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Erschienen in: Breast Cancer Research 1/2000

01.12.2000 | Paper Report

Estrogen receptor β in breast cancer

verfasst von: Balvinder Shoker

Erschienen in: Breast Cancer Research | Ausgabe 1/2000

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Excerpt

Approximately 30-40% of hormone receptor positive breast cancers do not respond to endocrine therapy. The recent discovery of ERβ suggests that the mechanism of action of estrogens is more complex than at first thought. Estrogens bind ERβ with affinity similar to ERα and the transcriptional activation is identical for both receptor forms. Furthermore ERα and ERβ can form biologically functional receptor heterodimers. However, little is known about ERβ expression and its role in breast cancer. …
Literatur
1.
Zurück zum Zitat Jarvinen TAH, Pelto-Huikkl M, Holli K, Isola J: Estrogen receptor β is coexpressed with ERa and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 2000, 156: 29-35.CrossRefPubMedPubMedCentral Jarvinen TAH, Pelto-Huikkl M, Holli K, Isola J: Estrogen receptor β is coexpressed with ERa and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 2000, 156: 29-35.CrossRefPubMedPubMedCentral
Metadaten
Titel
Estrogen receptor β in breast cancer
verfasst von
Balvinder Shoker
Publikationsdatum
01.12.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2000-66708

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