Background
Methods
Patients and ascitic fluid and peritoneal lavages collection
EVs isolation
Nanoparticle tracking analysis
Total RNA extraction and OpenArray analysis
Preprocessing and differential expression analysis
Development of predictors
miRNA target genes prediction and bioinformatics analysis
Results
Colon Cancer | Control | |
---|---|---|
Age | ||
Median | 74 | 65 |
Minimum | 50 | 52 |
Maximum | 88 | 90 |
Gender | ||
Female | 12 | 4 |
Male | 7 | 18 |
Pathology | ||
Colon cancer | 19 | – |
ADC low grade | 15 | – |
ADC other types | 4 | – |
Hepatic cirrhosis | – | 20 |
Others | – | 2 |
miRNA | LogFC | p-value | Adj. p-value | AUC | AUC 95% CI_lower | AUC 95% CI_upper | Accuracy | Sensitivity | Specificity |
---|---|---|---|---|---|---|---|---|---|
hsa-miR-199b-5p_478486_mir | − 12.82 | 2.59E−08 | 9.85E−07 | 1 | 1 | 1 | 0.967 | 0.968 | 0.964 |
hsa-miR-150-5p_477918_mir | 2.58 | 7.10E−05 | 3.41E−04 | 0.978 | 0.959 | 0.996 | 0.919 | 0.936 | 0.899 |
hsa-miR-29c-5p_478005_mir | − 2.93 | 2.78E−08 | 9.85E−07 | 0.973 | 0.954 | 0.991 | 0.943 | 0.943 | 0.944 |
hsa-miR-218-5p_477977_mir | − 8.16 | 6.51E−07 | 8.25E−06 | 0.97 | 0.945 | 0.995 | 0.913 | 0.905 | 0.921 |
hsa-miR-99a-3p_479224_mir | − 4.89 | 1.51E−08 | 8.95E−07 | 0.97 | 0.95 | 0.99 | 0.94 | 0.976 | 0.9 |
hsa-miR-383-5p_478079_mir | − 8.33 | 3.55E−15 | 1.26E−12 | 0.968 | 0.952 | 0.985 | 0.939 | 0.94 | 0.938 |
hsa-miR-199a-3p_477961_mir | − 6.16 | 2.84E−09 | 2.65E−07 | 0.968 | 0.942 | 0.994 | 0.905 | 0.92 | 0.887 |
hsa-miR-193a-5p_477954_mir | − 3.62 | 1.32E−06 | 1.56E−05 | 0.962 | 0.932 | 0.991 | 0.873 | 0.852 | 0.897 |
hsa-miR-10b-5p_478494_mir | − 2.79 | 2.58E−07 | 4.17E−06 | 0.957 | 0.93 | 0.983 | 0.871 | 0.875 | 0.866 |
hsa-miR-181c-5p_477934_mir | − 3.52 | 1.23E−05 | 8.74E−05 | 0.952 | 0.929 | 0.974 | 0.833 | 0.859 | 0.803 |
hsa-miR-708-5p_478197_mir | − 6.45 | 9.72E−08 | 2.29E−06 | 0.946 | 0.917 | 0.975 | 0.877 | 0.834 | 0.926 |
hsa-miR-125b-5p_477885_mir | − 2.35 | 9.27E−07 | 1.13E−05 | 0.946 | 0.918 | 0.974 | 0.885 | 0.884 | 0.885 |
hsa-miR-140-5p_477909_mir | − 5.82 | 4.59E−05 | 2.39E−04 | 0.943 | 0.919 | 0.968 | 0.817 | 0.825 | 0.807 |
hsa-miR-451a_478107_mir | − 8.35 | 1.34E−07 | 2.64E−06 | 0.942 | 0.913 | 0.972 | 0.843 | 0.881 | 0.8 |
hsa-miR-148b-3p_477824_mir | − 3.05 | 1.42E−07 | 2.66E−06 | 0.942 | 0.916 | 0.968 | 0.834 | 0.853 | 0.813 |
hsa-miR-130a-3p_477851_mir | − 2.62 | 1.85E−06 | 2.00E−05 | 0.94 | 0.909 | 0.972 | 0.861 | 0.884 | 0.835 |
hsa-miR-214-3p_477974_mir | − 7.59 | 1.19E−07 | 2.49E−06 | 0.937 | 0.901 | 0.972 | 0.896 | 0.94 | 0.846 |
hsa-miR-10a-5p_479241_mir | − 2.19 | 1.44E−02 | 2.82E−02 | 0.937 | 0.906 | 0.969 | 0.897 | 0.904 | 0.889 |
hsa-miR-497-5p_478138_mir | − 3.68 | 2.13E−04 | 8.08E−04 | 0.936 | 0.911 | 0.961 | 0.814 | 0.829 | 0.797 |
hsa-miR-143-3p_477912_mir | − 3.15 | 1.58E−06 | 1.81E−05 | 0.936 | 0.906 | 0.965 | 0.86 | 0.868 | 0.85 |
hsa-miR-20a-5p_478586_mir | − 2.79 | 5.14E−08 | 1.30E−06 | 0.933 | 0.901 | 0.964 | 0.877 | 0.906 | 0.843 |
