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Erschienen in: Der Nervenarzt 1/2018

20.09.2017 | Enzephalitis | CME

Update Anti-N-Methyl-D-Aspartat-Rezeptor-Enzephalitis

verfasst von: S. Kovac, J. Alferink, D. Ahmetspahic, V. Arolt, PD Dr. N. Melzer

Erschienen in: Der Nervenarzt | Ausgabe 1/2018

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Zusammenfassung

Autoimmunenzephalitiden sind eine Gruppe autoimmun-entzündlicher Erkrankungen der grauen und weißen Substanz des zentralen Nervensystems. Die Enzephalitis mit Autoantikörpern gegen den N‑Methyl-D-Aspartat-Rezeptor (NMDA-R) ist die häufigste autoimmune Enzephalitis. Sie manifestiert sich meist mit einer Abfolge typischer psychiatrischer und neurologischer Symptome, und ihre Therapie erfordert damit eine enge interdisziplinäre Zusammenarbeit. Der Beitrag gibt eine aktualisierte Übersicht über den derzeitigen Kenntnisstand zur Diagnostik, Pathogenese und Therapie der Anti-NMDA-R-Enzephalitis aus psychiatrischer und neurologischer Perspektive.
Literatur
1.
Zurück zum Zitat Lancaster E, Martinez-Hernandez E, Dalmau J (2011) Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77:179–189CrossRefPubMedPubMedCentral Lancaster E, Martinez-Hernandez E, Dalmau J (2011) Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77:179–189CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Dalmau J, Tüzün E, Wu H et al (2007) Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61:25–36CrossRefPubMedPubMedCentral Dalmau J, Tüzün E, Wu H et al (2007) Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61:25–36CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Irani SR, Vincent A (2012) The expanding spectrum of clinically-distinctive, immunotherapy-responsive autoimmune encephalopathies. Arq Neuropsiquiatr 70:300–304CrossRefPubMed Irani SR, Vincent A (2012) The expanding spectrum of clinically-distinctive, immunotherapy-responsive autoimmune encephalopathies. Arq Neuropsiquiatr 70:300–304CrossRefPubMed
4.
Zurück zum Zitat Gable MS, Sheriff H, Dalmau J, Tilley DH, Glaser CA (2012) The frequency of autoimmune N‑methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 54:899–904CrossRefPubMedPubMedCentral Gable MS, Sheriff H, Dalmau J, Tilley DH, Glaser CA (2012) The frequency of autoimmune N‑methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 54:899–904CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Prüß H, Dalmau J, Arolt V, Wandinger K‑P (2010) Anti-NMDA-Rezeptor-Enzephalitis. Nervenarzt 81:396–408CrossRefPubMed Prüß H, Dalmau J, Arolt V, Wandinger K‑P (2010) Anti-NMDA-Rezeptor-Enzephalitis. Nervenarzt 81:396–408CrossRefPubMed
6.
Zurück zum Zitat Titulaer MJ, McCracken L, Gabilondo I et al (2013) Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 12:157–165CrossRefPubMedPubMedCentral Titulaer MJ, McCracken L, Gabilondo I et al (2013) Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 12:157–165CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R (2011) Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 10:63–74CrossRefPubMedPubMedCentral Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R (2011) Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 10:63–74CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Irani SR, Bera K, Waters P et al (2010) N‑methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 133:1655–1667CrossRefPubMedPubMedCentral Irani SR, Bera K, Waters P et al (2010) N‑methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 133:1655–1667CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Baizabal-Carvallo JF, Stocco A, Muscal E, Jankovic J (2013) The spectrum of movement disorders in children with anti-NMDA receptor encephalitis. Mov Disord 28:543–547CrossRefPubMed Baizabal-Carvallo JF, Stocco A, Muscal E, Jankovic J (2013) The spectrum of movement disorders in children with anti-NMDA receptor encephalitis. Mov Disord 28:543–547CrossRefPubMed
10.
Zurück zum Zitat Leypoldt F, Armangue T, Dalmau J (2015) Autoimmune encephalopathies. Ann N Y Acad Sci 1338:94–114CrossRefPubMed Leypoldt F, Armangue T, Dalmau J (2015) Autoimmune encephalopathies. Ann N Y Acad Sci 1338:94–114CrossRefPubMed
11.
Zurück zum Zitat Hammer C, Stepniak B, Schneider A et al (2014) Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 19:1143–1149CrossRefPubMed Hammer C, Stepniak B, Schneider A et al (2014) Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 19:1143–1149CrossRefPubMed
12.
