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Inflammation Research
Erschienen in: Inflammation Research 1/2021

24.11.2020 | Review

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

verfasst von: Omar Ramos-Lopez, Fermin I. Milagro, Jose I. Riezu-Boj, J. Alfredo Martinez

Erschienen in: Inflammation Research | Ausgabe 1/2021

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Abstract

Aim and objective

Emerging translational evidence suggests that epigenetic alterations (DNA methylation, miRNA expression, and histone modifications) occur after external stimuli and may contribute to exacerbated inflammation and the risk of suffering several diseases including diabetes, cardiovascular diseases, cancer, and neurological disorders. This review summarizes the current knowledge about the harmful effects of high-fat/high-sugar diets, micronutrient deficiencies (folate, manganese, and carotenoids), obesity and associated complications, bacterial/viral infections, smoking, excessive alcohol consumption, sleep deprivation, chronic stress, air pollution, and chemical exposure on inflammation through epigenetic mechanisms. Additionally, the epigenetic phenomena underlying the anti-inflammatory potential of caloric restriction, n-3 PUFA, Mediterranean diet, vitamin D, zinc, polyphenols (i.e., resveratrol, gallic acid, epicatechin, luteolin, curcumin), and the role of systematic exercise are discussed.

Methods

Original and review articles encompassing epigenetics and inflammation were screened from major databases (including PubMed, Medline, Science Direct, Scopus, etc.) and analyzed for the writing of the review paper.

Conclusion

Although caution should be exercised, research on epigenetic mechanisms is contributing to understand pathological processes involving inflammatory responses, the prediction of disease risk based on the epigenotype, as well as the putative design of therapeutic interventions targeting the epigenome.
Literatur
1.
Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140:771–6.PubMed
2.
Bennett JM, Reeves G, Billman GE, Sturmberg JP. Inflammation-nature’s way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases. Front Med (Lausanne). 2018;5:316.
3.
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9:7204–18.PubMedPubMedCentral
4.
Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20:6008.PubMedCentral
5.
Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem. 2012;68:701–11.PubMed
6.
Shanmugam MK, Sethi G. Role of epigenetics in inflammation-associated diseases. Subcell Biochem. 2013;61:627–57.PubMed
7.
8.
Gonzalez-Jaramillo V, Portilla-Fernandez E, Glisic M, Voortman T, Ghanbari M, Bramer W, Chowdhury R, Nijsten T, Dehghan A, Franco OH, Nano J. Epigenetics and inflammatory markers: a systematic review of the current evidence. Int J Inflam. 2019;2019:6273680.PubMedPubMedCentral
9.
10.
Ramallal R, Toledo E, Martínez JA, Shivappa N, Hébert JR, Martínez-González MA, Ruiz-Canela M. Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: the SUN cohort. Obesity (Silver Spring). 2017;25:997–1005.
11.
Christ A, Lauterbach M, Latz E. Western diet and the immune system: an inflammatory connection. Immunity. 2019;51:794–811.PubMed
12.
Milagro FI, Mansego ML, De Miguel C, Martínez JA. Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives. Mol Aspects Med. 2013;34:782–812.PubMed
13.
Martínez JA, Cordero P, Campión J, Milagro FI. Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. Proc Nutr Soc. 2012;71:276–83.PubMed
14.
Zheng J, Zhang Q, Mul JD, Yu M, Xu J, Qi C, Wang T, Xiao X. Maternal high-calorie diet is associated with altered hepatic microRNA expression and impaired metabolic health in offspring at weaning age. Endocrine. 2016;54:70–80.PubMed
15.
Ding Y, Li J, Liu S, Zhang L, Xiao H, Li J, Chen H, Petersen RB, Huang K, Zheng L. DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding. Int J Obes (Lond). 2014;38:198–204.
16.
Nicodemus-Johnson J, Sinnott RA. Fruit and juice epigenetic signatures are associated with independent immunoregulatory pathways. Nutrients. 2017;9:752.PubMedCentral
17.
DiStefano JK. Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis. Cell Mol Life Sci. 2020;77:2079–90.PubMedPubMedCentral
18.
Zheng J, Xiao X, Zhang Q, Wang T, Yu M, Xu J. Maternal low-protein diet modulates glucose metabolism and hepatic microRNAs expression in the early life of offspring†. Nutrients. 2017;9:205.PubMedCentral
19.
González-Becerra K, Ramos-Lopez O, Barrón-Cabrera E, Riezu-Boj JI, Milagro FI, Martínez-López E, Martínez JA. Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review. Lipids Health Dis. 2019;18(1):178.PubMedPubMedCentral
20.
Flores-Sierra J, Arredondo-Guerrero M, Cervantes-Paz B, Rodríguez-Ríos D, Alvarado-Caudillo Y, Nielsen FC, Wrobel K, Wrobel K, Zaina S, Lund G. The trans fatty acid elaidate affects the global DNA methylation profile of cultured cells and in vivo. Lipids Health Dis. 2016;15:75.PubMedPubMedCentral
21.
Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748.PubMedPubMedCentral
22.
Hermsdorff HH, Mansego ML, Campión J, Milagro FI, Zulet MA, Martínez JA. TNF-α promoter methylation in peripheral white blood cells: relationship with circulating TNFα, truncal fat and n-6 PUFA intake in young women. Cytokine. 2013;64:265–71.PubMed
23.
Cuevas-Sierra A, Ramos-Lopez O, Riezu-Boj JI, Milagro FI, Martinez JA. Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications. Adv Nutr. 2019;10:S17–30.PubMedPubMedCentral
24.
Tremblay BL, Guénard F, Rudkowska I, Lemieux S, Couture P, Vohl MC. Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation. Clin Epigenetics. 2017;9:43.PubMedPubMedCentral
25.
Silva-Martínez GA, Rodríguez-Ríos D, Alvarado-Caudillo Y, Vaquero A, Esteller M, Carmona FJ, Moran S, Nielsen FC, Wickström-Lindholm M, Wrobel K, Wrobel K, Barbosa-Sabanero G, Zaina S, Lund G. Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016;11:321–34.PubMedPubMedCentral
26.
Chen L, Dong Y, Wang X, Hao G, Huang Y, Gutin B, Zhu H. Epigenome-Wide Association Study of dietary fiber intake in African American adolescents. Mol Nutr Food Res. 2018;62:e1800155.PubMedPubMedCentral
27.
Ramos-Lopez O, Samblas M, Milagro FI, Zulet MA, Mansego ML, Riezu-Boj JI, Martinez JA. Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects. Nutr Res. 2018;50:53–62.PubMed
28.
