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Erschienen in:
01.08.2017 | Erratum
Erratum to: Managing the genomic revolution in cancer diagnostics
Erschienen in: Virchows Archiv | Ausgabe 2/2017
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Erratum to: Virchows Arch
Table 2
ᅟ
|
Clinical Laboratory
|
Test Name
|
Panel Details
|
Methodology/ Platform
|
Tumor/Normal Sequencing
|
Turnaround Time (TAT)
|
CPT® Code(s)
|
URL Source/Reference
|
|---|---|---|---|---|---|---|---|
|
Brigham and Women’s Hospital, Center for Advanced Molecular Diagnostics Boston, MA
|
OncoPanel
|
275 genes (full coding regions) plus selected intronic regions of 30 genes
|
Hybrid-capture, Illumina (HiSeq™)
|
Plans to implement in the future
|
3 weeks
|
Not specified
|
[12]
|
|
City of Hope Clinical Molecular Diagnostic Laboratory Duarte, CA
|
OncoMutations Panel
|
49 genes (mutation hotspots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
14 days
|
81,445, 88,381, G0452
|
|
|
OncoComplete (OncoMutations PLUS OncoFusions)
|
49 genes (mutation hotspots), fusion transcripts for 53 genes
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
14 days
|
81,445, 81,479, 88,381, G0452(×2)
|
||
|
Columbia University Laboratory for Personalized Genomic Medicine New York, NY
|
TruSeq Targeted Cancer Panel
|
48 genes
|
Amplicon-based, Illumina (TruSeq®)
|
No
|
30 days
|
81,445, 88,381
|
|
|
Combined Cancer Panel (CCCP)
|
467 genes (393-exons only; 74-whole genes)
|
Amplicon-based, Illumina (TruSeq®)
|
No
|
30 days
|
81,455, 88,381
|
||
|
Duke University Health System Durham, NC
|
Solid Tumor Hotspot NGS Panel
|
50 genes (mutation hotspots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
14 days
|
81,445
|
|
|
Emory University Molecular Diagnostics Lab Atlanta, GA
|
Cancer Mutation Panel 26 (CMP26)
|
26 genes (whole-exon coverage)
|
Amplicon-based, Illumina (TruSight® Tumor 26)
|
No
|
7–10 days
|
81,445, G0452
|
|
|
Jefferson Cancer Genomics Laboratory Philadelphia, PA
|
Ion Ampliseq™ Cancer Panel
|
50 genes
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
14 days
|
Not specified
|
|
|
Johns Hopkins Molecular Diagnostics Laboratory Baltimore, MD
|
50 Gene Panel
|
50 genes (mutation hotpots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
10–14 days
|
81,445
|
|
|
Massachusetts General Hospital, Center for Integrated Diagnostics Boston, MA
|
NGS SNaPshot
|
39 genes (mutation hotspots)
|
Primer single-base extension, SNaPShot™ methodology
|
No
|
3 weeks
|
Not specified
|
|
|
Memorial Sloan Kettering Cancer Center New York, NY
|
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT™)
|
410 genes, 17 rearrangements
|
Hybrid-capture, Illumina (HiSeq™)
|
Yes
|
Not specified
|
Not specified
|
[34]
|
|
New York Presbyterian Hospital/Weill Cornell Molecular Pathology Laboratory New York, NY
|
Cancer Gene Mutation Panel-50 (CGMP-50)
|
50 genes (mutation hotspots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
7–10 days
|
81,445
|
|
|
Oregon Health & Science University, Knight Diagnostic Laboratories Portland, OR
|
GeneTrails® Comprehensive Solid Tumor Panel
|
124 genes
|
Amplicon-based, Illumina (NextSeq™)
|
No
|
14 days
|
81,455
|
|
|
GeneTrails® Solid Tumor Fusion Gene Panel
|
fusions in 20 target genes, gene expression for 8 genes
|
Next generation RNA sequencing, confirmation by FISH
