Erratum
Abstract
Introduction
Material and methods
Study design and setting
Overall Mortality, n (%) | ||||
---|---|---|---|---|
Specialty/Department |
n (%) | Duration of admission in days (mean) | 7-days | 90-days |
Emergency Department | 570 (36.7) | 0.3 | 119 (20.9) | 193 (33.9) |
General Internal Medicine | 160 (10.3) | 8.7 | 50 (31.3) | 77 (48.1) |
Cardiology | 143 (9.2) | 5.5 | 40 (28.0) | 64 (44.8) |
Gastroenterology | 128 (8.2) | 8.5 | 26 (20.3) | 43 (33.6) |
Geriatriology | 111 (7.2) | 10.4 | 23 (20.7) | 63 (56.8) |
General Surgery | 95 (7.2) | 9.2 | 22 (23.2) | 45 (47.4) |
Orthopedic Surgery | 53 (3.4) | 14.2 | 9 (17.0) | 19 (35.9) |
Pulmonology | 52 (3.4) | 10.2 | 14 (26.9) | 25 (48.1) |
Endocrinology | 46 (3.0) | 7.1 | 10 (21.7) | 21 (45.7) |
Infectious Diseases | 48 (3.1) | 9.8 | 12 (25.0) | 22 (45.8) |
Heart, Pulmonary and vascular Surgery | 39 (2.5) | 8.5 | 16 (41.0) | 21 (53.9) |
Neurology | 40 (2.6) | 18.8 | 9 (22.5) | 13 (32.5) |
Nephrology | 16 (1.0) | 3.5 | 7 (43.8) | 10 (62.5) |
Hematology | 9 (0.6) | 14.6 | 1 (11.1) | 3 (33.3) |
Rheumatology | 9 (0.6) | 14.4 | 0 (0.0) | 4 (44.4) |
Oncology | 8 (0.5) | 6.8 | 2 (25.0) | 4 (50.0) |
Urology | 8 (0.5) | 9.1 | 1 (12.5) | 4 (50.0) |
Otorhinolaryngology | 6 (0.4) | 5.7 | 0 (0.0) | 0 (0.0) |
Neurosurgery | 4 (0.3) | 15.0 | 1 (25.0) | 2 (50.0) |
Plastic Surgery | 5 (0.3) | 17.2 | 0 (0.0) | 2 (40.0) |
Hospice | 3 (0.2) | 28.0 | 0 (0.0) | 3 (100.0) |
Total | 1553 (100.0) | 6.0 | 362 (23.3) | 638 (41.1) |
MECU, n (%)* | Overall Mortality, n (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Specialty/Department | ED contacts, n (%) | Prehospital contacts, n (%) | Intravenous fluid therapy | Intravenous vasopressor therapy | Mechanical ventilation | Cardiac arrest | ICU admission, n (%) | 7-days | 90-days |
Emergency Department | 193 (26.1) | 35 (18.1) | 14 (7.3) | 9 (4.7) | 10 (5.2) | 4 (2.1) | 9 (4.7) | 44 (22.7) | 65 (33.7) |
General Internal Medicine | 36 (4.9) | 2 (5.6) | 1 (2.8) | 0 (0.0) | 1 (2.8) | 1 (2.8) | 14 (38.9) | 10 (27.8) | 14 (38.9) |
Cardiology | 73 (9.9) | 17 (23.3) | 11 (15.1) | 11 (15.1) | 11 (15.1) | 10 (12.3) | 19 (26.0) | 22 (30.1) | 35 (47.9) |
Gastroenterology | 67 (9.1) | 9 (13.4) | 7 (10.5) | 2 (3.0) | 3 (4.5) | 0 (0.0) | 15 (22.4) | 13 (19.4) | 25 (37.3) |
Geriatriology | 75 (10.1) | 16 (21.3) | 5 (6.7) | 2 (2.7) | 5 (6.7) | 2 (2.7) | 3 (4.0) | 15 (20.0) | 42 (56.0) |
General Surgery | 53 (7.2) | 5 (9.4) | 3 (5.7) | 1 (1.9) | 1 (1.9) | 1 (1.9) | 18 (34.0) | 14 (26.4) | 27 (50.0) |
Orthopedic Surgery | 34 (4.6) | 4 (11.8) | 3 (8.8) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 8 (23.5) | 6 (17.1) | 13 (38.2) |
Pulmonology | 52 (7.0) | 12 (23.1) | 11 (21.2) | 5 (9.6) | 6 (11.5) | 2 (3.9) | 15 (28.9) | 14 (26.9) | 25 (48.1) |
Endocrinology | 27 (3.6) | 1 (3.7) | 1 (3.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (11.1) | 2 (7.4) | 8 (29.6) |
Infectious Diseases | 48 (6.5) | 18 (37.5) | 9 (18.8) | 5 (10.4) | 6 (12.5) | 1 (2.1) | 26 (54.2) | 12 (25.0) | 22 (45.8) |
Heart, Pulmonary and vascular Surgery | 20 (2.7) | 4 (20.0) | 3 (15.0) | 2 (10.0) | 2 (10.0) | 0 (0.0) | 9 (45.0) | 8 (40.0) | 9 (45.0) |
Neurology | 17 (2.3) | 8 (47.1) | 4 (23.5) | 3 (17.7) | 2 (11.8) | 0 (0.0) | 7 (41.2) | 1 (5.9) | 2 (11.8) |
Nephrology | 12 (1.6) | 1 (8.3) | 1 (8.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (33.3) | 6 (50.0) | 8 (66.7) |
Hematology | 4 (0.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 0 (0.0) | 0 (0.0) |
