Skip to main content
Erschienen in: InFo Hämatologie + Onkologie 11/2020

16.11.2020 | Darmmikrobiom | Schwerpunkt

Schwerpunkt Fatigue

Zusammenhänge zwischen Fatigue und Mikronährstoffen sowie Darmmikrobiom

verfasst von: Dr. med. Claudia Löffler

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 11/2020

Einloggen, um Zugang zu erhalten

Auszug

Viele Krebspatienten greifen auf Nahrungsergänzungsmittel und andere Substanzen zurück, in der Hoffnung, die Erkrankung und ihre Folgen - etwa Fatigue - günstig beeinflussen zu können. Lesen Sie in der folgenden kurzen Übersicht, für welche ergänzenden Wirkstoffe gewisse Erfolgshinweise vorliegen und vor allem auch, wo aufgrund von drohenden Interaktionen mit der onkologischen Therapie große Vorsicht geboten ist.
Literatur
1.
Zurück zum Zitat Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol. 2008;26(4):665-73 Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol. 2008;26(4):665-73
3.
Zurück zum Zitat Mayland C et al. Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response. Ann Clin Biochem. 2004;41(Pt 2):138-41 Mayland C et al. Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response. Ann Clin Biochem. 2004;41(Pt 2):138-41
4.
Zurück zum Zitat Gröber U et al. Micronutrients in Oncological Intervention. Nutrients. 2016;8(3):163 Gröber U et al. Micronutrients in Oncological Intervention. Nutrients. 2016;8(3):163
5.
Zurück zum Zitat Plant AS, Tisman Gleen. Frequency of combined deficiencies of vitamin D and holotranscobalamin in cancer patients. Nutr Cancer. 2006;56(2):143-8 Plant AS, Tisman Gleen. Frequency of combined deficiencies of vitamin D and holotranscobalamin in cancer patients. Nutr Cancer. 2006;56(2):143-8
6.
Zurück zum Zitat Nowak A et al. Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. Medicine (Baltimore). 2016;95(52):e5353 Nowak A et al. Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. Medicine (Baltimore). 2016;95(52):e5353
7.
Zurück zum Zitat Koole JL et al. Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment. Cancer Epidemiol Biomarkers Prev. 2020;29(6):1135-44 Koole JL et al. Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment. Cancer Epidemiol Biomarkers Prev. 2020;29(6):1135-44
8.
Zurück zum Zitat Höck AD et al. Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases. In Vivo. 2014;28(1):133-45 Höck AD et al. Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases. In Vivo. 2014;28(1):133-45
9.
Zurück zum Zitat Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81 Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81
10.
Zurück zum Zitat Krause D, Roupas P. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. J Nutr Health Aging. 2015;19(7):745-53 Krause D, Roupas P. Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. J Nutr Health Aging. 2015;19(7):745-53
11.
Zurück zum Zitat Goodwill AM et al. A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition. J Am Geriatr Soc. 2017;65(10):2161-8 Goodwill AM et al. A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition. J Am Geriatr Soc. 2017;65(10):2161-8
12.
Zurück zum Zitat Anglin RES et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013;202:100-7 Anglin RES et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013;202:100-7
13.
Zurück zum Zitat Parker GP et al. Vitamin D and depression. J Affect Disord. 2017;208:56-61 Parker GP et al. Vitamin D and depression. J Affect Disord. 2017;208:56-61
14.
Zurück zum Zitat Dev R et al. Preliminary report: vitamin D deficiency in advanced cancer patients with symptoms of fatigue or anorexia. Oncologist. 2011;16(11):1637-41 Dev R et al. Preliminary report: vitamin D deficiency in advanced cancer patients with symptoms of fatigue or anorexia. Oncologist. 2011;16(11):1637-41
15.
Zurück zum Zitat van Harten-Gerritsen AS et al. Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies. Cancer Epidemiol Biomarkers Prev. 2015;24(12):1820-8 van Harten-Gerritsen AS et al. Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies. Cancer Epidemiol Biomarkers Prev. 2015;24(12):1820-8
16.
Zurück zum Zitat Bower JE et al. Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597-609 Bower JE et al. Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597-609
17.
Zurück zum Zitat Schubert C et al. The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review. Brain Behav Immun. 2007;21(4):413-27 Schubert C et al. The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review. Brain Behav Immun. 2007;21(4):413-27