hsa-miR-29c-3p_479229_mir | − 3.55 | 2.14E−04 | 8.08E−04 | 0.931 | 0.897 | 0.965 | 0.86 | 0.84 | 0.883 |
hsa-miR-17-5p_478447_mir | − 3.68 | 4.83E−05 | 2.41E−04 | 0.93 | 0.893 | 0.966 | 0.874 | 0.898 | 0.847 |
hsa-miR-486-5p_478128_mir | − 11.10 | 2.21E−07 | 3.73E−06 | 0.929 | 0.899 | 0.958 | 0.853 | 0.818 | 0.893 |
hsa-miR-145-5p_477916_mir | − 3.07 | 6.47E−06 | 5.34E−05 | 0.929 | 0.899 | 0.958 | 0.877 | 0.901 | 0.851 |
hsa-miR-214-5p_478768_mir | − 8.13 | 2.33E−08 | 9.85E−07 | 0.923 | 0.885 | 0.96 | 0.877 | 0.906 | 0.844 |
hsa-miR-20b-5p_477804_mir | − 11.65 | 3.73E−09 | 2.65E−07 | 0.921 | 0.887 | 0.956 | 0.883 | 0.879 | 0.887 |
hsa-miR-551b-3p_478159_mir | − 9.71 | 2.07E−10 | 3.68E−08 | 0.919 | 0.885 | 0.953 | 0.852 | 0.906 | 0.79 |
hsa-miR-107_478254_mir | − 4.70 | 1.35E−03 | 3.73E−03 | 0.917 | 0.883 | 0.951 | 0.919 | 0.938 | 0.898 |
hsa-miR-202-5p_478755_mir | − 7.19 | 5.11E−08 | 1.30E−06 | 0.915 | 0.876 | 0.954 | 0.855 | 0.867 | 0.842 |
hsa-miR-93-5p_478210_mir | − 2.84 | 3.88E−04 | 1.30E−03 | 0.915 | 0.875 | 0.954 | 0.86 | 0.872 | 0.847 |
hsa-miR-483-3p_478122_mir | − 7.01 | 3.69E−09 | 2.65E−07 | 0.913 | 0.877 | 0.949 | 0.837 | 0.884 | 0.784 |
hsa-miR-652-3p_478189_mir | − 2.05 | 2.63E−05 | 1.70E−04 | 0.913 | 0.882 | 0.945 | 0.825 | 0.831 | 0.818 |
hsa-miR-29b-3p_478369_mir | − 3.59 | 3.71E−06 | 3.47E−05 | 0.911 | 0.877 | 0.945 | 0.836 | 0.834 | 0.838 |
hsa-miR-328-3p_478028_mir | − 5.03 | 2.86E−04 | 1.01E−03 | 0.908 | 0.874 | 0.941 | 0.819 | 0.798 | 0.842 |
hsa-miR-25-3p_477994_mir | − 2.37 | 3.44E−05 | 1.99E−04 | 0.908 | 0.87 | 0.946 | 0.865 | 0.899 | 0.827 |
hsa-miR-26a-5p_477995_mir | − 2.30 | 1.99E−05 | 1.38E−04 | 0.904 | 0.872 | 0.937 | 0.796 | 0.799 | 0.791 |
hsa-miR-296-5p_477836_mir | − 6.51 | 3.42E−05 | 1.99E−04 | 0.903 | 0.865 | 0.941 | 0.878 | 0.796 | 0.973 |
hsa-miR-144-3p_477913_mir | − 5.05 | 3.53E−05 | 1.99E−04 | 0.903 | 0.867 | 0.938 | 0.827 | 0.85 | 0.801 |
hsa-miR-769-5p_478203_mir | − 3.98 | 3.53E−05 | 1.99E−04 | 0.903 | 0.864 | 0.942 | 0.899 | 0.901 | 0.896 |
hsa-miR-181a-5p_477857_mir | − 2.13 | 5.21E−06 | 4.52E−05 | 0.902 | 0.865 | 0.939 | 0.843 | 0.895 | 0.783 |
hsa-miR-29a-3p_478587_mir | − 3.12 | 1.16E−03 | 3.38E−03 | 0.901 | 0.86 | 0.942 | 0.878 | 0.854 | 0.905 |
hsa-miR-152-3p_477921_mir | − 3.98 | 2.17E−05 | 1.48E−04 | 0.9 | 0.866 | 0.934 | 0.804 | 0.791 | 0.819 |
hsa-miR-125b-1-3p_478665_mir | − 9.13 | 1.93E−07 | 3.42E−06 | 0.895 | 0.86 | 0.931 | 0.86 | 0.868 | 0.851 |
hsa-miR-30a-3p_478273_mir | − 1.66 | 9.38E−05 | 4.27E−04 | 0.891 | 0.854 | 0.928 | 0.812 | 0.793 | 0.834 |
hsa-miR-449b-5p_479528_mir | − 10.10 | 2.30E−08 | 9.85E−07 | 0.889 | 0.846 | 0.932 | 0.88 | 0.908 | 0.847 |
hsa-miR-219a-5p_477980_mir | − 6.58 | 5.10E−07 | 7.54E−06 | 0.889 | 0.852 | 0.926 | 0.84 | 0.854 | 0.824 |
hsa-miR-125a-5p_477884_mir | − 1.40 | 1.48E−03 | 4.02E−03 | 0.888 | 0.846 | 0.93 | 0.827 | 0.84 | 0.813 |
hsa-miR-374b-3p_479421_mir | − 4.64 | 2.15E−06 | 2.24E−05 | 0.887 | 0.845 | 0.929 | 0.8 | 0.791 | 0.81 |