Kresovich JK, Bulka CM, Joyce BT, Vokonas PS, Schwartz J, Baccarelli AA, Hibler EA, Hou L. The inflammatory potential of dietary manganese in a cohort of elderly men. Biol Trace Elem Res. 2018;183:49–57.PubMed
29.
Bollati V, Favero C, Albetti B, Tarantini L, Moroni A, Byun HM, Motta V, Conti DM, Tirelli AS, Vigna L, Bertazzi PA, Pesatori AC. Nutrients intake is associated with DNA methylation of candidate inflammatory genes in a population of obese subjects. Nutrients. 2014;6:4625–39.PubMedPubMedCentral
30.
Ricker MA, Haas WC. Anti-inflammatory diet in clinical practice: a review. Nutr Clin Pract. 2017;32:318–25.PubMed
31.
Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10:1618.PubMedCentral
32.
33.
Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ, Dávalos A, Gil-Zamorano J, Gonzálvez M, García-Almagro FJ, Ruiz Ros JA, Tomás-Barberán FA, Espín JC, García-Conesa MT. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69–82.PubMed
34.
Kim H, Banerjee N, Barnes RC, Pfent CM, Talcott ST, Dashwood RH, Mertens-Talcott SU. Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo. Mol Carcinog. 2017;56:197–207.PubMed
35.
Cordero-Herrera I, Chen X, Ramos S, Devaraj S. (–)-Epicatechin attenuates high-glucose-induced inflammation by epigenetic modulation in human monocytes. Eur J Nutr. 2017;56:1369–73.PubMed
36.
Kim A, Yun JM. Combination treatments with luteolin and fisetin enhance anti-inflammatory effects in high glucose-treated THP-1 cells through histone acetyltransferase/histone deacetylase regulation. J Med Food. 2017;20(8):782–9.PubMed
37.
Yun JM, Jialal I, Devaraj S. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem. 2011;22:450–8.PubMed
38.
Bordoni L, Fedeli D, Fiorini D, Gabbianelli R. Extra virgin olive oil and nigella sativa oil produced in central Italy: a comparison of the nutrigenomic effects of two mediterranean oils in a low-grade inflammation model. Antioxidants (Basel). 2019;9:20.
39.
Arpón A, Milagro FI, Razquin C, Corella D, Estruch R, Fitó M, Marti A, Martínez-González MA, Ros E, Salas-Salvadó J, Riezu-Boj JI, Martínez JA. Impact of consuming extra-virgin olive oil or nuts within a mediterranean diet on DNA methylation in peripheral white blood cells within the PREDIMED-navarra randomized controlled trial: a role for dietary lipids. Nutrients. 2017;10:15.PubMedCentral
40.
Arpón A, Riezu-Boj JI, Milagro FI, Marti A, Razquin C, Martínez-González MA, Corella D, Estruch R, Casas R, Fitó M, Ros E, Salas-Salvadó J, Martínez JA. Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. J Physiol Biochem. 2016;73:445–55.PubMed
41.
de la Garza AL, Etxeberria U, Palacios-Ortega S, Haslberger AG, Aumueller E, Milagro FI, Martínez JA. Modulation of hyperglycemia and TNFα-mediated inflammation by helichrysum and grapefruit extracts in diabetic db/db mice. Food Funct. 2014;5:2120–8.PubMed
42.
Kim S, Lee MS, Jung S, Son HY, Park S, Kang B, Kim SY, Kim IH, Kim CT, Kim Y. Ginger extract ameliorates obesity and inflammation via regulating microRNA-21/132 expression and AMPK activation in white adipose tissue. Nutrients. 2018;10:1567.PubMedCentral
43.
Delaney C, Hoeltzel M, Garg SK, Warner R, Johnson K, Yung R. Maternal micronutrient supplementation suppresses T cell chemokine receptor expression and function in F1 mice. J Nutr. 2012;142:1329–35.PubMedPubMedCentral
44.
Alehagen U, Johansson P, Aaseth J, Alexander J, Wågsäter D. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. PLoS ONE. 2017;12:e0174880.PubMedPubMedCentral
45.
Karkeni E, Bonnet L, Marcotorchino J, Tourniaire F, Astier J, Ye J, Landrier JF. Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: a new mechanism for the regulation of inflammation by vitamin D. Epigenetics. 2018;13:156–62.PubMedPubMedCentral
46.
Li C, Guo S, Gao J, Guo Y, Du E, Lv Z, Zhang B. Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks. J Nutr Biochem. 2015;26:173–83.PubMed
47.
Hernández-Saavedra D, Moody L, Xu GB, Chen H, Pan YX. Epigenetic regulation of metabolism and inflammation by calorie restriction. Adv Nutr. 2019;10:520–36.PubMedPubMedCentral
48.
Cordero P, Campion J, Milagro FI, Goyenechea E, Steemburgo T, Javierre BM, Martinez JA. Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. J Physiol Biochem. 2011;67:463–70.PubMed
49.
Campión J, Milagro FI, Goyenechea E, Martínez JA. TNF-α promoter methylation as a predictive biomarker for weight-loss response. Obesity (Silver Spring). 2009;17:1293–7.
50.
Perez-Cornago A, de la Iglesia R, Lopez-Legarrea P, Abete I, Navas-Carretero S, Lacunza CI, Lahortiga F, Martinez-Gonzalez MA, Martinez JA, Zulet MA. A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study. Nutr J. 2014;13:36.PubMedPubMedCentral
51.
Gögebakan O, Kohl A, Osterhoff MA, van Baak MA, Jebb SA, Papadaki A, Martinez JA, Handjieva-Darlenska T, Hlavaty P, Weickert MO, Holst C, Saris WH, Astrup A, Pfeiffer AF. DiOGenes. Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation. 2011;124:2829–38.PubMed
52.
de la Iglesia R, Mansego ML, Sánchez-Muniz FJ, Zulet MA, Martinez JA. Arylesterase activity is associated with antioxidant intake and paraoxonase-1 (PON1) gene methylation in metabolic syndrome patients following an energy restricted diet. EXCLI J. 2014;13:416–26.PubMedPubMedCentral
53.
Lopez-Legarrea P, Mansego ML, Zulet MA, Martinez JA. SERPINE1, PAI-1 protein coding gene, methylation levels and epigenetic relationships with adiposity changes in obese subjects with metabolic syndrome features under dietary restriction. J Clin Biochem Nutr. 2013;53:139–44.PubMedPubMedCentral
54.
