Erschienen in:
01.07.2008 | Case Report
Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy
verfasst von:
Hitoshi Ohno, Norikazu Nagata, Kotaro Isoda
Erschienen in:
International Journal of Hematology
|
Ausgabe 1/2008
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Abstract
We herein report the case of a 67-year-old man who initially presented with fever and hepatosplenomegaly, and soon died of progressive liver failure. The bone marrow was infiltrated with tumor cells showing a variable morphology and macrophages phagocytosing blood cells. The tumor cells were CD2+, CD3+, CD4−, CD8+, CD25+, CD56+/−, and HLA-DR+ and exhibited clonal cytogenetic abnormalities. Microscopic examination of the liver postmortem revealed, prominent cellular infiltrates that were confined within the portal area. The infiltrated cells were medium-sized with the CD3+, CD4−, CD8+, CD56+/−, and granzyme B+ phenotype. In situ hybridization detected Epstein–Barr virus (EBV)-encoded RNA-positive cells in the liver and spleen as well as the bone marrow obtained before his death. These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient.