Eu-estrogenemia, WHI, timing and the “geripause”

Excerpt

The premature termination of the Women’s Health Initiative (WHI) in 2002 has dominated the debates in health care for menopausal women for the past 6 years. Each new release of the findings in a particular subset of patients has prompted a re-analysis of the basic question—“to take estrogen or not to take estrogen”. Three decades of observational large-cohort studies have been re-evaluated in the light of WHI findings. In his Personal Perspective published in Menopause entitled, “NIH and WHI—time for a mea culpa and steps beyond”, Wulf Utian, the executive director of the North American Menopause Society (NAMS), chastised the investigators for their interpretations of the WHI data [1]. …