Zurück zum Zitat Kirkpatrick MP, Clarke CD, Sonmezturk HH, Abou-Khalil B (2011) Rhythmic delta activity represents a form of nonconvulsive status epilepticus in anti-NMDA receptor antibody encephalitis. Epilepsy Behav 20:392–394CrossRefPubMed Kirkpatrick MP, Clarke CD, Sonmezturk HH, Abou-Khalil B (2011) Rhythmic delta activity represents a form of nonconvulsive status epilepticus in anti-NMDA receptor antibody encephalitis. Epilepsy Behav 20:392–394CrossRefPubMed
13.
Zurück zum Zitat Sands TT, Nash K, Tong S, Sullivan J (2015) Focal seizures in children with anti-NMDA receptor antibody encephalitis. Epilepsy Res 112:31–36CrossRefPubMed Sands TT, Nash K, Tong S, Sullivan J (2015) Focal seizures in children with anti-NMDA receptor antibody encephalitis. Epilepsy Res 112:31–36CrossRefPubMed
14.
Zurück zum Zitat Viaccoz A, Desestret V, Ducray F et al (2014) Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology 82:556–563CrossRefPubMed Viaccoz A, Desestret V, Ducray F et al (2014) Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology 82:556–563CrossRefPubMed
15.
Zurück zum Zitat Gascon GG, al-Jarallah AA, Okamoto E, al Ahdal M, Kessie G, Frayha H (1993) Chorea as a presentation of herpes simplex encephalitis relapse. Brain Dev 15:178–181CrossRefPubMed Gascon GG, al-Jarallah AA, Okamoto E, al Ahdal M, Kessie G, Frayha H (1993) Chorea as a presentation of herpes simplex encephalitis relapse. Brain Dev 15:178–181CrossRefPubMed
16.
Zurück zum Zitat Armangue T, Moris G, Cantarín-Extremera V et al (2015) Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology 85:1736–1743CrossRefPubMedPubMedCentral Armangue T, Moris G, Cantarín-Extremera V et al (2015) Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology 85:1736–1743CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Armangue T, Leypoldt F, Málaga I et al (2014) Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 75:317–323CrossRefPubMedPubMedCentral Armangue T, Leypoldt F, Málaga I et al (2014) Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 75:317–323CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Hacohen Y, Deiva K, Pettingill P et al (2014) N‑methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. Mov Disord 29:90–96CrossRefPubMed Hacohen Y, Deiva K, Pettingill P et al (2014) N‑methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. Mov Disord 29:90–96CrossRefPubMed
19.
Zurück zum Zitat Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y, Sangha N, Martinez-Lage M, Dalmau J (2011) Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis. Neurology 77:589–593CrossRefPubMedPubMedCentral Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y, Sangha N, Martinez-Lage M, Dalmau J (2011) Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis. Neurology 77:589–593CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Camdessanché J‑P, Streichenberger N, Cavillon G et al (2011) Brain immunohistopathological study in a patient with anti-NMDAR encephalitis. Eur J Neurol 18:929–931CrossRefPubMed Camdessanché J‑P, Streichenberger N, Cavillon G et al (2011) Brain immunohistopathological study in a patient with anti-NMDAR encephalitis. Eur J Neurol 18:929–931CrossRefPubMed
21.
Zurück zum Zitat Blanke ML, VanDongen AMJ (2009) Activation Mechanisms of the NMDA Receptor. In: Van Dongen AM (Hrsg) Biology of the NMDA Receptor. CRC Press Taylor & Francis, Boca Raton FL Blanke ML, VanDongen AMJ (2009) Activation Mechanisms of the NMDA Receptor. In: Van Dongen AM (Hrsg) Biology of the NMDA Receptor. CRC Press Taylor & Francis, Boca Raton FL
22.
Zurück zum Zitat Howes O, McCutcheon R, Stone J (2015) Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol (oxford) 29:97–115CrossRef Howes O, McCutcheon R, Stone J (2015) Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol (oxford) 29:97–115CrossRef
23.
Zurück zum Zitat Joubert B, Honnorat J (2015) Autoimmune channelopathies in paraneoplastic neurological syndromes. Biochim Biophys Acta 1848:2665–2676CrossRefPubMed Joubert B, Honnorat J (2015) Autoimmune channelopathies in paraneoplastic neurological syndromes. Biochim Biophys Acta 1848:2665–2676CrossRefPubMed
24.
Zurück zum Zitat Dalmau J, Gleichman AJ, Hughes EG et al (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098CrossRefPubMedPubMedCentral Dalmau J, Gleichman AJ, Hughes EG et al (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Gleichman AJ, Spruce LA, Dalmau J, Seeholzer SH, Lynch DR (2012) Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci 32:11082–11094CrossRefPubMedPubMedCentral Gleichman AJ, Spruce LA, Dalmau J, Seeholzer SH, Lynch DR (2012) Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci 32:11082–11094CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Mikasova L, De Rossi P, Bouchet D et al (2012) Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain 135:1606–1621CrossRefPubMed Mikasova L, De Rossi P, Bouchet D et al (2012) Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain 135:1606–1621CrossRefPubMed
