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International Archives of Occupational and Environmental Health

Erschienen in:

27.02.2024 | Original Article

Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents

verfasst von: Yi-Fan Wang, Li Li, Xu Wang, Ya-Nan Yun, Xue-Lin Wang, En-Yang He, Ming-Kun Song, Xue-Hong Xia, Ying-Xue Zou

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 3/2024

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Abstract

Background

Previous epidemiological studies about the relationship between per- and polyfluoroalkyl substances (PFAS) concentrations and adolescent asthma have typically examined single PFAS, without considering the mixtures effects of PFAS.

Methods

Using data from the 2013–2018 National Health and Nutrition Examination Survey (NHANES), 886 adolescents aged 12–19 years were included in this study. We explored the association between PFAS mixture concentrations and adolescent asthma using weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models, respectively.

Results

After adjusting for confounders, the results of the WQS regression and BKMR models were consistent, with mixed exposure to the five PFAS not significantly associated with asthma in all adolescents. The association remained nonsignificant in the subgroup analysis by sex.

Conclusions

Our study demonstrated no significant association between mixed exposure to PFAS and adolescent asthma, and more large cohort studies are needed to confirm this in the future.

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Titel: Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents
verfasst von: Yi-Fan Wang
Li Li
Xu Wang
Ya-Nan Yun
Xue-Lin Wang
En-Yang He
Ming-Kun Song
Xue-Hong Xia
Ying-Xue Zou
Publikationsdatum: 27.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 3/2024
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-024-02047-1

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Abstract

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