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29.10.2018 | New Technology | Ausgabe 2/2019

Surgical Endoscopy 2/2019

EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas

Zeitschrift:
Surgical Endoscopy > Ausgabe 2/2019
Autoren:
Jae Min Lee, Hyuk Soon Choi, Hoon Jai Chun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Hong Bae Kim
Wichtige Hinweise
Jae Min Lee and Hyuk Soon Choi have contributed equally to this work.

Abstract

Background

Endoscopic irreversible electroporation (IRE) can be performed using a flexible, thin, needle-shaped electrode for an endoscopic ultrasound (EUS)-guided procedure. This study aimed to evaluate the feasibility and efficacy of performing EUS-guided IRE with endoscopic needle-electrode in porcine pancreas.

Methods

Experimental endoscopic IRE on the pancreas were performed by EUS-guided approach in three pigs and compared with surgical approach in three pigs. The animals were killed after 24 h and their pancreases collected.

Results

IRE ablation using endoscopic needle-electrode was successful technically in EUS-guided approaches for the pancreas. Immediately following IRE, the ablated pancreatic tissue showed no gross change except focal hemorrhage. H&E staining presented a well-demarcated ablation site measuring 1.0–1.5 cm in diameter in the pancreas. TUNEL immunohistochemistry showed diffuse cell death along the puncture site 24 h after IRE. No complication was observed in pigs after endoscopic IRE ablation.

Conclusion

EUS-guided IRE ablation was feasible and effective for pancreas using the newly developed device.

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