hsa-miR-101-3p_477863_mir | − 4.19 | 6.98E−05 | 3.39E−04 | 0.886 | 0.845 | 0.927 | 0.832 | 0.896 | 0.759 |
hsa-miR-452-5p_478109_mir | − 3.88 | 2.89E−05 | 1.80E−04 | 0.886 | 0.852 | 0.92 | 0.751 | 0.737 | 0.766 |
hsa-miR-193a-3p_478306_mir | − 2.46 | 2.37E−03 | 5.97E−03 | 0.884 | 0.841 | 0.928 | 0.869 | 0.899 | 0.835 |
hsa-miR-148a-3p_477814_mir | − 1.48 | 1.24E−03 | 3.52E−03 | 0.884 | 0.845 | 0.923 | 0.822 | 0.818 | 0.826 |
hsa-miR-133a-3p_478511_mir | − 6.89 | 1.67E−04 | 6.73E−04 | 0.883 | 0.843 | 0.922 | 0.827 | 0.853 | 0.797 |
hsa-miR-675-5p_478196_mir | − 4.22 | 5.46E−06 | 4.61E−05 | 0.883 | 0.845 | 0.92 | 0.766 | 0.721 | 0.817 |
hsa-miR-34a-5p_478048_mir | − 2.04 | 3.41E−05 | 1.99E−04 | 0.882 | 0.841 | 0.922 | 0.823 | 0.801 | 0.848 |
hsa-miR-582-5p_478166_mir | − 8.33 | 3.37E−07 | 5.20E−06 | 0.881 | 0.842 | 0.92 | 0.84 | 0.767 | 0.923 |
hsa-miR-2110_477971_mir | − 4.46 | 2.45E−06 | 2.48E−05 | 0.879 | 0.837 | 0.92 | 0.782 | 0.794 | 0.769 |
hsa-miR-185-5p_477939_mir | − 2.69 | 1.09E−02 | 2.18E−02 | 0.879 | 0.836 | 0.921 | 0.828 | 0.872 | 0.777 |
hsa-miR-144-5p_477914_mir | − 11.46 | 4.47E−08 | 1.30E−06 | 0.877 | 0.833 | 0.921 | 0.873 | 0.944 | 0.791 |
hsa-miR-199a-5p_478231_mir | − 7.83 | 1.24E−04 | 5.31E−04 | 0.877 | 0.831 | 0.923 | 0.772 | 0.712 | 0.84 |
hsa-miR-361-5p_478056_mir | − 1.48 | 9.56E−04 | 2.83E−03 | 0.877 | 0.837 | 0.918 | 0.821 | 0.86 | 0.778 |
hsa-miR-195-5p_477957_mir | − 2.80 | 2.19E−04 | 8.17E−04 | 0.875 | 0.832 | 0.919 | 0.835 | 0.822 | 0.849 |
hsa-miR-136-5p_478307_mir | − 8.01 | 5.88E−07 | 8.03E−06 | 0.873 | 0.834 | 0.913 | 0.828 | 0.821 | 0.836 |
hsa-miR-548d-5p_480870_mir | − 3.80 | 3.79E−03 | 8.96E−03 | 0.873 | 0.827 | 0.919 | 0.755 | 0.65 | 0.875 |
hsa-miR-30b-5p_478007_mir | − 2.55 | 2.64E−03 | 6.47E−03 | 0.873 | 0.829 | 0.916 | 0.774 | 0.795 | 0.751 |
hsa-miR-363-3p_478060_mir | − 8.98 | 3.58E−05 | 1.99E−04 | 0.869 | 0.825 | 0.914 | 0.782 | 0.776 | 0.789 |
hsa-miR-27b-3p_478270_mir | − 2.46 | 2.87E−02 | 4.90E−02 | 0.868 | 0.828 | 0.908 | 0.76 | 0.815 | 0.698 |
hsa-miR-24-3p_477992_mir | − 2.06 | 4.68E−05 | 2.40E−04 | 0.868 | 0.823 | 0.913 | 0.859 | 0.9 | 0.813 |
hsa-miR-499a-5p_478139_mir | − 4.05 | 4.42E−05 | 2.34E−04 | 0.864 | 0.821 | 0.908 | 0.851 | 0.875 | 0.824 |
hsa-miR-15a-5p_477858_mir | − 1.96 | 3.80E−04 | 1.28E−03 | 0.863 | 0.823 | 0.903 | 0.77 | 0.781 | 0.758 |
hsa-miR-31-3p_478012_mir | − 5.27 | 2.92E−04 | 1.02E−03 | 0.86 | 0.817 | 0.904 | 0.799 | 0.766 | 0.836 |
hsa-miR-18a-3p_477944_mir | − 4.70 | 5.55E−05 | 2.74E−04 | 0.859 | 0.817 | 0.901 | 0.761 | 0.747 | 0.777 |
hsa-miR-92a-3p_477827_mir | − 1.48 | 5.48E−04 | 1.74E−03 | 0.859 | 0.811 | 0.907 | 0.813 | 0.822 | 0.804 |
hsa-miR-130b-3p_477840_mir | − 5.57 | 3.72E−04 | 1.27E−03 | 0.858 | 0.815 | 0.901 | 0.748 | 0.644 | 0.866 |
hsa-let-7b-5p_478576_mir | − 1.57 | 5.76E−04 | 1.81E−03 | 0.858 | 0.814 | 0.902 | 0.76 | 0.758 | 0.761 |
hsa-miR-30e-3p_478388_mir | − 4.70 | 5.51E−03 | 1.22E−02 | 0.854 | 0.81 | 0.899 | 0.753 | 0.628 | 0.897 |
