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Erschienen in: The European Journal of Health Economics 6/2017

28.07.2016 | Original Paper

Evaluating the consequences of rheumatoid arthritis

Erschienen in: The European Journal of Health Economics | Ausgabe 6/2017

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Abstract

Patients and non-patients tend to attach different utility values to the state of suffering from specific illnesses. This observation naturally leads to the question whose utility values should be used as the basis in cost-effectiveness analysis (CEA). Intuitively, one would presume that patients are better informed about the consequences of their illness, and public authorities should, therefore, use the patients’ utility values in CEA. Contrary to this presumption, it has been argued that society at large should determine which values are to be used and not the patients because, in the end, it is societal resources that are to be allocated. Against this background, we use data from a discrete choice experiment (DCE) that was completed by patients of rheumatoid arthritis (RA) and non-patients to explore the discrepancies between the two groups' utility estimates for typical consequences of RA. Our results indicate that both groups attach remarkably similar part-worth utilities to the symptoms pain, fatigue, and functional limitations. However, non-patients significantly undervalue the ability to work when compared to patients.
Fußnoten
1
Note that this is a rather conservative estimation. Fuchs et al. [13] report an estimated prevalence of lifetime RA of 2.5 % of all 18–79-year-olds in Germany.
 
2
Note that we employ a generic DCE. That means that the alternatives in our choice sets are not labeled, at least not in a meaningful way.
 
3
We include the lower bounds of the income categories in the regression. The results are, however, robust with regard to significance when alternatively including the category means or the upper bounds and excluding responses from the highest and boundless income category.
 
4
We include the category “3 or more persons” as 3 in the regression analysis.
 
5
Note that a positive sign means that the according level increases choice probability and the respondents were asked to choose the worse of the two alternatives in every choice set.
 
6
Note that this calculation is critically dependent on our assumption regarding the structure of the indirect utility function \(V_{in}\) and our assumption about the absence of significant interaction effects among the mentioned attributes.
 
7
Note that one could of course also analyze the discrepancies between patients and non-patients with regard to the valuation of disease symptoms or consequences by employing TTO and SG.
 
