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Erschienen in: Acta Neuropathologica 2/2016

01.02.2016 | Erratum

Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity

verfasst von: Ulrich Herrlinger, David T. W. Jones, Martin Glas, Elke Hattingen, Dorothee Gramatzki, Moritz Stuplich, Jörg Felsberg, Oliver Bähr, Gerrit H. Gielen, Matthias Simon, Dorothee Wiewrodt, Martin Schabet, Volker Hovestadt, David Capper, Joachim P. Steinbach, Andreas von Deimling, Peter Lichter, Stefan M. Pfister, Michael Weller, Guido Reifenberger

Erschienen in: Acta Neuropathologica | Ausgabe 2/2016

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Excerpt

The original version of this article contained errors in the alignment of several entries in Tables 4 and 5. The corrected Tables 4 and 5 are given below. The original article has been updated accordingly.
Table 4
Univariate and multivariate Cox regression analysis regarding overall survival and single genetic factors
 
Median survival in months
Risk ratio (lower–upper 95 % CI)
p
Condition 1
Condition 2
Condition 1 vs. condition 2
Univariate analysis
 MGMT promoter status
Methylated
Unmethylated
0.09 (0.02–0.44)
0.004
>37.1
8.9
 IDH/CIMP status
Mutant/positive
Wildtype/negative
0.31 (0.08–1.23)
0.08
36.3
14.1
 1p/19q status
Codeleted
Not codeleted
>16.5
34.8
0.44 (0.05–3.6)
0.44
 Chromosome 7 gain
Yes
No
6.32 (1.78–22.5)
0.004
8.98
>36.3
 EGFR amplification
Yes
No
10.1 (2.0–51.1)
0.005
7.9
36.3
 9p21 deletion
Yes
No
1.15 (0.33–4.0)
0.82
37.1
34.6
 Chromosome 10 deletion
Yes
No
2.6 (0.77–8.73)
0.12
12.2
36.3
 CDK4 amplification
Yes
No
0.52 (0.1–2.6)
0.42
36.2
34.6
 MDM2 or MDM4 amplification
Yes
No
1.06 (0.28–4.1)
0.93
14.1
34.6
Multivariate analysis
 MGMT promoter status
Methylated
Unmethylated
0.16 (0.03–0.95)
0.04
 IDH/CIMP status
Mutant/positive
Wildtype/negative
1.27 (0.14–11.6)
0.83
 Chromosome 7 gain
Yes
No
4.2 (0.49–36.3)
0.19
 EGFR amplification
Yes
No
3.0 (0.56–16.3)
0.20
Significant p values lower than 0.05 are in bold
Table 5
Univariate Cox regression analysis regarding the prognostic value MRI features for overall survival
MRI appearance
HR
95 % CI
p
Infratentorial involvement, yes vs. no
0.4
0.05–3.1
0.38
Involvement of 6 or more lobes, yes vs. no
1.08
0.33–3.5
0.9
Bilateral involvement, yes vs. no
0.67
0.08–5.4
0.71
Contrast enhancing lesionsa, yes vs. no
1.39
0.37–5.3
0.63
HR hazard ratio, CI confidence interval
aOn the first MRI fulfilling the criteria of GC
Metadaten
Titel
Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity
verfasst von
Ulrich Herrlinger
David T. W. Jones
Martin Glas
Elke Hattingen
Dorothee Gramatzki
Moritz Stuplich
Jörg Felsberg
Oliver Bähr
Gerrit H. Gielen
Matthias Simon
Dorothee Wiewrodt
Martin Schabet
Volker Hovestadt
David Capper
Joachim P. Steinbach
Andreas von Deimling
Peter Lichter
Stefan M. Pfister
Michael Weller
Guido Reifenberger
Publikationsdatum
01.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Acta Neuropathologica / Ausgabe 2/2016
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-015-1523-z

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