hsa-miR-23b-5p_477991_mir | − 3.62 | 3.36E−05 | 1.99E−04 | 0.853 | 0.81 | 0.896 | 0.756 | 0.758 | 0.754 |
hsa-miR-29b-2-5p_478003_mir | − 4.33 | 2.79E−06 | 2.75E−05 | 0.85 | 0.806 | 0.894 | 0.797 | 0.806 | 0.786 |
hsa-miR-30e-5p_479235_mir | − 8.36 | 6.16E−04 | 1.92E−03 | 0.849 | 0.802 | 0.896 | 0.709 | 0.638 | 0.791 |
hsa-miR-200c-3p_478351_mir | − 7.14 | 2.32E−05 | 1.53E−04 | 0.848 | 0.802 | 0.894 | 0.802 | 0.721 | 0.894 |
hsa-miR-1180-3p_477869_mir | − 3.91 | 4.43E−05 | 2.34E−04 | 0.847 | 0.798 | 0.896 | 0.806 | 0.754 | 0.866 |
hsa-miR-190a-5p_478358_mir | − 1.89 | 1.87E−02 | 3.48E−02 | 0.847 | 0.801 | 0.892 | 0.829 | 0.814 | 0.847 |
hsa-miR-151b_477811_mir | − 9.82 | 2.25E−04 | 8.31E−04 | 0.846 | 0.801 | 0.892 | 0.761 | 0.733 | 0.792 |
hsa-miR-505-5p_478957_mir | − 5.86 | 4.24E−05 | 2.32E−04 | 0.846 | 0.801 | 0.891 | 0.796 | 0.805 | 0.786 |
hsa-miR-196b-5p_478585_mir | − 6.46 | 1.86E−06 | 2.00E−05 | 0.845 | 0.795 | 0.894 | 0.767 | 0.67 | 0.879 |
hsa-miR-324-5p_478024_mir | − 1.51 | 8.13E−03 | 1.65E−02 | 0.843 | 0.797 | 0.889 | 0.777 | 0.754 | 0.802 |
hsa-miR-224-5p_477986_mir | − 2.72 | 1.58E−04 | 6.45E−04 | 0.842 | 0.8 | 0.883 | 0.746 | 0.695 | 0.804 |
hsa-miR-139-5p_478312_mir | − 5.12 | 2.43E−04 | 8.80E−04 | 0.839 | 0.794 | 0.885 | 0.727 | 0.725 | 0.729 |
hsa-miR-545-5p_479003_mir | − 5.30 | 8.42E−06 | 6.79E−05 | 0.838 | 0.79 | 0.886 | 0.79 | 0.79 | 0.79 |
hsa-miR-222-3p_477982_mir | − 2.08 | 7.82E−04 | 2.37E−03 | 0.838 | 0.791 | 0.884 | 0.728 | 0.762 | 0.689 |
hsa-miR-340-5p_478042_mir | − 9.05 | 9.31E−06 | 7.18E−05 | 0.836 | 0.79 | 0.882 | 0.803 | 0.817 | 0.786 |
hsa-miR-504-5p_478144_mir | − 3.54 | 1.86E−04 | 7.18E−04 | 0.836 | 0.787 | 0.886 | 0.778 | 0.729 | 0.833 |
hsa-miR-106a-5p_478225_mir | − 10.76 | 4.30E−08 | 1.30E−06 | 0.834 | 0.784 | 0.883 | 0.816 | 0.924 | 0.693 |
hsa-miR-1271-5p_478674_mir | − 9.10 | 3.87E−06 | 3.52E−05 | 0.834 | 0.785 | 0.883 | 0.823 | 0.9 | 0.734 |
hsa-miR-125b-2-3p_478666_mir | − 6.80 | 9.11E−06 | 7.18E−05 | 0.834 | 0.782 | 0.886 | 0.804 | 0.866 | 0.735 |
hsa-miR-339-3p_478325_mir | − 3.60 | 6.56E−03 | 1.39E−02 | 0.834 | 0.782 | 0.886 | 0.778 | 0.692 | 0.876 |
hsa-miR-483-5p_478432_mir | − 6.45 | 5.42E−07 | 7.69E−06 | 0.832 | 0.783 | 0.882 | 0.785 | 0.871 | 0.687 |
hsa-miR-584-5p_478167_mir | − 10.36 | 6.40E−07 | 8.25E−06 | 0.831 | 0.781 | 0.882 | 0.803 | 0.906 | 0.685 |
hsa-miR-17-3p_477932_mir | − 8.43 | 2.22E−05 | 1.49E−04 | 0.831 | 0.779 | 0.883 | 0.805 | 0.861 | 0.741 |
hsa-miR-570-3p_479053_mir | − 4.46 | 1.11E−04 | 4.79E−04 | 0.831 | 0.785 | 0.876 | 0.766 | 0.697 | 0.844 |
hsa-miR-625-5p_479469_mir | − 10.93 | 4.36E−06 | 3.87E−05 | 0.83 | 0.781 | 0.88 | 0.806 | 0.865 | 0.738 |
hsa-miR-196a-5p_478230_mir | − 7.37 | 1.01E−05 | 7.64E−05 | 0.83 | 0.777 | 0.883 | 0.812 | 0.879 | 0.735 |
hsa-miR-7-1-3p_478198_mir | − 7.37 | 1.00E−04 | 4.52E−04 | 0.829 | 0.783 | 0.874 | 0.762 | 0.646 | 0.895 |
