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2018 | OriginalPaper | Buchkapitel

3. Epidemiologie, Ätiologie und Klassifikation des Harnblasenkarzinoms

verfasst von : Priv.-Doz. Dr. med. Frank vom Dorp

Erschienen in: Urinzytologie und Sedimentanalyse

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Das Harnblasenkarzinom repräsentiert eine der häufigsten onkologischen Erkrankungen weltweit. 130.000 Menschen versterben jährlich weltweit an einem Harnblasenkarzinom. Männer erkranken doppelt so häufig wie Frauen, wobei das mittlere Erkrankungsalter bei 69 Jahren für Männer und bei 73,4 Jahren bei Frauen liegt. Zahlreiche kanzerogene Substanzen sind identifiziert worden, deren Exposition ursächlich mit der Entstehung des Harnblasenkarzinoms vergesellschaftet ist. Allen voran ist der Zigarettenkonsum zu nennen, gefolgt von aromatischen Aminen, deren Exposition zum Teil beruflich bedingt ist. Die Strahlentherapie kann ursächlich sein für die Entstehung von Sekundärmalignomen, unter anderem können Harnblasenkarzinome entstehen.
Literatur
Zurück zum Zitat Aghaji AE, Mbonu OO (1989) Bladder tumors in Enugu, Nigeria. Br J Urol 64:399 Aghaji AE, Mbonu OO (1989) Bladder tumors in Enugu, Nigeria. Br J Urol 64:399
Zurück zum Zitat Anderström C, Johansson SL, van Schulz L (1983) Primary adenocarcinoma of urinary bladder. Cancer 52:1273 Anderström C, Johansson SL, van Schulz L (1983) Primary adenocarcinoma of urinary bladder. Cancer 52:1273
Zurück zum Zitat Babaya K, Takahashi S, Momose H et al. (1987) Effects of single chemotherapeutic agents in development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats. Urol Res 15: 329–334 Babaya K, Takahashi S, Momose H et al. (1987) Effects of single chemotherapeutic agents in development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats. Urol Res 15: 329–334
Zurück zum Zitat Baker GL, Kahl LE, Zee BC, Stolzer BL, Agarwal AK, Medsger TA (1987) Malignancy following treatment of rheumatoid arthritis with cyclophosphamide. Long-term case-result follow-up study. Am J Med; 83:1–9 Baker GL, Kahl LE, Zee BC, Stolzer BL, Agarwal AK, Medsger TA (1987) Malignancy following treatment of rheumatoid arthritis with cyclophosphamide. Long-term case-result follow-up study. Am J Med; 83:1–9
Zurück zum Zitat Bedwani R, Renganathan E, El Kwhsky F et al. (1998) Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt. Br J Cancer 77 (7):1186–1189 Bedwani R, Renganathan E, El Kwhsky F et al. (1998) Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt. Br J Cancer 77 (7):1186–1189
Zurück zum Zitat Brennan P, Bogillot O, Cordier S, Greiser E, Schill W, Vineis P, et al.(2000) Cigarette smoking and bladder cancer in men: a pooled analysis of 11 case-control studies. Int J Cancer.; 86:289–294 Brennan P, Bogillot O, Cordier S, Greiser E, Schill W, Vineis P, et al.(2000) Cigarette smoking and bladder cancer in men: a pooled analysis of 11 case-control studies. Int J Cancer.; 86:289–294
Zurück zum Zitat Case RAM, Pearson JT (1954) Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Part II: Further consideration of the role of aniline and of the manufacture of auramine and magenta (fuchsine) as possible causative agents. Br J Ind Med 11:213 Case RAM, Pearson JT (1954) Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Part II: Further consideration of the role of aniline and of the manufacture of auramine and magenta (fuchsine) as possible causative agents. Br J Ind Med 11:213
Zurück zum Zitat Cole P (1971) Coffee-drinking and cancer of the lower urinary tract. Lancet I:1335 Cole P (1971) Coffee-drinking and cancer of the lower urinary tract. Lancet I:1335