Barrón-Cabrera E, Ramos-Lopez O, González-Becerra K, Riezu-Boj JI, Milagro FI, Martínez-López E, Martínez JA. Epigenetic modifications as outcomes of exercise interventions related to specific metabolic alterations: a systematic review. Lifestyle Genom. 2019;12:25–44.PubMedPubMedCentral
55.
Nishida Y, Hara M, Higaki Y, Taguchi N, Nakamura K, Nanri H, Horita M, Shimanoe C, Yasukata J, Miyoshi N, Yamada Y, Higashimoto K, Soejima H, Tanaka K. Habitual light-intensity physical activity and ASC methylation in a middle-aged population. Int J Sports Med. 2019;40:670–7.PubMed
56.
Butts B, Butler J, Dunbar SB, Corwin E, Gary RA. Effects of exercise on ASC methylation and IL-1 cytokines in heart failure. Med Sci Sports Exerc. 2018;50:1757–66.PubMedPubMedCentral
57.
Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S. NFκB2 gene as a novel candidate that epigenetically responds to interval walking training. Int J Sports Med. 2015;36:769–75.PubMed
58.
Morikawa M, Nakano S, Mitsui N, Murasawa H, Masuki S, Nose H. Effects of dried tofu supplementation during interval walking training on the methylation of the NFKB2 gene in the whole blood of older women. J Physiol Sci. 2018;68:749–57.PubMed
59.
Masuki S, Nishida K, Hashimoto S, Morikawa M, Takasugi S, Nagata M, Taniguchi S, Rokutan K, Nose H. Effects of milk product intake on thigh muscle strength and NFKB gene methylation during home-based interval walking training in older women: a randomized, controlled pilot study. PLoS ONE. 2017;12:e0176757.PubMedPubMedCentral
60.
Russo A, Bartolini D, Mensà E, Torquato P, Albertini MC, Olivieri F, Testa R, Rossi S, Piroddi M, Cruciani G, De Feo P, Galli F. Physical activity modulates the overexpression of the inflammatory miR-146a-5p in obese patients. IUBMB Life. 2018;70:1012–22.PubMed
61.
Bao F, Slusher AL, Whitehurst M, Huang CJ. Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. Physiol Behav. 2018;197:15–21.PubMed
62.
Li Y, Yao M, Zhou Q, Cheng Y, Che L, Xu J, Xiao J, Shen Z, Bei Y. Dynamic regulation of circulating micrornas during acute exercise and long-term exercise training in basketball athletes. Front Physiol. 2018;9:282.PubMedPubMedCentral
63.
de Gonzalo-Calvo D, Dávalos A, Montero A, García-González Á, Tyshkovska I, González-Medina A, Soares SM, Martínez-Camblor P, Casas-Agustench P, Rabadán M, Díaz-Martínez ÁE, Úbeda N, Iglesias-Gutiérrez E. Circulating inflammatory miRNA signature in response to different doses of aerobic exercise. J Appl Physiol. 1985;2015(119):124–34.
64.
Koltai E, Bori Z, Osvath P, Ihasz F, Peter S, Toth G, Degens H, Rittweger J, Boldogh I, Radak Z. Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. Redox Biol. 2018;19:46–51.PubMedPubMedCentral
65.
Dorneles GP, Boeira MCR, Schipper LL, Silva IRV, Elsner VR, Dal Lago P, Peres A, Romão PRT. Acute strenuous exercise induces an imbalance on histone H4 acetylation/histone deacetylase 2 and increases the proinflammatory profile of PBMC of obese individuals. Oxid Med Cell Longev. 2017;2017:1530230.PubMedPubMedCentral
66.
Crujeiras AB, Cordero P, Garcia-Diaz DF, Stachowska E, González-Muniesa P. Molecular basis of the inflammation related to obesity. Oxid Med Cell Longev. 2019;2019:5250816.PubMedPubMedCentral
67.
Lorente-Cebrián S, González-Muniesa P, Milagro FI, Martínez JA. MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets. Clin Sci (Lond). 2019;133:23–40.
68.
Ahmed M, de Winther MPJ, Van den Bossche J. Epigenetic mechanisms of macrophage activation in type 2 diabetes. Immunobiology. 2017;222:937–43.PubMed
69.
Keating ST, Plutzky J, El-Osta A. Epigenetic changes in diabetes and cardiovascular risk. Circ Res. 2016;118:1706–22.PubMedPubMedCentral
70.
71.
Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M. Adipocyte expression of SLC19A1 links DNA hypermethylation to adipose tissue inflammation and insulin resistance. J Clin Endocrinol Metab. 2018;103:710–21.PubMed
72.
Pietiläinen KH, Ismail K, Järvinen E, Heinonen S, Tummers M, Bollepalli S, Lyle R, Muniandy M, Moilanen E, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Ollikainen M. DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs. Int J Obes (Lond). 2016;40:654–61.
73.
Remely M, Aumueller E, Jahn D, Hippe B, Brath H, Haslberger AG. Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity. Benef Microbes. 2014;5:33–43.PubMed
74.
Na YK, Hong HS, Lee WK, Kim YH, Kim DS. Increased methylation of interleukin 6 gene is associated with obesity in Korean women. Mol Cells. 2015;38:452–6.PubMedPubMedCentral
75.
Arpón A, Milagro FI, Ramos-Lopez O, Mansego ML, Riezu-Boj JI, Martínez JA, MENA Project. Methylome-Wide Association Study in peripheral white blood cells focusing on central obesity and inflammation. Genes (Basel). 2019;10:444.PubMedCentral
76.
Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S. Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond). 2019;43:1256–68.
77.
Guénard F, Tchernof A, Deshaies Y, Pérusse L, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC. Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances. Physiol Genomics. 2014;46:216–22.PubMed
78.
Crujeiras AB, Pissios P, Moreno-Navarrete JM, Diaz-Lagares A, Sandoval J, Gomez A, Ricart W, Esteller M, Casanueva FF, Fernandez-Real JM. An epigenetic signature in adipose tissue is linked to nicotinamide N-Methyltransferase gene expression. Mol Nutr Food Res. 2018;62:e1700933.
79.
Yang X, Wang X, Liu D, Yu L, Xue B, Shi H. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b. Mol Endocrinol. 2014;28:565–74.PubMedPubMedCentral
80.
Kamei Y, Suganami T, Ehara T, Kanai S, Hayashi K, Yamamoto Y, Miura S, Ezaki O, Okano M, Ogawa Y. Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice. Obesity (Silver Spring). 2010;18:314–21.
81.
Iwaya C, Kitajima H, Yamamoto K, Maeda Y, Sonoda N, Shibata H, Inoguchi T. DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue. Biochem Biophys Res Commun. 2018;497:908–15.PubMed
82.
