E et al (2007) Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21:12–17PubMedCrossRef
47.
Zurück zum Zitat de Witte T, Brand R, van Biezen A et al (2006) The role of stem cell source in autologous hematopoietic stem cell transplantation for patients with myelodysplastic syndromes. Haematologica 91:750–756PubMed de Witte T, Brand R, van Biezen A et al (2006) The role of stem cell source in autologous hematopoietic stem cell transplantation for patients with myelodysplastic syndromes. Haematologica 91:750–756PubMed
Metadaten
Titel
Entstehung, Entwicklung und Erfolge des Kompetenznetzes Akute und Chronische Leukämien (KNL)
verfasst von
Ute Kossak-Roth
Susanne Saußele
Carlo Aul
Thomas Büchner
Hartmut Döhner
Martin Dugas
Gerhard Ehninger
Arnold Ganser
Aristoteles Giagounidis
Nicola Gökbuget
Martin Griesshammer
Jörg Hasford
Michael Heuser
Wolfgang Hiddemann
Andreas Hochhaus
Dieter Hoelzer
Dietger Niederwieser
Andreas Reiter
Christoph Röllig
Prof. Dr. Rüdiger Hehlmann
Publikationsdatum
01.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz / Ausgabe 4/2016
Print ISSN: 1436-9990
Elektronische ISSN: 1437-1588
DOI
https://doi.org/10.1007/s00103-016-2315-x

Weitere Artikel der Ausgabe 4/2016

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 4/2016 Zur Ausgabe

Leitlinien kompakt für die Allgemeinmedizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Facharzt-Training Allgemeinmedizin

Die ideale Vorbereitung zur anstehenden Prüfung mit den ersten 24 von 100 klinischen Fallbeispielen verschiedener Themenfelder

Mehr erfahren

Update Allgemeinmedizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.