hsa-miR-450b-5p_478914_mir | − 9.65 | 1.03E−07 | 2.29E−06 | 0.828 | 0.775 | 0.88 | 0.803 | 0.906 | 0.685 |
hsa-miR-221-5p_478778_mir | − 5.01 | 3.08E−04 | 1.06E−03 | 0.827 | 0.779 | 0.875 | 0.745 | 0.64 | 0.865 |
hsa-miR-128-3p_477892_mir | − 1.32 | 5.21E−03 | 1.16E−02 | 0.823 | 0.772 | 0.874 | 0.743 | 0.741 | 0.746 |
hsa-miR-491-5p_478132_mir | − 3.50 | 1.88E−03 | 4.92E−03 | 0.822 | 0.774 | 0.87 | 0.743 | 0.703 | 0.79 |
hsa-miR-136-3p_477902_mir | − 7.94 | 2.78E−05 | 1.76E−04 | 0.821 | 0.771 | 0.871 | 0.786 | 0.855 | 0.707 |
hsa-miR-101-5p_478620_mir | − 7.44 | 1.09E−05 | 8.08E−05 | 0.819 | 0.766 | 0.873 | 0.812 | 0.877 | 0.738 |
hsa-miR-151a-3p_477919_mir | − 1.93 | 2.85E−04 | 1.01E−03 | 0.819 | 0.769 | 0.87 | 0.803 | 0.854 | 0.745 |
hsa-miR-28-3p_477999_mir | − 2.25 | 4.30E−03 | 1.00E−02 | 0.817 | 0.771 | 0.863 | 0.738 | 0.728 | 0.749 |
hsa-miR-489-3p_478130_mir | − 4.40 | 1.33E−04 | 5.62E−04 | 0.815 | 0.766 | 0.865 | 0.76 | 0.736 | 0.787 |
hsa-miR-106b-3p_477866_mir | − 2.41 | 6.48E−03 | 1.39E−02 | 0.815 | 0.765 | 0.866 | 0.72 | 0.693 | 0.751 |
hsa-miR-324-3p_478023_mir | − 7.87 | 2.85E−04 | 1.01E−03 | 0.814 | 0.766 | 0.861 | 0.761 | 0.686 | 0.847 |
hsa-miR-125a-3p_477883_mir | − 3.24 | 4.18E−04 | 1.39E−03 | 0.811 | 0.76 | 0.862 | 0.765 | 0.741 | 0.791 |
hsa-let-7i-3p_477862_mir | − 6.66 | 4.69E−04 | 1.54E−03 | 0.81 | 0.759 | 0.861 | 0.747 | 0.665 | 0.841 |
hsa-miR-33b-5p_478479_mir | − 5.49 | 2.06E−03 | 5.30E−03 | 0.81 | 0.758 | 0.862 | 0.704 | 0.626 | 0.793 |
hsa-miR-503-5p_478143_mir | − 2.80 | 6.04E−03 | 1.31E−02 | 0.81 | 0.757 | 0.863 | 0.762 | 0.726 | 0.805 |
hsa-miR-301a-3p_477815_mir | − 5.08 | 1.51E−03 | 4.05E−03 | 0.809 | 0.76 | 0.858 | 0.723 | 0.608 | 0.856 |
hsa-miR-330-3p_478030_mir | − 5.72 | 7.79E−04 | 2.37E−03 | 0.805 | 0.754 | 0.856 | 0.761 | 0.645 | 0.892 |
hsa-miR-425-5p_478094_mir | − 1.51 | 2.66E−02 | 4.63E−02 | 0.805 | 0.757 | 0.852 | 0.728 | 0.714 | 0.744 |
hsa-miR-16-2-3p_477931_mir | − 3.32 | 1.12E−02 | 2.22E−02 | 0.804 | 0.747 | 0.862 | 0.78 | 0.769 | 0.793 |
hsa-miR-548k_479374_mir | − 14.17 | 8.73E−03 | 1.76E−02 | 0.801 | 0.757 | 0.845 | 0.718 | 0.654 | 0.79 |
hsa-miR-429_477849_mir | − 2.00 | 1.76E−02 | 3.37E−02 | 0.801 | 0.747 | 0.854 | 0.768 | 0.807 | 0.723 |
hsa-miR-598-3p_478172_mir | − 1.51 | 4.51E−03 | 1.04E−02 | 0.8 | 0.754 | 0.847 | 0.696 | 0.726 | 0.661 |
hsa-miR-887-3p_479189_mir | − 5.41 | 1.42E−04 | 5.95E−04 | 0.799 | 0.748 | 0.85 | 0.737 | 0.632 | 0.858 |
hsa-miR-93-3p_478209_mir | − 4.60 | 2.28E−04 | 8.33E−04 | 0.798 | 0.745 | 0.852 | 0.749 | 0.702 | 0.801 |
hsa-miR-629-5p_478183_mir | − 6.16 | 1.75E−04 | 6.90E−04 | 0.796 | 0.746 | 0.846 | 0.753 | 0.678 | 0.839 |
hsa-miR-21-5p_477975_mir | 1.32 | 7.91E−03 | 1.61E−02 | 0.796 | 0.751 | 0.842 | 0.683 | 0.688 | 0.677 |
hsa-miR-140-3p_477908_mir | − 3.42 | 6.10E−03 | 1.31E−02 | 0.793 | 0.743 | 0.843 | 0.734 | 0.752 | 0.713 |
hsa-miR-425-3p_478093_mir | − 5.28 | 9.90E−04 | 2.90E−03 | 0.792 | 0.74 | 0.844 | 0.728 | 0.588 | 0.888 |
