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Virchows Archiv

Erschienen in:

15.10.2017 | Invited Annual Review Issue

Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges

verfasst von: Melanie E. Johncilla, Amitabh Srivastava

Erschienen in: Virchows Archiv | Ausgabe 1/2018

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Abstract

There has been much progress in our understanding of esophageal inflammatory disorders in the past few years. This is particularly true about esophageal eosinophilia and PPI responsiveness, lymphocytic esophagitis and motility disorders, and short-term risk of neoplasia in esophageal leukoplakia. The current review will summarize esophageal injury patterns that primarily occur due to non-reflux causes, with a focus on usual pitfalls in biopsy diagnosis and recent advances in our knowledge of the more common forms of esophagitis.

Wishingrad M (1999) Sexually transmitted esophagitis: primary herpes simplex virus type 2 infection in a healthy man. Gastrointest Endosc 50(6):845–846PubMedCrossRef

Maiorana A et al (2003) Human cytomegalovirus infection of the gastrointestinal tract in apparently immunocompetent patients. Hum Pathol 34(12):1331–1336PubMedCrossRef

Chen Z, Scudiere JR, Montgomery E (2009) Medication-induced upper gastrointestinal tract injury. J Clin Pathol 62(2):113–119PubMedCrossRef

Parfitt JR, Driman DK (2007) Pathological effects of drugs on the gastrointestinal tract: a review. Hum Pathol 38(4):527–536PubMedCrossRef

Abraham SC, Yardley JH, Wu TT (1999) Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity. Am J Surg Pathol 23(10):1241–1247PubMedCrossRef

Lee FD (1994) Drug-related pathological lesions of the intestinal tract. Histopathology 25(4):303–308PubMedCrossRef

Boyce HW Jr (1998) Drug-induced esophageal damage: diseases of medical progress. Gastrointest Endosc 47(6):547–550PubMedCrossRef

Graham DY (2002) What the gastroenterologist should know about the gastrointestinal safety profiles of bisphosphonates. Dig Dis Sci 47(8):1665–1678PubMedCrossRef

de Groen PC et al (1996) Esophagitis associated with the use of alendronate. N Engl J Med 335(14):1016–1021PubMedCrossRef

10.

Abraham SC et al (1999) Alendronate-associated esophageal injury: pathologic and endoscopic features. Mod Pathol 12(12):1152–1157PubMed

11.

Millar AJ, Cox SG (2015) Caustic injury of the oesophagus. Pediatr Surg Int 31(2):111–121PubMedCrossRef

12.

Uygun I et al (2012) Clinico-epidemiological study of caustic substance ingestion accidents in children in Anatolia: the DROOL score as a new prognostic tool. Acta Chir Belg 112(5):346–354PubMedCrossRef

13.

Kay M, Wyllie R (2009) Caustic ingestions in children. Curr Opin Pediatr 21(5):651–654PubMedCrossRef

14.

Riffat F, Cheng A (2009) Pediatric caustic ingestion: 50 consecutive cases and a review of the literature. Dis Esophagus 22(1):89–94PubMedCrossRef

15.

Purdy JK, Appelman HD, McKenna BJ (2012) Sloughing esophagitis is associated with chronic debilitation and medications that injure the esophageal mucosa. Mod Pathol 25(5):767–775PubMedCrossRef

16.

Carmack SW et al (2009) Esophagitis dissecans superficialis (“sloughing esophagitis”): a clinicopathologic study of 12 cases. Am J Surg Pathol 33(12):1789–1794PubMedCrossRef

17.

Trabulo D et al (2015) Esophageal stenosis with sloughing esophagitis: a curious manifestation of graft-vs-host disease. World J Gastroenterol 21(30):9217–9222PubMedPubMedCentralCrossRef

18.

Baum S, Sakka N, Artsi O et al (2014 Apr-May) Diagnosis and classification of autoimmune blistering diseases. Autoimmun Rev 13(4–5):482–489PubMedCrossRef

19.

Goldberg NS, Weiss SS (1989 Nov) Pemphigus vulgaris of the esophagus in women. J Am Acad Dermatol 21(5 Pt 2):1115–1118PubMedCrossRef

20.

Ahmadi B, DePasquale JR (2003) Esophageal bullous pemphigoid. Am J Gastroenterol 98:S214–S215

21.

Chang S, Park SJ, Kim SW et al (2014 Sep) Esophageal involvement of Pemphigus vulgaris associated with upper gastrointestinal bleeding. Clin Endosc 47(5):452–454PubMedPubMedCentralCrossRef

22.