Zurück zum Zitat Coleman M, Babb P, Damiecki P, Grosclaude P, Honjo S, Jones J, Knerer G, Pitard A, Quinn M, Scoggett A, De Stavoua B (1999) Cancer Survival Trends in England and Wales, 1971–1995 : Deprivation and NHS Region. London: The Stationary Office Coleman M, Babb P, Damiecki P, Grosclaude P, Honjo S, Jones J, Knerer G, Pitard A, Quinn M, Scoggett A, De Stavoua B (1999) Cancer Survival Trends in England and Wales, 1971–1995 : Deprivation and NHS Region. London: The Stationary Office
Zurück zum Zitat Dalbagni G, Vora K, Kaag M, Cronin A, Bochner B, Donat SM, Herr HW (2009) Clinical outcome in a contemporary series of restaged patients with clinical T1 bladder cancer. Eur Urol 56:903-910 Dalbagni G, Vora K, Kaag M, Cronin A, Bochner B, Donat SM, Herr HW (2009) Clinical outcome in a contemporary series of restaged patients with clinical T1 bladder cancer. Eur Urol 56:903-910
Zurück zum Zitat Deutz FJ, Rübben H, Küpper W, Hofstädter F (1988) Morphologie der Harnblase und des Darms nach Harnleiter-Sigmaimplantation unter Karzinogenexposition. 9. Symposium Experimentelle Urologie. Aachen, 16.–18.6 Deutz FJ, Rübben H, Küpper W, Hofstädter F (1988) Morphologie der Harnblase und des Darms nach Harnleiter-Sigmaimplantation unter Karzinogenexposition. 9. Symposium Experimentelle Urologie. Aachen, 16.–18.6
Zurück zum Zitat Donato F, Boffetta P, Fazioli R, Gelatti U, Porru S (1998) Reliability of data on smoking habit and coffee drinking collected by personal interview in a hospital-based case-control study. Eur J Epidemiol 14 (3) :259–267 Donato F, Boffetta P, Fazioli R, Gelatti U, Porru S (1998) Reliability of data on smoking habit and coffee drinking collected by personal interview in a hospital-based case-control study. Eur J Epidemiol 14 (3) :259–267
Zurück zum Zitat Fairchild WV, Spence CR, Solomon HD, Gangai MP (1979) The incidence of bladder cancer after cyclophosphamide therapy. J Urol 122:163 Fairchild WV, Spence CR, Solomon HD, Gangai MP (1979) The incidence of bladder cancer after cyclophosphamide therapy. J Urol 122:163
Zurück zum Zitat Gontero P, Sylvester R, Pisano F, Joniau S, Oderda M, Serretta V et al (2016) The impact of re-transurethral resection on clinical outcomes in a large multicentre cohort of patients with T1 high grade / Grade 3 bladder cancer treated with bacilli- Calmette Guerin BJU Int 118:44-52 Gontero P, Sylvester R, Pisano F, Joniau S, Oderda M, Serretta V et al (2016) The impact of re-transurethral resection on clinical outcomes in a large multicentre cohort of patients with T1 high grade / Grade 3 bladder cancer treated with bacilli- Calmette Guerin BJU Int 118:44-52
Zurück zum Zitat Gonheim MA, Ashamallah AK, Awaad HK, Whitemore WF Jr (1985) Randomized trial with cystectomy with preoperative radiotherapy for carcinoma of the bilharzial bladder. J Urol 134:266 Gonheim MA, Ashamallah AK, Awaad HK, Whitemore WF Jr (1985) Randomized trial with cystectomy with preoperative radiotherapy for carcinoma of the bilharzial bladder. J Urol 134:266
Zurück zum Zitat Gonwa TA, Corbett WT, Schey HM, Buckalew VM (1980) Analgesic associated nephropathy and transitional cell carcinoma of the urinary tract. Ann Intern Med 93:249 Gonwa TA, Corbett WT, Schey HM, Buckalew VM (1980) Analgesic associated nephropathy and transitional cell carcinoma of the urinary tract. Ann Intern Med 93:249
Zurück zum Zitat Hecht SS, Tso TC, Hoffmann D (1976) Selective reduction of tumorgenicity of tobacco smoke. IV Approaches to the reduction of N-nitrosamines and aromatic amines. Proceedings of Third World Conference o smoking and health. Dept Health Education and Welfare Publ No (NIH) 76:535 Hecht SS, Tso TC, Hoffmann D (1976) Selective reduction of tumorgenicity of tobacco smoke. IV Approaches to the reduction of N-nitrosamines and aromatic amines. Proceedings of Third World Conference o smoking and health. Dept Health Education and Welfare Publ No (NIH) 76:535
