Background
Methods
Study subjects
Mother | |||
---|---|---|---|
Parameters | Healthy | Obese | Diabetic |
N = 49
| 11 | 23 | 15 |
Maternal age (years) | 25.1 (±3.3) | 30.3 (±1.1) | 35 (±1.2) |
Maternal initial weight (kg) | 58.3 (±2.1) | 74.2 (±2.5) | 77.3 (±2.7) |
Maternal final weight (kg) | 67.9 (±2.6) | 85.6 (±3.2) | 89.4 (±3.9) |
Maternal height (cm) | 156.4 (±2.2) | 157.1 (±1.3) | 157.3 (±1) |
Gestational age at delivery, (weeks) | 38.8 (±0.2) | 38 (±0.4) | 39 (±0.3) |
Initial Maternal BMI (kg/m2) | 24.3 (±0.4) | 30.7 (±0.8) | 31.3 (±0.8) |
Final Maternal BMI (kg/m2) | 27.7 (±0.5) | 34.7 (±1.2) | 36 (±1.4) |
Parity | 1.7 (±0.3) | 2.7 (±0.2) | 2.6 (±0.3) |
Males/Females | 5M/6F | 7M/8F | 11M/11F |
Neonatal birth weight (kg) | 2.87 (±0.14) | 2.88 (±0.09) | 3.22 (±0.09) |
Neonatal birth body length (cm) | 47.9 (±0.6) | 47.9 (±0.4) | 48.3 (±0.7) |
Neonatal head circumference (cm) | 34.4 (±0.3) | 33.8 (±0.2) | 34.7 (±0.3) |
Neonatal BMI | 12.45 (±0.4) | 12.52 (±0.3) | 13.88 (±0.4) |
5-min APGAR score | 9 | 8.9 (±0.07) | 9 (±0.06) |
Leptin and Insulin determination by ELISA
Database
ANN learning and testing
Input Variables (n = 49) | Range | Output variables | Range |
---|---|---|---|
Maternal Morbidity, MM | Healthy, Obese or diabetic | Umbilical cord blood leptin, (ng/ml) | 0.17–27 (mean 5.1) |
Maternal initial weight, MWi (kg) | 49–96 (mean 72) | ||
Maternal final weight, MWf (kg) | 55–117 (mean 83) | Umbilical cord blood insulin, (μU/ml) | 0.7–12 (mean 1.9) |
Maternal height, MH (cm) | 149–173 (mean 157) | ||
Maternal initial BMI, MBMi (kg/m2) | 22–40 (mean 29.5) | ||
Maternal final BMI, MBMf (kg/m2) | 24–42 (mean 33.5) | ||
Gestational age at delivery, GE (weeks) Neonatal gender, NG | 37–41 (mean 39) | ||
Neonatal birth weight, NW (kg) | 2.01–4.19 (mean 2.98) | ||
Neonatal birth body length, NH (cm) | 45–54 (mean 48) | ||
Neonatal head circumference, NHC (cm) | 32–37 (mean 34) | ||
Neonatal BMI, NBMI | 10–15 (mean 13) | ||
Parity, P | 1–5 (mean 2.3) | ||
Maternal age, MA (years) | 16–43 (mean 30) |
Statistical test
Results
Mother | |||
---|---|---|---|
Parameters | Healthy | Obese | Diabetic |
N = 49
| 11 | 23 | 15 |
Leptin (ng/ml) | 3.5 (±1) | 6.7 (±1.5) | 4.9 (±0.4) |
Insulin (μU/ml) | 1.3 (±0.4) | 1.06 (±0.08) | 3.6 (±1) |
Proposed ANN perinatal model
Validation of the ANN perinatal model
Leptin | Insulin | ||
---|---|---|---|
alower
| aupper
| alower
| aupper
|
−0.6321
|
0.9118
|
−0.3411
|
0.1564
|
blower
| bupper
| blower
| bupper
|
0.8624
|
1.0833
|
0.9564
|
1.1156
|
Sensitivity analysis of the ANN perinatal model
Proposed ANN prenatal model
Validation of the ANN prenatal model
Leptin | Insulin | ||
---|---|---|---|
alower
| aupper
| alower
| aupper
|
0.8508
|
1.1131
|
0.8838
|
1.0574
|
blower
| bupper
| blower
| bupper
|
−0.8453
|
0.9886
|
−0.2069
|
0.3357
|