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01.12.2016 | Research | Ausgabe 1/2016 Open Access

Radiation Oncology 1/2016

Establishing the feasibility of the dosimetric compliance criteria of RTOG 1308: phase III randomized trial comparing overall survival after photon versus proton radiochemotherapy for inoperable stage II-IIIB NSCLC

Zeitschrift:
Radiation Oncology > Ausgabe 1/2016
Autoren:
Tawfik Giaddui, Wenzhou Chen, Jialu Yu, Liyong Lin, Charles B. Simone II, Lulin Yuan, Yutao U. T. Gong, Q. Jackie Wu, Radhe Mohan, Xiaodong Zhang, Jaques B. Bluett, Michael Gillin, Kevin Moore, Elizabeth O’Meara, Jennifer Presley, Jeffrey D. Bradley, Zhongxing Liao, James Galvin, Ying Xiao
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TG: Analysis of data and writing the manuscript, WC: Analysis of data, JY: Analysis of Data, LL: Designing the dosimetric criteria, treatment plans of first institution and contribution to manuscript writing, CS: Designing of the clinical trial, treatment plans of first institution and contribution to manuscript writing, LY: Developing the KBE model, YG: Analysis of KBE data, JW: Developing the KBE model, designing the dosimetric criteria, RM: Designing the dosimetric criteria, treatment plans of second institution, XZ: Designing the dosimetric criteria, treatment plans of second institution, JB: Designing the dosimetric criteria, treatment plans of second institution, MG: Designing the dosimetric criteria, treatment plans of second institution, KM: Designing the dosimetric criteria, EO: Help in trial development, JP: Help in trial development, JB: Development of the clinical trial, ZL: Clinical trial Chair, Treatment plans of second institution, JG: Help in development and designing of the clinical trial and its compliance criteria, YX: Designing the dosimetric criteria, overall supervision of the study and senior author of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

To establish the feasibility of the dosimetric compliance criteria of the RTOG 1308 trial through testing against Intensity Modulation Radiation Therapy (IMRT) and Passive Scattering Proton Therapy (PSPT) plans.

Methods

Twenty-six lung IMRT and 26 proton PSPT plans were included in the study. Dose Volume Histograms (DVHs) for targets and normal structures were analyzed. The quality of IMRT plans was assessed using a knowledge-based engineering tool.

Results

Most of the RTOG 1308 dosimetric criteria were achieved. The deviation unacceptable rates were less than 10 % for most criteria; however, a deviation unacceptable rate of more than 20 % was computed for the planning target volume minimum dose compliance criterion. Dose parameters for the target volume were very close for the IMRT and PSPT plans. However, the PSPT plans led to lower dose values for normal structures. The dose parameters in which PSPT plans resulted in lower values than IMRT plans were: lung V5Gy (%) (34.4 in PSPT and 47.2 in IMRT); maximum spinal cord dose (31.7 Gy in PSPT and 43.5 Gy in IMRT); heart V5Gy (%) (19 in PSPT and 47 in IMRT); heart V30Gy (%) (11 in PSPT and 19 in IMRT); heart V45Gy (%) (7.8 in PSPT and 12.1 in IMRT); heart V50% (Gy) (7.1 in PSPT and 9.8 in IMRT) and mean heart dose (7.7 Gy in PSPT and 14.9 Gy in IMRT).

Conclusions

The revised RTOG 1308 dosimetric compliance criteria are feasible and achievable.
Literatur
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