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27.02.2024 | Review

Epithelial recognition and elimination against aberrant cells

verfasst von: Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama

Erschienen in: Seminars in Immunopathology | Ausgabe 4-6/2024

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Abstract

Epithelial cells, which are non-immune cells, not only function as a physical defence barrier but also continuously monitor and eliminate aberrant epithelial cells in their vicinity. In other words, it has become evident that epithelial cells possess immune cell-like functions. In fact, recent research has revealed that epithelial cells recognise the Major Histocompatibility Complex I (MHC-I) of aberrant cells as a mechanism for surveillance. This cellular defence mechanism of epithelial cells probably detects aberrant cells more promptly than the conventional immune response, making it a novel and primary biological defence. Furthermore, there is the potential for this new immune-like biological defence mechanism to establish innovative treatment for disease prevention, leading to increasing anticipation for its future medical applications. In this review, we aim to summarise the recognition and attack mechanisms of aberrant cells by epithelial cells in mammals, with a particular focus on the field of cancer. Additionally, we discuss the potential therapeutic applications of epithelial cell-based defence against cancer, including novel prophylactic treatment methods based on molecular mechanisms.

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Titel: Epithelial recognition and elimination against aberrant cells
verfasst von: Shiyu Ayukawa
Nagisa Kamoshita
Takeshi Maruyama
Publikationsdatum: 27.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 4-6/2024
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-024-01001-0

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Epithelial recognition and elimination against aberrant cells

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