Jacobsen MJ, Mentzel CM, Olesen AS, Huby T, Jørgensen CB, Barrès R, Fredholm M, Simar D. Altered methylation profile of lymphocytes is concordant with perturbation of lipids metabolism and inflammatory response in obesity. J Diabetes Res. 2016;2016:8539057.PubMed
83.
Raciti GA, Spinelli R, Desiderio A, Longo M, Parrillo L, Nigro C, D’Esposito V, Mirra P, Fiory F, Pilone V, Forestieri P, Formisano P, Pastan I, Miele C, Beguinot F. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity. Sci Rep. 2017;7:43526.PubMedPubMedCentral
84.
Desiderio A, Longo M, Parrillo L, Campitelli M, Cacace G, de Simone S, Spinelli R, Zatterale F, Cabaro S, Dolce P, Formisano P, Milone M, Miele C, Beguinot F, Raciti GA. Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity. Clin Epigenetics. 2019;11:181.PubMedPubMedCentral
85.
Cifuentes-Zúñiga F, Arroyo-Jousse V, Soto-Carrasco G, Casanello P, Uauy R, Krause BJ, Castro-Rodríguez JA. IL-10 expression in macrophages from neonates born from obese mothers is suppressed by IL-4 and LPS/INFγ. J Cell Physiol. 2017;232:3693–701.PubMed
86.
Sureshchandra S, Wilson RM, Rais M, Marshall NE, Purnell JQ, Thornburg KL, Messaoudi I. Maternal pregravid obesity remodels the DNA methylation landscape of cord blood monocytes disrupting their inflammatory program. J Immunol. 2017;199:2729–44.PubMed
87.
Zhang XM, Guo L, Chi MH, Sun HM, Chen XW. Identification of active miRNA and transcription factor regulatory pathways in human obesity-related inflammation. BMC Bioinf. 2015;16:76.
88.
Yang Z, Wei Z, Wu X, Yang H. Screening of exosomal miRNAs derived from subcutaneous and visceral adipose tissues: determination of targets for the treatment of obesity and associated metabolic disorders. Mol Med Rep. 2018;18:3314–24.PubMedPubMedCentral
89.
Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Influence of overweight and obesity on circulating inflammation-related microRNA. Microrna. 2018;7:148–54.PubMed
90.
Ortega FJ, Moreno M, Mercader JM, Moreno-Navarrete JM, Fuentes-Batllevell N, Sabater M, Ricart W, Fernández-Real JM. Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants. Clin Epigenetics. 2015;7:49.PubMedPubMedCentral
91.
Doumatey AP, He WJ, Gaye A, Lei L, Zhou J, Gibbons GH, Adeyemo A, Rotimi CN. Circulating MiR-374a-5p is a potential modulator of the inflammatory process in obesity. Sci Rep. 2018;8:7680.PubMedPubMedCentral
92.
Vega-Cárdenas M, Uresti-Rivera EE, Cortés-García JD, Briones-Espinoza M, Ruíz-Rodríguez VM, Reynaga-Hernández E, Mendez-Mancilla A, Portales-Pérez DP. Increased levels of adipose tissue-resident Th17 cells in obesity associated with miR-326. Immunol Lett. 2019;211:60–7.PubMed
93.
Miranda K, Yang X, Bam M, Murphy EA, Nagarkatti PS, Nagarkatti M. MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages. Int J Obes (Lond). 2018;42:1140–50.
94.
Pan Y, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A. Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation. J Clin Invest. 2019;129:834–49.PubMedPubMedCentral
95.
Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X. Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155. J Mol Cell Biol. 2016;8:505–17.PubMed
96.
Karkeni E, Astier J, Tourniaire F, El Abed M, Romier B, Gouranton E, Wan L, Borel P, Salles J, Walrand S, Ye J, Landrier JF. Obesity-associated inflammation induces microRNA-155 expression in adipocytes and adipose tissue: outcome on adipocyte function. J Clin Endocrinol Metab. 2016;101:1615–26.PubMedPubMedCentral
97.
Yao F, Yu Y, Feng L, Li J, Zhang M, Lan X, Yan X, Liu Y, Guan F, Zhang M, Chen L. Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity. Exp Cell Res. 2017;355:105–12.PubMed
98.
Zhang M, Zhou Z, Wang J, Li S. MiR-130b promotes obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through alleviating M2 macrophage polarization via repression of PPAR-γ. Immunol Lett. 2016;180:1–8.PubMed
99.
100.
Peng J, Zhou Y, Deng Z, Zhang H, Wu Y, Song T, Yang Y, Wei H, Peng J. miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1). J Cell Biochem. 2018;119:6418–28.PubMed
101.
Deiuliis JA, Syed R, Duggineni D, Rutsky J, Rengasamy P, Zhang J, Huang K, Needleman B, Mikami D, Perry K, Hazey J, Rajagopalan S. Visceral adipose microRNA 223 is upregulated in human and murine obesity and modulates the inflammatory phenotype of macrophages. PLoS ONE. 2016;11:e0165962.PubMedPubMedCentral
102.
Arner E, Mejhert N, Kulyté A, Balwierz PJ, Pachkov M, Cormont M, Lorente-Cebrián S, Ehrlund A, Laurencikiene J, Hedén P, Dahlman-Wright K, Tanti JF, Hayashizaki Y, Rydén M, Dahlman I, van Nimwegen E, Daub CO, Arner P. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes. 2012;61:1986–93.PubMedPubMedCentral
103.
Liu L, Li Q, Xiao X, Wu C, Gao R, Peng C, Li D, Zhang W, Du T, Wang Y, Yang S, Zhen Q, Ge Q. miR-1934, downregulated in obesity, protects against low-grade inflammation in adipocytes. Mol Cell Endocrinol. 2016;428:109–17.PubMedPubMedCentral
104.
Ge Q, Gérard J, Noël L, Scroyen I, Brichard SM. MicroRNAs regulated by adiponectin as novel targets for controlling adipose tissue inflammation. Endocrinology. 2012;153:5285–96.PubMed
105.
Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O’Connell RM. Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet. 2019;15:e1007970.PubMedPubMedCentral
106.
Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young. Lean Male Mice Offspring Endocrinol. 2016;157:4246–56.
107.
Mazloom H, Alizadeh S, Esfahani EN, Razi F, Meshkani R. Decreased expression of microRNA-21 is associated with increased cytokine production in peripheral blood mononuclear cells (PBMCs) of obese type 2 diabetic and non-diabetic subjects. Mol Cell Biochem. 2016;419:11–7.PubMed
108.