Zurück zum Zitat Hicks RM, Walters CL, El Sebai I, El Asser AB, El Merzabani M, Grough TA (1977) Demonstration of nitrosamines in human urine. Preliminary observations on a possible aetiology for bladder cancer in association with chronic urinary tract infection. Proc R Soc Med 70:413 Hicks RM, Walters CL, El Sebai I, El Asser AB, El Merzabani M, Grough TA (1977) Demonstration of nitrosamines in human urine. Preliminary observations on a possible aetiology for bladder cancer in association with chronic urinary tract infection. Proc R Soc Med 70:413
Zurück zum Zitat Hoffmann D, Masuda Y, Wynder EL (1969) Alpha-naphthylamine and beta-naphthylamine in cigarette smoke. Nature 221:254 Hoffmann D, Masuda Y, Wynder EL (1969) Alpha-naphthylamine and beta-naphthylamine in cigarette smoke. Nature 221:254
Zurück zum Zitat Hueper WC, Wiley FH, Wolfe HD (1938) Experimental production or bladder tumours in dogs by administration of beta-naphthylamine. J Indust Hyg Toxiol 20/1:46 Hueper WC, Wiley FH, Wolfe HD (1938) Experimental production or bladder tumours in dogs by administration of beta-naphthylamine. J Indust Hyg Toxiol 20/1:46
Zurück zum Zitat Irving CC, Murphy WM, Damil DS (1984) Comparative carinogenicity of N-Butyl-N-(3 carboxypropyl)-Nitrosamin and N-Butyl-N(4 hydroxybutyl) nitrosamine for the urinary bladder of (C5BL/6×DBA/2)F1 mice. JNCI 73/3:753–756 Irving CC, Murphy WM, Damil DS (1984) Comparative carinogenicity of N-Butyl-N-(3 carboxypropyl)-Nitrosamin and N-Butyl-N(4 hydroxybutyl) nitrosamine for the urinary bladder of (C5BL/6×DBA/2)F1 mice. JNCI 73/3:753–756
Zurück zum Zitat Ito N (1984) Histogenesis of urinary bladder tumors induced by nitrosamine in rats. J Cancer Res Clin Oncol 108:169–173 Ito N (1984) Histogenesis of urinary bladder tumors induced by nitrosamine in rats. J Cancer Res Clin Oncol 108:169–173
Zurück zum Zitat Ito N (1988) Early changes caused by nitrosamine in the bladder epithelium of different animal species. Jpn J Cancer Res 79 (4):413–417 Ito N (1988) Early changes caused by nitrosamine in the bladder epithelium of different animal species. Jpn J Cancer Res 79 (4):413–417
Zurück zum Zitat Jakse G, Jakobi GH, Altwein JE (1979) Das Adenokarzinom der Harnblase. Urologe A 18:86 Jakse G, Jakobi GH, Altwein JE (1979) Das Adenokarzinom der Harnblase. Urologe A 18:86
Zurück zum Zitat Johansson SL, Cohen SM. (1997) Epidemiology and etiology of bladder cancer. Semin Surg Oncol.; 13:291–298 Johansson SL, Cohen SM. (1997) Epidemiology and etiology of bladder cancer. Semin Surg Oncol.; 13:291–298
Zurück zum Zitat Johnson DE, Schoenwald MB, Ayala AG, Miller LS (1976) Sqamous cell carcinoma of the bladder. J Urol 115:542 Johnson DE, Schoenwald MB, Ayala AG, Miller LS (1976) Sqamous cell carcinoma of the bladder. J Urol 115:542
Zurück zum Zitat Kaufmann JM, Fam B, Jacobs SC, Gabrilondo F, Yalla S, Kane JP, Rossier AB (1977) Bladder cancer and squamous metaplasia in spinal cord injury patients. J Urol 118:967 Kaufmann JM, Fam B, Jacobs SC, Gabrilondo F, Yalla S, Kane JP, Rossier AB (1977) Bladder cancer and squamous metaplasia in spinal cord injury patients. J Urol 118:967
Zurück zum Zitat Kunze E, Calude J, Frentzel-Beyme R (1986) Associalion of cancer ot the lower urinary tract with consumption of alcoholic beverages — a case control study. Carcinogenesis 7:163 Kunze E, Calude J, Frentzel-Beyme R (1986) Associalion of cancer ot the lower urinary tract with consumption of alcoholic beverages — a case control study. Carcinogenesis 7:163