hsa-miR-200a-5p_478752_mir | 3.05 | 2.34E−02 | 4.15E−02 | 0.792 | 0.735 | 0.85 | 0.713 | 0.693 | 0.736 |
hsa-miR-590-3p_478168_mir | − 4.77 | 1.27E−03 | 3.56E−03 | 0.791 | 0.739 | 0.842 | 0.702 | 0.637 | 0.776 |
hsa-miR-30a-5p_479448_mir | − 8.52 | 7.71E−04 | 2.37E−03 | 0.789 | 0.738 | 0.841 | 0.734 | 0.726 | 0.744 |
hsa-let-7 g-3p_477850_mir | − 6.38 | 1.74E−04 | 6.90E−04 | 0.787 | 0.733 | 0.84 | 0.756 | 0.608 | 0.926 |
hsa-miR-542-3p_478153_mir | − 8.15 | 2.88E−06 | 2.76E−05 | 0.786 | 0.729 | 0.842 | 0.778 | 0.901 | 0.638 |
hsa-miR-31-5p_478015_mir | − 1.78 | 7.34E−03 | 1.51E−02 | 0.786 | 0.737 | 0.835 | 0.676 | 0.708 | 0.64 |
hsa-miR-379-5p_478077_mir | − 5.15 | 5.46E−04 | 1.74E−03 | 0.78 | 0.724 | 0.835 | 0.755 | 0.773 | 0.734 |
hsa-miR-194-5p_477956_mir | − 1.66 | 1.21E−03 | 3.48E−03 | 0.78 | 0.724 | 0.836 | 0.778 | 0.861 | 0.683 |
hsa-miR-34c-5p_478052_mir | − 2.51 | 4.47E−03 | 1.04E−02 | 0.779 | 0.726 | 0.832 | 0.685 | 0.639 | 0.738 |
hsa-miR-576-5p_478165_mir | − 6.85 | 8.70E−05 | 4.01E−04 | 0.778 | 0.721 | 0.836 | 0.774 | 0.853 | 0.684 |
hsa-miR-28-5p_478000_mir | − 5.87 | 1.45E−03 | 3.96E−03 | 0.778 | 0.726 | 0.829 | 0.731 | 0.64 | 0.835 |
hsa-miR-708-3p_479162_mir | − 2.77 | 2.27E−03 | 5.75E−03 | 0.772 | 0.715 | 0.828 | 0.738 | 0.74 | 0.736 |
hsa-miR-505-3p_478145_mir | − 2.12 | 3.62E−03 | 8.67E−03 | 0.771 | 0.718 | 0.824 | 0.758 | 0.737 | 0.781 |
hsa-miR-26b-5p_478418_mir | − 1.01 | 2.37E−02 | 4.19E−02 | 0.768 | 0.717 | 0.819 | 0.692 | 0.714 | 0.666 |
hsa-miR-365a-3p_478065_mir | − 4.75 | 2.67E−02 | 4.63E−02 | 0.767 | 0.713 | 0.822 | 0.661 | 0.495 | 0.85 |
hsa-miR-423-3p_478327_mir | − 1.63 | 1.58E−03 | 4.19E−03 | 0.765 | 0.716 | 0.815 | 0.65 | 0.687 | 0.607 |
hsa-miR-338-5p_478038_mir | − 3.61 | 2.40E−03 | 6.01E−03 | 0.761 | 0.703 | 0.819 | 0.704 | 0.719 | 0.687 |
hsa-miR-210-3p_477970_mir | − 1.17 | 1.67E−02 | 3.22E−02 | 0.761 | 0.708 | 0.815 | 0.672 | 0.698 | 0.643 |
hsa-miR-551a_478158_mir | − 5.58 | 1.97E−03 | 5.10E−03 | 0.76 | 0.699 | 0.822 | 0.741 | 0.69 | 0.8 |
hsa-miR-889-3p_478208_mir | − 8.68 | 1.14E−05 | 8.28E−05 | 0.759 | 0.698 | 0.82 | 0.789 | 0.922 | 0.637 |
hsa-miR-301b-3p_477825_mir | − 5.75 | 1.87E−02 | 3.48E−02 | 0.758 | 0.7 | 0.816 | 0.751 | 0.851 | 0.637 |
hsa-miR-590-5p_478367_mir | − 3.83 | 1.63E−02 | 3.15E−02 | 0.757 | 0.703 | 0.812 | 0.707 | 0.59 | 0.841 |
hsa-miR-548am-5p_480872_mir | − 3.25 | 1.13E−02 | 2.22E−02 | 0.757 | 0.703 | 0.81 | 0.663 | 0.526 | 0.82 |
hsa-miR-187-3p_477941_mir | − 4.47 | 6.97E−03 | 1.46E−02 | 0.754 | 0.701 | 0.807 | 0.704 | 0.644 | 0.772 |
hsa-miR-450a-5p_478106_mir | − 7.12 | 1.26E−03 | 3.56E−03 | 0.753 | 0.692 | 0.814 | 0.743 | 0.646 | 0.853 |
hsa-miR-376a-5p_478859_mir | − 5.94 | 1.04E−04 | 4.56E−04 | 0.75 | 0.688 | 0.811 | 0.738 | 0.832 | 0.631 |
hsa-miR-1296-5p_479451_mir | − 4.26 | 2.49E−03 | 6.17E−03 | 0.75 | 0.695 | 0.806 | 0.703 | 0.719 | 0.686 |
hsa-miR-181c-3p_477933_mir | − 3.64 | 9.29E−04 | 2.77E−03 | 0.748 | 0.685 | 0.811 | 0.715 | 0.805 | 0.613 |