Literatur
1.
Zurück zum Zitat Arns, P.G., Linney, J.A.: Work, self, and life satisfaction for persons with severe and persistent mental disorders. Psychiatr. Rehabil. J. 17(2), 63–79 (1993) Arns, P.G., Linney, J.A.: Work, self, and life satisfaction for persons with severe and persistent mental disorders. Psychiatr. Rehabil. J. 17(2), 63–79 (1993)
2.
Zurück zum Zitat Boyd, N.F., Sutherland, H.J., Heasman, K.Z., Trichtler, D.L., Cummings, B.J.: Whose utilities for decision analysis? Med. Decis. Mak. 10(1), 58–67 (1990)CrossRef Boyd, N.F., Sutherland, H.J., Heasman, K.Z., Trichtler, D.L., Cummings, B.J.: Whose utilities for decision analysis? Med. Decis. Mak. 10(1), 58–67 (1990)CrossRef
3.
Zurück zum Zitat Brazier, J.: Valuing health states for use in cost-effectiveness analysis. Pharmacoeconomics 26(9), 769–779 (2008)CrossRefPubMed Brazier, J.: Valuing health states for use in cost-effectiveness analysis. Pharmacoeconomics 26(9), 769–779 (2008)CrossRefPubMed
4.
Zurück zum Zitat Burton, W., Morrison, A., Maclean, R., Ruderman, E.: Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup. Med. 56(1), 18–27 (2006)CrossRef Burton, W., Morrison, A., Maclean, R., Ruderman, E.: Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup. Med. 56(1), 18–27 (2006)CrossRef
5.
Zurück zum Zitat Campbell, R.C., Batley, M., Hammond, A., Ibrahim, F., Kingsley, G., Scott, D.L.: The impact of disease activity, pain, disability and treatments on fatigue in established rheumatoid arthritis. Clin. Rheumatol. 31(4), 717–722 (2012)CrossRefPubMed Campbell, R.C., Batley, M., Hammond, A., Ibrahim, F., Kingsley, G., Scott, D.L.: The impact of disease activity, pain, disability and treatments on fatigue in established rheumatoid arthritis. Clin. Rheumatol. 31(4), 717–722 (2012)CrossRefPubMed
6.
Zurück zum Zitat Carmona, L., Cross, M., Williams, B., Lassere, M., March, L.: Rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 24(6), 733–745 (2010)CrossRefPubMed Carmona, L., Cross, M., Williams, B., Lassere, M., March, L.: Rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 24(6), 733–745 (2010)CrossRefPubMed
7.
Zurück zum Zitat Covic, T., Adamson, B., Hough, M.: The impact of passive coping on rheumatoid arthritis pain. Rheumatology 39(9), 1027–1030 (2000)CrossRefPubMed Covic, T., Adamson, B., Hough, M.: The impact of passive coping on rheumatoid arthritis pain. Rheumatology 39(9), 1027–1030 (2000)CrossRefPubMed
8.
Zurück zum Zitat de Wit, G.A., Busschbach, J.J., de Charro, F.T.: Sensitivity and perspective in the valuation of health status: whose values count? Health Econ. 9(2), 109–126 (2000)CrossRefPubMed de Wit, G.A., Busschbach, J.J., de Charro, F.T.: Sensitivity and perspective in the valuation of health status: whose values count? Health Econ. 9(2), 109–126 (2000)CrossRefPubMed
9.
Zurück zum Zitat Dolan, P., Kahneman, D.: Interpretations of utility and their implications for the valuation of health. Econ. J. 118(525), 215–234 (2008)CrossRef Dolan, P., Kahneman, D.: Interpretations of utility and their implications for the valuation of health. Econ. J. 118(525), 215–234 (2008)CrossRef
10.
Zurück zum Zitat Emery, D., Barron, F.: Axiomatic and numerical conjoint measurement: an evaluation of diagnostic efficacy. Psychometrika 44(2), 195–210 (1979)CrossRef Emery, D., Barron, F.: Axiomatic and numerical conjoint measurement: an evaluation of diagnostic efficacy. Psychometrika 44(2), 195–210 (1979)CrossRef
11.
Zurück zum Zitat Fifield, J., Reisine, S.T., Grady, K.: Work disability and the experience of pain and depression in rheumatoid arthritis. Soc. Sci. Med. 33(5), 579–585 (1991)CrossRefPubMed Fifield, J., Reisine, S.T., Grady, K.: Work disability and the experience of pain and depression in rheumatoid arthritis. Soc. Sci. Med. 33(5), 579–585 (1991)CrossRefPubMed