18.
Zurück zum Zitat Fakih MG et al. Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis. 2009;24(2):219-24 Fakih MG et al. Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis. 2009;24(2):219-24
19.
Zurück zum Zitat Savoie MB et al. Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation. J Gastrointest Cancer. 2019;50(4):769-79 Savoie MB et al. Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation. J Gastrointest Cancer. 2019;50(4):769-79
20.
Zurück zum Zitat Santini S et al. Longitudinal evaluation of vitamin D plasma levels during anthracycline- and docetaxel-based adjuvant chemotherapy in early-stage breast cancer patients. Ann Oncol. 2010;21(1):185-6 Santini S et al. Longitudinal evaluation of vitamin D plasma levels during anthracycline- and docetaxel-based adjuvant chemotherapy in early-stage breast cancer patients. Ann Oncol. 2010;21(1):185-6
21.
Zurück zum Zitat Kim H et al. Changes in serum hydroxyvitamin D levels of breast cancer patients during tamoxifen treatment or chemotherapy in premenopausal breast cancer patients. Eur J Cancer. 2014;50(8):1403-11 Kim H et al. Changes in serum hydroxyvitamin D levels of breast cancer patients during tamoxifen treatment or chemotherapy in premenopausal breast cancer patients. Eur J Cancer. 2014;50(8):1403-11
22.
Zurück zum Zitat Duntas LH. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res. 2009;41(6):443-7 Duntas LH. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res. 2009;41(6):443-7
23.
Zurück zum Zitat Rayman MP et al. The importance of selenium to human health. Lancet. 2000;356(9225):233-41 Rayman MP et al. The importance of selenium to human health. Lancet. 2000;356(9225):233-41
24.
Zurück zum Zitat Rayman MP et al. Selenium and human health. Lancet. 2012;379(9822):1256-68 Rayman MP et al. Selenium and human health. Lancet. 2012;379(9822):1256-68
25.
Zurück zum Zitat Castaño A et al. Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat. Neurochem Int. 1997;30(6):549-55 Castaño A et al. Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat. Neurochem Int. 1997;30(6):549-55
26.
Zurück zum Zitat Minton O et al. Drug therapy for the management of cancer related fatigue. Cochrane Database Syst Rev. 2008;(1):CD006704 Minton O et al. Drug therapy for the management of cancer related fatigue. Cochrane Database Syst Rev. 2008;(1):CD006704
27.
Zurück zum Zitat Saligan LN et al. Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain Behav Immun. 2013;27(1):63-70 Saligan LN et al. Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain Behav Immun. 2013;27(1):63-70
28.
Zurück zum Zitat Cutando A et al. Role of melatonin in cancer treatment. Anticancer Res. 2012;32(7):2747-53 Cutando A et al. Role of melatonin in cancer treatment. Anticancer Res. 2012;32(7):2747-53
29.
Zurück zum Zitat Melamud L et al. Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. J Neurol Sci. 2012;314(1-2):37-40 Melamud L et al. Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. J Neurol Sci. 2012;314(1-2):37-40
30.
Zurück zum Zitat Wang YM et al. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol. 2012;69(5):1213-20 Wang YM et al. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol. 2012;69(5):1213-20
31.
Zurück zum Zitat van Maanen A et al. The effects of light therapy on sleep problems: A systematic review and meta-analysis. Sleep Med Rev. 2016;29:52-62 van Maanen A et al. The effects of light therapy on sleep problems: A systematic review and meta-analysis. Sleep Med Rev. 2016;29:52-62
32.
Zurück zum Zitat Starreveld DEJ et al. Light therapy as a treatment of cancer-related fatigue in (non-)Hodgkin lymphoma survivors (SPARKLE trial): study protocol of a multicenter randomized controlled trial. BMC Cancer. 2018;18(1):880 Starreveld DEJ et al. Light therapy as a treatment of cancer-related fatigue in (non-)Hodgkin lymphoma survivors (SPARKLE trial): study protocol of a multicenter randomized controlled trial. BMC Cancer. 2018;18(1):880
33.
Zurück zum Zitat Powell ND et al. Psychosocial stress and inflammation in cancer. Brain Behav Immun. 2013;30 Suppl:S41-7 Powell ND et al. Psychosocial stress and inflammation in cancer. Brain Behav Immun. 2013;30 Suppl:S41-7
34.
Zurück zum Zitat Lieverse R et al. Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial. Arch Gen Psychiatry. 2011;68(1):61-70 Lieverse R et al. Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial. Arch Gen Psychiatry. 2011;68(1):61-70
