Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
DI-G carried out experimental work, analyzed the data and wrote the manuscript. Y-CC conducted experimental work and analyzed the data; NJ, CS, JB, ZS, and IP performed experiments. LE provided the TMA. PW performed immunohistochemical work and analyzed the results. BMK discussed the results, provided reagents and help to draft the manuscript. NY supervised animal experiments. AF-M designed, supervised and coordinated the study and wrote the manuscript. All authors read and approved the final manuscript.