Skip to main content
Erschienen in: Oral Radiology 2/2017

01.05.2017 | Original Article

Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography

verfasst von: Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintaro Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura

Erschienen in: Oral Radiology | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer.

Methods

Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as “pressure,” “wedge-shaped,” or “permeated.” Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived.

Results

The correlation between TD and MS was significant (Spearman rank correlation ρ = 0.552, p < 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: \( D \, = \, - 2.801 \, + \, 0.093x \, + \, 0.872y \), where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was −0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p < 0.05). The cut-off value for classifying cases was −0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified.

Conclusions

MS and TD are useful predictors of tongue cancer prognosis.
Literatur
1.
Zurück zum Zitat Peters LJ, Withers HD. Applying radiobiological principles to combined modality treatment of head and neck cancer—the time factor. Int J Radiat Oncol Biol Phys. 1997;39:831–6.CrossRefPubMed Peters LJ, Withers HD. Applying radiobiological principles to combined modality treatment of head and neck cancer—the time factor. Int J Radiat Oncol Biol Phys. 1997;39:831–6.CrossRefPubMed
2.
Zurück zum Zitat Yamane M, Ishii J, Izumo T, Nagasawa T, Amagasa T. Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography. Head Neck. 2007;29:307–14.CrossRefPubMed Yamane M, Ishii J, Izumo T, Nagasawa T, Amagasa T. Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography. Head Neck. 2007;29:307–14.CrossRefPubMed
3.
Zurück zum Zitat Kaneoya A, Hasegawa S, Tanaka Y, Omura K. Quantitative analysis of invasive front in tongue cancer using ultrasonography. J Oral Maxillofac Surg. 2009;67:40–6.CrossRefPubMed Kaneoya A, Hasegawa S, Tanaka Y, Omura K. Quantitative analysis of invasive front in tongue cancer using ultrasonography. J Oral Maxillofac Surg. 2009;67:40–6.CrossRefPubMed
4.
Zurück zum Zitat Shintani S, Nakayama B, Matsuura H, Hasegawa Y. Intraoral ultrasonography is useful to evaluate tumor thickness in tongue carcinoma. Am J Surg. 1997;173:345–7.CrossRefPubMed Shintani S, Nakayama B, Matsuura H, Hasegawa Y. Intraoral ultrasonography is useful to evaluate tumor thickness in tongue carcinoma. Am J Surg. 1997;173:345–7.CrossRefPubMed
5.
Zurück zum Zitat Shintani S, Yoshihama Y, Ueyama Y, Terakado N, Kamei S, Fijimoto Y, et al. The usefulness of intraoral ultrasonography in the evaluation of oral cancer. Int J Oral Maxillofac Surg. 2001;30:139–43.CrossRefPubMed Shintani S, Yoshihama Y, Ueyama Y, Terakado N, Kamei S, Fijimoto Y, et al. The usefulness of intraoral ultrasonography in the evaluation of oral cancer. Int J Oral Maxillofac Surg. 2001;30:139–43.CrossRefPubMed
6.
Zurück zum Zitat Shinozaki Y, Jinbu Y, Ito H, Noguchi T, Kusama M, Matsumoto N, et al. Relationship between appearance of tongue carcinoma on intraoral ultrasonography and histopathologic findings. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:634–9.CrossRefPubMed Shinozaki Y, Jinbu Y, Ito H, Noguchi T, Kusama M, Matsumoto N, et al. Relationship between appearance of tongue carcinoma on intraoral ultrasonography and histopathologic findings. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:634–9.CrossRefPubMed
7.
Zurück zum Zitat Natori T, Koga M, Anegawa E, Nakashima Y, Tetsuka M, Yoh J, et al. Usefulness of intra-oral ultrasonography to predict neck metastasis in patients with tongue cancer. Oral Dis. 2008;14:591–9.CrossRefPubMed Natori T, Koga M, Anegawa E, Nakashima Y, Tetsuka M, Yoh J, et al. Usefulness of intra-oral ultrasonography to predict neck metastasis in patients with tongue cancer. Oral Dis. 2008;14:591–9.CrossRefPubMed
8.
Zurück zum Zitat Yuen AP, Ng RW, Lam PK, Ho A. Preoperative measurement of tumor thickness of oral tongue carcinoma with intraoral ultrasonography. Head Neck. 2008;30:230–4.CrossRefPubMed Yuen AP, Ng RW, Lam PK, Ho A. Preoperative measurement of tumor thickness of oral tongue carcinoma with intraoral ultrasonography. Head Neck. 2008;30:230–4.CrossRefPubMed
9.