35.
Zurück zum Zitat Inglis JE et al. Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review. Nutr Cancer. 2019;71(1):21-40 Inglis JE et al. Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review. Nutr Cancer. 2019;71(1):21-40
36.
Zurück zum Zitat Mantovani G et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev. 2006;15(5):1030-4 Mantovani G et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev. 2006;15(5):1030-4
37.
Zurück zum Zitat Chapple IL et al. Antioxidant Micronutrients and Oxidative Stress Biomarkers. Methods Mol Biol. 2017;1537:61-77 Chapple IL et al. Antioxidant Micronutrients and Oxidative Stress Biomarkers. Methods Mol Biol. 2017;1537:61-77
38.
Zurück zum Zitat Labriola D, Livingston R. Possible Interactions Between Dietary Antioxidants and Chemotherapy. Oncology (Williston Park). 1999;13(7):1003-8 Labriola D, Livingston R. Possible Interactions Between Dietary Antioxidants and Chemotherapy. Oncology (Williston Park). 1999;13(7):1003-8
39.
Zurück zum Zitat Gröber U et al., Antioxidanzien und andere Mikronährstoffe in der komplementären Onkologie. Onkologe;2010(16):73-9 Gröber U et al., Antioxidanzien und andere Mikronährstoffe in der komplementären Onkologie. Onkologe;2010(16):73-9
40.
Zurück zum Zitat Ambrosone CB et al. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). J Clin Oncol. 2020;38(8):804-14 Ambrosone CB et al. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). J Clin Oncol. 2020;38(8):804-14
41.
Zurück zum Zitat Jung AY et al. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy. Am J Clin Nutr. 2019;109(1):69-78 Jung AY et al. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy. Am J Clin Nutr. 2019;109(1):69-78
42.
Zurück zum Zitat Leitzmann MF et al. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2003;95(13):1004-7 Leitzmann MF et al. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2003;95(13):1004-7
43.
Zurück zum Zitat Harvie M. Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book. 2014;e478-86 Harvie M. Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book. 2014;e478-86
44.
Zurück zum Zitat Brasky TM et al. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol. 2017;35(30):3440-8 Brasky TM et al. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol. 2017;35(30):3440-8
45.
Zurück zum Zitat Goodman GE et al. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst. 2004;96(23):1743-50 Goodman GE et al. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst. 2004;96(23):1743-50
46.
Zurück zum Zitat Bjelakovic G et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842-57 Bjelakovic G et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842-57
47.
Zurück zum Zitat Biesalski HK et al. Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials. Nutrients. 2010;2(9):929-49 Biesalski HK et al. Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials. Nutrients. 2010;2(9):929-49
48.
Zurück zum Zitat Palesh O et al. Management of side effects during and post-treatment in breast cancer survivors. Breast J. 2018;24(2):167-75 Palesh O et al. Management of side effects during and post-treatment in breast cancer survivors. Breast J. 2018;24(2):167-75
49.
Zurück zum Zitat Majeed F et al. Ginseng phytochemicals as therapeutics in oncology: Recent perspectives. Biomed Pharmacother. 2018;100:52-63 Majeed F et al. Ginseng phytochemicals as therapeutics in oncology: Recent perspectives. Biomed Pharmacother. 2018;100:52-63
50.
Zurück zum Zitat Barton DL et al. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105(16):1230-8 Barton DL et al. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105(16):1230-8
51.
Zurück zum Zitat Viale PH et al. Can ginseng alleviate cancer-related fatigue? J Adv Pract Oncol. 2013;4(6):392-3 Viale PH et al. Can ginseng alleviate cancer-related fatigue? J Adv Pract Oncol. 2013;4(6):392-3
52.
Zurück zum Zitat Park HJ et al. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:197459 Park HJ et al. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:197459
53.
Zurück zum Zitat Yennurajalingam S et al. A Double-Blind, Randomized, Placebo-Controlled Trial of Panax Ginseng for Cancer-Related Fatigue in Patients With Advanced Cancer. J Natl Compr Canc Netw. 2017;15(9):1111-20 Yennurajalingam S et al. A Double-Blind, Randomized, Placebo-Controlled Trial of Panax Ginseng for Cancer-Related Fatigue in Patients With Advanced Cancer. J Natl Compr Canc Netw. 2017;15(9):1111-20
54.
