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Odontology
Erschienen in: Odontology 2/2020

03.07.2019 | Review Article

Estrogen signaling impacts temporomandibular joint and periodontal disease pathology

verfasst von: Jennifer L. Robinson, Pamela M. Johnson, Karolina Kister, Michael T. Yin, Jing Chen, Sunil Wadhwa

Erschienen in: Odontology | Ausgabe 2/2020

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Abstract

Women experience a higher incidence of oral diseases including periodontal diseases and temporomandibular joint disease (TMD) implicating the role of estrogen signaling in disease pathology. Fluctuating levels of estrogen during childbearing age potentiates facial pain, high estrogen levels during pregnancy promote gingivitis, and low levels of estrogen during menopause predisposes the TMJ to degeneration and increases alveolar bone loss. In this review, an overview of estrogen signaling pathways in vitro and in vivo that regulate pregnancy-related gingivitis, TMJ homeostasis, and alveolar bone remodeling is provided. Deciphering the specific estrogen signaling pathways for individual oral diseases is crucial for potential new drug therapies to promote and maintain healthy tissue.
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Metadaten
Titel
Estrogen signaling impacts temporomandibular joint and periodontal disease pathology
verfasst von
Jennifer L. Robinson
Pamela M. Johnson
Karolina Kister
Michael T. Yin
Jing Chen
Sunil Wadhwa
Publikationsdatum
03.07.2019
Verlag
Springer Singapore
Erschienen in
Odontology / Ausgabe 2/2020
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-019-00439-1

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