Rheumatology | 9 (1.2) | 1 (11.1) | 1 (11.1) | 0 (0.0) | 1 (11.1) | 0 (0.0) | 2 (22.2) | 0 (0.0) | 4 (44.4) |
Oncology | 6 (0.8) | 2 (33.3) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 2 (33.3) | 4 (66.7) |
Urology | 2 (0.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) |
Otorhinolaryngology | 5 (0.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (20.0) | 0 (0.0) | 0 (0.0) |
Neurosurgery | 4 (0.5) | 3 (80.0) | 4 (75.0) | 1 (25.0) | 2 (50.0) | 1 (25.0) | 4 (100.0) | 1 (25.0) | 2 (50.0) |
Plastic Surgery | 2 (0.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) |
Hospice | 1 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) |
Total | 740 (100.0) | 138 (18.6) | 78 (10.5) | 41 (5.5) | 52 (6.8) | 21 (2.8) | 159 (21.5) | 180 (24.3) | 308 (41.6) |
Participants
Data sources and processing
Database
Population-based registers
The Danish National Patient Registry
Outcome measures, exposure and possible confounders
Statistical analysis
Incidence rates
All-cause mortality analysis
Ethics committee approval
Results
Participants
Variable | Total (%) |
---|---|
N (%) | 1553 (100) |
Age in years, Median (IQR) | 70 (56–81) |
Sex (%) | |
Male | 830 (53.4) |
Female | 723 (46.6) |
Age in age groups, yr. (%) | |
18–39 | 147 (9.5) |
40–64 | 468 (30.1) |
65–84 | 691 (44.5) |
85+ | 247 (15.9) |
Charlson Comorbidity Index (%) | |
0 | 477 (30.7) |
1 | 589 (37.9) |
> 2 | 487 (31.4) |
Vital variables | |
Systolic blood pressure, Median (IQR) | 88 (80–94) |
Diastolic blood pressure, Median (IQR) | 52 (44–62) |
Heart rate, Median (IQR) | 101 (88–115) |
Shock Index (SI), n (%) | |
SI, Median (IQR) | 1.2 (1.0–1.4) |
SI ≤ 0.7 | 68 (4.5) |
0.7 > SI ≤1 | 204 (13.4) |
SI >1.0 | 1245 (82.1) |
Number of organ failures, n (%) | |
1 | 1160 (74.7) |
2 | 311 (20.0) |
3+ | 82 (5.3) |
Site of organ failure (%) | |
Cardiovascular | 1245 (80.2) |
Renal | 333 (21.4) |
Coagulation | 387 (24.9) |
Hepatic | 72 (4.6) |
Incidence of shock
Mortality among patients with shock
Prognostic factors of death among patients with shock
0–7 days | 8–90 days | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
N, total (%) |
N, died (%) | Crude HR (95% CI) |
p Value | Adjusted HR (95% CI)* |
p Value |
N, died (%) | Crude HR (95% CI) |
p Value | Adjusted HR (95% CI)* |
p Value | |
Gender | |||||||||||
Female (reference) | 723 (46.6%) | 162 (22.4) | 1 | 1 | 129 (17.8) | 1 | 1 | ||||
Male | 830 (53.4%) | 200 (24.1) | 1.10 (0.90–1.35) | 0.391 | 1.08 (0.87–1.33) | 0.496 | 147 (17.7) | 1.01 (0.80–1.28) | 0.928 | 1.00 (0.79–1.27) | 0.994 |
Age (continous) | 1.03 (1.03–1.04) | <0.001 | 1.03 (1.03–1.04) | <0.001 | 1.04 (1.04–1.05) | <0.001 | 1.04 (1.03–1.05) | <0.001 | |||
Comorbidity level | |||||||||||
0 (reference) | 477 (30.7%) | 92 (19.3) | 1 | 1 | 50 (13.0) | 1 | 1 | ||||
1 to 2 | 589 (37.9%) | 125 (21.2) | 1.11 (0.85–1.46) | 0.436 | 0.87 (0.66–1.14) | 0.304 | 102 (22.3) | 1.79 (1.28–2.51) | 0.001 | 1.31 (0.93–1.84) | 0.121 |
> 2 | 487 (31.4%) | 145 (29.8) | 1.61 (1.24–2.09) | <0.001 | 1.19 (0.91–1.55) | 0.204 | 124 (36.9) | 3.26 (2.34–4.53) | <0.001 | 2.23 (1.60–3.11) | <0.001 |
Number of organ failures | |||||||||||
1 (reference) | 1160 (74.7%) | 210 (18.1) | 1 | 1 | 194 (16.7) | 1 | 1 | ||||
2 | 311 (20.0%) | 113 (36.3) | 2.20 (1.75–2.76) | <0.001 | 2.09 (1.66–2.63) | <0.001 | 70 (22.5) | 1.90 (1.45–2.50) | <0.001 | 1.90 (1.45–2.50) | <0.001 |
3+ | 82 (5.3%) | 39 (47.6) | 3.14 (2.23–4.42) | <0.001 | 3.30 (2.33–4.66) | <0.001 | 20 (24.4) | 1.44 (0.81–2.58) | 0.218 | 1.50 (0.83–2.68) | 0.180 |