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Clinical Autonomic Research

Erschienen in:

25.02.2019 | Review Article

Epidemiology and pathophysiology of autonomic seizures: a systematic review

verfasst von: Christoph Baumgartner, Johannes Koren, Martha Britto-Arias, Simone Schmidt, Susanne Pirker

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2019

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Abstract

Purpose

To review the epidemiology and pathophysiology of autonomic symptoms and signs during epileptic seizures.

Methods

We performed a systematic literature search on the following autonomic symptoms and signs during epileptic seizures: cardiovascular changes, respiratory manifestations, gastrointestinal symptoms, cutaneous manifestations, sexual and genital manifestations, and urinary symptoms.

Results

Autonomic symptoms and signs can represent the predominant symptom at the onset of a focal seizure, which would then lead to the seizure being classified as a focal onset autonomic seizure. Conversely, clinically relevant autonomic symptoms and signs frequently accompany seizures of focal, generalized, and/or unknown onset, but the seizure is regardless classified according to other, more relevant features. Autonomic symptoms and signs do not represent mere reactions to motor activity or other behavioral seizure manifestations, but rather they are generated by epileptic discharges affecting the central autonomic network. We have reviewed the localizing and lateralizing information currently available on the seizure onset zone and on seizure propagation pathways as provided by systematic analysis of specific autonomic seizure symptoms and signs. We present data on how autonomic seizure symptoms and signs are useful for gaining a better understanding of the anatomical and functional organization of the central autonomic network. Finally, we discuss the differential diagnosis of focal autonomic seizures with autonomic symptoms and signs representing the sole seizure manifestation versus various non-epileptic conditions.

Conclusions

Autonomic seizure symptoms and signs are relevant in clinical epileptology and open a unique window on the functional organization and pathophysiology of the central autonomic network.

Freeman R, Schachter SC (1995) Autonomic epilepsy. Semin Neurol 15:158–166CrossRefPubMed

Freeman R (2006) Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res 16:12–17. https://doi.org/10.1007/s10286-006-0278-y CrossRefPubMed

Liporace JD, Sperling MR (1997) Simple autonomic seizures. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven Publishers, Philadelphia, pp 549–555

Reeves AL (1997) Autonomic activity in epilepsy: diagnostic considerations and implications. J Epilepsy 10:111–116CrossRef

Lesser RP, Lüders H, Dinner DS, Morris HHI (1987) Simple partial seizures. In: Lüders H, Lesser RP (eds) Epilepsy: electroclinical syndromes. Springer, London, pp 223–278CrossRef

Baumgartner C, Lurger S, Leutmezer F (2001) Autonomic symptoms during epileptic seizures. Epileptic Disord 3:103–116PubMed

Janszky J, Fogarasi A, Toth V, Magalova V, Gyimesi C, Kovacs N, Schulz R, Ebner A (2007) Peri-ictal vegetative symptoms in temporal lobe epilepsy. Epilepsy Behav 11:125–129. https://doi.org/10.1016/j.yebeh.2007.04.015 CrossRefPubMed

Baysal-Kirac L, Baykan B (2015) Current view of autonomic findings during epileptic seizures. Turk J Neurol 21:147–153CrossRef

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshe SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM (2017) Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia 58:522–530. https://doi.org/10.1111/epi.13670 CrossRefPubMed

10.

Benarroch EE (1993) The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc 68:988–1001CrossRefPubMed

11.

Cersosimo MG, Benarroch EE (2013) Central control of autonomic function and involvement in neurodegenerative disorders. Handb Clin Neurol 117:45–57. https://doi.org/10.1016/b978-0-444-53491-0.00005-5 CrossRefPubMed

12.

Eggleston KS, Olin BD, Fisher RS (2014) Ictal tachycardia: the head–heart connection. Seizure 23:496–505. https://doi.org/10.1016/j.seizure.2014.02.012 CrossRefPubMed

13.

Surges R, Scott CA, Walker MC (2010) Enhanced QT shortening and persistent tachycardia after generalized seizures. Neurology 74:421–426. https://doi.org/10.1212/WNL.0b013e3181ccc706 CrossRefPubMedPubMedCentral

14.

Nilsen KB, Haram M, Tangedal S, Sand T, Brodtkorb E (2010) Is elevated pre-ictal heart rate associated with secondary generalization in partial epilepsy? Seizure 19:291–295. https://doi.org/10.1016/j.seizure.2010.03.003 CrossRefPubMed

15.

Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC (1992) Cardiovascular effects of human insular cortex stimulation. Neurology 42:1727–1732CrossRefPubMed

16.

Schernthaner C, Lindinger G, Potzelberger K, Zeiler K, Baumgartner C (1999) Autonomic epilepsy—the influence of epileptic discharges on heart rate and rhythm. Wien Klin Wochenschr 111:392–401PubMed

17.

Leutmezer F, Schernthaner C, Lurger S, Potzelberger K, Baumgartner C (2003) Electrocardiographic changes at the onset of epileptic seizures. Epilepsia 44:348–354CrossRefPubMed

18.

Massetani R, Strata G, Galli R, Gori S, Gneri C, Limbruno U, Di Santo D, Mariani M, Murri L (1997) Alteration of cardiac function in patients with temporal lobe epilepsy: different roles of EEG–ECG monitoring and spectral analysis of RR variability. Epilepsia 38:363–369CrossRefPubMed

19.

