nach oben

Erschienen in:

01.10.2015 | Brief Report

Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease

verfasst von: Micaela Brandolini, Marta Corbella, Annalisa De Silvestri, Carmine Tinelli, Giulia Albonico, Riccardo Albertini, Serena Ludovisi, Raffaele Bruno, Piero Marone, Lorenzo Minoli, Elena Seminari

Erschienen in: Infection | Ausgabe 5/2015

Einloggen, um Zugang zu erhalten

Abstract

Observational retrospective study to evaluate the etiology, the outcome and the risk factors of bloodstream infections (BSIs) in patients with liver disease. One hundred and forty-eight BSIs were diagnosed (infection rate: 0.60 per 100 days of hospital stay), 62 BSIs (41.9 %) were associated with Gram-positive bacteria (infection rate: 0.25 per 100 days of hospital stay) and 80 (54.4 %) with Gram-negative bacteria (infection rate: 0.32 per 100 days of hospital stay). Admission-associated mortality was higher in patients with BSI than in those without BSI (20.6 versus 5.0 %, p < 0.001). Patients with cirrhosis had an increased risk to develop a BSI compared with patients with chronic hepatitis, specifically for Gram-positive (and Staphylococcus spp)-related BSI.

Mellencamp MA, Preheim LC. Pneumococcal pneumonia in a rat model of cirrhosis: effects of cirrhosis on pulmonary defense mechanisms against Streptococcus pneumoniae. J Infect Dis. 1991;163(1):102–8.CrossRefPubMed

Christou L, Pappas G, Falagas ME. Bacterial infection-related morbidity and mortality in cirrhosis. Am J Gastroenterol. 2007;102(7):1510–7.CrossRefPubMed

Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014;60(6):1310–24.CrossRefPubMed

Brann OS. Infectious complications of cirrhosis. Curr Gastroenterol Rep. 2001;3(4):285–92.CrossRefPubMed

Park HJ, Lee YM, Bang KM, Park SY, Moon SM, Park KH, et al. Clinical significance of Staphylococcus aureus bacteremia in patients with liver cirrhosis. Eur J ClinMicrobiol Infect Dis. 2012;31(12):3309–16.CrossRef

Kuo CH, Changchien CS, Yang CY, Sheen IS, Liaw YF, et al. Bacteremia in patients with cirrhosis of the liver. Liver. 1991;11(6):334–9.CrossRefPubMed

Kang CI, Song JH, Chung DR, Peck KR, Yeom JS, Ki HK, et al. Liver cirrhosis as a risk factor for mortality in a national cohort of patients with bacteremia. J Infect. 2011;63(5):336–43.CrossRefPubMed

Bartoletti M, Giannella M, Caraceni P, Domenicali M, Ambretti S, Tedeschi S, et al. Epidemiology and outcomes of bloodstream infection in patients with cirrhosis. J Hepatol. 2014;61(1):51–8.CrossRefPubMed

Fernández Guerrero ML. González López J, Górgolas M. Infectious endocarditis in patients with cirrhosis of the liver: a model of infection in the frail patient. Eur J ClinMicrobiol. Infect Dis. 2010;29(10):1271–5.

10.

Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518–26.CrossRefPubMed

11.

Sheth M, Riggs M, Patel T. Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis. BMC Gastroenterol. 2002;2:2.PubMedCentralCrossRefPubMed

12.

Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;29(338):b2393.CrossRef

13.

Al-Hasan MN, Lahr BD, Eckel-Passow JE, Baddour LM. Predictive scoring model of mortality in Gram-negative bloodstream infection. Clin Microbiol Infect. 2013;19(10):948–54.CrossRefPubMed

14.

Linderoth G, Jepsen P, Schønheyder HC, Johnsen SP, Sørensen HT. Short-term prognosis of community-acquired bacteremia in patients with liver cirrhosis or alcoholism: A population-based cohort study. Alcohol ClinExp Res. 2006;30(4):636–41.CrossRef

15.