Li H, Xue M, Xu J, Qin X. MiR-301a is involved in adipocyte dysfunction during obesity-related inflammation via suppression of PPARγ. Pharmazie. 2016;71:84–8.PubMed
109.
Xie Q, Wei M, Kang X, et al. Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes. Biosci Rep. 2015;35:e00204.PubMedPubMedCentral
110.
111.
Hanzu FA, Musri MM, Sánchez-Herrero A, Claret M, Esteban Y, Kaliman P, Gomis R, Párrizas M. Histone demethylase KDM1A represses inflammatory gene expression in preadipocytes. Obesity (Silver Spring). 2013;21:E616–25.
112.
Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes. 2011;60:3235–45.PubMedPubMedCentral
113.
Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC Jr, Finck BN, Harris TE. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol. 2010;30:3126–39.PubMedPubMedCentral
114.
Makene VW, Pool EJ. The effects of endocrine disrupting chemicals on biomarkers of inflammation produced by lipopolysaccharide stimulated RAW264.7 macrophages. Int J Environ Res Public Health. 2019;16:2914.PubMedCentral
115.
Helsley RN, Zhou C. Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view. Environ Epigenet. 2017;3:dvx017.PubMedPubMedCentral
116.
Han C, Hong YC. Bisphenol A, hypertension, and cardiovascular diseases: epidemiological, laboratory, and clinical trial evidence. Curr Hypertens Rep. 2016;18:11.PubMed
117.
Park MH, Gutiérrez-García AK, Choudhury M. Mono-(2-ethylhexyl) phthalate aggravates inflammatory response via Sirtuin regulation and inflammasome activation in RAW 264.7 cells. Chem Res Toxicol. 2019;32:935–42.PubMed
118.
Jahreis S, Trump S, Bauer M, Bauer T, Thürmann L, Feltens R, Wang Q, Gu L, Grützmann K, Röder S, Averbeck M, Weichenhan D, Plass C, Sack U, Borte M, Dubourg V, Schüürmann G, Simon JC, von Bergen M, Hackermüller J, Eils R, Lehmann I, Polte T. Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J Allergy Clin Immunol. 2018;141:741–53.PubMed
119.
O’Brien E, Dolinoy DC, Mancuso P. Perinatal bisphenol A exposures increase production of pro-inflammatory mediators in bone marrow-derived mast cells of adult mice. J Immunotoxicol. 2014;11:205–12.PubMed
120.
Song W, Puttabyatappa M, Zeng L, Vazquez D, Pennathur S, Padmanabhan V. Developmental programming: prenatal bisphenol A treatment disrupts mediators of placental function in sheep. Chemosphere. 2020;243:125301.PubMed
121.
Hamid S, Mir MY, Rohela GK. Novel coronavirus disease (COVID-19): a pandemic (epidemiology, pathogenesis and potential therapeutics). New Microbes New Infect. 2020;35:100679.PubMedPubMedCentral
122.
Zhang Q, Cao X. Epigenetic regulation of the innate immune response to infection. Nat Rev Immunol. 2019;19:417–32.PubMed
123.
124.
Yamashita S, Nanjo S, Rehnberg E, Iida N, Takeshima H, Ando T, Maekita T, Sugiyama T, Ushijima T. Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori. Clin Epigenetics. 2019;11:191.PubMedPubMedCentral
125.
Maeda M, Moro H, Ushijima T. Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway. Gastric Cancer. 2017;20:8–15.PubMed
126.
Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM Jr, Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics. 2013;8:1153–61.PubMedPubMedCentral
127.
Kiga K, Mimuro H, Suzuki M, Shinozaki-Ushiku A, Kobayashi T, Sanada T, Kim M, Ogawa M, Iwasaki YW, Kayo H, Fukuda-Yuzawa Y, Yashiro M, Fukayama M, Fukao T, Sasakawa C. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun. 2014;5:4497.PubMed
128.
Palioto DB, Finoti LS, Kinane DF, Benakanakere M. Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge. J Clin Periodontol. 2019;46:819–29.PubMedPubMedCentral
129.
Corsetti PP, de Almeida LA, Gonçalves ANA, Gomes MTR, Guimarães ES, Marques JT, Oliveira SC. miR-181a-5p regulates TNF-α and miR-21a-5p influences gualynate-binding protein 5 and IL-10 expression in macrophages affecting host control of Brucella abortus infection. Front Immunol. 2018;9:1331.PubMedPubMedCentral
130.
Sanders AP, Gennings C, Svensson K, Motta V, Mercado-Garcia A, Solano M, Baccarelli AA, Tellez-Rojo MM, Wright RO, Burris HH. Bacterial and cytokine mixtures predict the length of gestation and are associated with miRNA expression in the cervix. Epigenomics. 2017;9:33–45.PubMed
131.
Modak R, Das Mitra S, Vasudevan M, Krishnamoorthy P, Kumar M, Bhat AV, Bhuvana M, Ghosh SK, Shome BR, Kundu TK. Epigenetic response in mice mastitis: role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection. Clin Epigenetics. 2014;6:12.PubMedPubMedCentral
132.
Modak R, Das Mitra S, Krishnamoorthy P, Bhat A, Banerjee A, Gowsica BR, Bhuvana M, Dhanikachalam V, Natesan K, Shome R, Shome BR, Kundu TK. Histone H3K14 and H4K8 hyperacetylation is associated with Escherichia coli-induced mastitis in mice. Epigenetics. 2012;7:492–501.PubMed
133.
Lorente-Sorolla C, Garcia-Gomez A, Català-Moll F, Toledano V, Ciudad L, Avendaño-Ortiz J, Maroun-Eid C, Martín-Quirós A, Martínez-Gallo M, Ruiz-Sanmartín A, Del Campo ÁG, Ferrer-Roca R, Ruiz-Rodriguez JC, Álvarez-Errico D, López-Collazo E, Ballestar E. Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis. Genome Med. 2019;11:66.PubMedPubMedCentral
134.
Carson WF 4th, Kunkel SL. Regulation of cellular immune responses in sepsis by histone modifications. Adv Protein Chem Struct Biol. 2017;106:191–225.PubMed
135.
Bhargavan B, Woollard SM, Kanmogne GD. Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication. Cell Signal. 2016;28:7–22.PubMed
136.
Ptaschinski C, Mukherjee S, Moore ML, Albert M, Helin K, Kunkel SL, Lukacs NW. RSV-induced H3K4 demethylase KDM5B leads to regulation of dendritic cell-derived innate cytokines and exacerbates pathogenesis in vivo. PLoS Pathog. 2015;11:e1004978.PubMedPubMedCentral
137.