Di Gennaro G, Quarato PP, Sebastiano F, Esposito V, Onorati P, Grammaldo LG, Meldolesi GN, Mascia A, Falco C, Scoppetta C, Eusebi F, Manfredi M, Cantore G (2004) Ictal heart rate increase precedes EEG discharge in drug-resistant mesial temporal lobe seizures. Clin Neurophysiol 115:1169–1177. https://doi.org/10.1016/j.clinph.2003.12.016 CrossRefPubMed

20.

Mayer H, Benninger F, Urak L, Plattner B, Geldner J, Feucht M (2004) EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy. Neurology 63:324–328CrossRefPubMed

21.

Saleh Y, Kirchner A, Pauli E, Hilz MJ, Neundorfer B, Stefan H (2000) Temporallappenepilepsien: einfluss der Fokusseite auf die autonome Herzfrequenz? Nervenarzt 71:477–480CrossRefPubMed

22.

Hirsch M, Altenmuller DM, Schulze-Bonhage A (2015) Latencies from intracranial seizure onset to ictal tachycardia: a comparison to surface EEG patterns and other clinical signs. Epilepsia 56:1639–1647. https://doi.org/10.1111/epi.13117 CrossRefPubMed

23.

van der Lende M, Surges R, Sander JW, Thijs RD (2016) Cardiac arrhythmias during or after epileptic seizures. J Neurol Neurosurg Psychiatry 87:69–74. https://doi.org/10.1136/jnnp-2015-310559 CrossRefPubMed

24.

Smith PE, Howell SJ, Owen L, Blumhardt LD (1989) Profiles of instant heart rate during partial seizures. Electroencephalogr Clin Neurophysiol 72:207–217CrossRefPubMed

25.

Blumhardt LD, Smith PE, Owen L (1986) Electrocardiographic accompaniments of temporal lobe epileptic seizures. Lancet 1:1051–1056CrossRefPubMed

26.

Britton JW, Ghearing GR, Benarroch EE, Cascino GD (2006) The ictal bradycardia syndrome: localization and lateralization. Epilepsia 47:737–744. https://doi.org/10.1111/j.1528-1167.2006.00509.x CrossRefPubMed

27.

Rugg-Gunn FJ, Simister RJ, Squirrell M, Holdright DR, Duncan JS (2004) Cardiac arrhythmias in focal epilepsy: a prospective long-term study. Lancet 364:2212–2219. https://doi.org/10.1016/s0140-6736(04)17594-6 CrossRefPubMed

28.

Nei M, Sperling MR, Mintzer S, Ho RT (2012) Long-term cardiac rhythm and repolarization abnormalities in refractory focal and generalized epilepsy. Epilepsia 53:e137–e140. https://doi.org/10.1111/j.1528-1167.2012.03561.x CrossRefPubMed

29.

Hampel KG, Thijs RD, Elger CE, Surges R (2017) Recurrence risk of ictal asystole in epilepsy. Neurology 89:785–791. https://doi.org/10.1212/wnl.0000000000004266 CrossRefPubMedPubMedCentral

30.

Tenyi D, Gyimesi C, Kupo P, Horvath R, Bone B, Barsi P, Kovacs N, Simor T, Siegler Z, Kornyei L, Fogarasi A, Janszky J (2017) Ictal asystole: a systematic review. Epilepsia 58:356–362. https://doi.org/10.1111/epi.13644 CrossRefPubMed

31.

Strzelczyk A, Cenusa M, Bauer S, Hamer HM, Mothersill IW, Grunwald T, Hillenbrand B, Ebner A, Steinhoff BJ, Kramer G, Rosenow F (2011) Management and long-term outcome in patients presenting with ictal asystole or bradycardia. Epilepsia 52:1160–1167. https://doi.org/10.1111/j.1528-1167.2010.02961.x CrossRefPubMed

32.

Newey CR, Sarwal A (2015) Ictal asystole in focal epilepsy: to pace or not to pace? Neurohospitalist 5:NP3–6. https://doi.org/10.1177/1941874415569070 CrossRefPubMedPubMedCentral

33.

Bestawros M, Darbar D, Arain A, Abou-Khalil B, Plummer D, Dupont WD, Raj SR (2015) Ictal asystole and ictal syncope: insights into clinical management. Circ Arrhythm Electrophysiol 8:159–164. https://doi.org/10.1161/circep.114.001667 CrossRefPubMed

34.

Kohno R, Abe H, Akamatsu N, Benditt DG (2016) Long-term follow-up of ictal asystole in temporal lobe epilepsy: is permanent pacemaker therapy needed? J Cardiovasc Electrophysiol 27:930–936. https://doi.org/10.1111/jce.13009 CrossRefPubMed

35.

Benditt DG, van Dijk G, Thijs RD (2015) Ictal asystole: life-threatening vagal storm or a benign seizure self-termination mechanism? Circ Arrhythm Electrophysiol 8:11–14. https://doi.org/10.1161/circep.114.002546 CrossRefPubMed

36.

Moseley BD, Ghearing GR, Munger TM, Britton JW (2011) The treatment of ictal asystole with cardiac pacing. Epilepsia 52:e16–e19. https://doi.org/10.1111/j.1528-1167.2010.02972.x CrossRefPubMed

37.

Schuele SU, Bermeo AC, Locatelli E, Burgess RC, Luders HO (2008) Ictal asystole: a benign condition? Epilepsia 49:168–171. https://doi.org/10.1111/j.1528-1167.2007.01330.x CrossRefPubMed

38.

