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Journal of Natural Medicines
Erschienen in:

24.10.2024 | Note

Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway

verfasst von: Wenyi Jiang, Zhengyou He, Ruijiao Yao, Wenyan Xiao, Zhiyang Chen, Xia Zeng, Miao Zheng, Jing Wang, Jia Li, Yong Jiang

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition marked by renal fibrosis and persistent inflammation, has become popular. Eucommiae cortex (EC) is a vital herb for strengthening bones and muscles and tonifying the kidneys and liver. In the study, C57 BL/6 mice were given a diet containing 0.2% adenine to create a CKD model. The findings demonstrated that exogenous EC supplementation successfully decreased the levels of creatinine and urea nitrogen, down-regulated the TGF-β1/Smad signaling pathway's expression levels of TGF-β1, α-SMA, Smad3, and phospho-Smad3, and prevented renal fibrosis. Consequently, it was determined that EC might have a nephroprotective impact.

Graphical abstract

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Metadaten
Titel
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
verfasst von
Wenyi Jiang
Zhengyou He
Ruijiao Yao
Wenyan Xiao
Zhiyang Chen
Xia Zeng
Miao Zheng
Jing Wang
Jia Li
Yong Jiang
Publikationsdatum
24.10.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01848-5

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