You-Chiuan Chien and Heng-Chieh Chiang contributed equally to this work.
The authors declare that they have no competing interests.
YCC, HCC and YLC conceptualised and planned the study. YCC writing of the manuscript, collection and analysis of data and writing of the manuscript drafts. HCC, PYL and YLC advised on study design and manuscript drafts. All authors read and approved the final manuscript.
Impaired liver function in men can result in erectile dysfunction or hypogonadism or both. We investigated whether living donor liver transplantation (LDLT) results in improvement in male sexual function.
A total of 58 patients with end-stage liver disease (ESLD) were included in this prospective, cross-sectional study. Erectile function was measured before and after LDLT using a five-item modified version of the International Index of Erectile Function scale (IIEF-5) and hypogonadism was evaluated before and after LDLT using the Androgen Deficiency in the Aging Male (ADAM) questionnaire. Differences in mean values from the questionnaires before and after the operation were than evaluated to determine whether there is an association between LDLT and improvement in sexual function.
We found that mean IIEF-5 scores significantly increased after LDLT (from 11.7 ± 7.7 before LDLT to 14.7 ± 7.5 after LDLT, p <0.01), indicating that the operation played a role in improving erectile function. In addition, the prevalence of hypogonadism among the patients with ESLD decreased markedly after liver transplantation (hypogonadism before LDLT, n = 41 versus hypogonadism after LDLT, n = 31, p = 0.03). Patients with hypogonadism reported a higher prevalence of erectile dysfunction after LDLT than patients without hypogonadism (p <0.01).
LDLT results in improvement in erectile function. In addition, improvement in erectile function is associated with self-reported absence of hypogonadism.
Bravata DM, Olkin I, Barnato AE, Keeffe EB, Owens DK. Health-related quality of life after liver transplantation: a meta-analysis. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 1999;5:318–31. CrossRef
Madersbacher S, Ludvik G, Stulnig T, Grunberger T, Maier U. The impact of liver transplantation on endocrine status in men. Clin Endocrinol (Oxf). 1996;44:461–6. CrossRef
Huyghe E, Kamar N, Wagner F, Yeung SJ, Capietto AH, El-Kahwaji L, et al. Erectile dysfunction in liver transplant patients. Am j transplant : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2008;8:2580–9. CrossRef
Tancredi A, Reginster JY, Schleich F, Pire G, Maassen P, Luyckx F, et al. Interest of the androgen deficiency in aging males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers. Eur j endocrinol / European Federation of Endocrine Societies. 2004;151:355–60. CrossRef
Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metab: clin exp. 2000;49:1239–42. CrossRef
Heidelbaugh JJ. Management of erectile dysfunction. Am Fam Physician. 2010;81:305–12. PubMed
Sorrell JH, Brown JR. Sexual functioning in patients with end-stage liver disease before and after transplantation. Liver transpl : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2006;12:1473–7. CrossRef
Wang G, Yang J, Li M, Liu B, Jiang N, Fu B, et al. Liver transplant may improve erectile function in patients with benign end-stage liver disease: single-center Chinese experience. Exp clin transplant : official journal of the Middle East Society for Organ Transplantation. 2013;11:332–8. CrossRef
Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur j endocrinol / European Federation of Endocrine Societies. 2005;152:501–13. CrossRef
Klein J, Tran SN, Mentha-Dugerdil A, Giostra E, Majno P, Morard I, et al. Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation. Ann transplant : quarterly of the Polish Transplantation Society. 2013;18:136–45. CrossRef
Ho JK, Ko HH, Schaeffer DF, Erb SR, Wong C, Buczkowski AK, et al. Sexual health after orthotopic liver transplantation. Liver transpl: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2006;12:1478–84. CrossRef
- Erectile function in men with end-stage liver disease improves after living donor liver transplantation
- BioMed Central
Neu im Fachgebiet Urologie
Meistgelesene Bücher in der Urologie
Mail Icon II