Zurück zum Zitat Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-98 Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-98
55.
Zurück zum Zitat Bilgi N et al. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother. 2010;44(5):926-8 Bilgi N et al. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother. 2010;44(5):926-8
56.
Zurück zum Zitat Goey AKL et al. Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer Treat Rev. 2013;39(7):773-83 Goey AKL et al. Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer Treat Rev. 2013;39(7):773-83
57.
Zurück zum Zitat Hermann R et al. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med. 2012;78(13):1458-77 Hermann R et al. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med. 2012;78(13):1458-77
58.
Zurück zum Zitat Malati CY et al. Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. J Clin Pharmacol. 2012;52(6):932-9 Malati CY et al. Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. J Clin Pharmacol. 2012;52(6):932-9
59.
Zurück zum Zitat de Oliveira Campos MP et al. Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy. J Altern Complement Med. 2011;17(6):505-12 de Oliveira Campos MP et al. Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy. J Altern Complement Med. 2011;17(6):505-12
60.
Zurück zum Zitat da Costa Miranda et al. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study. J Altern Complement Med. 2009;15(4):431-3 da Costa Miranda et al. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study. J Altern Complement Med. 2009;15(4):431-3
61.
Zurück zum Zitat de Melo Sette CV et al. Purified Dry Paullinia cupana (PC-18) Extract for Chemotherapy-Induced Fatigue: Results of Two Double-Blind Randomized Clinical Trials. J Diet Suppl. 2018;15(5):673-83 de Melo Sette CV et al. Purified Dry Paullinia cupana (PC-18) Extract for Chemotherapy-Induced Fatigue: Results of Two Double-Blind Randomized Clinical Trials. J Diet Suppl. 2018;15(5):673-83
62.
Zurück zum Zitat Yonekura L et al. Bioavailability of catechins from guaraná (Paullinia cupana) and its effect on antioxidant enzymes and other oxidative stress markers in healthy human subjects. Food Funct. 2016;7(7):2970-8 Yonekura L et al. Bioavailability of catechins from guaraná (Paullinia cupana) and its effect on antioxidant enzymes and other oxidative stress markers in healthy human subjects. Food Funct. 2016;7(7):2970-8
63.
Zurück zum Zitat Basile A et al. Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart. J Ethnopharmacol. 2005;102(1):32-6 Basile A et al. Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart. J Ethnopharmacol. 2005;102(1):32-6
64.
Zurück zum Zitat Zhang WJ, Frei B. Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice. Mediators Inflamm. 2015;2015:274314 Zhang WJ, Frei B. Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice. Mediators Inflamm. 2015;2015:274314
65.
Zurück zum Zitat Guo Z et al. In vivo and in vitro immunmodulatory and anti-inflammatory effects of total flavonoids of Astragalus. Afr J Tradit Complement Altern Med. 2016;13(4):60-73 Guo Z et al. In vivo and in vitro immunmodulatory and anti-inflammatory effects of total flavonoids of Astragalus. Afr J Tradit Complement Altern Med. 2016;13(4):60-73
66.
Zurück zum Zitat Huang Y et al. Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9573291 Huang Y et al. Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9573291
67.
Zurück zum Zitat De Bock K et al. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14(3):298-307 De Bock K et al. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14(3):298-307
68.
Zurück zum Zitat Darbinyan V et al. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71 Darbinyan V et al. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71
69.
Zurück zum Zitat Olsson EM et al. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-12 Olsson EM et al. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-12
70.
Zurück zum Zitat Lin SSC et al. In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standardised solution and its major constituent, salidroside. Phytother Res. 2011;25(11):1604-11 Lin SSC et al. In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standardised solution and its major constituent, salidroside. Phytother Res. 2011;25(11):1604-11
71.
Zurück zum Zitat van Diermen D. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009;122(2):397-401 van Diermen D. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009;122(2):397-401