27.
29.
Zurück zum Zitat Planagumà J, Leypoldt F, Mannara F et al (2015) Human N‑methyl D‑aspartate receptor antibodies alter memory and behaviour in mice. Brain 138:94–109CrossRefPubMed Planagumà J, Leypoldt F, Mannara F et al (2015) Human N‑methyl D‑aspartate receptor antibodies alter memory and behaviour in mice. Brain 138:94–109CrossRefPubMed
30.
Zurück zum Zitat Kayser MS, Dalmau J (2016) Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res 176:36–40CrossRefPubMed Kayser MS, Dalmau J (2016) Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res 176:36–40CrossRefPubMed
31.
Zurück zum Zitat Olney JW, Newcomer JW, Farber NB (1999) NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33:523–533CrossRefPubMed Olney JW, Newcomer JW, Farber NB (1999) NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33:523–533CrossRefPubMed
32.
Zurück zum Zitat Coyle JT (2006) Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol 26:365–384CrossRefPubMed Coyle JT (2006) Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol 26:365–384CrossRefPubMed
33.
Zurück zum Zitat Schmitt A, Malchow B, Keeser D, Falkai P, Hasan A (2015) Neurobiologie der Schizophrenie. Nervenarzt 86:324–331CrossRefPubMed Schmitt A, Malchow B, Keeser D, Falkai P, Hasan A (2015) Neurobiologie der Schizophrenie. Nervenarzt 86:324–331CrossRefPubMed
34.
Zurück zum Zitat Deakin J, Lennox BR, Zandi MS (2014) Antibodies to the N‑methyl-D-aspartate receptor and other synaptic proteins in psychosis. Biol Psychiatry 75:284–291CrossRefPubMed Deakin J, Lennox BR, Zandi MS (2014) Antibodies to the N‑methyl-D-aspartate receptor and other synaptic proteins in psychosis. Biol Psychiatry 75:284–291CrossRefPubMed
35.
Zurück zum Zitat Ezeoke A, Mellor A, Buckley P, Miller B (2013) A systematic, quantitative review of blood autoantibodies in schizophrenia. Schizophr Res 150:245–251CrossRefPubMed Ezeoke A, Mellor A, Buckley P, Miller B (2013) A systematic, quantitative review of blood autoantibodies in schizophrenia. Schizophr Res 150:245–251CrossRefPubMed
36.
Zurück zum Zitat Zandi MS, Irani SR, Lang B et al (2011) Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 258:686–688CrossRefPubMed Zandi MS, Irani SR, Lang B et al (2011) Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 258:686–688CrossRefPubMed
37.
Zurück zum Zitat Steiner J, Walter M, Glanz W et al (2013) Increased prevalence of diverse N‑methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N‑methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 70:271–278CrossRefPubMed Steiner J, Walter M, Glanz W et al (2013) Increased prevalence of diverse N‑methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N‑methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 70:271–278CrossRefPubMed
38.
Zurück zum Zitat Pollak TA, McCormack R, Peakman M, Nicholson TR, David AS (2014) Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis. Psychol Med 44:2475–2487CrossRefPubMed Pollak TA, McCormack R, Peakman M, Nicholson TR, David AS (2014) Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis. Psychol Med 44:2475–2487CrossRefPubMed
39.
Zurück zum Zitat Dahm L, Ott C, Steiner J et al (2014) Seroprevalence of autoantibodies against brain antigens in health and disease. Ann Neurol 76:82–94CrossRefPubMed Dahm L, Ott C, Steiner J et al (2014) Seroprevalence of autoantibodies against brain antigens in health and disease. Ann Neurol 76:82–94CrossRefPubMed
40.
Zurück zum Zitat Busse S, Busse M, Brix B et al (2014) Seroprevalence of N‑methyl-D-aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients. Eur Arch Psychiatry Clin Neurosci 264:545–550CrossRefPubMed Busse S, Busse M, Brix B et al (2014) Seroprevalence of N‑methyl-D-aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients. Eur Arch Psychiatry Clin Neurosci 264:545–550CrossRefPubMed
41.
Zurück zum Zitat Gresa-Arribas N, Titulaer MJ, Torrents A et al (2014) Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol 13:167–177CrossRefPubMed Gresa-Arribas N, Titulaer MJ, Torrents A et al (2014) Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol 13:167–177CrossRefPubMed
43.
Zurück zum Zitat Lennox BR, Palmer-Cooper EC, Pollak T et al (2017) Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. Lancet Psychiatry 4:42–48CrossRefPubMed Lennox BR, Palmer-Cooper EC, Pollak T et al (2017) Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. Lancet Psychiatry 4:42–48CrossRefPubMed
44.
Zurück zum Zitat Manto M, Dalmau J, Didelot A, Rogemond V, Honnorat J (2010) In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction. Orphanet J Rare Dis 5:31CrossRefPubMedPubMedCentral Manto M, Dalmau J, Didelot A, Rogemond V, Honnorat J (2010) In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction. Orphanet J Rare Dis 5:31CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Bien CG, Vincent A, Barnett MH et al (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain 135:1622:1638 Bien CG, Vincent A, Barnett MH et al (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain 135:1622:1638
47.
Zurück zum Zitat Veciana M, Becerra JL, Fossas P et al (2015) EEG extreme delta brush: An ictal pattern in patients with anti-NMDA receptor encephalitis. Epilepsy Behav 49:280–285CrossRefPubMed Veciana M, Becerra JL, Fossas P et al (2015) EEG extreme delta brush: An ictal pattern in patients with anti-NMDA receptor encephalitis. Epilepsy Behav 49:280–285CrossRefPubMed
48.
Zurück zum Zitat Schmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J, Friedman D (2012) Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology 79:1094–1100CrossRefPubMedPubMedCentral Schmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J, Friedman D (2012) Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology 79:1094–1100CrossRefPubMedPubMedCentral
49.
Zurück zum Zitat Clancy RR, Bergqvist AGC, Dlugos DJ (2003) Neonatal Electroencephalography. Current Practice of Clinical Electroencephalography. Lippincott Williams &Wilkins, Philadelphia Baltimore, S 160–234 Clancy RR, Bergqvist AGC, Dlugos DJ (2003) Neonatal Electroencephalography. Current Practice of Clinical Electroencephalography. Lippincott Williams &Wilkins, Philadelphia Baltimore, S 160–234
50.
Zurück zum Zitat Chanson E, Bicilli É, Lauxerois M et al (2016) Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus? Neurophysiol Clin 46:17–25CrossRefPubMed Chanson E, Bicilli É, Lauxerois M et al (2016) Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus? Neurophysiol Clin 46:17–25CrossRefPubMed
51.
Zurück zum Zitat Iizuka T, Yoshii S, Kan S et al (2010) Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study. J Neurol 257:1686–1691CrossRefPubMedPubMedCentral Iizuka T, Yoshii S, Kan S et al (2010) Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study. J Neurol 257:1686–1691CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Llorens V, Gabilondo I, Gómez-Esteban JC et al (2010) Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis. J Neurol 257:1568–1569CrossRefPubMed Llorens V, Gabilondo I, Gómez-Esteban JC et al (2010) Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis. J Neurol 257:1568–1569CrossRefPubMed
53.
54.
Zurück zum Zitat Dogan Onugoren M, Golombeck KS, Bien C et al (2016) Immunoadsorption therapy in autoimmune encephalitides. Neurol Neuroimmunol Neuroinflamm 3:e207CrossRefPubMedPubMedCentral Dogan Onugoren M, Golombeck KS, Bien C et al (2016) Immunoadsorption therapy in autoimmune encephalitides. Neurol Neuroimmunol Neuroinflamm 3:e207CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607CrossRefPubMed van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607CrossRefPubMed
56.
Zurück zum Zitat Behrendt V, Krogias C, Reinacher-Schick A, Gold R, Kleiter I (2016) Bortezomib treatment for patients with anti-N-methyl-d-Aspartate receptor encephalitis. JAMA Neurol 73:1251–1253CrossRefPubMed Behrendt V, Krogias C, Reinacher-Schick A, Gold R, Kleiter I (2016) Bortezomib treatment for patients with anti-N-methyl-d-Aspartate receptor encephalitis. JAMA Neurol 73:1251–1253CrossRefPubMed
57.
Zurück zum Zitat Scheibe F, Prüss H, Mengel AM et al (2017) Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology 88:366–370CrossRefPubMed Scheibe F, Prüss H, Mengel AM et al (2017) Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology 88:366–370CrossRefPubMed
58.
Zurück zum Zitat Lee W‑J, Lee S‑T, Moon J et al (2016) Tocilizumab in autoimmune encephalitis refractory to Rituximab: an institutional cohort study. Neurotherapeutics 13:824–832CrossRefPubMedPubMedCentral Lee W‑J, Lee S‑T, Moon J et al (2016) Tocilizumab in autoimmune encephalitis refractory to Rituximab: an institutional cohort study. Neurotherapeutics 13:824–832CrossRefPubMedPubMedCentral
Metadaten
Titel
Update Anti-N-Methyl-D-Aspartat-Rezeptor-Enzephalitis
verfasst von
S. Kovac
J. Alferink
D. Ahmetspahic
V. Arolt
PD Dr. N. Melzer
Publikationsdatum
20.09.2017
Verlag
Springer Medizin
Erschienen in
Der Nervenarzt / Ausgabe 1/2018
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-017-0405-0

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