12.
Zurück zum Zitat Fox, J.T.: Firm-size wage gaps, job responsibility and hierarchical matching. J. Labor Econ. 27(1), 83–126 (2009)CrossRef Fox, J.T.: Firm-size wage gaps, job responsibility and hierarchical matching. J. Labor Econ. 27(1), 83–126 (2009)CrossRef
13.
Zurück zum Zitat Fuchs, J., Rabenberg, M., Scheidt-Nave, C.: Prevalence of selected musculoskeletal conditions in germany—results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt 56(5), 668–677 (2013) Fuchs, J., Rabenberg, M., Scheidt-Nave, C.: Prevalence of selected musculoskeletal conditions in germany—results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt 56(5), 668–677 (2013)
14.
Zurück zum Zitat Gold, M.R., Siegel, J., Russell, L.B., Weinstein, M.: Cost-effectiveness in Health and Medicine. Oxford University Press, New York (1999) Gold, M.R., Siegel, J., Russell, L.B., Weinstein, M.: Cost-effectiveness in Health and Medicine. Oxford University Press, New York (1999)
15.
Zurück zum Zitat Hauber, A., Arden, N., Mohamed, A., Johnson, F., Peloso, P., Watson, D., Mavros, P., Gammaitoni, A., Sen, S., Taylor, S.: A discrete-choice experiment of United Kingdom patients’ willingness to risk adverse events for improved function and pain control in osteoarthritis. Osteoarthr. Cartil. 21(2), 289–297 (2013)CrossRefPubMed Hauber, A., Arden, N., Mohamed, A., Johnson, F., Peloso, P., Watson, D., Mavros, P., Gammaitoni, A., Sen, S., Taylor, S.: A discrete-choice experiment of United Kingdom patients’ willingness to risk adverse events for improved function and pain control in osteoarthritis. Osteoarthr. Cartil. 21(2), 289–297 (2013)CrossRefPubMed
16.
Zurück zum Zitat Hays, R.D., Vickrey, B.G., Hermann, B.P., Perrine, K., Cramer, J., Meador, K., Spritzer, K., Devinsky, O.: Agreement between self reports and proxy reports of quality of life in epilepsy patients. Qual. Life Res. 4(2), 159–168 (1995)CrossRefPubMed Hays, R.D., Vickrey, B.G., Hermann, B.P., Perrine, K., Cramer, J., Meador, K., Spritzer, K., Devinsky, O.: Agreement between self reports and proxy reports of quality of life in epilepsy patients. Qual. Life Res. 4(2), 159–168 (1995)CrossRefPubMed
17.
Zurück zum Zitat Hensher, D.A., Rose, J.M., Greene, W.H.: Applied Choice Analysis. Cambridge University Press, Cambridge (2007) Hensher, D.A., Rose, J.M., Greene, W.H.: Applied Choice Analysis. Cambridge University Press, Cambridge (2007)
18.
Zurück zum Zitat Johnson, F.R., Lancsar, E., Marshall, D., Kilambi, V., Mühlbacher, A., Regier, D.A., Bresnahan, B., Kannien, B., Bridges, J.F.P.: Constructing experimental designs for discrete-choice experiments: Report of the ISPOR conjoint analysis experimental design good research practices task force. Value Health 16(1), 3–13 (2013)CrossRef Johnson, F.R., Lancsar, E., Marshall, D., Kilambi, V., Mühlbacher, A., Regier, D.A., Bresnahan, B., Kannien, B., Bridges, J.F.P.: Constructing experimental designs for discrete-choice experiments: Report of the ISPOR conjoint analysis experimental design good research practices task force. Value Health 16(1), 3–13 (2013)CrossRef
19.
Zurück zum Zitat Kassenboehmer, S.C., Haisken-DeNew, J.P.: You’re fired! the causal negative effect of entry unemployment on life satisfaction. Econ. J. 119(536), 448–462 (2009)CrossRef Kassenboehmer, S.C., Haisken-DeNew, J.P.: You’re fired! the causal negative effect of entry unemployment on life satisfaction. Econ. J. 119(536), 448–462 (2009)CrossRef
20.
Zurück zum Zitat Kazis, L.E., Meenan, R.F., Anderson, J.J.: Pain in the rheumatic diseases. Investigation of a key health status component. Arthritis Rheum. 26(8), 1017–1022 (1983)CrossRefPubMed Kazis, L.E., Meenan, R.F., Anderson, J.J.: Pain in the rheumatic diseases. Investigation of a key health status component. Arthritis Rheum. 26(8), 1017–1022 (1983)CrossRefPubMed
