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01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

BMC Public Health 1/2015

Establishing a birth cohort to investigate the course and aetiology of asthma and allergies across three generations – rationale, design, and methods of the ACROSSOLAR study

BMC Public Health > Ausgabe 1/2015
Tobias Weinmann, Jessica Gerlich, Sabine Heinrich, Dennis Nowak, Jennifer Gerdes, Jenny Schlichtiger, Erika von Mutius, Bianca Schaub, Christian Vogelberg, Diana Roller, Katja Radon
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TW was involved in data collection and management and drafted the manuscript. JesG, SH, KR, and CV are principle investigators for SOLAR and ACROSSOLAR and are responsible for the design, coordination and conduct of the study. They were also involved in drafting the manuscript. JenG and JS made contributions to the field phase of the study, especially collection and management of data. DN, EvM, BS, and DR contributed to the planning and conception of the study. All authors read and approved the final manuscript.



Atopic diseases are a major burden of disease on a global scale. Regarding their aetiology, the early years of life are assumed to play a crucial role. In addition, there is growing evidence that elucidating the impact of cross-generational effects and epigenetic mechanisms such as DNA methylation can substantially widen the scientific knowledge of the occurrence and progression of these diseases. We are thus aiming at following the course of asthma, allergies, and potential risk factors for their occurrence across three generations by establishing a birth cohort in the offspring of an existing population-based cohort.


2051 young adults who have been recruited in 1995 for Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and who have subsequently been followed-up by the Study on Occupational Allergy Risks (SOLAR) are asked bi-annually since 2009 if they conceived a child in the meantime. If parenthood is reported, parents are invited to enrol along with their children in the ACROSSOLAR cohort. Participation involves completing a questionnaire assessing general and health-related information about the course of the pregnancy and the first year of life of their children. Subsequently, the children are followed up until primary school age when asthma and allergies can be diagnosed reliably. In addition, DNA for epigenetic analysis will be collected and analysed. Longitudinal data analysis techniques will then be used to assess potential associations between early-life exposures and onset of childhood asthma and allergies taking into account epigenetics.


Birth cohorts are especially suited to elucidate the impact of genetic predisposition, epigenetics, exposures during the first years of life, and gene-environment interactions on the occurrence and progression of asthma and allergies. By building upon an existing cohort, ACROSSOLAR offers a unique and cost-effective opportunity to investigate the aetiology of atopic disease in a prospective and cross-generational way.
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