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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Dong-Sik Cho, Sookyoung Woo, Seonwoo Kim, Christopher D Byrne, Joon-Hyuk Kong, Ki-Chul Sung
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-55) contains supplementary material, which is available to authorized users.
Dong-Sik Cho, Sookyoung Woo contributed equally to this work.

Competing interests

All authors have no relevant conflicts of interests.

Authors’ contributions

K-CS; study concept and design, acquisition of data; analysis and interpretation of data. D-SC; critical revision of the manuscript for important intellectual content. J-HK; critical revision of the manuscript for important intellectual content. SW; acquisition of data; analysis and interpretation of data. SK; acquisition of data; analysis and interpretation of data. CDB; critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.

Abstract

Background

Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration.

Aim and methods

Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.

Results

The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB = −33.12 + 0.675*LDL + 11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937)).

Conclusion

Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.
Zusatzmaterial
Authors’ original file for figure 1
12933_2012_512_MOESM1_ESM.gif
Literatur
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