Erschienen in:

Open Access 01.12.2016 | Erratum

Erratum to: Absorption, distribution and excretion of intravenously injected ⁶⁸Ge/⁶⁸Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

verfasst von: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs, Anne Roivainen

Erschienen in: EJNMMI Research | Ausgabe 1/2016

The online version of the original article can be found under doi:10.1186/s13550-015-0117-z.

The online version of the original article can be found at http://dx.doi.org/10.1186/s13550-015-0117-z.

Erratum

After publishing of the paper [1], substantial errors in Tables 4, 5, 6 and 7 have been noticed. The correct Tables 4, 5, 6 and 7 are presented here. Authors regret any inconvenience.

Table 4

Human residence times and radiation dose estimates for ⁶⁸Ga radioactivity extrapolated from the rat biodistribution data

Organ	Residence time (h)		Dose (mSv/MBq)
	Female rat data	Male rat data	Female rat data	Male rat data
Adrenals			0.01140	0.00931
Blood	0.2080	0.5000
Bone	0.6645	0.3089
Bone marrow	0.0907	0.0479
Brain	0.0348	0.0326	0.01800	0.01340
Breasts			0.00587	0.00615
Gallbladder wall			0.00955	0.00810
Heart wall	0.0208	0.0187	0.17400	0 30300
Kidneys	0.0196	0.0100	0.03850	0.01970
Liver	0.2526	0.2653	0.09720	0.07660
Lower large intestine wall			0.00319	0.00152
Lungs	0.3174	0.2770	0.18600	0.13400
Muscle	0.1014	0.1084	0.00729	0.00510
Osteogenic cells			0.11600	0.04310
Ovaries	0.0004		0.01880	0.00169
Pancreas	0.0019	0.0023	0.01870	0.01870
Red marrow			0.02250	0.01380
Skin			0.000292	0.00202
Small intestine			0.00388	0.00222
Spleen			0.00554	0.00412
Stomach wall			0.0565	0.00477
Testes		0.000028		0.00077
Thymus			0.01000	0.00139
Thyroid	0.0087	0.0095	0.22100	0.19800
Upper large intestine wall			0.00399	0.00268
Urinary bladder wall			0.00232	0.00106
Uterus	0.0137		0.007920	0.00142
Whole body			0.01770	0.01150
Effective dose			0.0483	0.0338

Table 5

Additional dosimetry estimates based on a female rat distribution data

	Absorbed dose per unit radioactivity administered (mSv/MBq)
Organ	15-year-old (50 kg)	10-year-old (30 kg)	5-year-old (17 kg)	1-year-old (10 kg)	Newborn (5 kg)
Adrenals	0.01120	0.01640	0.02380	0.04030	0.07820
Brain	0.01590	0.01760	0.02060	0.02920	0.06670
Breasts	0.00581	0.01100	0.01630	0.02690	0.05450
Gallbladder wall	0.00920	0.01270	0.02010	0.03900	0.07500
Heart wall	0.19400	0.30100	0.48300	0.87300	1.72000
Kidneys	0.04210	0.06000	0.08880	0.16000	0.41500
Liver	0.09740	0.14800	0.22000	0.42700	0.98900
Lower large intestine wall	0.00321	0.00504	0.00771	0.01330	0.02920
Lungs	0.22400	0.31900	0.49300	0.98400	2.71000
Muscle	0.00757	0.01310	0.03190	0.06220	0.09540
Osteogenic cells	0.11400	0.18400	0.31000	0.73500	2.35000
Ovaries	0.02030	0.05660	0.09880	0.22500	0.45900
Pancreas	0.002180	0.04060	0.05470	0.11200	0.34000
Red marrow	0.02560	0.04150	0.07770	0.17700	0.57100
Skin	0.00281	0.00435	0.00671	0.01220	0.02710
Small intestine	0.00386	0.00619	0.00986	0.01780	0.03760
Spleen	0.00562	0.00858	0.01300	0.02380	0.04920
Stomach wall	0.00559	0.00800	0.01330	0.02500	0.05020
Thymus	0.01020	0.01330	0.01900	0.02970	0.05700
Thyroid	0.29800	0.46000	1.02000	1.93000	2.63000
Upper large intestine wall	0.00389	0.00669	0.01040	0.01900	0.04250
Urinary bladder wall	0.00223	0.00377	0.00625	0.01100	0.02220
Uterus	0.08020	1.34000	2.03000	3.69000	1.47000
Total body	0.01780	0.02890	0.04680	0.09200	0.23400
Effective dose (mSv/MBq)	0.05740	0.12300	0.20900	0.41000	0.71700