|
No
|
14–17 days
|
81,455
|
||
|
Stanford Molecular Pathology Laboratory Palo Alto, CA
|
Solid Tumor Actionable Mutation Panel (STAMP)
|
130 genes (either in part or fully)
|
Hybrid-capture, Illumina (MiSeq™)
|
No
|
28 days
|
81,455
|
|
|
Cancer Somatic Mutation Panel, Non-Blood
|
48 genes (targeted regions and hotspot mutations)
|
Hybrid-capture, Illumina (MiSeq™); primer single-base extension, SNaPShot™ methodology for 2 genes
|
No
|
28 days
|
81,445
|
||
|
The Ohio State University Wexner Medical Center Molecular Pathology Laboratory Columbus, OH
|
Lung Cancer Mutation Panel (PULMOL)
|
26 genes (commonly mutated regions)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
Not specified
|
81,445, G0452
|
|
|
Colon Cancer Mutation Panel (COLMOL)
|
26 genes (commonly mutated regions)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
Not specified
|
81,445, G0452
|
||
|
UC San Diego Health, Center for Advanced Laboratory Medicine, Clinical Genomics Laboratory San Diego, CA
|
Comprehensive NGS Solid Tumor Mutation Panel
|
397 genes (all exons), transcripts for 28 genes
|
NGS
|
Yes
|
16 days
|
Not specified
|
|
|
UC San Francisco Clinical Cancer Genomics Laboratory San Francisco, CA
|
UCSF500 Cancer Gene Panel
|
~500 genes (including select introns), fusions involving 42 genes
|
Hybrid-capture, Illumina (HiSeq™)
|
Yes
|
3–4 weeks
|
Not specified
|
|
|
University of Chicago Molecular Pathology Laboratory Chicago, IL
|
OncoPlus Universal Cancer Mutation Analysis Panel
|
147 clinically reported genes, fusions in ALK, RET, ROS1
|
Hybrid-capture, Illumina (HiSeq™)
|
No
|
14–20 days
|
81,455
|
|
|
University of Nebraska Medical Center Regional Pathology Services Omaha, NE
|
50 Gene Panel
|
50 genes (mutation hotpots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
10–14 days
|
Not specified
|
|
|
University of Pennsylvania, Center for Personalized Diagnostics Philadelphia, PA
|
Comprehensive Solid Tumor Panel
|
153 genes (mutation hotspots)
|
Amplicon-based, Agilent HaloplexHS enrichment, Illumina (MiSeq™)
|
No
|
≤ 21 days
|
Not specified
|
|
|
University of Pittsburgh Medical Center Molecular & Genomic Pathology Laboratory Pittsburgh, PA
|
OncoSeq
|
28 genes (mutation hotspots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
7 days
|
Not specified
|
|
|
Personalized Cancer Mutation Panel
|
50 genes (targeted regions)
|
Amplicon-based, Ion AmpliSeq™ technology
|
Yes, for LOH and MSI analyses
|
7–14 days
|
Not specified
|
||
|
University of Texas MD Anderson Cancer Center Houston, TX, USA
|
Ion Torrent AmpliSeq™ Cancer Panel
|
46 genes (mutation hotspots)
|
Amplicon-based, Ion AmpliSeq™ technology
|
No
|
Not specified
|
Not specified
|
[32]
|
|
University of Texas Southwestern Medical Center, Veripath Laboratory Dallas, TX
|
Cancer Mutation 50-Gene Panel
|
50 genes
|
Amplicon-based, Ion Torrent PGM™
|
No
|
< 20 days
|
81,455, 88,381
|
|
|
University of Washington Medical Center Genetics Laboratory Seattle, WA
|
UW-OncoPlex™
|
262 genes (select regions and introns)
|
Hybrid-capture, Illumina (HiSeq™, MiSeq™)
|
No
|
4–6 weeks
|
81,455 (88,381 if applicable)
|
|
|
Washington University Genomics and Pathology Services St. Louis, MO
|
Solid Tumor Gene Set
|
65 genes (all coding region and select introns)
|
Hybrid-capture, Illumina (HiSeq™)
|
No
|
3 weeks
|
81,455
|