Kia L, Hirano I (2015) Distinguishing GERD from eosinophilic oesophagitis: concepts and controversies. Nat Rev Gastroenterol Hepatol 12(7):379–386PubMedPubMedCentralCrossRef

23.

Liacouras CA et al (2011) Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 128(1):3–20 e6 quiz 21-2PubMedCrossRef

24.

Straumann A et al (2012) Pediatric and adult eosinophilic esophagitis: similarities and differences. Allergy 67(4):477–490PubMedCrossRef

25.

Furuta GT et al (2007) Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 133(4):1342–1363PubMedCrossRef

26.

Molina-Infante J et al (2011) Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin Gastroenterol Hepatol 9(2):110–117PubMedCrossRef

27.

Wen T et al (2015) Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation. J Allergy Clin Immunol 135(1):187–197PubMedCrossRef

28.

Dellon ES et al (2013) Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study. Am J Gastroenterol 108(12):1854–1860PubMedPubMedCentralCrossRef

29.

Moawad FJ et al (2013) Randomized controlled trial comparing aerosolized swallowed fluticasone to esomeprazole for esophageal eosinophilia. Am J Gastroenterol 108(3):366–372PubMedCrossRef

30.

Molina-Infante J et al (2014) Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression. Aliment Pharmacol Ther 40(8):955–965PubMedCrossRef

31.

Iwakura N et al (2015) Basophil infiltration in eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia. Aliment Pharmacol Ther 41(8):776–784PubMedCrossRef

32.

Warners MJ et al (2015) PPI-responsive esophageal eosinophilia cannot be distinguished from eosinophilic esophagitis by endoscopic signs. Eur J Gastroenterol Hepatol 27(5):506–511PubMedCrossRef

33.

Hirano I et al (2013) Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut 62(4):489–495PubMedCrossRef

34.

Collins MH (2014) Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Gastroenterol Clin N Am 43(2):257–268CrossRef

35.

Sayej WN et al (2009) Treatment with high-dose proton pump inhibitors helps distinguish eosinophilic esophagitis from noneosinophilic esophagitis. J Pediatr Gastroenterol Nutr 49(4):393–399PubMedCrossRef

36.

Isomoto H et al (2004) Mucosal concentrations of proinflammatory cytokines and chemokines at gastric cardia: implication of Helicobacter pylori infection and gastroesophageal reflux. Am J Gastroenterol 99(6):1063–1068PubMedCrossRef

37.

Wen T et al (2013) Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology 145(6):1289–1299PubMedCrossRef

38.

Peterson KA et al (2010) Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis. Dig Dis Sci 55(5):1313–1319PubMedCrossRef

39.

Lucendo AJ, Arias A, and Molina-Infante J (2016) Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol 14(1): p. 13-22 e1PubMedCrossRef

40.

Rubio CA, Sjodahl K, Lagergren J (2006) Lymphocytic esophagitis: a histologic subset of chronic esophagitis. Am J Clin Pathol 125(3):432–437PubMedCrossRef

41.

Haque S, Genta RM (2012) Lymphocytic oesophagitis: clinicopathological aspects of an emerging condition. Gut 61(8):1108–1114PubMedCrossRef

42.

Purdy JK et al (2008) Lymphocytic esophagitis: a chronic or recurring pattern of esophagitis resembling allergic contact dermatitis. Am J Clin Pathol 130(4):508–513PubMedCrossRef

43.

Xue Y et al (2015) Lymphocytic esophagitis with CD4 T-cell-predominant intraepithelial lymphocytes and primary esophageal motility abnormalities: a potential novel clinicopathologic entity. Am J Surg Pathol 39(11):1558–1567PubMedCrossRef

44.

Rubio CA, Ichiya T, Schmidt PT (2017 Mar) Lymphocytic oesophagitis, eosinophilic oesophagitis and compound lymphocytic-eosinophilic oesophagitis I: histological and immunohistochemical findings. J Clin Pathol 70(3):208–216PubMedCrossRef

45.

Ebach DR et al (2011) Lymphocytic esophagitis: a possible manifestation of pediatric upper gastrointestinal Crohn’s disease. Inflamm Bowel Dis 17(1):45–49PubMedCrossRef

46.

Sutton LM et al (2014) Lymphocytic esophagitis in children. Inflamm Bowel Dis 20(8):1324–1328PubMedCrossRef

47.

Cohen S et al (2012) Lymphocytic esophagitis: a diagnosis of increasing frequency. J Clin Gastroenterol 46(10):828–832PubMedPubMedCentralCrossRef

48.

