Background
Methods
Study sample
Measures
Risk group 1 = patients with very high risk | |
---|---|
ATC Code | Agents |
C01DA | Vasodilators used in cardiac diseases (organic nitrates) |
or
| |
B01AC04 | Clopidogrel |
or
| |
B01AC05 | Ticlopidine |
or
| |
C02 and/or C03 and/or C07 and/or C08 and/or C09 | Antihypertensives, diuretics, beta blocking agents, calcium channel blockers, agents acting on the renin-angiotensin system |
and
| |
A10 | Antidiabetics |
and
| |
Male > 49 years or female > 54 years | |
Risk group 2 = patients with high risk
| |
ATC Code
|
Agents
|
C02 | Antihypertensives |
or
| |
C03 | Diuretics |
or
| |
C07 | Beta blocking agents |
or
| |
C08 | Calcium channel blocker |
or
| |
C09 | Agents acting on the renin-angiotensin system |
or
| |
A10 | Antidiabetics |
or
| |
B01AA | Vitamin K antagonists |
or
| |
B01AC06 | Acetyl salicylic acid |
and
| |
Male > 49 years or female > 54 years | |
Risk group 3 = patients with intermediate risk
| |
ATC Code
|
Agents
|
C02 | Antihypertensives |
or
| |
C03 | Diuretics |
or
| |
C07 | Beta blockers |
or
| |
C08 | Calcium channel blocker |
or
| |
C09 | Agents acting on the renin-angiotensin system |
or
| |
A10 | Antidiabetics |
or
| |
B01AA | Vitamin K antagonists |
or
| |
B01AC06 | Acetyl salicylic acid |
Low risk group 4 = all the others
| |
ATC Code
|
Agents
|
All patients with medication > 35 years |
Statistical analysis
Results
Prescribing patterns
Risk group | Statins | Total | Odds ratios | |||
---|---|---|---|---|---|---|
No | Yes | (95% confidence interval) | ||||
Group 1very high risk | Intervention | n | 3745 | 958 | 4703 | |
% | 79.6% | 20.4% | 100.0% | |||
Controls | n | 3534 | 878 | 4412 | 0.97 | |
% | 80.1% | 19.9% | 100.0% | (0.88-1.08) | ||
Group 2 high risk | Intervention | n | 12929 | 1433 | 14362 | |
% | 90.0% | 10.0% | 100.0% | |||
Controls | n | 11647 | 1125 | 12772 | 0.87 | |
% | 91.2% | 8.8% | 100.0% | (0.80-0.95) | ||
Group 3 intermediate risk | Intervention | n | 2496 | 132 | 2628 | |
% | 95.0% | 5.0% | 100.0% | |||
Controls | n | 2412 | 104 | 2516 | 0.82 | |
% | 95.9% | 4.1% | 100.0% | (0.63-1.06) | ||
Group 4 low risk | Intervention | n | 16717 | 469 | 17186 | |
% | 97.3% | 2.7% | 100.0% | |||
Controls | n | 16417 | 391 | 16808 | 0.85 | |
% | 97.7% | 2.3% | 100.0% | (0.74-0.97) |
Risk group | Statins | Total | Odds ratios | |||
---|---|---|---|---|---|---|
No | Yes | (95% confidence interval) | ||||
Group 1 very high risk | Intervention | n | 3905 | 1183 | 5088 | |
% | 76.7% | 23.3% | 100.0% | |||
Controls | n | 3409 | 1069 | 4478 | 1.04 | |
% | 76.1% | 23.9% | 100.0% | (0.94-1.14) | ||
Group 2 high risk | Intervention | n | 14003 | 1735 | 15738 | |
% | 89.0% | 11.0% | 100.0% | |||
Controls | n | 12383 | 1469 | 13852 | 0.96 | |
% | 89.4% | 10.6% | 100.0% | (0.89-1.03) | ||
Group 3 intermediate risk | Intervention | n | 2686 | 149 | 2835 | |
% | 94.7% | 5.3% | 100.0% | |||
Controls | n | 2459 | 127 | 2586 | 0.93 | |
% | 95.1% | 4.9% | 100.0% | (0.73-1.19) | ||
Group 4 low risk | Intervention | n | 16823 | 538 | 17361 | |
% | 96.9% | 3.1% | 100.0% | |||
Controls | n | 15724 | 477 | 16201 | 0.95 | |
% | 97.1% | 2.9% | 100.0% | (0.84-1.08) |
Antidiabetics | Ticlopidine | Clopidogrel | Nitrates | Statins DV | p intervention group | p control group |
---|---|---|---|---|---|---|
No | No | No | Yes | No | p = .0002 | ------ |
No | No | Yes | No | No | p < .000001 | ------ |
No | No | Yes | No | Yes | ------ | p < .000001 |
No | No | Yes | Yes | Yes | p < .000001 | p = .0005 |
Yes | No | No | No | No | p = .000004 | ------ |
Yes | No | No | Yes | No | p = .0005 | ------ |
Yes | No | Yes | No | Yes | ------ | p < .000001 |
Antidiabetics | Ticlopidine | Clopidogrel | Nitrates | Statins DV | p intervention group | p control group |
---|---|---|---|---|---|---|
No | No | No | Yes | No | p = .00009 | p = .0014 |
No | No | Yes | No | Yes | p < .000001 | p < .000001 |
No | No | Yes | Yes | Yes | ------ | p = .0006 |
Yes | No | No | No | No | p < .000001 | p < .000001 |
Yes | No | No | Yes | Yes | p < .000001 | ------ |
Yes | No | Yes | No | Yes | p < .000001 | p < .000001 |
Yes | No | Yes | Yes | Yes | ------ | p = .0003 |