Zurück zum Zitat Linn JFJ, Rübben H. (1995) Die Wirkung von Keyhole-Limpet-Haemocyanin auf chemisch induzierte Blasentumore bei Ratten. Vergleich subkutaner vs. intraversikaler Applikation vs. Kontrollgruppe. 12. Symposium für experimentelle Urologie. 18.03.95, Berlin Linn JFJ, Rübben H. (1995) Die Wirkung von Keyhole-Limpet-Haemocyanin auf chemisch induzierte Blasentumore bei Ratten. Vergleich subkutaner vs. intraversikaler Applikation vs. Kontrollgruppe. 12. Symposium für experimentelle Urologie. 18.03.95, Berlin
Zurück zum Zitat Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Autrup H, et al. (2000) Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev. 9:461–467 Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Autrup H, et al. (2000) Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev. 9:461–467
Zurück zum Zitat McCredie M, Stewart JH, Ford JM, McLennan RA (1983) Phenacetin-containing analgesics and cancer of the bladder or renal pelvis in women. Br J Urol; 55: 220–224 McCredie M, Stewart JH, Ford JM, McLennan RA (1983) Phenacetin-containing analgesics and cancer of the bladder or renal pelvis in women. Br J Urol; 55: 220–224
Zurück zum Zitat Micheli A, Mariotto A, Giorgio Rossi A, Gatta G, Muti P (1998) Eurocare Working Group, The prognostic role of gender in survival of adult cancer patients. Eur J Cancer; 14: 2271–2278 Micheli A, Mariotto A, Giorgio Rossi A, Gatta G, Muti P (1998) Eurocare Working Group, The prognostic role of gender in survival of adult cancer patients. Eur J Cancer; 14: 2271–2278
Zurück zum Zitat Morrison AS, Cole P (1982) Urinary tract. In: Schottenfeld D, Fraumeni FJ, Saunders WB (eds) Cancer epidemiology and prevention. Saunders, Philadelphia, p. 925 Morrison AS, Cole P (1982) Urinary tract. In: Schottenfeld D, Fraumeni FJ, Saunders WB (eds) Cancer epidemiology and prevention. Saunders, Philadelphia, p. 925
Zurück zum Zitat Mostafa MH, Helmi S, Badawi AF, Tricker AR, Spiegelhalder B, Preussmann R (1994) Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patients. Carcinogenesis; 15: 619–625 Mostafa MH, Helmi S, Badawi AF, Tricker AR, Spiegelhalder B, Preussmann R (1994) Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patients. Carcinogenesis; 15: 619–625
Zurück zum Zitat Norpoth K, Woitowitz HJ (1994) Beruflich verursachte Tumoren. Dt. Ärzte Verlag, Köln, S. 25–31 Norpoth K, Woitowitz HJ (1994) Beruflich verursachte Tumoren. Dt. Ärzte Verlag, Köln, S. 25–31
Zurück zum Zitat Ohkawa T, Fujinaga T, Doi J, Ebisuno S, Takamatsu M, Nakamura J, Kido R (1982) Clinical study on occupational uroepithelial cancer in Wakayama City. J Urol 128:520 Ohkawa T, Fujinaga T, Doi J, Ebisuno S, Takamatsu M, Nakamura J, Kido R (1982) Clinical study on occupational uroepithelial cancer in Wakayama City. J Urol 128:520
Zurück zum Zitat Olsen CA, Vere White RW de (1979) Cancer of the bladder. In: Javadpour N (ed) Principles and management of urologic cancer. Williams & Wilkins, Baltimore, p.337 Olsen CA, Vere White RW de (1979) Cancer of the bladder. In: Javadpour N (ed) Principles and management of urologic cancer. Williams & Wilkins, Baltimore, p.337
Zurück zum Zitat Parkin DM, Bray F, Ferley J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer Oct 15,94(2):153–6 Parkin DM, Bray F, Ferley J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer Oct 15,94(2):153–6
Zurück zum Zitat Pashos CL, Botteman MF, Laskin BL, Redaelle A; Bladder cancer (2002) Epidemiology, Diagnosis and Management Cancer Practice Nov/Dec; 10 (6):311–322 Pashos CL, Botteman MF, Laskin BL, Redaelle A; Bladder cancer (2002) Epidemiology, Diagnosis and Management Cancer Practice Nov/Dec; 10 (6):311–322