Esteki-Zadeh A, Karimi M, Strååt K, Ammerpohl O, Zeitelhofer M, Jagodic M, Mehrab-Mohseni M, Sjöholm L, Rahbar A, Söderberg-Nauclér C, Ekström TJ. Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity. Epigenetics. 2012;7:585–93.PubMed
138.
Zhao Q, Fan YC, Zhao J, Gao S, Zhao ZH, Wang K. DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B. J Viral Hepat. 2013;20:430–7.PubMed
139.
Wu DW, Tsai LH, Chen PM, Lee MC, Wang L, Chen CY, Cheng YW, Lee H. Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer. Am J Pathol. 2012;181:1796–806.PubMed
140.
Bala S, Tilahun Y, Taha O, Alao H, Kodys K, Catalano D, Szabo G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med. 2012;10:151.PubMedPubMedCentral
141.
Singer BD, Mock JR, Aggarwal NR, Garibaldi BT, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, Yegnasubramanian S, King LS, D’Alessio FR. Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Am J Respir Cell Mol Biol. 2015;52:641–52.PubMedPubMedCentral
142.
Cole J, Morris P, Dickman MJ, Dockrell DH. The therapeutic potential of epigenetic manipulation during infectious diseases. Pharmacol Ther. 2016;167:85–99.PubMedPubMedCentral
143.
Lecoeur H, Prina E, Rosazza T, Kokou K, N’Diaye P, Aulner N, Varet H, Bussotti G, Xing Y, Milon G, Weil R, Meng G, Späth GF. Targeting macrophage histone H3 modification as a leishmania strategy to dampen the NF-κB/NLRP3-mediated inflammatory response. Cell Rep. 2020;30:1870–82 ((e4)).PubMed
144.
Domínguez-Andrés J, Ferreira AV, Jansen T, Smithers N, Prinjha RK, Furze RC, Netea MG. Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction. Eur J Immunol. 2019;49:2044–50.PubMedPubMedCentral
145.
Pan Y, Wang J, Xue Y, Zhao J, Li D, Zhang S, Li K, Hou Y, Fan H. GSKJ4 protects mice against early sepsis via reducing proinflammatory factors and up-regulating MiR-146a. Front Immunol. 2018;9:2272.PubMedPubMedCentral
146.
Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019;33:10515–27.PubMedPubMedCentral
147.
Kaur G, Bagam P, Pinkston R, Singh DP, Batra S. Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms. Toxicology. 2018;398–399:52–67.PubMed
148.
Ringh MV, Hagemann-Jensen M, Needhamsen M, Kular L, Breeze CE, Sjöholm LK, Slavec L, Kullberg S, Wahlström J, Grunewald J, Brynedal B, Liu Y, Almgren M, Jagodic M, Öckinger J, Ekström TJ. Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells. EBioMedicine. 2019;46:290–304.PubMedPubMedCentral
149.
Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I. Cigarette smoke induces proinflammatory cytokine release by activation of NF-κB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol. 2006;291:L46-57.PubMed
150.
Lee JW, Jaffar Z, Pinkerton KE, Porter V, Postma B, Ferrini M, Holian A, Roberts K, Cho YH. Alterations in DNA methylation and airway hyperreactivity in response to in utero exposure to environmental tobacco smoke. Inhal Toxicol. 2015;27:724–30.PubMedPubMedCentral
151.
Kõks G, Uudelepp ML, Limbach M, Peterson P, Reimann E, Kõks S. Smoking-induced expression of the GPR15 gene indicates its potential role in chronic inflammatory pathologies. Am J Pathol. 2015;185:2898–906.PubMed
152.
Dogan MV, Shields B, Cutrona C, Gao L, Gibbons FX, Simons R, Monick M, Brody GH, Tan K, Beach SR, Philibert RA. The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics. 2014;15:151.PubMedPubMedCentral
153.
Weng JT, Wu LS, Lee CS, Hsu PW, Cheng AT. Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. Comput Biol Med. 2015;64:299–306.PubMed
154.
Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Richards JR, Halsted CH. S-adenosyl-l-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcohol Clin Exp Res. 2011;35:1960–5.PubMedPubMedCentral
155.
Heo MJ, Kim TH, You JS, Blaya D, Sancho-Bru P, Kim SG. Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression. Gut. 2019;68:708–20.PubMed
156.
Lippai D, Bala S, Catalano D, Kodys K, Szabo G. Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice. Alcohol Clin Exp Res. 2014;38:2217–24.PubMedPubMedCentral
157.
Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor alpha (TNFα) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011;286:1436–44.PubMed
158.
Bala S, Csak T, Kodys K, Catalano D, Ambade A, Furi I, Lowe P, Cho Y, Iracheta-Vellve A, Szabo G. Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease. J Leukoc Biol. 2017;102:487–98.PubMedPubMedCentral
159.
Lippai D, Bala S, Csak T, Kurt-Jones EA, Szabo G. Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice. PLoS ONE. 2013;8:e70945.PubMedPubMedCentral
160.
Zhang Y, Wei G, Di Z, Zhao Q. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway. Biochem Biophys Res Commun. 2014;452:450–6.PubMed
161.
Motivala SJ. Sleep and inflammation: psychoneuroimmunology in the context of cardiovascular disease. Ann Behav Med. 2011;42:141–52.PubMed
162.
Andrabi M, Andrabi MM, Kunjunni R, Sriwastva MK, Bose S, Sagar R, Srivastava AK, Mathur R, Jain S, Subbiah V. Lithium acts to modulate abnormalities at behavioral, cellular, and molecular levels in sleep deprivation-induced mania-like behavior. Bipolar Disord. 2020;22:266–80.PubMed
163.
Chen W, Guo X, Jin Z, Li R, Shen L, Li W, Cai W, Zhang G. Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction. Syst Biol Reprod Med. 2020;66:99–111.PubMed
164.
Li X, Joehanes R, Hoeschele I, Rich SS, Rotter JI, Levy D, Liu Y, Redline S, Sofer T. Association between sleep disordered breathing and epigenetic age acceleration: evidence from the Multi-Ethnic Study of Atherosclerosis. EBioMedicine. 2019;50:387–94.PubMedPubMedCentral
165.
Kim J, Bhattacharjee R, Khalyfa A, Kheirandish-Gozal L, Capdevila OS, Wang Y, Gozal D. DNA methylation in inflammatory genes among children with obstructive sleep apnea. Am J Respir Crit Care Med. 2012;185:330–8.PubMedPubMedCentral
166.