72.
Zurück zum Zitat Hellum BH et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med. 2010;76(4):331-8 Hellum BH et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med. 2010;76(4):331-8
73.
Zurück zum Zitat Spanakis M et al. Pharmacokinetic interaction between losartan and Rhodiola rosea in rabbits. Pharmacology. 2013;91(1-2):112-6 Spanakis M et al. Pharmacokinetic interaction between losartan and Rhodiola rosea in rabbits. Pharmacology. 2013;91(1-2):112-6
74.
Zurück zum Zitat Thu OK et al. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016;72(3):295-300 Thu OK et al. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016;72(3):295-300
75.
Zurück zum Zitat Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207-14 Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207-14
76.
Zurück zum Zitat David LA et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-63 David LA et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-63
77.
Zurück zum Zitat Helmink BA et al. The microbiome, cancer, and cancer therapy. Nat Med. 2019;25(3):377-388 Helmink BA et al. The microbiome, cancer, and cancer therapy. Nat Med. 2019;25(3):377-388
78.
Zurück zum Zitat Podolsky SH et al. Metchnikoff and the microbiome. Lancet. 2012;380(9856):1810-1 Podolsky SH et al. Metchnikoff and the microbiome. Lancet. 2012;380(9856):1810-1
79.
Zurück zum Zitat Kim D et al. The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. Exp Mol Med. 2017;49(5):e339 Kim D et al. The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. Exp Mol Med. 2017;49(5):e339
80.
Zurück zum Zitat Lakhan SE et al. Gut inflammation in chronic fatigue syndrome. Nutr Metab (Lond). 2010;7:79 Lakhan SE et al. Gut inflammation in chronic fatigue syndrome. Nutr Metab (Lond). 2010;7:79
81.
Zurück zum Zitat Frémont M et al. High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients. Anaerobe. 2013;22:50-6 Frémont M et al. High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients. Anaerobe. 2013;22:50-6
82.
Zurück zum Zitat Sheedy JR et al. Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo. 2009;23(4):621-8 Sheedy JR et al. Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo. 2009;23(4):621-8
83.
Zurück zum Zitat Logan AC et al. Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses. 2003;60(6):915-23 Logan AC et al. Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses. 2003;60(6):915-23
84.
Zurück zum Zitat Guest DD et al. Diet components associated with perceived fatigue in breast cancer survivors. Eur J Cancer Care (Engl). 2013;22(1):51-9 Guest DD et al. Diet components associated with perceived fatigue in breast cancer survivors. Eur J Cancer Care (Engl). 2013;22(1):51-9
85.
Zurück zum Zitat Groeger D et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325-39 Groeger D et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325-39
86.
Zurück zum Zitat Lee JY et al. Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: a double-blind, randomized, placebo-controlled trial. Dig Liver Dis. 2014;46(12):1126-32 Lee JY et al. Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: a double-blind, randomized, placebo-controlled trial. Dig Liver Dis. 2014;46(12):1126-32
87.
Zurück zum Zitat Frankel AE et al. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017;19(10):848-55 Frankel AE et al. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017;19(10):848-55
88.
Zurück zum Zitat Routy B et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359(6371):91-97 Routy B et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359(6371):91-97
89.
Zurück zum Zitat Matson V et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 2018;359(6371):104-8 Matson V et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 2018;359(6371):104-8
90.
Zurück zum Zitat Heshiki Y et al. Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome. 2020;8(1):28 Heshiki Y et al. Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome. 2020;8(1):28
Metadaten
Titel
Schwerpunkt Fatigue
Zusammenhänge zwischen Fatigue und Mikronährstoffen sowie Darmmikrobiom
verfasst von
Dr. med. Claudia Löffler
Publikationsdatum
16.11.2020
Verlag
Springer Medizin
Schlagwörter
Darmmikrobiom
Fatigue
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 11/2020
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-020-8273-3

Weitere Artikel der Ausgabe 11/2020

InFo Hämatologie + Onkologie 11/2020 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.