nach oben

Erschienen in:

24.01.2018 | Original Paper

Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients

verfasst von: Sana Maher Hasan Aghbari, Soheir Mohamed Gaafar, Olfat Gamil Shaker, Shahira El Ashiry, Shaimaa Omar Zayed

Erschienen in: Archives of Dermatological Research | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cells against basal epithelial cells. MicroRNAs (MiRNAs) are short non-coding RNA that plays critical role in gene expression at post-transcriptional levels. Much evidence showed that miRNAs play an important role in regulating immune response and cancer development. The purpose of the present study was to compare the expression of miRNA 27b and miRNA 137 in tissues and saliva between OLP patients and controls by using RT-qPCR and to evaluate their use as biomarkers of disease activity and potential malignant transformation. Our results showed down expression of miRNA 27b and miRNA 137 in tissue and saliva of OLP patients compared to controls; among OLP subgroups, erosive-type miRNA 137 revealed the lowest level in tissue and saliva. In conclusion, alteration of miRNA 27b and miRNA 137 gene expression signify their use as biomarkers for diseases activity and tendency of malignant transformation, and down expression of miRNA 137 especially in erosive-type favors the use of saliva sample as a noninvasive method for monitoring a potential malignant transformation of OLP.

Aghbari SM, Abushouk AI, Attia A, Elmaraezy. A, Menshawy. A, Ahmed MS, Elsaadany BA, Ahmed EM (2017) Malignant transformation of oral lichen planus and oral lichenoid lesions: a meta-analysis of 20095 patient data. Oral Oncol 68:92–102. https://doi.org/10.1016/j.oraloncology.2017.03.012 CrossRefPubMed

Akhtar N, Rasheed Z, Ramamurthy S, Anbazhagan AN, Voss FR, Haqqi TM (2010) MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum 62(5):1361–1371. https://doi.org/10.1002/art.27329 CrossRefPubMedPubMedCentral

Arão TC, Guimarães ALS, de Paula AMB, Gomes CC, Gomez RS (2012) Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. Arch Dermatol Res 304(5):371–375. https://doi.org/10.1007/s00403-011-1197-x CrossRefPubMed

Bartel DP, Lee R, Feinbaum R (2004) MicroRNAs: genomics, biogenesis, mechanism and function. Cell 116(2):281–297CrossRefPubMed

Bombeccari GP, Guzzi G, Tettamanti M, Giannì AB, Baj A, Pallotti F, Spadari F (2011) Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(3):328–334. https://doi.org/10.1016/j.tripleo.2011.04.009 CrossRefPubMed

Buck aMYH, Perot J, Chisholm M, Kumar DS, Cognat RIE, Marcinowski L, Tuddenham LEE (2010). Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection. RNA 16(2):307–315. https://doi.org/10.1261/rna.1819210 CrossRefPubMedPubMedCentral

Dai R, Ahmed S (2011) microRNA, a new paradigm for underestanding immunoregulation, inflamation an autoimmune diseases. Transl Res 157(4):163–179. https://doi.org/10.1016/j.trsl.2011.01.007 CrossRefPubMedPubMedCentral

Dang J, Bian Y, Sun JY, Chen F, Dong G, Liu Q, Wang Q et al. (2013) MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med 42(4):315–321. https://doi.org/10.1111/jop.12012 CrossRefPubMed

Danielsson K, Ebrahimi M, Wahlin YB, Nylander K, Boldrup L (2012) Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease. J Eur Acad Dermatol Venereol 26(11):1415–1419. https://doi.org/10.1111/j.1468-3083.2011.04306.x CrossRefPubMed

10.

Danielsson K, Wahlin YB, Gu X, Boldrup L, Nylander K (2012) Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. J Oral Pathol Med 41(1):90–95. https://doi.org/10.1111/j.1600-0714.2011.01084.x CrossRefPubMed

11.

Graham JR, Williams CMM, Yang Z (2014) MicroRNA-27b targets gremlin 1 to modulate fibrotic responses in pulmonary cells. J Cell Biochem 115(9):1539–1548. https://doi.org/10.1002/jcb.24809 CrossRefPubMed

12.

Guerra EN, Acevedo AC, Leite AF, Gozal D, Chardin H, De Luca Canto G (2015) Diagnostic capability of salivary biomarkers in the assessment of head and neck cancer: a systematic review and meta-analysis. Oral Oncol 51(9):805–818. https://doi.org/10.1016/j.oraloncology.2015.06.010 CrossRefPubMed

13.

Hildebrand J, Rütze M, Walz N, Gallinat S, Wenck H, Deppert W, Knott A (2011) A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol 131(1):20–29. https://doi.org/10.1038/jid.2010.268 CrossRefPubMed

14.

Karbiener M, Fischer C, Nowitsch S, Opriessnig P, Papak C, Ailhaud G, Scheideler M et al. (2009) microRNA miR-27b impairs human adipocyte differentiation and targets PPAR gamma. Biochem Biophys Res Commun 390(2):247–251. https://doi.org/10.1016/j.bbrc.2009.09.098 CrossRefPubMed

15.