Zurück zum Zitat Patterson JM, Ray EH, Mendiondo OA, Medina WD, Gee WF (1988) A new treatment for invasive sqamous cell bladder cancer: the nigro regimen:preoperative chemotherapy and radiation therapy. J Urol 140:379 Patterson JM, Ray EH, Mendiondo OA, Medina WD, Gee WF (1988) A new treatment for invasive sqamous cell bladder cancer: the nigro regimen:preoperative chemotherapy and radiation therapy. J Urol 140:379
Zurück zum Zitat Patrianakos C, Hoffmann D (1979) Chemical studies on tobacco smoke. LXIV On the analysis of aromatic amines in cigarette smoke. J Anal Toxicol 3:150 Patrianakos C, Hoffmann D (1979) Chemical studies on tobacco smoke. LXIV On the analysis of aromatic amines in cigarette smoke. J Anal Toxicol 3:150
Zurück zum Zitat Pearson RM, Soloway MS (1978) Does cyclophosphamide induce bladder cancer? Urology 4:437 Pearson RM, Soloway MS (1978) Does cyclophosphamide induce bladder cancer? Urology 4:437
Zurück zum Zitat Pedersen-Bjergaard J, Ersboll J, Hansen VL et al. (1988); Carcinoma of the urinary bladder after treatment with cyclophosphamide for non-Hodgkin lymphoma. N Engl J Med 318: 1028–1032 Pedersen-Bjergaard J, Ersboll J, Hansen VL et al. (1988); Carcinoma of the urinary bladder after treatment with cyclophosphamide for non-Hodgkin lymphoma. N Engl J Med 318: 1028–1032
Zurück zum Zitat Petkovic S, Multavdzik M, Petronic V, Marcovic V (1971) Tumours of the renal pelvis and ureter: clinical and aetiologic studies. J Urol Nephrol (Paris) 77:429 Petkovic S, Multavdzik M, Petronic V, Marcovic V (1971) Tumours of the renal pelvis and ureter: clinical and aetiologic studies. J Urol Nephrol (Paris) 77:429
Zurück zum Zitat Probert JL, Persad RA, Greenwood RP, Gillatt DA, Smith PJ (1998) Epidemiology of transitional cell carcinoma of the bladder: profile of an urban population in the south-west of England. Br J Urol 82 (5): 660–666 Probert JL, Persad RA, Greenwood RP, Gillatt DA, Smith PJ (1998) Epidemiology of transitional cell carcinoma of the bladder: profile of an urban population in the south-west of England. Br J Urol 82 (5): 660–666
Zurück zum Zitat Quilty PM, Duncan W (1986) Primary radical radiotherapy for T3 transitional cell cancer of the bladder: an analysis of survival and control. Int J Radiat Oncol Biol Phys 12:853 Quilty PM, Duncan W (1986) Primary radical radiotherapy for T3 transitional cell cancer of the bladder: an analysis of survival and control. Int J Radiat Oncol Biol Phys 12:853
Zurück zum Zitat Raghavan D, Huben R, (1995) Management of bladder cancer Curr Probl Cancer 19:1–64 Raghavan D, Huben R, (1995) Management of bladder cancer Curr Probl Cancer 19:1–64
Zurück zum Zitat Riede UN, Schaefer HE (1995) Allgemeine und spezielle Pathologie. Georg Thieme Verlag, Stuttgart, New York Riede UN, Schaefer HE (1995) Allgemeine und spezielle Pathologie. Georg Thieme Verlag, Stuttgart, New York
Zurück zum Zitat Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, et al. (2000) SEER Cancer Statistics Review, 1973–1997. Bethesda, Md: National Cancer Institute Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, et al. (2000) SEER Cancer Statistics Review, 1973–1997. Bethesda, Md: National Cancer Institute
Zurück zum Zitat Ries LAG, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK (eds) (1999) SEER Cancer Statistics Review, 1973-1996. Bethesda MD: National Cancer Institute. NIH; Pub. No. 99–2789 Ries LAG, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK (eds) (1999) SEER Cancer Statistics Review, 1973-1996. Bethesda MD: National Cancer Institute. NIH; Pub. No. 99–2789