Schuele SU, Bermeo AC, Alexopoulos AV, Burgess RC (2010) Anoxia-ischemia: a mechanism of seizure termination in ictal asystole. Epilepsia 51:170–173. https://doi.org/10.1111/j.1528-1167.2009.02168.x CrossRefPubMed

39.

Moseley BD, Ghearing GR, Benarroch EE, Britton JW (2011) Early seizure termination in ictal asystole. Epilepsy Res 97:220–224. https://doi.org/10.1016/j.eplepsyres.2011.08.008 CrossRefPubMed

40.

Ryvlin P, Nashef L, Lhatoo SD, Bateman LM, Bird J, Bleasel A, Boon P, Crespel A, Dworetzky BA, Hogenhaven H, Lerche H, Maillard L, Malter MP, Marchal C, Murthy JM, Nitsche M, Pataraia E, Rabben T, Rheims S, Sadzot B, Schulze-Bonhage A, Seyal M, So EL, Spitz M, Szucs A, Tan M, Tao JX, Tomson T (2013) Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study. Lancet Neurol 12:966–977. https://doi.org/10.1016/s1474-4422(13)70214-x CrossRefPubMed

41.

Peng W, Danison JL, Seyal M (2017) Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic–clonic seizures in sleep and wakefulness. Epilepsia 58:1409–1414. https://doi.org/10.1111/epi.13805 CrossRefPubMed

42.

Nei M, Ho RT, Sperling MR (2000) EKG abnormalities during partial seizures in refractory epilepsy. Epilepsia 41:542–548CrossRefPubMed

43.

Keilson MJ, Hauser WA, Magrill JP (1989) Electrocardiographic changes during electrographic seizures. Arch Neurol 46:1169–1170CrossRefPubMed

44.

Surges R, Thijs RD, Tan HL, Sander JW (2009) Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol 5:492–504. https://doi.org/10.1038/nrneurol.2009.118 CrossRefPubMed

45.

Lamberts RJ, Blom MT, Wassenaar M, Bardai A, Leijten FS, de Haan GJ, Sander JW, Thijs RD, Tan HL (2015) Sudden cardiac arrest in people with epilepsy in the community: circumstances and risk factors. Neurology 85:212–218. https://doi.org/10.1212/wnl.0000000000001755 CrossRefPubMedPubMedCentral

46.

Park KJ, Sharma G, Kennedy JD, Seyal M (2017) Potentially high-risk cardiac arrhythmias with focal to bilateral tonic-clonic seizures and generalized tonic-clonic seizures are associated with the duration of periictal hypoxemia. Epilepsia 58:2164–2171. https://doi.org/10.1111/epi.13934 CrossRefPubMed

47.

Foldvary N, Lee N, Thwaites G, Mascha E, Hammel J, Kim H, Friedman AH, Radtke RA (1997) Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy. Neurology 49:757–763CrossRefPubMed

48.

Harvey AS, Hopkins IJ, Bowe JM, Cook DJ, Shield LK, Berkovic SF (1993) Frontal lobe epilepsy: clinical seizure characteristics and localization with ictal 99mTc-HMPAO SPECT. Neurology 43:1966–1980CrossRefPubMed

49.

Bateman LM, Li CS, Seyal M (2008) Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain 131:3239–3245. https://doi.org/10.1093/brain/awn277 CrossRefPubMedPubMedCentral

50.

Lacuey N, Zonjy B, Hampson JP, Rani MRS, Zaremba A, Sainju RK, Gehlbach BK, Schuele S, Friedman D, Devinsky O, Nei M, Harper RM, Allen L, Diehl B, Millichap JJ, Bateman L, Granner MA, Dragon DN, Richerson GB, Lhatoo SD (2018) The incidence and significance of periictal apnea in epileptic seizures. Epilepsia 59:573–582. https://doi.org/10.1111/epi.14006 PubMedCentralCrossRefPubMed

51.

Blum AS, Ives JR, Goldberger AL, Al-Aweel IC, Krishnamurthy KB, Drislane FW, Schomer DL (2000) Oxygen desaturations triggered by partial seizures: implications for cardiopulmonary instability in epilepsy. Epilepsia 41:536–541CrossRefPubMed

52.

Leutmezer F, Serles W, Lehrner J, Pataraia E, Zeiler K, Baumgartner C (1998) Postictal nose wiping: a lateralizing sign in temporal lobe complex partial seizures. Neurology 51:1175–1177CrossRefPubMed

53.

Wennberg R (2000) Electroclinical analysis of postictal noserubbing. Can J Neurol Sci 27:131–136CrossRefPubMed

54.

Hirsch L, Lain A, Walczak T (1998) Postictal nosewiping lateralizes and localizes to the ipsilateral temporal lobe. Epilepsia 39:991–997CrossRefPubMed

55.

Geyer J, Payne T, Faught E, Drury I (1999) Postictal nose-rubbing in the diagnosis, lateralization, and localization of seizures. Neurology 52:743–745CrossRefPubMed

56.

Dupont S, Samson Y, Nguyen-Michel VH, Zavanone C, Navarro V, Baulac M, Adam C (2015) Lateralizing value of semiology in medial temporal lobe epilepsy. Acta Neurol Scand 132:401–409. https://doi.org/10.1111/ane.12409 CrossRefPubMed

57.

Baykan B, Gurses C, Gokyigit A (2000) Nose wiping: an unrecognized automatism in absence seizures. Clin Electroencephalogr 31:157–159CrossRefPubMed

58.

Asadi-Pooya AA, Shabo L, Wyeth D, Nei M (2017) Ictal coughing: clinical features and differential diagnoses. Epilepsy Behav 73:51–53. https://doi.org/10.1016/j.yebeh.2017.04.044 CrossRefPubMed

59.

Van Ness PC, Marotta J, Kucera A, Klem G, Chee M (1993) Postictal cough is a sign of temporal lobe epilepsy. Neurology 43[Suppl 2]:A273

60.

Gil Nagel A, Risinger MW (1997) Ictal semiology in hippocampal versus extrahippocampal temporal lobe epilepsy. Brain 120:183–192CrossRefPubMed

61.

Fauser S, Wuwer Y, Gierschner C, Schulze-Bonhage A (2004) The localizing and lateralizing value of ictal/postictal coughing in patients with focal epilepsies. Seizure 13:403–410. https://doi.org/10.1016/j.seizure.2003.09.007 CrossRefPubMed

62.

Musilova K, Kuba R, Brazdil M, Tyrlikova I, Rektor I (2010) Occurrence and lateralizing value of “rare” peri-ictal vegetative symptoms in temporal lobe epilepsy. Epilepsy Behav 19:372–375. https://doi.org/10.1016/j.yebeh.2010.07.010 CrossRefPubMed

63.

Hoffmann JM, Elger CE, Kleefuss-Lie AA (2009) The localizing value of hypersalivation and postictal coughing in temporal lobe epilepsy. Epilepsy Res 87:144–147. https://doi.org/10.1016/j.eplepsyres.2009.08.005 CrossRefPubMed

64.

Wennberg R (2001) Postictal coughing and noserubbing coexist in temporal lobe epilepsy. Neurology 56:133–134CrossRefPubMed

65.

Gelisse P, Genton P (2008) Cough syncope misinterpreted as epileptic seizure. Epileptic Disord 10:223–224. https://doi.org/10.1684/epd.2008.0204 CrossRefPubMed

66.

Cohen HA, Ashkenazi A, Barzilai A, Lahat E (2000) Nocturnal acute laryngospasm in children: a possible epileptic phenomenon. J Child Neurol 15:202–204CrossRefPubMed

67.

Oldani A, Zucconi M, Castronovo C, Ferini-Strambi L (1998) Nocturnal frontal lobe epilepsy misdiagnosed as sleep apnea syndrome. Acta Neurol Scand 98:67–71CrossRefPubMed

68.

Isnard J, Guenot M, Sindou M, Mauguiere F (2004) Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia 45:1079–1090. https://doi.org/10.1111/j.0013-9580.2004.68903.x CrossRefPubMed

69.

Henkel A, Noachtar S, Pfander M, Luders HO (2002) The localizing value of the abdominal aura and its evolution: a study in focal epilepsies. Neurology 58:271–276CrossRefPubMed

70.

Gupta AK, Jeavons PM, Hughes RC, Covanis A (1983) Aura in temporal lobe epilepsy: clinical and electroencephalographic correlation. J Neurol Neurosurg Psychiatry 46:1079–1083CrossRefPubMedPubMedCentral

71.

Taylor DC, Lochery M (1987) Temporal lobe epilepsy: origin and significance of simple and complex auras. J Neurol Neurosurg Psychiatry 50:673–681CrossRefPubMedPubMedCentral

72.

Palmini A, Gloor P (1992) The localizing value of auras in partial seizures: a prospective and retrospective study. Neurology 42:801–808CrossRefPubMed

73.

Fried I, Spencer DD, Spencer SS (1995) The anatomy of epileptic auras: focal pathology and surgical outcome. J Neurosurg 83:60–66CrossRefPubMed

74.

Marks WJ Jr, Laxer KD (1998) Semiology of temporal lobe seizures: value in lateralizing the seizure focus. Epilepsia 39:721–726CrossRefPubMed

75.

Mitchell WG, Greenwood RS, Messenheimer JA (1983) Abdominal epilepsy: cyclic vomiting as the major symptom of simple partial seizures. Arch Neurol 40:251–252CrossRefPubMed

76.

Fiol ME, Leppik IE, Mireles R, Maxwell R (1988) Ictus emeticus and the insular cortex. Epilepsy Res 2:127–131CrossRefPubMed

77.

Kramer RE, Lüders H, Goldstick LP, Dinner DS, Morris HH, Lesser RP, Wyllie E (1988) Ictus emeticus: an electroclinical analysis. Neurology 38:1045–1052CrossRef

78.

Guerrini R, Ferrari AR, Battaglia A, Salvadori P, Bonanni P (1994) Occipitotemporal seizures with ictus emeticus induced by intermittent photic stimulation. Neurology 44:253–259CrossRefPubMed

79.

Devinsky O, Frasca J, Pacia SV, Luciano DJ, Paraiso J, Doyle W (1995) Ictus emeticus: further evidence of nondominant temporal involvement. Neurology 45:1158–1160CrossRefPubMed

80.

Kotagal P, Lüders HO, Williams G, Nichols TR, McPherson J (1995) Psychomotor seizures of temporal lobe onset: analysis of symptom clusters and sequences. Epilepsy Res 20:49–67CrossRefPubMed

81.

Baumgartner C, Olbrich A, Lindinger G, Pataraia E, Groppel G, Bacher J, Aull S, Serles W, Hoffmann M, Leutmezer F, Czech T, Prayer D, Pietrzyk U, Asenbaum S, Podreka I (1999) Regional cerebral blood flow during temporal lobe seizures associated with ictal vomiting: an ictal SPECT study in two patients. Epilepsia 40:1085–1091CrossRefPubMed

82.

Chen C, Yen DJ, Yiu CH, Shih YH, Yu HY, Su MS (1999) Ictal vomiting in partial seizures of temporal lobe origin. Eur Neurol 42:235–239CrossRefPubMed

83.

Schauble B, Britton JW, Mullan BP, Watson J, Sharbrough FW, Marsh WR (2002) Ictal vomiting in association with left temporal lobe seizures in a left hemisphere language-dominant patient. Epilepsia 43:1432–1435CrossRefPubMed

84.

Schindler K, Wieser HG (2006) Ictal vomiting in a left hemisphere language-dominant patient with left-sided temporal lobe epilepsy. Epilepsy Behav 8:323–327. https://doi.org/10.1016/j.yebeh.2005.10.014 CrossRefPubMed

85.

Tarnutzer AA, Mothersill I, Imbach LL (2018) Ictal nausea and vomiting—Is it left or right? Seizure 61:83–88. https://doi.org/10.1016/j.seizure.2018.08.011 CrossRefPubMed

86.

Penfield W, Jasper H (1954) Epilepsy and the functional anatomy of the brain. Little Brown & Co, BostonCrossRef

87.

Van Buren JM (1963) The abdominal aura: a study of abdominal sensations occurring in epilepsy and produced by depth stimulation. Electroencephalogr Clin Neurophysiol 15:1–19CrossRef

88.

Catenoix H, Isnard J, Guenot M, Petit J, Remy C, Mauguiere F (2008) The role of the anterior insular cortex in ictal vomiting: a stereotactic electroencephalography study. Epilepsy Behav 13:560–563. https://doi.org/10.1016/j.yebeh.2008.06.019 CrossRefPubMed

89.

Pietrafusa N, de Palma L, De Benedictis A, Trivisano M, Marras CE, Vigevano F, Specchio N (2015) Ictal vomiting as a sign of temporal lobe epilepsy confirmed by stereo-EEG and surgical outcome. Epilepsy Behav 53:112–116. https://doi.org/10.1016/j.yebeh.2015.10.009 CrossRefPubMed

90.

Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M (2016) Idiopathic focal epilepsies: the “lost tribe”. Epileptic Disord 18:252–288. https://doi.org/10.1684/epd.2016.0839 CrossRef

91.

Panayiotopoulos CP (1989) Benign nocturnal childhood epilepsy: a new syndrome with nocturnal seizures, tonic deviation of the eyes, and vomiting. J Child Neurol 4:43–48CrossRefPubMed

92.

Panayiotopoulos CP (1989) Benign childhood epilepsy with occipital paroxysms. A 15-year prospective study. Ann Neurol 26:51–56CrossRefPubMed

93.

Panayiotopoulos CP (1999) Early-onset benign childhood occipital seizure susceptibility syndrome: a syndrome to recognize. Epilepsia 40:621–630CrossRefPubMed

94.

Ferrie C, Caraballo R, Covanis A, Demirbilek V, Dervent A, Kivity S, Koutroumanidis M, Martinovic Z, Oguni H, Verrotti A, Vigevano F, Watanabe K, Yalcin D, Yoshinaga H (2006) Panayiotopoulos syndrome: a consensus view. Dev Med Child Neurol 48:236–240. https://doi.org/10.1017/s0012162206000508 CrossRefPubMed

95.

Specchio N, Trivisano M, Di Ciommo V, Cappelletti S, Masciarelli G, Volkov J, Fusco L, Vigevano F (2010) Panayiotopoulos syndrome: a clinical, EEG, and neuropsychological study of 93 consecutive patients. Epilepsia 51:2098–2107. https://doi.org/10.1111/j.1528-1167.2010.02639.x CrossRefPubMed

96.

Guerrini R, Dravet C, Genton P, Bureau M, Bonanni P, Ferrari AR, Roger J (1995) Idiopathic photosensitive occipital lobe epilepsy. Epilepsia 36:883–891CrossRefPubMed

97.

Panayiotopoulos CP (1988) Vomiting as an ictal manifestation of epileptic seizures and syndromes. J Neurol Neurosurg Psychiatry 51:1448–1451CrossRefPubMedPubMedCentral

98.

Hockaday JM, Newton RW (1988) Migraine and epilepsy. In: Hockaday JM (ed) Migraine in childhood. Butterworth, London, pp 88–143CrossRef

99.

Voss NF, Davies KG, Boop FA, Montouris GD, Hermann BP (1999) Spitting automatism in complex partial seizures: a nondominant temporal localizing sign? Epilepsia 40:114–116CrossRefPubMed

100.

Vojvodic N, Ristic AJ, Bascarevic V, Popovic L, Parojcic A, Koprivsek K, Sveljo O, Sokic D (2013) Ictal spitting in left temporal lobe epilepsy and fMRI speech lateralization. Clin Neurol Neurosurg 115:495–497. https://doi.org/10.1016/j.clineuro.2012.06.009 CrossRefPubMed

101.

Kellinghaus C, Loddenkemper T, Kotagal P (2003) Ictal spitting: clinical and electroencephalographic features. Epilepsia 44:1064–1069CrossRefPubMed

102.

Ozkara C, Hanoglu L, Eskazan E, Kulaksizogvlu IB, Ozyurt E (2000) Ictal spitting during a left emporal lobe-originated complex partial seizure: a case report. Epileptic Disord 2:169–172PubMed

103.