Kozaki KI, Imoto I, Mogi S, Omura K, Inazawa J (2008) Exploration of tumor-suppressive MicroRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68(7):2094–2105. https://doi.org/10.1158/0008-5472.CAN-07-5194 CrossRefPubMed

16.

Langevin SM, Stone RA, Bunker H, Grandis JR, Sobol RW (2010) MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Carcinogenesis 31(5):864–870. https://doi.org/10.1093/carcin/bgq051 CrossRefPubMedPubMedCentral

17.

Liu G-X, Sun J-T, Yang M-X, Qi X-M, Shao Q-Q, Xie Q, Sun S-Z et al. (2011) OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral lichen planus. Clin Immunol 138(3):291–298. https://doi.org/10.1016/j.clim.2010.12.007 CrossRefPubMed

18.

Navazesh M (1993) Methods for collecting saliva. Ann N Y Acad Sci 694:72–77. https://doi.org/10.1111/j.1749-6632.1993.tb18343.x CrossRefPubMed

19.

Nylander E, Ebrahimi M, Wahlin YB, Boldrup L, Nylander K (2012) Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. J Oral Pathol Med 41(1):86–89. https://doi.org/10.1111/j.1600-0714.2011.01063.x CrossRefPubMed

20.

Pritchard CC, Cheng HH, Tewari M (2012) MicroRNA profiling: approaches and considerations. Nat Rev Genet 13(5):358–369. https://doi.org/10.1038/nrg3198 CrossRefPubMedPubMedCentral

21.

Rad M, Hashemipoor MA, Mojtahedi A, Zarei MR, Chamani G, Kakoei S, Izadi N (2009). Correlation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(6):796–800. https://doi.org/10.1016/j.tripleo.2009.02.020 CrossRefPubMed

22.

Rogler CE, LeVoci L, Ader T, Massimi A, Tchaikovskaya T, Norel R, Rogler LE (2009). MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology, 50(2):575–584. https://doi.org/10.1002/hep.22982 CrossRefPubMed

23.

Schwartz EI, Smilenov LB, Price MA, Osredkar T, Baker RA, Ghosh S, Kruman II (2007). Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle 6(3):318–329. https://doi.org/10.4161/cc.6.3.3752 CrossRefPubMed

24.

Smith AR, Marquez RT, Tsao W, Pathak S, Roy A, Ping J, Kristi L (2015) Tumor suppressive microRNA-137 negatively Musashi-1 and colorectal cancer progression regulates. Oncotarget 6(14):12558–12573. https://doi.org/10.18632/oncotarget.3726 CrossRefPubMedPubMedCentral

25.

Tao X-A, Li C-Y, Xia J, Yang X, Chen X-H, Jian Y-T, Cheng B (2009) Differential gene expression profiles of whole lesions from patients with oral lichen planus. J Oral Pathol Med 38(5):427–433. https://doi.org/10.1111/j.1600-0714.2009.00764.x CrossRefPubMed

26.

Wang J-M, Tao J, Chen D-D, Cai J-J, Irani K, Wang Q, Chen AF (2014) MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 34(1):99–109. https://doi.org/10.1161/ATVBAHA.113.302104 CrossRefPubMed

27.

Zhang W, Liu W, Zhou Y, Shen X, Wang Y, Tang G (2012) Altered microRNA expression profile with miR-27b down-regulation correlated with disease activity of oral lichen planus. Oral Dis 18(3):265–270. https://doi.org/10.1111/j.1601-0825.2011.01869.x CrossRefPubMed

Titel: Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients
verfasst von: Sana Maher Hasan Aghbari
Soheir Mohamed Gaafar
Olfat Gamil Shaker
Shahira El Ashiry
Shaimaa Omar Zayed
Publikationsdatum: 24.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 3/2018
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-018-1805-0

Leitlinien kompakt für die Dermatologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Dermatologie

16.04.2024 | Infektiologie | Nachrichten

Update Dermatologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients

Abstract

Leitlinien kompakt für die Dermatologie

Neu im Fachgebiet Dermatologie

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt

Dupilumab ist mit kutanen T-Zell-Lymphomen assoziiert

Chemotherapie mit Hindernissen

Update Dermatologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2018

Subcutaneous injection of multipotent mesenchymal stromal cells admixed with melanoma cells in mice favors tumor incidence and growth: a systematic review and meta-analysis

Skin depigmenting action of silkworm (Bombyx mori L.) droppings in zebrafish

Construction of a plasmid vector containing epidermal growth factor receptor and C-Jun shRNA

Skin barrier and microbiome in acne

BPDAI and ABSIS correlate with serum anti-BP180 NC16A IgG but not with anti-BP230 IgG in patients with bullous pemphigoid

Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis

Leitlinien kompakt für die Dermatologie

Neu im Fachgebiet Dermatologie

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt

Dupilumab ist mit kutanen T-Zell-Lymphomen assoziiert

Chemotherapie mit Hindernissen

Update Dermatologie