Basseri B et al (2013) Evaluation of peripapillary lymphocytosis and lymphocytic esophagitis in adult inflammatory bowel disease. Gastroenterol Hepatol (N Y) 9(8):505–511

49.

Putra J et al (2016) Lymphocytic esophagitis in nonachalasia primary esophageal motility disorders: improved criteria, prevalence, strength of association, and natural history. Am J Surg Pathol 40(12):1679–1685PubMedPubMedCentralCrossRef

50.

Zerbib F, Roman S (2015) Current therapeutic options for esophageal motor disorders as defined by the Chicago Classification. J Clin Gastroenterol 49(6):451–460PubMedCrossRef

51.

Scully C, el-Kom M (1985) Lichen planus: review and update on pathogenesis. J Oral Pathol 14(6):431–458PubMedCrossRef

52.

Lund WS (1976) Treatment of superficial lesions of the mouth and pharynx. J Laryngol Otol 90(1):105–112PubMedCrossRef

53.

Abraham SC et al (2000) Esophageal lichen planus: case report and review of the literature. Am J Surg Pathol 24(12):1678–1682PubMedCrossRef

54.

Chryssostalis A et al (2008) Esophageal lichen planus: a series of eight cases including a patient with esophageal verrucous carcinoma. A case series. Endoscopy 40(9):764–768PubMedCrossRef

55.

Quispel R et al (2009) High prevalence of esophageal involvement in lichen planus: a study using magnification chromoendoscopy. Endoscopy 41(3):187–193PubMedCrossRef

56.

Salaria SN et al (2013) Lichenoid esophagitis: clinicopathologic overlap with established esophageal lichen planus. Am J Surg Pathol 37(12):1889–1894PubMedCrossRef

57.

Katzka DA et al (2010) Variations in presentations of esophageal involvement in lichen planus. Clin Gastroenterol Hepatol 8(9):777–782PubMedCrossRef

58.

Silverman S Jr, Gorsky M, Lozada-Nur F (1985) A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association. Oral Surg Oral Med Oral Pathol 60(1):30–34PubMedCrossRef

59.

Silverman S Jr et al (1991) A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 72(6):665–670PubMedCrossRef

60.

Briggs GW (1961) Amyloidosis. Ann Intern Med 55:943–957PubMedCrossRef

61.

Tada S et al (1990) Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest Endosc 36(1):10–14PubMedCrossRef

62.

Costigan DJ, Clouse RE (1983) Achalasia-like esophagus from amyloidosis. Successful treatment with pneumatic bag dilatation. Dig Dis Sci 28(8):763–765PubMedCrossRef

63.

Lazaraki G et al (2009) A rare case of multiple myeloma initially presenting with pseudoachalasia. Dis Esophagus 22(6):E21–E24PubMedCrossRef

64.

Rubinow A et al (1983) Esophageal manometry in systemic amyloidosis. A study of 30 patients. Am J Med 75(6):951–956PubMedCrossRef

65.

Ip S et al (2016) Sensitivities of biopsy sites in the endoscopic evaluation of graft-versus-host disease: retrospective review from a tertiary center. Dig Dis Sci 61(8):2351–2356PubMedCrossRef

66.

Novak JM et al (1979) Effects of radiation on the human gastrointestinal tract. J Clin Gastroenterol 1(1):9–39PubMedCrossRef

67.

Seaman WB, Ackerman LV (1957) The effect of radiation on the esophagus; a clinical and histologic study of the effects produced by the betatron. Radiology 68(4):534–541PubMedCrossRef

68.

Taggart MW et al (2013) Oesophageal hyperkeratosis: clinicopathological associations. Histopathology 63(4):463–473PubMed

69.

Kaye MD (1987) Esophageal leukoplakia. Gastrointest Endosc 33(3):254–259PubMedCrossRef

70.

Singhi AD et al (2014) Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients. Mod Pathol 27(1):38–43PubMedCrossRef

71.

Ezoe Y et al (2011) Epidermoid metaplasia of the esophagus: endoscopic feature and differential diagnosis. Hepato-Gastroenterology 58(107–108):809–813PubMed

72.

Postlethwait RW, Musser AW (1974) Changes in the esophagus in 1,000 autopsy specimens. J Thorac Cardiovasc Surg 68(6):953–956PubMedCrossRef

Titel: Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges
verfasst von: Melanie E. Johncilla
Amitabh Srivastava
Publikationsdatum: 15.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 1/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2238-4

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