The online version of this article (doi:10.1186/1475-2840-11-116) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
PH wrote the manuscript. JS contributed to discussion and reviewed and edited the manuscript. HK performed the statistical analyses and reviewed and edited the manuscript. PM contributed the discussion and reviewed and edited the manuscript. MV researched data, contributed to discussion and reviewed and edited manuscript. All authors read and approved the final manuscript.
Increased ferritin concentrations are associated with metabolic syndrome (MetS). The association between ferritin as well as hemoglobin level and individual MetS components is unclear. Erythropoietin levels in subjects with MetS have not been determined previously. The aim of this study was to compare serum erythropoietin, ferritin, haptoglobin, hemoglobin, and transferrin receptor (sTFR) levels between subjects with and without MetS and subjects with individual MetS components.
A population based cross-sectional study of 766 Caucasian, middle-aged subjects (341 men and 425 women) from five age groups born in Pieksämäki, Finland who were invited to a health check-up in 2004 with no exclusion criteria. Laboratory analyzes of blood samples collected in 2004 were done during year 2010. MetS was defined by National Cholesterol Education Program criteria.
159 (53%) men and 170 (40%) women of study population met MetS criteria. Hemoglobin and ferritin levels as well as erythropoietin and haptoglobin levels were higher in subjects with MetS (p < 0.001, p = 0.018). sTFR level did not differ significantly between subjects with or without MetS. Hemoglobin level was significantly higher in subjects with any of the MetS components (p < 0.001, p = 0.002). Ferritin level was significantly higher in subjects with abdominal obesity or high TG or elevated glucose or low high density cholesterol component (p < 0.001, p = 0.002, p = 0.02). Erythropoietin level was significantly higher in subjects with abdominal obesity component (p = 0.015) but did not differ significantly between subjects with or without other MetS components. Haptoglobin level was significantly higher in subjects with blood pressure or elevated glucose component o MetS (p = 0.028, p = 0.025).
Subjects with MetS have elevated hemoglobin, ferritin, erythropoietin and haptoglobin concentrations. Higher hemoglobin levels are related to all components of MetS. Higher ferritin levels associate with TG, abdominal obesity, elevated glucose or low high density cholesterol. Haptoglobin levels associate with blood pressure or elevated glucose. However, erythropoietin levels are related only with abdominal obesity. Higher serum erythropoietin concentrations may suggest underlying adipose tissue hypoxemia in MetS.
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Lecube A, Hernandez C, Pelegri D, Simo R: Factors accounting for high ferritin levels in obesity. Int J Obes (Lond). 2008, 32 (11): 1665-1669. 10.1038/ijo.2008.154. CrossRef
Jelkmann W: Erythropoietin: structure, control of production, and function. Physiol Rev. 1992, 72 (2): 449-489. PubMed
Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, Rood JC, Burk DH, Smith SR: Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes. 2009, 58 (3): 718-725. PubMedCentralCrossRefPubMed
Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC: International Diabetes Federation Task Force on Epidemiology and Prevention, Hational Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009, 120 (16): 1640-1645. 10.1161/CIRCULATIONAHA.109.192644. CrossRefPubMed
Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, Coupaye M, Pelloux V, Hugol D, Bouillot JL, Bouloumie A, Barbatelli G, Cinti S, Svensson PA, Barsh GS, Zucker JD, Basdevant A, Langin D, Clement K: Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005, 54 (8): 2277-2286. 10.2337/diabetes.54.8.2277. CrossRefPubMed
Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kiyama M, Kitamura A, Sato S, Shimamoto T, Konishi M, Iso H, CIRCS Investigators: Nocturnal intermittent hypoxia and metabolic syndrome; the effect of being overweight: the CIRCS study. J Atheroscler Thromb. 2010, 17 (4): 369-377. 10.5551/jat.3319. CrossRefPubMed
Cahan C, Decker MJ, Arnold JL, Goldwasser E, Strohl KP: Erythropoietin levels with treatment of obstructive sleep apnea. J Appl Physiol. 1995, 79 (4): 1278-1285. PubMed
Calvin AD, Somers VK, Steensma DP, Rio Perez JA, van der Walt C, Fitz-Gibbon JM, Scott CG, Olson LJ: Advanced heart failure and nocturnal hypoxaemia due to central sleep apnoea are associated with increased serum erythropoietin. Eur J Heart Fail. 2010, 12 (4): 354-359. 10.1093/eurjhf/hfq005. PubMedCentralCrossRefPubMed
Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, Ballantyne CM, Hoogeveen RC, Harris ZL, Pankow JS: A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol. 2007, 165 (9): 1047-1054. 10.1093/aje/kwk093. CrossRefPubMed
Zuliani G, Volpato S, Galvani M, Ble A, Bandinelli S, Corsi AM, Lauretani F, Maggio M, Guralnik JM, Fellin R, Ferrucci L: Elevated C-reactive protein levels and metabolic syndrome in the elderly: the role of central obesity data from the InChianti study. Atherosclerosis. 2009, 203: 626-632. 10.1016/j.atherosclerosis.2008.07.038. PubMedCentralCrossRefPubMed
Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y: Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology. 2006, 131 (3): 788-796. 10.1053/j.gastro.2006.07.007. CrossRefPubMed
Chiellini C, Santini F, Marsili A, Berti P, Bertacca A, Pelosini C, Scartabelli G, Pardini E, Lopez-Soriano J, Centoni R, Ciccarone AM, Benzi L, Vitti P, Del Prato S, Pinchera A, Maffei M: Serum haptoglobin: a novel marker of adiposity in humans. J Clin Endocrinol Metab. 2004, 89 (6): 2678-2683. 10.1210/jc.2003-031965. CrossRefPubMed
Skikne BS, Flowers CH, Cook JD: Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990, 75 (9): 1870-1876. PubMed
Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, Braunschweig C: Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring). 2010, 18 (7): 1449-1456. 10.1038/oby.2009.319. CrossRef
- Erythropoietin, ferritin, haptoglobin, hemoglobin and transferrin receptor in metabolic syndrome: a case control study
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