hsa-miR-1247-5p_477882_mir | − 3.36 | 2.43E−02 | 4.26E−02 | 0.748 | 0.692 | 0.804 | 0.698 | 0.586 | 0.827 |
hsa-miR-34a-3p_478047_mir | − 2.32 | 1.77E−02 | 3.37E−02 | 0.748 | 0.694 | 0.803 | 0.658 | 0.727 | 0.579 |
hsa-miR-654-3p_479135_mir | − 7.56 | 4.77E−04 | 1.55E−03 | 0.74 | 0.681 | 0.799 | 0.76 | 0.692 | 0.839 |
hsa-miR-411-5p_478086_mir | − 5.12 | 7.16E−03 | 1.49E−02 | 0.738 | 0.68 | 0.796 | 0.715 | 0.647 | 0.793 |
hsa-miR-181d-5p_479517_mir | − 5.67 | 4.10E−03 | 9.63E−03 | 0.733 | 0.675 | 0.791 | 0.686 | 0.554 | 0.838 |
hsa-miR-200b-3p_477963_mir | − 3.43 | 7.26E−03 | 1.50E−02 | 0.733 | 0.674 | 0.792 | 0.683 | 0.609 | 0.767 |
hsa-miR-299-3p_478792_mir | − 6.51 | 4.73E−05 | 2.40E−04 | 0.732 | 0.67 | 0.794 | 0.748 | 0.893 | 0.582 |
hsa-miR-182-5p_477935_mir | − 8.68 | 8.37E−05 | 3.91E−04 | 0.73 | 0.666 | 0.795 | 0.753 | 0.9 | 0.585 |
hsa-miR-410-3p_478085_mir | − 5.65 | 1.22E−03 | 3.48E−03 | 0.728 | 0.67 | 0.787 | 0.753 | 0.771 | 0.733 |
hsa-miR-744-5p_478200_mir | − 3.55 | 1.81E−02 | 3.40E−02 | 0.725 | 0.67 | 0.781 | 0.657 | 0.637 | 0.68 |
hsa-miR-96-5p_478215_mir | − 6.84 | 1.03E−04 | 4.56E−04 | 0.724 | 0.658 | 0.79 | 0.744 | 0.886 | 0.583 |
hsa-miR-133b_480871_mir | − 3.18 | 1.98E−02 | 3.66E−02 | 0.724 | 0.664 | 0.783 | 0.686 | 0.651 | 0.726 |
hsa-miR-544a_478156_mir | − 5.67 | 1.37E−03 | 3.77E−03 | 0.719 | 0.66 | 0.779 | 0.756 | 0.81 | 0.694 |
hsa-miR-497-3p_478946_mir | − 6.92 | 1.44E−04 | 5.95E−04 | 0.718 | 0.652 | 0.784 | 0.753 | 0.899 | 0.585 |
hsa-miR-331-3p_478323_mir | − 5.93 | 3.27E−03 | 7.90E−03 | 0.715 | 0.656 | 0.774 | 0.761 | 0.775 | 0.744 |
hsa-let-7f-2-3p_477843_mir | − 3.26 | 1.19E−02 | 2.33E−02 | 0.715 | 0.655 | 0.776 | 0.682 | 0.567 | 0.814 |
hsa-miR-195-3p_478744_mir | − 4.54 | 6.67E−03 | 1.40E−02 | 0.712 | 0.652 | 0.773 | 0.717 | 0.712 | 0.723 |
hsa-miR-378a-5p_478076_mir | − 5.30 | 2.12E−03 | 5.41E−03 | 0.71 | 0.65 | 0.769 | 0.723 | 0.584 | 0.882 |
hsa-miR-1-3p_477820_mir | − 6.27 | 6.10E−03 | 1.31E−02 | 0.706 | 0.644 | 0.768 | 0.732 | 0.778 | 0.679 |
hsa-miR-615-3p_478175_mir | − 3.14 | 4.99E−03 | 1.13E−02 | 0.706 | 0.643 | 0.769 | 0.696 | 0.652 | 0.746 |
hsa-miR-545-3p_479002_mir | − 2.99 | 1.99E−02 | 3.66E−02 | 0.704 | 0.64 | 0.767 | 0.675 | 0.678 | 0.672 |
hsa-miR-548a-3p_478157_mir | − 3.75 | 4.83E−03 | 1.10E−02 | 0.703 | 0.641 | 0.765 | 0.716 | 0.572 | 0.881 |
hsa-miR-1248_478653_mir | − 2.64 | 1.08E−02 | 2.17E−02 | 0.702 | 0.642 | 0.763 | 0.707 | 0.764 | 0.643 |
hsa-miR-381-3p_477816_mir | − 5.10 | 5.97E−03 | 1.31E−02 | 0.701 | 0.639 | 0.763 | 0.734 | 0.727 | 0.742 |
hsa-miR-627-5p_478427_mir | − 4.94 | 5.01E−04 | 1.62E−03 | 0.701 | 0.632 | 0.77 | 0.735 | 0.863 | 0.589 |
hsa-miR-1301-3p_477897_mir | − 5.30 | 5.52E−03 | 1.22E−02 | 0.696 | 0.638 | 0.754 | 0.711 | 0.596 | 0.843 |
hsa-miR-486-3p_478422_mir | − 6.30 | 1.86E−04 | 7.18E−04 | 0.692 | 0.626 | 0.758 | 0.725 | 0.891 | 0.535 |
hsa-miR-200a-3p_478490_mir | − 4.37 | 1.79E−02 | 3.39E−02 | 0.691 | 0.626 | 0.756 | 0.719 | 0.792 | 0.635 |
