We report for the first time DICER1 mutations in two infantile cerebellar embryonal tumors not otherwise specified (NOS). Two girls, aged 11 months (case 1) and 8 months (case 2) presented with psychomotor delay. Both MRIs showed a midline posterior fossa tumor (Fig. 1a, b). After gross total resection of the tumor, case 1 was treated with two cycles of etoposide/carboplatin. The controlled MRI showed spinal and leptomeningeal metastasis. After a subtotal resection, case 2 was treated according to institutional protocol for infant with high-risk CNS PNET. MRI showed an increase of the residual mass during maintenance chemotherapy.
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