Background
Methods
Study population
Sample collection and HPV genotyping
Statistical analysis
Results
The overall prevalence of HPV infection
Time trends in prevalence of HPV infection
Year | Age Median (rang) | HPV positive (n) | HPV negative (n) | Total (n) | Prevalence (%) | 95% CI of infection rate (%) |
---|---|---|---|---|---|---|
2009 | 37 (18–68) | 209 | 503 | 712 | 29.4 | 25.8–32.6 |
2010 | 37 (17–71) | 268 | 516 | 784 | 34.2 | 31.0–37.4 |
2011 | 38 (15–76) | 403 | 614 | 1017 | 39.6 | 36.7–42.7 |
2012 | 39 (18–84) | 499 | 799 | 1298 | 38.4 | 35.7–41.1 |
2013 | 40 (15–82) | 578 | 905 | 1483 | 39.0 | 36.4–41.7 |
2014 | 41 (13–80) | 758 | 1215 | 1973 | 38.4 | 36.3–40.3 |
2015 | 41 (12–77) | 613 | 798 | 1411 | 43.4 | 40.9–46.1 |
Total | 39 (12–84) | 3328 | 5350 | 8678 | 38.3 | 37.3–39.4 |
HPV type | Year | Total | Frequency for all sample (%) | Frequency for positive sample (%) | 95% CI for all samples (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2009 N(%) | 2010 N(%) | 2011 N(%) | 2012 N(%) | 2013 N(%) | 2014 N(%) | 2015 N(%) | |||||
16 | 57(8.0) | 70(8.9) | 87(8.6) | 124(9.6) | 119(8.0) | 164(8.3) | 121(8.6) | 742 | 8.5 | 22.3 | 8.0–9.1 |
18 | 14(2.0) | 22(2.8) | 28(2.8) | 30(2.3) | 34(2.3) | 51(2.6) | 37(2.6) | 216 | 2.5 | 6.5 | 2.2–2.8 |
31 | 12(1.7) | 18(2.3) | 26(2.6) | 24(1.8) | 34(2.3) | 39(2.0) | 20(1.4) | 173 | 2.0 | 5.2 | 1.7–2.3 |
33 | 16(2.2) | 22(2.8) | 40(3.9) | 32(2.5) | 42(2.8) | 4(1.7) | 37(2.6) | 223 | 2.6 | 6.7 | 2.2–2.9 |
35 | 3(0.4) | 5(0.6) | 10(1.0) | 6(0.5) | 13(0.9) | 11(0.6) | 18(1.3) | 66 | 0.8 | 2.0 | 0.6–0.9 |
39
|
5(0.7)
|
10(1.3)
|
18(1.8)
|
23(1.8)
|
33(2.2)
|
66(3.3)
|
24(1.7)
|
179
|
2.1
|
5.4
|
1.8–2.4
|
45 | 2(0.3) | 2(0.3) | 4(0.4) | 8(0.6) | 10(0.7) | 5(0.3) | 10(0.7) | 41 | 0.5 | 1.2 | 0.3–0.6 |
51
|
9(1.3)
|
4(0.5)
|
4(0.4)
|
3(0.2)
|
23(1.6)
|
47(2.4)
|
58(4.1)
|
148
|
1.7
|
4.4
|
1.4–2.0
|
52
|
36(5.1)
|
47(6.0)
|
84(8.3)
|
84(6.5)
|
123(8.3)
|
172(8.7)
|
143(10.1)
|
689
|
7.9
|
20.7
|
7.4–8.5
|
53
|
15(2.1)
|
14(1.8)
|
34(3.3)
|
42(3.2)
|
58(3.9)
|
71(3.6)
|
72(5.1)
|
306
|
3.5
|
9.2
|
3.1–3.9
|
56
|
4(0.6)
|
13(1.7)
|
6(0.6)
|
18(1.4)
|
18(1.2)
|
28(1.4)
|
39(2,8)
|
126
|
1.5
|
3.8
|
1.2–1.7
|
58 | 33(4.6) | 38(4.8) | 67(6.6) | 81(6.2) | 97(6.5) | 135(6.8) | 84(6.0) | 535 | 6.2 | 16.1 | 5.7–6.7 |
59
|
5(0.7)
|
8(1.0)
|
8(0.8)
|
15(1.2)
|
13(0.9)
|
19(1.0)
|
30(2.1)
|
98
|
1.1
|
2.9
|
0.9–1.3
|
66 | 10(1.4) | 13(1.7) | 17(1.7) | 26(2.0) | 31(2.1) | 31(1.6) | 42(3.0) | 170 | 2.0 | 5.1 | 1.7–2.2 |
68
|
8(1.1)
|
8(1.0)
|
14(1.4)
|
35(2.7)
|
27(1.8)
|
43(2.2)
|
37(2.6)
|
172
|
2.0
|
5.2
|
1.7–2.3
|