Smith JA, Zhao W, Wang X, Ratliff SM, Mukherjee B, Kardia SLR, Liu Y, Roux AVD, Needham BL. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: the Multi-Ethnic Study of Atherosclerosis. Epigenetics. 2017;12:662–73.PubMedPubMedCentral
167.
Needham BL, Smith JA, Zhao W, Wang X, Mukherjee B, Kardia SL, Shively CA, Seeman TE, Liu Y, Diez Roux AV. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: the Multi-Ethnic Study of Atherosclerosis. Epigenetics. 2015;10:958–69.PubMedPubMedCentral
168.
Stringhini S, Polidoro S, Sacerdote C, Kelly RS, van Veldhoven K, Agnoli C, Grioni S, Tumino R, Giurdanella MC, Panico S, Mattiello A, Palli D, Masala G, Gallo V, Castagné R, Paccaud F, Campanella G, Chadeau-Hyam M, Vineis P. Life-course socioeconomic status and DNA methylation of genes regulating inflammation. Int J Epidemiol. 2015;44:1320–30.PubMed
169.
McDade TW, Ryan C, Jones MJ, MacIsaac JL, Morin AM, Meyer JM, Borja JB, Miller GE, Kobor MS, Kuzawa CW. Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood. Proc Natl Acad Sci USA. 2017;114:7611–6.PubMedPubMedCentral
170.
Janusek LW, Tell D, Gaylord-Harden N, Mathews HL. Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: an epigenetic link. Brain Behav Immun. 2017;60:126–35.PubMed
171.
Pfau ML, Menard C, Cathomas F, Desland F, Kana V, Chan KL, Shimo Y, LeClair K, Flanigan ME, Aleyasin H, Walker DM, Bouchard S, Mack M, Hodes GE, Merad MM, Russo SJ. Role of monocyte-derived microRNA106b∼25 in resilience to social stress. Biol Psychiatry. 2019;86:474–82.PubMedPubMedCentral
172.
Harkess KN, Ryan J, Delfabbro PH, Cohen-Woods S. Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Transl Psychiatry. 2016;6:e965.PubMedPubMedCentral
173.
Kaliman P, Alvarez-López MJ, Cosín-Tomás M, Rosenkranz MA, Lutz A, Davidson RJ. Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology. 2014;40:96–107.PubMed
174.
Chaix R, Fagny M, Cosin-Tomás M, Alvarez-López M, Lemee L, Regnault B, Davidson RJ, Lutz A, Kaliman P. Differential DNA methylation in experienced meditators after an intensive day of mindfulness-based practice: implications for immune-related pathways. Brain Behav Immun. 2020;84:36–44.PubMed
175.
Kim D, Kubzansky LD, Baccarelli A, Sparrow D, Spiro A 3rd, Tarantini L, Cantone L, Vokonas P, Schwartz J. Psychological factors and DNA methylation of genes related to immune/inflammatory system markers: the VA Normative Aging Study. BMJ Open. 2016;6:e009790.PubMedPubMedCentral
176.
Wang C, O’Brien KM, Xu Z, Sandler DP, Taylor JA, Weinberg CR. Long-term ambient fine particulate matter and DNA methylation in inflammation pathways: results from the Sister Study. Epigenetics. 2020;15:524–35.PubMed
177.
Wang C, Chen R, Shi M, Cai J, Shi J, Yang C, Li H, Lin Z, Meng X, Liu C, Niu Y, Xia Y, Zhao Z, Kan H, Weinberg CR. Possible mediation by methylation in acute inflammation following personal exposure to fine particulate air pollution. Am J Epidemiol. 2018;187:484–93.PubMed
178.
Zhong J, Colicino E, Lin X, Mehta A, Kloog I, Zanobetti A, Byun HM, Bind MA, Cantone L, Prada D, Tarantini L, Trevisi L, Sparrow D, Vokonas P, Schwartz J, Baccarelli AA. Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of toll-like receptor 2 and dietary flavonoid intake. J Am Heart Assoc. 2015;4:e001423.PubMedPubMedCentral
179.
Lepeule J, Bind MA, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study. Environ Health Perspect. 2014;122:566–72.PubMedPubMedCentral
180.
Bind MA, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A, Coull BA, Tarantini L, Vokonas PS, Koutrakis P, Schwartz J. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics. 2014;9:448–58.PubMedPubMedCentral
181.
Pardo M, Kuperman Y, Levin L, Rudich A, Haim Y, Schauer JJ, Chen A, Rudich Y. Exposure to air pollution interacts with obesogenic nutrition to induce tissue-specific response patterns. Environ Pollut. 2018;239:532–43.PubMed
182.
Fiorito G, Vlaanderen J, Polidoro S, Gulliver J, Galassi C, Ranzi A, Krogh V, Grioni S, Agnoli C, Sacerdote C, Panico S, Tsai MY, Probst-Hensch N, Hoek G, Herceg Z, Vermeulen R, Ghantous A, Vineis P, Naccarati A. EXPOsOMICS consortium‡. Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: a prospective study in nonsmokers. Environ Mol Mutagen. 2018;59:234–46.PubMed
183.
Cantone L, Iodice S, Tarantini L, Albetti B, Restelli I, Vigna L, Bonzini M, Pesatori AC, Bollati V. Particulate matter exposure is associated with inflammatory gene methylation in obese subjects. Environ Res. 2017;152:478–84.PubMedPubMedCentral
184.
Pavanello S, Bonzini M, Angelici L, Motta V, Pergoli L, Hoxha M, Cantone L, Pesatori AC, Apostoli P, Tripodi A, Baccarelli A, Bollati V. Extracellular vesicle-driven information mediates the long-term effects of particulate matter exposure on coagulation and inflammation pathways. Toxicol Lett. 2016;259:143–50.PubMedPubMedCentral
185.
Chen R, Li H, Cai J, Wang C, Lin Z, Liu C, Niu Y, Zhao Z, Li W, Kan H. Fine particulate air pollution and the expression of microRNAs and circulating cytokines relevant to inflammation, coagulation, and vasoconstriction. Environ Health Perspect. 2018;126:017007.PubMedPubMedCentral
186.
Li X, Jia Y, Nan A, Zhang N, Zhou H, Chen L, Pan X, Qiu M, Zhu J, Zhang H, Ling Y, Jiang Y. CircRNA104250 and lncRNAuc001.dgp.1 promote the PM2.5-induced inflammatory response by co-targeting miR-3607–5p in BEAS-2B cells. Environ Pollut. 2020;258:113749.PubMed
187.
Fry RC, Rager JE, Bauer R, Sebastian E, Peden DB, Jaspers I, Alexis NE. Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects. Am J Physiol Lung Cell Mol Physiol. 2014;306:L1129–37.PubMedPubMedCentral
188.