21.
Zurück zum Zitat Kirchhoff, T., Ruof, J., Mittendorf, T., Rihl, M., Bernateck, M., Mau, W., Zeidler, H., Schmidt, R.E., Merkesdal, S.: Cost of illness in rheumatoid arthritis in germany in 1997–98 and 2002: cost drivers and cost savings. Rheumatology 50(4), 756–761 (2011)CrossRefPubMed Kirchhoff, T., Ruof, J., Mittendorf, T., Rihl, M., Bernateck, M., Mau, W., Zeidler, H., Schmidt, R.E., Merkesdal, S.: Cost of illness in rheumatoid arthritis in germany in 1997–98 and 2002: cost drivers and cost savings. Rheumatology 50(4), 756–761 (2011)CrossRefPubMed
22.
Zurück zum Zitat Kirwan, J.R., Hewlett, S.: Patient perspective: reasons and methods for measuring fatigue in rheumatoid arthritis. J. Rheumatol. 34(5), 1171–1173 (2007)PubMed Kirwan, J.R., Hewlett, S.: Patient perspective: reasons and methods for measuring fatigue in rheumatoid arthritis. J. Rheumatol. 34(5), 1171–1173 (2007)PubMed
23.
Zurück zum Zitat Kløjgaard, M.E., Bech, M., Søgaard, R.: Designing a stated choice experiment: the value of a qualitative process. J. Choice Model. 5(2), 1–18 (2011)CrossRef Kløjgaard, M.E., Bech, M., Søgaard, R.: Designing a stated choice experiment: the value of a qualitative process. J. Choice Model. 5(2), 1–18 (2011)CrossRef
24.
Zurück zum Zitat Krokavcova, M., Nagyoa, I., Rosenberger, J., Gavelova, M., Berrie, M., Gdovinova, Z., Groothoff, J.W., van Dijk, J.P.: Employment status and perceived health status in younger and older people with multiple sclerosis. Int. J. Rehabil. Res. 35(1), 40–47 (2012)CrossRefPubMed Krokavcova, M., Nagyoa, I., Rosenberger, J., Gavelova, M., Berrie, M., Gdovinova, Z., Groothoff, J.W., van Dijk, J.P.: Employment status and perceived health status in younger and older people with multiple sclerosis. Int. J. Rehabil. Res. 35(1), 40–47 (2012)CrossRefPubMed
26.
Zurück zum Zitat Lancsar, E., Louviere, J.: Deleting irrational responses from discrete choice experiments. Health Econ. 15(8), 797–811 (2006)CrossRefPubMed Lancsar, E., Louviere, J.: Deleting irrational responses from discrete choice experiments. Health Econ. 15(8), 797–811 (2006)CrossRefPubMed
27.
Zurück zum Zitat Llewellyn-Thomas, H., Sutherland, H.J., Tibishirani, R., Ciampi, A., Till, J.E., Boyd, N.F.: Describing health states: methodologic issues in obtaining values for health states. Med. Care 22(6), 543–552 (1984)CrossRefPubMed Llewellyn-Thomas, H., Sutherland, H.J., Tibishirani, R., Ciampi, A., Till, J.E., Boyd, N.F.: Describing health states: methodologic issues in obtaining values for health states. Med. Care 22(6), 543–552 (1984)CrossRefPubMed
28.
Zurück zum Zitat Louviere, J.: Conjoint analysis modelling of stated preferences. J. Transp. Econ. Policy 22(1), 93–119 (1988) Louviere, J.: Conjoint analysis modelling of stated preferences. J. Transp. Econ. Policy 22(1), 93–119 (1988)
29.
Zurück zum Zitat Meenan, R.F., Gertman, P.M., Mason, J.H.: Measuring health status in arthritis—the arthritis impact measurement scales. Arthritis Rheum. 23(2), 146–152 (1980)CrossRefPubMed Meenan, R.F., Gertman, P.M., Mason, J.H.: Measuring health status in arthritis—the arthritis impact measurement scales. Arthritis Rheum. 23(2), 146–152 (1980)CrossRefPubMed
30.
Zurück zum Zitat Meenan, R.F., Mason, J.H., Anderson, J.J., Guccione, A.A., Kazis, L.E.: AIMS2—the content and properties of a revised and expanded arthritis impact measurement scales health status questionnaire. Arthritis Rheum. 35(1), 1–10 (1992)CrossRefPubMed Meenan, R.F., Mason, J.H., Anderson, J.J., Guccione, A.A., Kazis, L.E.: AIMS2—the content and properties of a revised and expanded arthritis impact measurement scales health status questionnaire. Arthritis Rheum. 35(1), 1–10 (1992)CrossRefPubMed
31.
Zurück zum Zitat Merkesdal, S., Ruof, J., Schöfski, O., Bernitt, K., Zeidler, H., Mau, W.: Indirect medical costs in early rheumatoid arthritis. Arthritis Rheum. 44(3), 528–534 (2001)CrossRefPubMed Merkesdal, S., Ruof, J., Schöfski, O., Bernitt, K., Zeidler, H., Mau, W.: Indirect medical costs in early rheumatoid arthritis. Arthritis Rheum. 44(3), 528–534 (2001)CrossRefPubMed
32.
Zurück zum Zitat Miguel, F.S., Ryan, M., Amaya-Amaya, M.: Irrational stated preferences: a quantitative and qualitative investigation. Health Econ. 14(3), 307–322 (2005)CrossRefPubMed Miguel, F.S., Ryan, M., Amaya-Amaya, M.: Irrational stated preferences: a quantitative and qualitative investigation. Health Econ. 14(3), 307–322 (2005)CrossRefPubMed
33.
Zurück zum Zitat Minnock, P., Fitzgerald, O., Bresnihan, B.: Women with established rheumatoid arthritis perceive pain as the predominant impairment of health status. Rheumatology 42(8), 995–1000 (2003)CrossRefPubMed Minnock, P., Fitzgerald, O., Bresnihan, B.: Women with established rheumatoid arthritis perceive pain as the predominant impairment of health status. Rheumatology 42(8), 995–1000 (2003)CrossRefPubMed
34.
Zurück zum Zitat Novella, J.L., Jochum, C., Jolly, D., Morrone, I., Ankri, J., Bureau, F., Blanchard, F.: Agreement between patients’ and proxies’ reports of quality of life in Alzheimer’s disease. Qual. Life Res. 10(5), 443–452 (2001)CrossRefPubMed Novella, J.L., Jochum, C., Jolly, D., Morrone, I., Ankri, J., Bureau, F., Blanchard, F.: Agreement between patients’ and proxies’ reports of quality of life in Alzheimer’s disease. Qual. Life Res. 10(5), 443–452 (2001)CrossRefPubMed
35.
Zurück zum Zitat Peeters, Y., Stiggelbout, A.M.: Health state valuations of patients and the general public analytically compared: a meta-analytical comparison of patient and population health state ultilities. Value Health 13(2), 306–309 (2010)CrossRefPubMed Peeters, Y., Stiggelbout, A.M.: Health state valuations of patients and the general public analytically compared: a meta-analytical comparison of patient and population health state ultilities. Value Health 13(2), 306–309 (2010)CrossRefPubMed
36.
Zurück zum Zitat Permain, D., Swanson, J., Kroes, E., Bradley, M.: Stated preference techniques: a guide to practice. Steer Davies Gleave and Hague Consulting Group, London (1991) Permain, D., Swanson, J., Kroes, E., Bradley, M.: Stated preference techniques: a guide to practice. Steer Davies Gleave and Hague Consulting Group, London (1991)
37.
Zurück zum Zitat Pyne, J.M., Fortney, J.C., Tripathi, S., Feeny, D., Ubel, P., Brazier, J.: How bad is depression? Preference score estimates from depressed patients and the general population. Health Serv. Res. 44(4), 1406–1423 (2009)CrossRefPubMedPubMedCentral Pyne, J.M., Fortney, J.C., Tripathi, S., Feeny, D., Ubel, P., Brazier, J.: How bad is depression? Preference score estimates from depressed patients and the general population. Health Serv. Res. 44(4), 1406–1423 (2009)CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Ratcliffe, J., Buxton, M., McGarry, T., Sheldon, R., Chancellor, J.: Patients’ preferences for characteristics associated with treatments for osteoarthritis. Rheumatology 43(3), 337–345 (2004)CrossRefPubMed Ratcliffe, J., Buxton, M., McGarry, T., Sheldon, R., Chancellor, J.: Patients’ preferences for characteristics associated with treatments for osteoarthritis. Rheumatology 43(3), 337–345 (2004)CrossRefPubMed
39.
Zurück zum Zitat Rosemann, T., Körner, T., Wensing, M., Schneider, A., Szecsenyi, J.: Evaluation and cultural adaptation of a German version of the AIMS2-SF questionnaire (German AIMS2-SF). Rheumatology 44(9), 1190–1195 (2005)CrossRefPubMed Rosemann, T., Körner, T., Wensing, M., Schneider, A., Szecsenyi, J.: Evaluation and cultural adaptation of a German version of the AIMS2-SF questionnaire (German AIMS2-SF). Rheumatology 44(9), 1190–1195 (2005)CrossRefPubMed