Thulstrup AM, Sørensen HT, Schønheyder HC, Møller JK, Tage-Jensen U. Population-based study of the risk and short-term prognosis for bacteremia in patients with liver cirrhosis. Clin Infect Dis. 2000;31(6):1357–61.CrossRefPubMed

16.

Campillo B, Richardet JP, Kheo T, Dupeyron C. Nosocomial spontaneous bacterial peritonitis and bacteremia in cirrhotic patients: impact of isolate type on prognosis and characteristics of infection. Clin Infect Dis. 2002;35(1):1–10.CrossRefPubMed

17.

Runyon BA. Monomicrobial non neutrocytic bacterascites: a variant of spontaneous bacterial peritonitis. Hepatology. 1990;12:710–5.CrossRefPubMed

18.

Kuo CHL, Changchien CS, Yang CY, Sheen IS, Liaw YF. Bacteremia in patients with cirrhosis of the liver. Liver. 1991;11(6):334–9.CrossRefPubMed

19.

Caly WRL, Strauss E. A prospective study of bacterial infections in patients with cirrhosis. J Hepatol. 1993;18(3):353–8.CrossRefPubMed

20.

Kang CI, Song JH, Ko KS, Chung DR, Peck KR. Clinical significance of Staphylococcus aureus infection in patients with chronic liver diseases. Liver Int. 2010;30(9):1333–8.CrossRefPubMed

21.

Squier C, Rihs JD, Risa KJ, Sagnimeni A, Wagener MM, Stout J, et al. Staphylococcus aureus rectal carriage and its association with infections in patients in a surgical intensive care unit and a liver transplant unit. Infect Control Hosp Epidemiol. 2002;23(9):495–501.CrossRefPubMed

22.

Paterson DL, Rihs JD, Squier C, Gayowski T, Marino IR, Sagnemeni A, et al. Lack of efficacy of mupirocin in the prevention of infections with methicillin-resistant Staphylococcus aureus in liver transplant recipients and candidates. Transplantation. 2003;75:194–8.CrossRefPubMed

23.

Dupeyron C, Campillo B, Richardet JP, Soussy CJ. Long-term efficacy of mupirocin in the prevention of infections with methicillin-resistant Staphylococcus aureus in a gastroenterology unit. J Hosp Infect. 2006;63(4):385–92.CrossRefPubMed

24.

Falcone M, Concia E, Iori I, Lo Cascio G, Mazzone A, Pea F, et al. Identification and management of invasive mycoses in internal medicine: a road-map for physicians. Intern Emerg Med. 2014;9(5):501–11.CrossRefPubMed

25.

Leber B, Spindelboeck W, Stadlbauer V. Infectious complications of acute and chronic liver disease. SeminRespirCrit Care Med. 2012;33(1):80–95.

26.

Hung TH, Hsieh YH, Tseng KC, Tsai CC, Tsai CC. The risk for bacterial endocarditis in cirrhotic patients: a population-based 3-year follow-up study. Int J Infect Dis. 2013;17(6):e391–3.CrossRefPubMed

27.

Titel: Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease
verfasst von: Micaela Brandolini
Marta Corbella
Annalisa De Silvestri
Carmine Tinelli
Giulia Albonico
Riccardo Albertini
Serena Ludovisi
Raffaele Bruno
Piero Marone
Lorenzo Minoli
Elena Seminari
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 5/2015
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-015-0794-6

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2015

Febrile ulceronecrotic Mucha–Habermann disease following suspected hemorrhagic chickenpox infection in a 20-month-old boy

On the search for novel treatment modalities for HIV-associated intestinal barrier dysfunction

Erratum to: Ageing with HIV: a multidisciplinary review

Atypical presentation of crusted (Norwegian) scabies

A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient

Toxoplasma gondii meningoencephalitis without cerebral MRI findings in a patient with ulcerative colitis under immunosuppressive treatment

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin