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Breast Cancer Research

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01.04.2011 | Viewpoint

ERBB receptors in cancer: signaling from the inside

verfasst von: Carlos L Arteaga

Erschienen in: Breast Cancer Research | Ausgabe 2/2011

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Abstract

ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.

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Titel: ERBB receptors in cancer: signaling from the inside
verfasst von: Carlos L Arteaga
Publikationsdatum: 01.04.2011
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 2/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2829

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ERBB receptors in cancer: signaling from the inside

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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