Quevedo-Diaz M, Campo AT, Vila-Vidal M, Principe A, Ley M, Rocamora R (2018) Ictal spitting in non-dominant temporal lobe epilepsy: an anatomo-electrophysiological correlation. Epileptic Disord 20:139–145. https://doi.org/10.1684/epd.2018.0963 CrossRefPubMed

104.

Park SM, Lee SA, Kim JH, Kang JK (2007) Ictal spitting in a patient with dominant temporal lobe epilepsy: supporting evidence of ictal spitting from the nondominant hemisphere. Eur Neurol 57:47–49. https://doi.org/10.1159/000097010 CrossRefPubMed

105.

Shah J, Zhai H, Fuerst D, Watson C (2006) Hypersalivation in temporal lobe epilepsy. Epilepsia 47:644–651. https://doi.org/10.1111/j.1528-1167.2006.00480.x CrossRefPubMed

106.

Strzelczyk A, Nowak M, Bauer S, Reif PS, Oertel WH, Knake S, Hamer HM, Rosenow F (2010) Localizing and lateralizing value of ictal flatulence. Epilepsy Behav 17:278–282. https://doi.org/10.1016/j.yebeh.2009.12.010 CrossRefPubMed

107.

Penfield W, Faulk ME Jr (1955) The insula; further observations on its function. Brain 78:445–470CrossRefPubMed

108.

Vittal NB, Singh P, Azar NJ (2009) Ictal flatulence: seizure onset in the nondominant hemisphere. Epilepsy Behav 16:663–665. https://doi.org/10.1016/j.yebeh.2009.09.019 CrossRefPubMed

109.

Koubeissi MZ, Crone NE, Lesser RP (2005) Seizures manifesting as an urge to defecate, with an ictal discharge in the right hemisphere. Epilepsia 46:1330–1332. https://doi.org/10.1111/j.1528-1167.2005.17505.x CrossRefPubMed

110.

Taieb G, Renard D, Labauge P, Janicot F, Briere C (2012) Ictal urge to defecate associated with a right-sided mesial temporal cavernoma. Epilepsy Behav 24:272–273. https://doi.org/10.1016/j.yebeh.2012.04.112 CrossRefPubMed

111.

Mulder D, Daly DD, Bailey A (1954) Visceral epilepsy. Arch Intern Med 93:481–493CrossRef

112.

Metz SA, Halter JB, Porte D Jr, Robertson RP (1978) Autonomic epilepsy: clonidine blockade of paroxysmal catecholamine release and flushing. Ann Intern Med 88:189–193CrossRefPubMed

113.

So NK, Andermann F (1997) Differential diagnosis. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven Publishers, Philadelphia, pp 791–797

114.

Pavone P, Pratico AD, Micali G, Greco F, Ruggieri M, Pavone L (2013) Autonomic dysfunction manifesting with asymmetric face flushing and paroxysmal nonconvulsive episodes. J Child Neurol 28:1673–1676. https://doi.org/10.1177/0883073812462627 CrossRefPubMed

115.

Cendes F, Andermann F, Gloor P, Gambardella A, Lopes-Cendes I, Watson C, Evans A, Carpenter S, Olivier A (1994) Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy. Brain 117:739–746CrossRefPubMed

116.

Garcia-Herrero D, Fernandez-Torre JL, Barrasa J, Calleja J, Pascual J (1998) Abdominal epilepsy in an adolescent with bilateral perisylvian polymicrogyria. Epilepsia 39:1370–1374CrossRefPubMed

117.

van Dijk JG, Thijs RD, van Zwet E, Tannemaat MR, van Niekerk J, Benditt DG, Wieling W (2014) The semiology of tilt-induced reflex syncope in relation to electroencephalographic changes. Brain 137:576–585. https://doi.org/10.1093/brain/awt332 CrossRefPubMed

118.

Penfield W, Kristiansen K (1951) Epileptic seizure patterns. Charles C. Thomas, Springfield

119.

Klein CJ, Silber MH, Halliwill JR, Schreiner SA, Suarez GA, Low PA (2001) Basal forebrain malformation with hyperhidrosis and hypothermia: variant of Shapiro’s syndrome. Neurology 56:254–256CrossRefPubMed

120.

Mendler MH, Sautereau D, Pillegand B, Ravon R (1998) A case of digestive epilepsy with late diagnosis: a disease not to be disregarded. Gastroenterol Clin Biol 22:235–239PubMed

121.

Cortes V, Landete L, Gomez E, Blasco R (1997) Partial simple vegetative crisis: importance of electroencephalographic findings. Rev Neurol 25:1931–1933PubMed

122.

Franco AC, Noachtar S, Remi J (2017) Ictal ipsilateral sweating in focal epilepsy. Seizure 50:4–5. https://doi.org/10.1016/j.seizure.2017.05.009 CrossRefPubMed

123.

Stefan H, Pauli E, Kerling F, Schwarz A, Koebnick C (2002) Autonomic auras: left hemispheric predominance of epileptic generators of cold shivers and goose bumps? Epilepsia 43:41–45CrossRefPubMed

124.

Rocamora R, Becerra JL, Fossas P, Gomez M, Vivanco-Hidalgo RM, Mauri JA, Molins A (2014) Pilomotor seizures: an autonomic semiology of limbic encephalitis? Seizure 23:670–673. https://doi.org/10.1016/j.seizure.2014.04.013 CrossRefPubMed

125.

Loddenkemper T, Kellinghaus C, Gandjour J, Nair DR, Najm IM, Bingaman W, Luders HO (2004) Localising and lateralising value of ictal piloerection. J Neurol Neurosurg Psychiatry 75:879–883CrossRefPubMedPubMedCentral

126.

Baysal-Kirac L, Tuzun E, Erdag E, Ulusoy C, Vanli-Yavuz EN, Ekizoglu E, Peach S, Sezgin M, Bebek N, Gurses C, Gokyigit A, Vincent A, Baykan B (2016) Neuronal autoantibodies in epilepsy patients with peri-ictal autonomic findings. J Neurol 263:455–466. https://doi.org/10.1007/s00415-015-8002-2 CrossRefPubMed

127.

Fisch L, Megevand P, Badoud S, Seeck M, Burkhard PR (2012) Pilomotor seizure: when paroxysmal gooseflesh heralds brain tumor. Neurology 78:1189. https://doi.org/10.1212/WNL.0b013e31824f80f5 CrossRefPubMed

128.

Asha MJ, Tansey RJ, Gan YC (2014) ‘Goose bumps’ as presenting feature of intraventricular glioblastoma multiforme. Br J Neurosurg 28:276–277. https://doi.org/10.3109/02688697.2013.817530 CrossRefPubMed

129.

Leutmezer F, Serles W, Bacher J, Groppel G, Pataraia E, Aull S, Olbrich A, Czech T, Baumgartner C (1999) Genital automatisms in complex partial seizures. Neurology 52:1188–1191CrossRefPubMed

130.

Mascia A, Di Gennaro G, Esposito V, Grammaldo LG, Meldolesi GN, Giampa T, Sebastiano F, Falco C, Onorati P, Manfredi M, Cantore G, Quarato PP (2005) Genital and sexual manifestations in drug-resistant partial epilepsy. Seizure 14:133–138. https://doi.org/10.1016/j.seizure.2004.12.002 CrossRefPubMed

131.

Aull-Watschinger S, Pataraia E, Baumgartner C (2008) Sexual auras: predominance of epileptic activity within the mesial temporal lobe. Epilepsy Behav 12:124–127CrossRefPubMed

132.

Bente D, Kluge E (1953) Sexuelle Reizzustände im Rahmen des Uncinatus-Syndroms. Arch Psychiat Nervenkr 190:357–376CrossRefPubMed

133.

Currier RD, Little SC, Suess JF, Andy OJ (1971) Sexual seizures. Arch Neurol 25:260–264CrossRefPubMed

134.

Freemon FR, Nevis AH (1969) Temporal lobe sexual seizures. Neurology 19:87–90CrossRefPubMed

135.

Remillard GM, Andermann F, Testa GF, Gloor P, Aube M, Martin JB, Feindel W, Guberman A, Simpson C (1983) Sexual ictal manifestations predominate in women with temporal lobe epilepsy: a finding suggesting sexual dimorphism in the human brain. Neurology 33:323–330CrossRefPubMed

136.

Janszky J, Szucs A, Halasz P, Borbely C, Hollo A, Barsi P, Mirnics Z (2002) Orgasmic aura originates from the right hemisphere. Neurology 58:302–304CrossRefPubMed

137.

Janszky J, Ebner A, Szupera Z, Schulz R, Hollo A, Szucs A, Clemens B (2004) Orgasmic aura—a report of seven cases. Seizure 13:441–444. https://doi.org/10.1016/j.seizure.2003.09.005 CrossRefPubMed

138.

Chaton L, Chochoi M, Reyns N, Lopes R, Derambure P, Szurhaj W (2018) Localization of an epileptic orgasmic feeling to the right amygdala, using intracranial electrodes. Cortex 109:347–351. https://doi.org/10.1016/j.cortex.2018.07.013 CrossRefPubMed

139.

Erickson TC (1945) Erotomania (nymphomania) as an expression of cortical epileptiform discharges. Arch Neurol Psychiatry 53:226–231CrossRef

140.

Ruff RL (1980) Orgasmic epilepsy. Neurology 30:1252CrossRefPubMed

141.

York GK, Gabor AJ, Dreyfus PM (1979) Paroxysmal genital pain: an unusual manifestation of epilepsy. Neurology 29:516–519CrossRefPubMed

142.

Calleja J, Carpizo R, Berciano J (1988) Orgasmic epilepsy. Epilepsia 29:635–639CrossRefPubMed

143.

Spencer SS, Spencer DD, Williamson PD, Mattson RH (1983) Sexual automatisms in complex partial seizures. Neurology 33:527–533CrossRefPubMed

144.

Williamson PD, Spencer DD, Spencer SS, Novelly RA, Mattson RH (1985) Complex partial seizures of frontal lobe origin. Ann Neurol 18:497–504CrossRefPubMed

145.

Jobst BC, Siegel AM, Thadani VM, Roberts DW, Rhodes HC, Williamson PD (2000) Intractable seizures of frontal lobe origin: clinical characteristics, localizing signs, and results of surgery. Epilepsia 41:1139–1152CrossRefPubMed

146.

Hooshmand H, Brawley BW (1969) Temporal lobe seizures and exhibitionism. Neurology 19:1119–1124CrossRefPubMed

147.

