Anzeige
Erschienen in:
14.09.2016 | Short Communication
Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin
Erschienen in: European Journal of Pediatrics | Ausgabe 12/2016
Einloggen, um Zugang zu erhaltenAbstract
Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis.
Conclusion: Isotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis.
What is Known:
•Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures.
What is New:
•Isotretinoin may cause drug-related acute tubulointerstitial nephritis.
|