6 | 22(3.1) | 17(2.2) | 17(1.7) | 28(2.2) | 37(2.5) | 39(2.0) | 37(2.6) | 197 | 2.3 | 5.9 | 2.0–2.6 |
11 | 18(2.5) | 28(3.6) | 27(2.7) | 27(2.1) | 43(2.9) | 33(1.7) | 18(1.3) | 194 | 2.2 | 5.8 | 1.9–2.5 |
42 | 3(0.4) | 0(0.0) | 4(0.4) | 7(0.5) | 9(0.6) | 6(0.3) | 37(2.6) | 66 | 0.8 | 2.0 | 0.6–1.0 |
43 | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 3(0.2) | 33(2.3) | 36 | 0.4 | 1.1 | 0.3–0.6 |
44 | 4(0.6) | 2(0.3) | 8(0.8) | 6(0.5) | 7(0.5) | 11(0.6) | 0(0.0) | 38 | 0.4 | 1.1 | 0.3–0.6 |
CP8304 | 7(1.0) | 20(2.6) | 36(3.5) | 53(4.1) | 74(5.0) | 63(3.2) | 57(4.0) | 310 | 3.6 | 9.3 | 3.2–4.0 |
Genotype-specific prevalence of HPV infection
Age-specific prevalence of HPV infection
HPV type | Age group (year) | HPV positive (N) | Frequency for all sample (%) | Frequency for positive sample (%) | 95% CI for all samples (%) | ||||
---|---|---|---|---|---|---|---|---|---|
≤ 24 N(%) | 25 ~ 34 N(%) | 35 ~ 44 N(%) | 45 ~ 54 N(%) | ≥ 55 N(%) | |||||
16 | 56(9.9) | 180(7.8) | 259(7.9) | 172(9.0) | 75(12.2) | 742 | 8.6 | 22.3 | 8.0–9.1 |
18 | 17(3.0) | 46(2.0) | 79(2.4) | 54(2.8) | 20(3.2) | 216 | 2.5 | 6.5 | 2.2–2.8 |
31 | 14(2.5) | 36(1.6) | 70(2.1) | 36(1.9) | 17(2.8) | 173 | 2.0 | 5.2 | 1.7–2.3 |
33 | 12(2.1) | 46(2.0) | 78(2.4) | 59(3.1) | 28(4.5) | 223 | 2.6 | 6.7 | 2.2–2.9 |
35 | 4(0.7) | 16(0.7) | 26(0.8) | 11(0.6) | 9(1.5) | 66 | 0.8 | 2.0 | 0.6–0.9 |
39 | 13(2.3) | 47(2.0) | 62(1.9) | 39(2.0) | 18(2.9) | 179 | 2.1 | 5.4 | 1.8–2.4 |
45 | 3(0.5) | 6(0.3) | 12(0.4) | 12(0.6) | 8(1.3) | 41 | 0.5 | 1.2 | 0.3–0.6 |
51 | 14(2.5) | 31(1.3) | 49(1.5) | 38(2.0) | 16(2.6) | 148 | 1.7 | 4.4 | 1.4–2.0 |
52 | 54(9.5) | 173(7.5) | 209(6.4) | 180(9.4) | 73(11.9) | 689 | 7.9 | 20.7 | 7.4–8.5 |
53 | 24(4.2) | 65(2.8) | 106(3.2) | 68(3.6) | 43(7.0) | 306 | 3.5 | 9.2 | 3.1–3.9 |
56 | 7(1.2) | 33(1.4) | 29(0.9) | 35(1.8) | 22(3.6) | 126 | 1.5 | 3.8 | 1.2–1.7 |
58 | 32(5.6) | 101(4.3) | 197(6.0) | 147(7.7) | 58(9.4) | 535 | 6.2 | 16.1 | 5.7–6.7 |
59 | 25(4.4) | 11(0.5) | 27(0.8) | 19(1.0) | 16(2.6) | 98 | 1.1 | 2.9 | 0.9–1.3 |
66 | 17(3.0) | 45(1.9) | 62(1.9) | 27(1.4) | 19(3.1) | 170 | 2.0 | 5.1 | 1.7–2.2 |
68 | 9(1.6) | 42(1.8) | 63(1.9) | 41(2.2) | 17(2.8) | 172 | 2.0 | 5.2 | 1.7–2.3 |
6 | 53(9.3) | 57(2.5) | 54(1.7) | 21(1.1) | 12(1.9) | 197 | 2.3 | 5.9 | 2.0–2.6 |
11 | 52(9.2) | 62(2.7) | 47(1.4) | 22(1.2) | 11(1.8) | 194 | 2.2 | 5.8 | 1.9–2.5 |
42 | 7(1.2) | 16(0.7) | 16(0.5) | 16(0.8) | 11(1.8) | 66 | 0.8 | 2.0 | 0.6–1.0 |
43 | 5(0.9) | 10(0.4) | 9(0.3) | 7(0.4) | 5(0.8) | 36 | 0.4 | 1.1 | 0.3–0.6 |
44 | 5(0.9) | 8(0.3) | 11(0.3) | 6(0.3) | 8(1.3) | 38 | 0.4 | 1.1 | 0.3–0.6 |
CP8304 | 33(5.8) | 68(2.9) | 111(3.4) | 64(3.4) | 34(5.5) | 310 | 3.6 | 9.3 | 3.2–4.0 |