Li J, Wang T, Wang Y, Xu M, Zhang L, Li X, Liu Z, Gao S, Jia Q, Fan Y, Wang Z, Wu N, Zhang X, Dai Y, Kong F, Wang W, Duan H. Particulate matter air pollution and the expression of microRNAs and pro-inflammatory genes: association and mediation among children in Jinan. China J Hazard Mater. 2020;389:121843.PubMed
189.
González-Muniesa P, Garcia-Gerique L, Quintero P, Arriaza S, Lopez-Pascual A, Martinez JA. Effects of hyperoxia on oxygen-related inflammation with a focus on obesity. Oxid Med Cell Longev. 2015;2015:8957827.PubMed
190.
Lopez-Pascual A, Lasa A, Portillo MP, Arós F, Mansego ML, González-Muniesa P, Martinez JA. Low oxygen consumption is related to a hypomethylation and an increased secretion of IL-6 in obese subjects with sleep apnea-hypopnea syndrome. Ann Nutr Metab. 2017;71:16–25.PubMed
191.
Butts B, Butler J, Dunbar SB, Corwin EJ, Gary RA. ASC methylation and interleukin-1β are associated with aerobic capacity in heart failure. Med Sci Sports Exerc. 2017;49:1072–8.PubMedPubMedCentral
192.
Ali MM, Phillips SA, Mahmoud AM. HIF1α/TET1 pathway mediates hypoxia-induced adipocytokine promoter hypomethylation in human adipocytes. Cells. 2020;9:134.PubMedCentral
193.
Badran M, Yassin BA, Lin DTS, Kobor MS, Ayas N, Laher I. Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring. J Physiol. 2019;597:5349–64.PubMed
194.
Huang L, Chen X, Dasgupta C, Chen W, Song R, Wang C, Zhang L. Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease. Cardiovasc Res. 2019;115:1306–19.PubMed
195.
Chouvarine P, Legchenko E, Geldner J, Riehle C, Hansmann G. Hypoxia drives cardiac miRNAs and inflammation in the right and left ventricle. J Mol Med (Berl). 2019;97:1427–38.
196.
Boddicker RL, Koltes JE, Fritz-Waters ER, Koesterke L, Weeks N, Yin T, Mani V, Nettleton D, Reecy JM, Baumgard LH, Spencer JD, Gabler NK, Ross JW. Genome-wide methylation profile following prenatal and postnatal dietary Ω-3 fatty acid supplementation in pigs. Anim Genet. 2016;47:658–71.PubMed
197.
Bigagli E, Cinci L, Paccosi S, Parenti A, D’Ambrosio M, Luceri C. Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Int Immunopharmacol. 2017;43:147–55.PubMed
198.
Izquierdo V, Palomera-Ávalos V, López-Ruiz S, Canudas AM, Pallàs M, Griñán-Ferré C. Maternal resveratrol supplementation prevents cognitive decline in senescent mice offspring. Int J Mol Sci. 2019;20:1134.PubMedCentral
199.
Maugeri A, Barchitta M, Mazzone MG, Giuliano F, Basile G, Agodi A. Resveratrol modulates SIRT1 and DNMT functions and restores LINE-1 methylation levels in ARPE-19 cells under oxidative stress and inflammation. Int J Mol Sci. 2018;19:2118.PubMedCentral
200.
Isac S, Panaitescu AM, Spataru A, Iesanu M, Totan A, Udriste A, Cucu N, Peltecu G, Zagrean L, Zagrean AM. Trans-resveratrol enriched maternal diet protects the immature hippocampus from perinatal asphyxia in rats. Neurosci Lett. 2017;653:308–13.PubMed
201.
Carpi S, Scoditti E, Massaro M, Polini B, Manera C, Digiacomo M, Esposito Salsano J, Poli G, Tuccinardi T, Doccini S, Santorelli FM, Carluccio MA, Macchia M, Wabitsch M, De Caterina R, Nieri P. The extra-virgin olive oil polyphenols oleocanthal and oleacein counteract inflammation-related gene and mirna expression in adipocytes by attenuating NF-κB activation. Nutrients. 2019;11:2855.PubMedCentral
202.
Scoditti E, Carpi S, Massaro M, Pellegrino M, Polini B, Carluccio MA, Wabitsch M, Verri T, Nieri P, De Caterina R. Hydroxytyrosol modulates adipocyte gene and miRNA expression under inflammatory condition. Nutrients. 2019;11:2493.PubMedCentral
203.
Otton R, Bolin AP, Ferreira LT, Marinovic MP, Rocha ALS, Mori MA. Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation. J Nutr Biochem. 2018;57:170–9.PubMed
204.
Gentile D, Fornai M, Colucci R, Pellegrini C, Tirotta E, Benvenuti L, Segnani C, Ippolito C, Duranti E, Virdis A, Carpi S, Nieri P, Németh ZH, Pistelli L, Bernardini N, Blandizzi C, Antonioli L. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. PLoS ONE. 2018;13:e0195502.PubMedPubMedCentral
205.
Heyman-Lindén L, Seki Y, Storm P, Jones HA, Charron MJ, Berger K, Holm C. Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. J Nutr Biochem. 2016;27:79–95.PubMed
206.
Kim HJ, Lee W, Yun JM. Luteolin inhibits hyperglycemia-induced proinflammatory cytokine production and its epigenetic mechanism in human monocytes. Phytother Res. 2014;28:1383–91.PubMed
207.
Lee W, Lee SY, Son YJ, Yun JM. Gallic acid decreases inflammatory cytokine secretion through histone acetyltransferase/histone deacetylase regulation in high glucose-induced human monocytes. J Med Food. 2015;18:793–801.PubMed
208.
Kim HJ, Kim SH, Yun JM. Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. Evid Based Complement Alternat Med. 2012;2012:639469.PubMedPubMedCentral
209.
Fan R, You M, Toney AM, Kim J, Giraud D, Xian Y, Ye F, Gu L, Ramer-Tait AE, Chung S. Red raspberry polyphenols attenuate high-fat diet-driven activation of NLRP3 inflammasome and its paracrine suppression of adipogenesis via histone modifications. Mol Nutr Food Res. 2020;64:e1900995.PubMed
210.
Yun JM, Jialal I, Devaraj S. Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers. Br J Nutr. 2010;103:1771–7.PubMed
Metadaten
Titel
Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition
verfasst von
Omar Ramos-Lopez
Fermin I. Milagro
Jose I. Riezu-Boj
J. Alfredo Martinez
Publikationsdatum
24.11.2020
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 1/2021
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-020-01425-y

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