Zurück zum Zitat Akizuki H. Intraoral ultrasonography in the evaluation of oral neoplasms. Jpn J Oral Maxillofac Surg. 1989;35:479–95.CrossRef Akizuki H. Intraoral ultrasonography in the evaluation of oral neoplasms. Jpn J Oral Maxillofac Surg. 1989;35:479–95.CrossRef
10.
Zurück zum Zitat Kusukawa J, Fukuda K, Yoshida M, Kameyama T. Evaluation of intraoral ultrasonography for squamous cell carcinoma of the tongue. Jpn J Oral Maxillofac Surg. 1999;45:233–40.CrossRef Kusukawa J, Fukuda K, Yoshida M, Kameyama T. Evaluation of intraoral ultrasonography for squamous cell carcinoma of the tongue. Jpn J Oral Maxillofac Surg. 1999;45:233–40.CrossRef
11.
Zurück zum Zitat Choi HG, Jeon EY, Won JY, Kim JH, Lee G, Kim SW, et al. Transbuccal sonographic evaluation of the local extent of tumors of the tongue with pathological correlation. J Clin Ultrasound. 2015;43:412–6.CrossRefPubMed Choi HG, Jeon EY, Won JY, Kim JH, Lee G, Kim SW, et al. Transbuccal sonographic evaluation of the local extent of tumors of the tongue with pathological correlation. J Clin Ultrasound. 2015;43:412–6.CrossRefPubMed
12.
Zurück zum Zitat Baek CH, Son YI, Jeong HS, Chung MK, Park KN, Ko YH, et al. Intraoral sonography-assisted resection of T1-2 tongue cancer for adequate deep resection. Otolaryngol Head Neck Surg. 2008;139:805–10.CrossRefPubMed Baek CH, Son YI, Jeong HS, Chung MK, Park KN, Ko YH, et al. Intraoral sonography-assisted resection of T1-2 tongue cancer for adequate deep resection. Otolaryngol Head Neck Surg. 2008;139:805–10.CrossRefPubMed
13.
Zurück zum Zitat Prabhakaran SS, Ramani P, Thiruvengadam C, Veeraiyan S, Premkumar P, Natesan A, et al. Ultrasonography-guided assessment of surgical margins in oral carcinoma—study of three cases. Commun Oncol. 2008;5:78–80.CrossRef Prabhakaran SS, Ramani P, Thiruvengadam C, Veeraiyan S, Premkumar P, Natesan A, et al. Ultrasonography-guided assessment of surgical margins in oral carcinoma—study of three cases. Commun Oncol. 2008;5:78–80.CrossRef
14.
Zurück zum Zitat Holsinger C. Ultrasonography may hold promise for pre- and intraoperative evaluation of head and neck cancers. Commun Oncol. 2008;5:80–1.CrossRef Holsinger C. Ultrasonography may hold promise for pre- and intraoperative evaluation of head and neck cancers. Commun Oncol. 2008;5:80–1.CrossRef
15.
Zurück zum Zitat Hayashi T. Application of ultrasonography in dentistry. Jpn Dent Sci Rev. 2012;48:5–13.CrossRef Hayashi T. Application of ultrasonography in dentistry. Jpn Dent Sci Rev. 2012;48:5–13.CrossRef
16.
Zurück zum Zitat Shim SJ, Cha J, Koom WS, Kim GE, Lee CG, Choi EC, et al. Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol. 2010;5:43.CrossRefPubMedPubMedCentral Shim SJ, Cha J, Koom WS, Kim GE, Lee CG, Choi EC, et al. Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol. 2010;5:43.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Almangus A, Bello IO, Santti HK, Makinen L, Kauppila JH, Pukkila M, et al. Depth of invasion, tumor budding, and worst pattern of invasion: prognostic indicators in early-stage oral cancer. Head Neck. 2014;36:811–8.CrossRef Almangus A, Bello IO, Santti HK, Makinen L, Kauppila JH, Pukkila M, et al. Depth of invasion, tumor budding, and worst pattern of invasion: prognostic indicators in early-stage oral cancer. Head Neck. 2014;36:811–8.CrossRef
18.
Zurück zum Zitat Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG. Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999;21:517–25.CrossRefPubMed Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG. Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999;21:517–25.CrossRefPubMed
19.
Zurück zum Zitat Keski-Santti H, Atula T, Tornwall J, Koivunen P, Makitie A. Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of the tongue. Oral Oncol. 2006;42:96–101.CrossRefPubMed Keski-Santti H, Atula T, Tornwall J, Koivunen P, Makitie A. Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of the tongue. Oral Oncol. 2006;42:96–101.CrossRefPubMed
20.
Zurück zum Zitat Shintani S, Matsuura H, Hasegawa Y, Nakayama B, Fujimoto J. The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue. Oncology. 1997;54:463–7.CrossRefPubMed Shintani S, Matsuura H, Hasegawa Y, Nakayama B, Fujimoto J. The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue. Oncology. 1997;54:463–7.CrossRefPubMed
21.
Zurück zum Zitat Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis. 1998;4:70–7.CrossRefPubMed Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis. 1998;4:70–7.CrossRefPubMed
22.
