Erschienen in:
01.06.2011 | Letter to the Editor
Estimating the correct way of calculating the carboplatin dose
verfasst von:
Jesús F. Sierra-Sánchez, Triana González-Carrascosa
Erschienen in:
Cancer Chemotherapy and Pharmacology
|
Ausgabe 6/2011
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Excerpt
Holweger et al. [
1] calculated carboplatin administered dose by a modified Calvert formula, whereas GFR was substituted by CrCl via 24-h urine collection or calculated by Jelliffe. We do not know how many patients were dosed with 24-h urine collection or with Jelliffe formula in this study. Observed the measured AUC results (5.8 ± 1.1 mg/ml × min) and the predicted AUC with 24-h urine collection estimation (4.8 ± 1.1 mg/ml × min), it is probably that most patients were dosified using this estimation. …