Dobesberger J, Walser G, Unterberger I, Embacher N, Luef G, Bauer G, Benke T, Bartha L, Ulmer H, Ortler M, Trinka E (2004) Genital automatisms: a video-EEG study in patients with medically refractory seizures. Epilepsia 45:777–780. https://doi.org/10.1111/j.0013-9580.2004.44003.x CrossRefPubMed

148.

Dede HO, Bebek N, Gurses C, Baysal-Kirac L, Baykan B, Gokyigit A (2018) Genital automatisms: reappraisal of a remarkable but ignored symptom of focal seizures. Epilepsy Behav 80:84–89. https://doi.org/10.1016/j.yebeh.2017.12.023 CrossRefPubMed

149.

Jacome DE, Risko MS (1983) Absence status manifested by compulsive masturbation. Arch Neurol 40:523–524CrossRefPubMed

150.

Lovaas I, Newsom C, Hickman C (1987) Self-stimulatory behavior and perceptual reinforcement. J Appl Behav Anal 20:45–68. https://doi.org/10.1901/jaba.1987.20-45 CrossRefPubMedPubMedCentral

151.

Feindel W, Penfield W (1954) Localization of discharge in temporal lobe automatism. AMA Arch Neurol Psychiatry 72:603–630CrossRefPubMed

152.

Baumgartner C, Groppel G, Leutmezer F, Aull-Watschinger S, Pataraia E, Feucht M, Trinka E, Unterberger I, Bauer G (2000) Ictal urinary urge indicates seizure onset in the nondominant temporal lobe. Neurology 55:432–434CrossRefPubMed

153.

Loddenkemper T, Foldvary N, Raja S, Neme S, Luders HO (2003) Ictal urinary urge: further evidence for lateralization to the nondominant hemisphere. Epilepsia 44:124–126CrossRefPubMed

154.

Gurgenashvili K, Massey SL, Grant M, Piatt J Jr, Legido A, Valencia I (2011) Intracranial localisation of ictal urinary urge epileptogenic zone to the non-dominant temporal lobe. Epileptic Disord 13:430–434. https://doi.org/10.1684/epd.2011.0476 CrossRefPubMed

155.

Yilmaz S, Gokben S, Turhan T, Serdaroglu G, Tekgul H (2015) Ictal urinary urge: localization and lateralization value in a pediatric case. Child’s Nerv Syst 31:2383–2385. https://doi.org/10.1007/s00381-015-2816-1 CrossRef

156.

Rengarajan R, Shamim S (2018) Urinary urge seizure semiology localization by intracranial monitoring. Proc (Bayl Univ Med Cent) 31:109–111. https://doi.org/10.1080/08998280.2017.1400880 CrossRef

157.

Blok BFM, Sturms LM, Holstege G (1998) Brain activation during micturition in women. Brain 121:2033–2042CrossRefPubMed

158.

Lennox W, Cobb S (1933) Aura in epilepsy: a statistical review of 1359 cases. Arch Neurol Psychiatry 30:374–387CrossRef

159.

Szucs A, Fogarasi A, Rasonyi G, Kelemen A, Narula L, Toth V, Janszky J, Halasz P (2007) Peri-ictal water drinking in temporal lobe epilepsy: is it a reliable lateralizing sign? Epilepsy Behav 11:578–581CrossRefPubMed

160.

Trinka E, Walser G, Unterberger I, Luef G, Benke T, Bartha L, Ortler M, Bauer G (2003) Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe. Neurology 60:873–876CrossRefPubMed

161.

Remillard GM, Andermann F, Gloor P, Olivier A, Martin JB (1981) Water-drinking as ictal behavior in complex partial seizures. Neurology 31:117–124CrossRefPubMed

162.

Errguig L, Lahjouji F, Belaidi H, Jiddane M, Elkhamlichi A, Dakka T, Ouazzani R (2013) Peri-ictal water drinking and other ictal vegetative symptoms: localizing and lateralizing the epileptogenic zone in temporal lobe epilepsy? Two case reports and review of the literature. Rev Neurol (Paris) 169:903–910. https://doi.org/10.1016/j.neurol.2013.06.005 CrossRef

163.

Sheikh Z, Olango W, Raval B, Marks D (2016) Ictal water-seeking in nondominant temporal lobe seizures. Neurology 86:1847–1848. https://doi.org/10.1212/wnl.0000000000002662 CrossRefPubMed

164.

Pietrafusa N, Trivisano M, de Palma L, Serino D, Moavero R, Benvenga A, Cappelletti S, Boero G, Vigevano F, La Neve A, Specchio N (2015) Peri-ictal water drinking: a rare automatic behaviour in temporal lobe epilepsy. Epileptic Disord 17:384–396. https://doi.org/10.1684/epd.2015.0776 CrossRefPubMed

Titel: Epidemiology and pathophysiology of autonomic seizures: a systematic review
verfasst von: Christoph Baumgartner
Johannes Koren
Martha Britto-Arias
Simone Schmidt
Susanne Pirker
Publikationsdatum: 25.02.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Autonomic Research / Ausgabe 2/2019
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-019-00596-x

Neu in den Fachgebieten Neurologie und Psychiatrie

16.04.2024 | Maligne primäre ZNS-Tumoren | Nachrichten

Springer Medizin

Epidemiology and pathophysiology of autonomic seizures: a systematic review

Abstract

Purpose

Methods

Results

Conclusions

Neu in den Fachgebieten Neurologie und Psychiatrie

Manche Gestagene können das Risiko für Meningeome erhöhen

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt

Perinatale PTBS: Signifikanter Anstieg der Diagnoserate

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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