Zurück zum Zitat MarkTaylor S, Drover C, MacEachern R, Bullock M, Hart R, Psooy B, et al. Is preoperative ultrasonography accurate in measuring tumor thickness and predicting incidence of cervical metastasis in oral cancer? Oral Oncol. 2010;46:38–41.CrossRef MarkTaylor S, Drover C, MacEachern R, Bullock M, Hart R, Psooy B, et al. Is preoperative ultrasonography accurate in measuring tumor thickness and predicting incidence of cervical metastasis in oral cancer? Oral Oncol. 2010;46:38–41.CrossRef
23.
Zurück zum Zitat Moore C, Kuhns JG, Greenberg RA. Thickness as prognostic aid in upper aerodigestive tract cancer. Arch Surg. 1986;121:1410–4.CrossRefPubMed Moore C, Kuhns JG, Greenberg RA. Thickness as prognostic aid in upper aerodigestive tract cancer. Arch Surg. 1986;121:1410–4.CrossRefPubMed
24.
Zurück zum Zitat Brown B, Barner L, Mazariegos J, Taylor F, Johnson J, Wagner RL. Prognostic factors in mobile tongue and floor of mouth carcinoma. Cancer. 1989;64:1195–202.CrossRefPubMed Brown B, Barner L, Mazariegos J, Taylor F, Johnson J, Wagner RL. Prognostic factors in mobile tongue and floor of mouth carcinoma. Cancer. 1989;64:1195–202.CrossRefPubMed
25.
Zurück zum Zitat Pentenero M, Gandolfo S, Carrozzo M. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of literature. Head Neck. 2005;27:1080–91.CrossRefPubMed Pentenero M, Gandolfo S, Carrozzo M. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of literature. Head Neck. 2005;27:1080–91.CrossRefPubMed
26.
Zurück zum Zitat Chammas MC, Macedo TA, Moyses RA, Gerhard R, Durazzo M, Cernea C, et al. Relationship between the appearance of tongue carcinoma on intraoral sonography and neck metastasis. Oral Radiol. 2011;27:1–7.CrossRef Chammas MC, Macedo TA, Moyses RA, Gerhard R, Durazzo M, Cernea C, et al. Relationship between the appearance of tongue carcinoma on intraoral sonography and neck metastasis. Oral Radiol. 2011;27:1–7.CrossRef
27.
Zurück zum Zitat An SY, Jung EJ, Lee M, Kwon TK, Sung MW, Jeon YK, et al. Factors related to regional recurrence in early stage squamous cell carcinoma of the oral tongue. Clin Exp Otorhinolaryngol. 2008;1:166–70.CrossRefPubMedPubMedCentral An SY, Jung EJ, Lee M, Kwon TK, Sung MW, Jeon YK, et al. Factors related to regional recurrence in early stage squamous cell carcinoma of the oral tongue. Clin Exp Otorhinolaryngol. 2008;1:166–70.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Po Wing Yuen A, Lam KY, Lam LK, Ho CM, Wong A, Chow TL, et al. Prognostic factors of clinically stage I and II oral tongue carcinoma-a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features. Head Neck. 2002;24:513–20.CrossRefPubMed Po Wing Yuen A, Lam KY, Lam LK, Ho CM, Wong A, Chow TL, et al. Prognostic factors of clinically stage I and II oral tongue carcinoma-a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features. Head Neck. 2002;24:513–20.CrossRefPubMed
29.
Zurück zum Zitat Jacobsson PA, Eneroth GM, Killander D, Moberger G, Martensson B. Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol. 1973;12:1–7. Jacobsson PA, Eneroth GM, Killander D, Moberger G, Martensson B. Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol. 1973;12:1–7.
30.
Zurück zum Zitat Yamamoto E, Kohama GI, Sunakawa H, Iwai M, Hiratsuka H. Mode of invasion, bleomycin sensitivity and clinical course in squamous cell carcinoma. Cancer. 1983;51:2175–80.CrossRefPubMed Yamamoto E, Kohama GI, Sunakawa H, Iwai M, Hiratsuka H. Mode of invasion, bleomycin sensitivity and clinical course in squamous cell carcinoma. Cancer. 1983;51:2175–80.CrossRefPubMed
31.
Zurück zum Zitat Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tomoyose T, Tanaka H. The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. J Oral Pathol Med. 2005;34:329–33.CrossRefPubMed Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tomoyose T, Tanaka H. The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. J Oral Pathol Med. 2005;34:329–33.CrossRefPubMed
Metadaten
Titel
Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography
verfasst von
Sitti Fadhillah Oemar Mattalitti
Toshiyuki Kawazu
Shintaro Kawano
Tatsuya Ikari
Hiroko Wada
Kazunori Yoshiura
Publikationsdatum
01.05.2017
Verlag
Springer Singapore
Erschienen in
Oral Radiology / Ausgabe 2/2017
Print ISSN: 0911-6028
Elektronische ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-016-0251-y

Weitere Artikel der Ausgabe 2/2017

Oral Radiology 2/2017 Zur Ausgabe

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.