40.
Zurück zum Zitat Ryan, M., Gerard, K.: Using discrete choice experiments to value health care programmes: current practice and future research reflections. Appl. Health Econ. Health Policy 2(1), 55–64 (2003)PubMed Ryan, M., Gerard, K.: Using discrete choice experiments to value health care programmes: current practice and future research reflections. Appl. Health Econ. Health Policy 2(1), 55–64 (2003)PubMed
41.
Zurück zum Zitat Skjoldborg, U.S., Lauridsen, J., Junker, P.: Reliability of the discrete choice experiment at the input and output level in patients with rheumatoid arthritis. Value Health 12(1), 153–158 (2009)CrossRefPubMed Skjoldborg, U.S., Lauridsen, J., Junker, P.: Reliability of the discrete choice experiment at the input and output level in patients with rheumatoid arthritis. Value Health 12(1), 153–158 (2009)CrossRefPubMed
42.
Zurück zum Zitat Street, D.J., Burgess, L., Louviere, J.J.: Quick and easy choice sets: constructing optimal and nearly optimal stated choice experiments. Int. J. Res. Mark. 22(4), 459–470 (2005)CrossRef Street, D.J., Burgess, L., Louviere, J.J.: Quick and easy choice sets: constructing optimal and nearly optimal stated choice experiments. Int. J. Res. Mark. 22(4), 459–470 (2005)CrossRef
44.
Zurück zum Zitat Ubel, P.A., Loewenstein, G., Hershey, J., Baron, J., Mohr, T., Asch, D.A., Jepson, C.: Do nonpatients underestimate the quality of life associated with chronic health conditions because of a focusing illusion? Med. Decis. Mak. 21(3), 190–199 (2001)CrossRef Ubel, P.A., Loewenstein, G., Hershey, J., Baron, J., Mohr, T., Asch, D.A., Jepson, C.: Do nonpatients underestimate the quality of life associated with chronic health conditions because of a focusing illusion? Med. Decis. Mak. 21(3), 190–199 (2001)CrossRef
45.
Zurück zum Zitat Ubel, P.A., Loewenstein, G., Jepson, C.: Whose quality of life? A commentary exploring discrepanices between health state evaluations of patients and the general public. Qual. Life Res. 12(6), 599–607 (2003)CrossRefPubMed Ubel, P.A., Loewenstein, G., Jepson, C.: Whose quality of life? A commentary exploring discrepanices between health state evaluations of patients and the general public. Qual. Life Res. 12(6), 599–607 (2003)CrossRefPubMed
46.
Zurück zum Zitat Ubel, P.A., Richardson, J., Menzel, P.: Societal value, the person trade-off, and the dilemma of whose values to measure for cost-effectiveness analysis. Health Econ. 9(2), 127–136 (2000)CrossRefPubMed Ubel, P.A., Richardson, J., Menzel, P.: Societal value, the person trade-off, and the dilemma of whose values to measure for cost-effectiveness analysis. Health Econ. 9(2), 127–136 (2000)CrossRefPubMed
47.
Zurück zum Zitat Winkelmann, L., Winkelmann, R.: Why are the unemployed so unhappy? Evidence from panel data. Economica 65(257), 1–15 (1998)CrossRef Winkelmann, L., Winkelmann, R.: Why are the unemployed so unhappy? Evidence from panel data. Economica 65(257), 1–15 (1998)CrossRef
48.
Zurück zum Zitat Wolfe, F., Hawley, D.J., Wilson, K.: The prevalence and meaning of fatigue in rheumatic disease. J. Rheumatol. 23(8), 1407–1417 (1996)PubMed Wolfe, F., Hawley, D.J., Wilson, K.: The prevalence and meaning of fatigue in rheumatic disease. J. Rheumatol. 23(8), 1407–1417 (1996)PubMed
Metadaten
Titel
Evaluating the consequences of rheumatoid arthritis
Publikationsdatum
28.07.2016
Erschienen in
The European Journal of Health Economics / Ausgabe 6/2017
Print ISSN: 1618-7598
Elektronische ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-016-0818-x

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