Zurück zum Zitat Sadetzki S, Bensal D, Blumstein T, Novikov I, Modan B (2000) Selected risk factors for transitional cell bladder cancer. Med Oncol.; 17:179–182 Sadetzki S, Bensal D, Blumstein T, Novikov I, Modan B (2000) Selected risk factors for transitional cell bladder cancer. Med Oncol.; 17:179–182
Zurück zum Zitat Schulte PA, Ringen K, Hemstreet GP (1986) Risk factors for bladder cancer in cohort exposed to aromatic amines, Cancer 58:2156 Schulte PA, Ringen K, Hemstreet GP (1986) Risk factors for bladder cancer in cohort exposed to aromatic amines, Cancer 58:2156
Zurück zum Zitat Sen SE, Malek RS, Farrow GM, Lieber MM (1985) Sarcoma and carcinosarcoma of the bladder in adults. J Urol 133:29–30 Sen SE, Malek RS, Farrow GM, Lieber MM (1985) Sarcoma and carcinosarcoma of the bladder in adults. J Urol 133:29–30
Zurück zum Zitat Sherif A, De la Torre M, Maömström PU et al. (2001) Lymphatic mapping and detection of sentinel nodes in patients with bladder cancer. J Urol 166:812–815 Sherif A, De la Torre M, Maömström PU et al. (2001) Lymphatic mapping and detection of sentinel nodes in patients with bladder cancer. J Urol 166:812–815
Zurück zum Zitat Shibata MA et al. (1989) The role of BBN in F344 rats. J Toxicol Environ Health 26 (3):255–265 Shibata MA et al. (1989) The role of BBN in F344 rats. J Toxicol Environ Health 26 (3):255–265
Zurück zum Zitat Silverman DT, Hartge P, Morrison AS, Devesa SS (1992) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 3:421–428 Silverman DT, Hartge P, Morrison AS, Devesa SS (1992) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 3:421–428
Zurück zum Zitat Simon R, Bürger H, Brinkschmidt C, Böcker W, Hertle L, Terpe H (1998) Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol; 185:345–351 Simon R, Bürger H, Brinkschmidt C, Böcker W, Hertle L, Terpe H (1998) Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol; 185:345–351
Zurück zum Zitat Vineis P, Pirastu R (1997) Cancer Causes Control 8:346–355 Vineis P, Pirastu R (1997) Cancer Causes Control 8:346–355
Zurück zum Zitat Wynder EL, Goldsmith R (1977) The epidemiology of bladder cancer: a second look. Cancer 40:1246 Wynder EL, Goldsmith R (1977) The epidemiology of bladder cancer: a second look. Cancer 40:1246
Zurück zum Zitat Zeegers MPA, Kellen E, Buntinx, Brandt van den PA (2004) The association between smoking, beverage consumption, diet and bladder cancer: a systemic literature review. World J Urol 21:392–401 Zeegers MPA, Kellen E, Buntinx, Brandt van den PA (2004) The association between smoking, beverage consumption, diet and bladder cancer: a systemic literature review. World J Urol 21:392–401
Zurück zum Zitat Zhao J, Richter J, Wagner U, Roth B, Schraml P, Zellweger T, Ackermann D, Schmid U, Moch H, Mihatsch MJ, Gasser TC, Sauter G (1999) Chromosomal imbalances in noninvasive papillary bladder neoplasms (pTa). Cancer Res. 59: 4685–4661 Zhao J, Richter J, Wagner U, Roth B, Schraml P, Zellweger T, Ackermann D, Schmid U, Moch H, Mihatsch MJ, Gasser TC, Sauter G (1999) Chromosomal imbalances in noninvasive papillary bladder neoplasms (pTa). Cancer Res. 59: 4685–4661
Zurück zum Zitat Zheng W, McLaughlin JK, Gao YT, Silverman DT, Gao RN, Blot WJ (1992) Bladder cancer and occupation in Shanghai, 1980-1984. Am J Ind Med. 21:877–885 Zheng W, McLaughlin JK, Gao YT, Silverman DT, Gao RN, Blot WJ (1992) Bladder cancer and occupation in Shanghai, 1980-1984. Am J Ind Med. 21:877–885
Metadaten
Titel
Epidemiologie, Ätiologie und Klassifikation des Harnblasenkarzinoms
verfasst von
Priv.-Doz. Dr. med. Frank vom Dorp
Copyright-Jahr
2018
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-55660-3_3

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