Eosinophil-basophil progenitors and atopic risk
- 06.12.2013
- Short Communication_Kurzbeitrag
Erschienen in:
- Verfasst von
- Dr. Judah Denburg
- Erschienen in
- Allergo Journal | Ausgabe 8/2013
Auszug
The recent and dramatic rise in allergic diseases, coupled with their manifestation within the first years of life, suggests that early life, even in utero, events are critically important to the inception of allergy. Epidemiological and experimental evidence suggest that both genetic factors and environmental exposures (e. g. nutrition, microbes) play a role in influencing immunity and thus the development of allergy. In this report, we show that hemopoietic cytokine receptors (HCR), Toll-like receptors (TLR) and TSLP (thymic stromal lymphopoietin) and its receptors are involved in both cord blood (CB) and peripheral blood (PB) CD34+ hemopoietic progenitor eosinophil-basophil (Eo/B) differentiation and lineage commitment, markers for which can predict the development of allergic inflammation and thus allergic diseases and asthma in early life. …
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- Titel
- Eosinophil-basophil progenitors and atopic risk
- Verfasst von
-
Dr. Judah Denburg
- Publikationsdatum
- 06.12.2013
- Verlag
- Urban & Vogel
- Erschienen in
-
Allergo Journal / Ausgabe 8/2013
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405 - DOI
- https://doi.org/10.1007/s15007-013-0443-2
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