hsa-miR-15a-3p_477928_mir | − 3.53 | 6.65E−03 | 1.40E−02 | 0.688 | 0.62 | 0.755 | 0.703 | 0.808 | 0.584 |
hsa-miR-548 g-3p_479020_mir | − 2.12 | 2.25E−02 | 4.04E−02 | 0.687 | 0.625 | 0.75 | 0.691 | 0.759 | 0.613 |
hsa-miR-432-5p_478101_mir | − 3.66 | 2.70E−02 | 4.65E−02 | 0.683 | 0.621 | 0.746 | 0.691 | 0.724 | 0.652 |
hsa-miR-15b-5p_478313_mir | − 6.53 | 2.89E−02 | 4.90E−02 | 0.682 | 0.619 | 0.745 | 0.666 | 0.692 | 0.637 |
hsa-miR-132-5p_478705_mir | − 6.01 | 3.23E−03 | 7.86E−03 | 0.68 | 0.614 | 0.745 | 0.734 | 0.867 | 0.582 |
hsa-let-7e-5p_478579_mir | − 5.40 | 2.04E−02 | 3.72E−02 | 0.679 | 0.614 | 0.744 | 0.655 | 0.556 | 0.769 |
hsa-miR-485-5p_478126_mir | − 2.09 | 2.46E−02 | 4.30E−02 | 0.678 | 0.613 | 0.743 | 0.688 | 0.734 | 0.634 |
hsa-miR-299-5p_478793_mir | − 5.05 | 8.70E−04 | 2.62E−03 | 0.672 | 0.603 | 0.741 | 0.702 | 0.858 | 0.524 |
hsa-miR-16-1-3p_478727_mir | − 4.44 | 1.55E−03 | 4.13E−03 | 0.669 | 0.603 | 0.735 | 0.699 | 0.841 | 0.537 |
hsa-miR-215-5p_478516_mir | − 7.23 | 8.19E−05 | 3.88E−04 | 0.668 | 0.601 | 0.735 | 0.718 | 0.896 | 0.514 |
hsa-miR-103a-2-5p_477864_mir | − 4.32 | 2.05E−02 | 3.73E−02 | 0.664 | 0.603 | 0.724 | 0.664 | 0.529 | 0.818 |
hsa-miR-29a-5p_478002_mir | − 6.48 | 2.54E−03 | 6.26E−03 | 0.643 | 0.568 | 0.717 | 0.723 | 0.896 | 0.524 |
hsa-miR-874-3p_478205_mir | − 2.80 | 2.77E−02 | 4.74E−02 | 0.638 | 0.575 | 0.701 | 0.617 | 0.524 | 0.722 |
hsa-miR-502-5p_478954_mir | − 4.03 | 2.18E−02 | 3.93E−02 | 0.637 | 0.573 | 0.701 | 0.662 | 0.53 | 0.813 |
hsa-miR-542-5p_478337_mir | − 5.28 | 3.71E−03 | 8.83E−03 | 0.633 | 0.564 | 0.702 | 0.68 | 0.855 | 0.481 |
hsa-miR-362-3p_478058_mir | − 5.81 | 1.73E−03 | 4.56E−03 | 0.632 | 0.564 | 0.701 | 0.69 | 0.879 | 0.475 |
hsa-miR-431-3p_478888_mir | − 4.55 | 4.63E−03 | 1.06E−02 | 0.624 | 0.552 | 0.696 | 0.678 | 0.853 | 0.478 |
hsa-miR-192-3p_478741_mir | − 4.08 | 5.15E−03 | 1.16E−02 | 0.61 | 0.535 | 0.685 | 0.674 | 0.85 | 0.474 |
hsa-miR-589-5p_479073_mir | − 2.81 | 2.28E−02 | 4.07E−02 | 0.582 | 0.512 | 0.652 | 0.633 | 0.795 | 0.448 |
hsa-miR-888-5p_479192_mir | − 3.79 | 2.06E−02 | 3.73E−02 | 0.559 | 0.489 | 0.63 | 0.656 | 0.861 | 0.422 |
hsa-miR-15b-3p_477929_mir | − 3.73 | 1.76E−02 | 3.37E−02 | 0.529 | 0.459 | 0.599 | 0.629 | 0.86 | 0.365 |
hsa-miR-651-5p_479131_mir | − 3.94 | 2.90E−02 | 4.90E−02 | 0.523 | 0.448 | 0.599 | 0.638 | 0.87 | 0.372 |
Tissue samples | Other type of samples | |
---|---|---|
miR-199b-5p | Not previously reported | Not previously reported |
miR-150-5p | Downregulated: serum [28] | |
miR-29c-5p | Not previously reported | Not previously reported |
miR-218-5p | Upregulated: [29] | Not previously reported |
miR-99a-3p | Not previously reported | Not previously reported |
miR-383-5p | Downregulated: [32] | Not previously reported |
miR-199a-3p | Upregulated: [26] | |
miR-193a-5p | Downregulated in CRC cell lines [35] | Not previously reported |
miR-10b-5p | Not previously reported | |
miR-181c-5p | Upregulated: [38] | Not previously reported |