Table 6

Additional dosimetry estimates based on a male rat distribution data

	Absorbed dose per unit radioactivity administered (mSv/MBq)
Organ	15-year-old (50 kg)	10-year-old (30 kg)	5-year-old (17 kg)	1-year-old (10 kg)	Newborn (5 kg)
Adrenals	0.01120	0.01650	0.02350	0.03770	0.07490
Brain	0.01370	0.01480	0.01700	0.02410	0.05630
Breasts	0.00743	0.01420	0.02130	0.03500	0.07250
Gallbladder wall	0.00960	0.01370	0.02130	0.04090	0.08030
Heart wall	0.39300	0.61100	0.98300	1.78000	3.4900
Kidneys	0.02410	0.03450	0.05100	0.09110	0.23100
Liver	0.10300	0.15700	0.23300	0.45000	1.04000
Lower large intestine wall	0.00197	0.00308	0.00506	0.00907	0.02040
Lungs	0.20000	0.28500	0.43900	0.87200	2.38000
Muscle	0.00739	0.01290	0.03260	0.06360	0.09610
Pancreas	0.02570	0.04800	0.06460	0.13100	0.40300
Red marrow	0.01540	0.02430	0.04410	0.09800	0.31100
Osteogenic cells	0.05580	0.09010	0.15100	0.35600	1.13000
Skin	0.00244	0.00362	0.00572	0.01030	0.02320
Small intestine	0.00287	0.00483	0.00796	0.01460	0.03090
Spleen	0.0327	0.0503	0.0801	0.1460	0.3780
Stomach wall	0.000657	0.00988	0.01530	0.02870	0.05600
Testes	0.00178	0.00745	0.00935	0.01380	0.02390
Thymus	0.01580	0.01940	0.02760	0.04170	0.07940
Thyroid	0.32500	0.50200	1.12000	2.1100	2.88000
Upper large intestine wall	0.00327	0.00581	0.00935	0.01820	0.03850
Urinary bladder wall	0.00129	0.00224	0.00393	0.00699	0.01520
Total body	0.01470	0.02370	0.03830	0.07480	0.19000
Effective dose (mSv/MBq)	0.05060	0.07560	0.13400	0.26000	0.55500

Table 7

Human effective doses of ⁶⁸Ga radiopharmaceuticals and ¹⁸F-FDG

Radiopharmaceutical	Effective dose (mSv/MBq)	Reference
⁶⁸Ga-DOTANOC	0.025	Pettinato 2008 [10]
⁶⁸Ga-DOTATOC	0.023	Hartmann 2009 [11]
⁶⁸Ga-DOTATATE	0.021	Sandström 2013 [12]
⁶⁸Ga-NOTA-2Rs15d	0.0218^a	Xavier 2013 [13]
BAY86-7548	0.051	Roivainen 2013 [14]
¹⁸F-FDG	0.0190	ICRP Publication 1998 [15]
⁶⁸Ga-eluate	0.0483^b, 0.0338^c	Present study

^aExtrapolated from tumour xenograft mice; ^bObtained by using female rat data; ^cObtained by using male rat data

Acknowledgements

The study was conducted within the Finnish Centre of Excellence in Cardiovascular and Metabolic Disease, supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Akademi University. This study was sponsored by Eckert & Ziegler Radiopharma GmbH, Berlin, Germany (conducted as part of preclinical studies), and further supported by a grant from the Academy of Finland (#258814). Helena Virtanen is a Ph.D. student financially supported by the Drug Research Doctoral Program, University of Turku Graduate School, Finland, and the Finnish Cultural Foundation. Aake Honkaniemi and Jouni Tuisku are thanked for their help in PET imaging.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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